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VEXAS综合征的临床特点及治疗现状

医学信息 2024年第13期37卷 174-178页

作者：李竹罗弘志成都中医药大学医学技术学院遵义医科大学第三附属医院/遵义市第一人民医院医学检验科

VEXAS综合征是一种由UBA1体细胞变异引起的具有风湿病和血液学特征的成人起病的炎症综合征，为一种严重的进展性疾病，表现出广泛的器官损害，与其他疾病鉴别困难，该类患者常常辗转于医院各大科室。临床实验室检查缺乏特异性，目前诊... 详细信息

VEXAS综合征是一种由UBA1体细胞变异引起的具有风湿病和血液学特征的成人起病的炎症综合征，为一种严重的进展性疾病，表现出广泛的器官损害，与其他疾病鉴别困难，该类患者常常辗转于医院各大科室。临床实验室检查缺乏特异性，目前诊断完全基于外周血中致病性UBA1变异的基因检测。当前VEXAS综合征缺乏有效的治疗措施，部分患者能通过细胞毒性、酶抑制及免疫抑制治疗缓解病情，而异基因造血干细胞移植也仅在极少数患者中取得较好的治疗效果。VEXAS综合征的临床特征不典型，诊断困难，且缺乏有效的治疗措施，这导致VEXAS综合征死亡率极高，所以及时诊断和尽早采取治疗措施至关重要。本文就VEXAS综合征的临床特点、实验室检查和治疗进行综述，以提高临床医师对VEXAS综合征的认识和诊疗能力。

关键词： VEXAS综合征 UBA1 自身免疫性炎症

Improved early diagnosis of cystadenocarcinoma of the pancreas

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Hepatobiliary & Pancreatic Diseases International 2007年第1期6卷 87-91页

作者： Wu, hong Cheng, Nan-Sheng Zhang, Yan-Ge luo, hong-zhi Yan, Lu-Nan Li, Jin Sichuan Univ W China Hosp Dept Gen Surg Chengdu 610041 Peoples R China

BACKGROUND: Cystadenocarcinoma of the pancreas is insensitive to radiotherapy and chemotherapy, and surgery is at present the definitive treatment. Early and accurate diagnosis of cystadenocarcinoma is crucial for increasing the five-year survival rate and the resectable rