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Science China Materials 2024年第1期67卷 18-30页

作者：石隽秋孙青梅王文立李畅尹海洋李浩澜滕润鑫范震朱云卿杜建忠 Department of Gynaecology and Obstetrics Shanghai Key Laboratory of Anesthesiology and Brain Functional ModulationClinical Research Center for Anesthesiology and Perioperative MedicineTranslational Research Institute of Brain and Brain-Like IntelligenceShanghai Fourth People’s HospitalSchool of MedicineTongji UniversityShanghai 200434China Department of Polymeric Materials School of Materials Science and EngineeringTongji UniversityShanghai 201804China

作为细胞中的主要运输系统,天然囊泡在物质的定点输运过程中具有至关重要的作用.高分子囊泡是与之结构相似的一种人工囊泡,具有优异的膜稳定性和胶体稳定性、高药物负载率、低膜穿透性、优异的可修饰性和长循环时间等优势,在生物医用领... 详细信息

作为细胞中的主要运输系统,天然囊泡在物质的定点输运过程中具有至关重要的作用.高分子囊泡是与之结构相似的一种人工囊泡,具有优异的膜稳定性和胶体稳定性、高药物负载率、低膜穿透性、优异的可修饰性和长循环时间等优势,在生物医用领域具有广泛的应用前景.然而,目前该领域尚面临一系列重要挑战,如合成和制备方法较为复杂、生物相容性较难预测、功能和递送途径有限等,限制了其临床转化之路.本文从囊泡的构建模块合成、自组装技术和潜在的生物医学应用等角度,提出了设计和制备下一代高分子囊泡需要解决的五个关键科学问题,指出了未来面临的重要挑战和发展方向,例如简化设计和合成过程,优化和规范自组装过程,拓展潜在的应用前景.

关键词：生物医学应用胶体稳定性自组装技术运输系统膜稳定性输运过程穿透性高分子

Zirconium-mediated Selective Synthesis of 1,4-Dialkyl（aryl）-hexa-substituted Benzenes from Two Silyl-substituted Alkynes and One Internal Alkyne

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Chemical Research in Chinese Universities 2016年第3期32卷 366-372页

作者： LI junqiu ZHANG Jiqian QU Hongmei LIU Jun LI Juan ZHOU Lishan Key Laboratory of Systems Bioengineering Ministry of Education Department of Pharmaceutical Engineering School of Chemical Engineering and Technology Tianjin University Tianjin 300072 P. R. China Nantong Dongchang Chemical Industrial Co. Ltd. Nantong 226407 P. R. China CNOOC Tianjin Chemical Research and Design Institute Tianjin 300131 P. R. China

Based on the formation of 2,5-bis（trimethylsilyl）-zirconacyclopentadienes from two silylalkynes with CpEZrBu2 and the Cu-mediated formation of 1,4-disilylbenzene via the cycloaddition of zirconacyclopentadienes to disubstituted alkynes, a selective synthesis of 1,4-dialkyl（aryl）-hexa-substituted benzenes was achieved followed by iodination and coupling reaction. The coupling reactions were carried out with either organolithium reagent or orga- nozinc reagent（Negishi coupling）, depending on the electrophilic species.

关键词： Zirconium Hexa-substituted benzene Iodination Coupling reaction

Review:Research Progress for Electric Vehicle Hub Motor Driving Technology

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Journal of Harbin Institute of Technology(New Series) 2020年第3期27卷 74-91页

作者： junqiu Li Jiwei Liu Chao Sun Fengchun Sun State Engineering Laboratory of Electric Vehicles Beijing Institute of TechnologyBeijing 100081China

Due to high efficiency,high controllability,high integration,lightweight,and other advantages,electric vehicle with hub motor driving technology has become an emerging trend of chassis *** paper concludes the current state⁃of⁃the⁃art of hub motor drive ***,it summarizes recent hub motor drive products and makes suggestions for hub motor drive schemes in different application *** research on hub motor drive key technologies such as integrated design,thermal optimization,lightweight,and intensity optimization is *** the high response accuracy and zero delay characteristic of hub motor driving system combined with advanced distributed dynamics control technology that can further improve vehicle performance,this paper also analyzes existing chassis dynamics control technologies of hub motor driving *** the development trend of vehicle electrification,intelligentization,network connection,and current research,this paper makes some forecasts for hub motor drive technologies development in the conclusion.

关键词： hub motor drive current research integrated optimization technique control technology development direction

蒲公英与木通提取物对断奶仔兔生长性能、肠道健康和药物转运体基因相对表达量的影响

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畜牧兽医学报 2024年第8期55卷 3725-3739页

作者：陈雨修子清 MGENI Musa 施屹张俊秋蒋小雨吕景智孙雅望西南大学动物科学技术学院重庆400715 西南大学动物医学院重庆400715

本试验旨在研究饲粮中添加蒲公英、木通提取物对断奶仔兔生长性能、腹泻情况、肠道形态结构、肠黏膜紧密连接蛋白和肝肠药物转运体蛋白基因表达的影响,探究二者联用对提高中药提取物生物利用度的效果。试验选取120只35日龄断奶仔兔,随... 详细信息

本试验旨在研究饲粮中添加蒲公英、木通提取物对断奶仔兔生长性能、腹泻情况、肠道形态结构、肠黏膜紧密连接蛋白和肝肠药物转运体蛋白基因表达的影响,探究二者联用对提高中药提取物生物利用度的效果。试验选取120只35日龄断奶仔兔,随机分为4个组,每组设置10个重复,每个重复3只兔。试验包括对照组(基础饲粮)、蒲公英组(基础饲粮添加0.5%蒲公英提取物)、木通组(基础饲粮添加0.5%木通提取物)和蒲公英+木通组(基础饲粮分别添加0.5%蒲公英和木通提取物)。试验时间为28 d。试验结果表明:1)第1周蒲公英组和木通组平均日增重显著高于对照组(P<0.05),料重比显著低于对照组(P<0.05)。2)蒲公英组仔兔空肠绒毛高度显著高于木通组(P<0.05)。3)蒲公英+木通组空肠黏膜总黄酮含量显著高于其它各组(P<0.05)。4)蒲公英+木通组闭合小环蛋白1(Z0-1)基因在回肠的相对表达量显著高于蒲公英组和木通组(P<0.05)。5)木通组空肠多药耐药相关蛋白2(MRP-2)、有机阴离子转运多肽2B1(organic anion transporting polypeptide 2B1,OATP2B1)基因的相对表达量显著低于对照组(P<0.05),蒲公英+木通组空肠OATP2B1基因相对表达水平显著低于对照组(P<0.05);蒲公英组和木通组多药耐药相关蛋白3(multidrug resistance-associated protein 3,MRP3)基因在回肠的相对表达量显著低于对照组(P<0.05);蒲公英+木通组乳腺癌耐药相关蛋白(BCRP)、MRP3基因在肝的相对表达量显著低于对照组(P<0.05),木通组和蒲公英+木通组OATP2B1基因在肝的相对表达量显著低于对照组(P<0.05)。综上所述,饲粮中分别添加蒲公英和木通提取物对断奶仔兔的生长性能有所改善,同时添加蒲公英和木通提取物能提高空肠组织总黄酮含量,饲粮中添加蒲公英和木通提取物能调节肝和肠黏膜组织中药物转运体基因表达水平。

关键词：蒲公英木通断奶仔兔生长性能肠道健康总黄酮药物转运体

Micro/nano-scale Characterization and Fatigue Fracture Resistance of Mechanoreceptor with Crack-shaped Slit Arrays in Scorpion

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Journal of Bionic Engineering 2019年第3期16卷 410-422页

作者： Kejun Wang junqiu Zhang Yuqiang Fang Daobing Chen Linpeng Liu Zhiwu Han Luquan Ren Key Laboratory for Bionic Engineerings Ministry of Education Jilin University Changchun 130022 China School of Mechanical and Aerospace Engineering Jilin University Changchun 130022 China

The nocturnal scorpion Heterometrus petersii uses Basitarsal Compound Slit Sensilla (BCSS) as mechanoreceptor to detect mechanical signal (e.g. substrate vibration, cyclic loads caused by walking) without fatigue failure such as initiation of fatigue crack and further propagation of crack-shaped slit. The outstanding perceptive function has been discovered for over half a century. However, it is not yet clear about the microstructure, material composition and micromechanical property which are all important factors that determine the fatigue fracture resistance of the BCSS. Here, the microscopic characteristics of the BCSS were thoroughly studied. The results dicate that anti-fatigue resilin and stiff chitinous cuticle form multilayered composite as the main body of the BCSS. Meanwhile, the pre-existing slit as mechanosensory structure is covered by cuticular membrane which has different mechanical property with the epicuticle. Theoretical analysis shows that the structure-composition-property synergistic relations of composites confer on the BCSS with extreme fatigue fracture tolerance.

关键词： slit-based mechanoreceptor materials characterization multilayered composite resilin fatigue fracture resistance

A Study on the Impact of Enterprise Digital Transformation on Business Model Innovation

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Frontiers of Business Research in China 2023年第4期17卷 498-519页

作者： ZHANG Zhengang ZHANG junqiu YE Baosheng CHEN Yihua School of Business Administration South China University of TechnologyGuangzhou 510641China Guangzhou Digital Innovation Research Center Guangzhou 510641China

Taking knowledge management and entrepreneurial orientation as variables,this study explores the impact mechanism and contextual effects of enterprise digital transformation on business model innovation,based on organization reform theory and the knowledge-based *** findings show that digital transformation has a significant and positive impact on business model innovation,that knowledge management plays an intermediary role in the impact of digital transformation on business model innovation,and that compared tolow-level entrepreneurial orientation,high-level entrepreneurial orientation strengthens the relationship between digital transformation and knowledge management,and weakens therelationship between knowledge management and business model innovation.

关键词： digital transformation business model innovation knowledge management entrepreneurial orientation

Rapid Fabrication of Bio-inspired Antireflection Film Replicating From Cicada Wings

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Journal of Bionic Engineering 2020年第1期17卷 34-44页

作者： Ze Wang Bo Li Xiaoming Feng Zhibin Jiao junqiu Zhang Shichao Niu Zhiwu Han Luquan Ren Key Laboratory of Bionic Engineering(Ministry of Education China)Jilin UniversityChangchun 130022China Department of Chemistry University of California-RiversideCalifornia 92521USA Department of Mechanical Engineering Columbia UniversityNew York 10027USA State Key Laboratory of Automotive Simulation and Control Jilin UniversityChangchun 130022China

Inspired by cicada wings,a flexible film with self-cleaning and broadband antireflection properties was fabricated with a rapid,straightforward and cost-effective *** cicada wing was selected as the original template,and a polymethyl methacrylate (PMMA) negative replica was obtained by evaporation solvent *** original template was directly peeled ***,the polydimethylsiloxane (PDMS) was spread in the as-prepared PMMA negative *** curing and peeling processes,the PDMS positive replica was manufactured *** morphologies and performances of cicada wings were perfectly inherited by the PDMS positive *** is more,the excellent optical property of cicada wing was investigated experimentally and *** with fiat PDMS film,the average reflectivity of structural PDMS film was reduced from 9% to 3.5% in the wavelength range of 500 nm-900 *** excellent antireflection properties of bio-inspired antireflection film can be attributed to the nanostructures which achieve a gradient refractive index between air and the materials,and the mechanism of the antireflection properties was revealed via effective medium ***,the bio-inspired broadband antireflective film exhibited superhydrophobic property after the surface treatment (a 152.1° water contact angle),and it also displayed satisfactory *** work provided a universal method to fabricate the exquisite biological structures,realizing the transfer of structure and ***,the multifunctional antireflection film exhibited the potential value for applications in optical communications,flexible display screens,and anti-dazzle glasses.

关键词： antireflection self-cleaning multifunctional surface flexible film biomimetic fabrication

Dendritic tellurides acting as antioxidants

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Chinese Science Bulletin 2006年第19期51卷 2315-2321页

作者： XU Huaping WANG Yapei WANG Zhiqiang LIU junqiu Mario Smet Wim Dehaen Key Lab of Organic Optoelectronics and Molecular Engineering Department of Chemistry Tsinghua University Beijing 100084 China Key Lab for Supramolecular Structure and Materials College of Chemistry Jilin University Changchun 130023 China Laboratory for Organic Synthesis University of Leuven Celestijnenlaan 200E B-3001 Leuven Belgium

We have described the synthesis of a series of poly(aryl ether) dendrimers with telluride in the core and oligo(ethylene oxide) chains at the pe- riphery which act as glutathione peroxidase (GPx) mimics. These series of compounds were well characterized by H-NMR, 1 13C-NMR and ESI-MS. Using different ROOH (H2O2, cumene hydroperoxide) for testing the antioxidizing properties of these com- pounds, we have found that from generation 0 to 2, the activity of the dendritic GPx mimics first de- creased and then increased. This can be explained on the basis of a greater steric hindrance, going from generation 0 to 1, and stronger binding interactions going from generation 1 to 2. In other words, there exists a balance between binding interactions and steric hindrance that may optimize the GPx activity.

关键词：抗氧化剂碲化物谷胱甘肽过氧化物酶氧化乙烯合成

Protein assembly:Controllable design strategies and applications in biology

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聚集体(英文)

聚集体(英文) 2023年第3期4卷 19-35页

作者： Yijia Li Ruizhen Tian Haolu Shi Jiayun Xu Tingting Wang junqiu Liu College of Material Chemistry and Chemical EngineeringKey Laboratory of Organosilicon Chemistry and Material TechnologyMinistry of EducationKey Laboratory of Organosilicon Material TechnologyZhejiang ProvinceHangzhou Normal UniversityHangzhouChina

Protein assembly is the structural basis for the collaboration between proteins to accomplish life activities due to its realization of the domain-limited and precise spatial arrangement of ***,artificial manipulation of protein selfassembly has profound implications in areas such as exploring the mysteries of life and developing *** this review,we not only summarize the classical assembly strategies and the structures of exquisite protein assemblies,but also aim to generalize the flexible and controllable assembly tools and the“interaction”between the assembled protein-based materials and the external *** the basis of this,the application,challenges and further development of protein assembly in biology are reviewed.

关键词： biomaterials controllable construction strategies protein nanostructures protein self-assembly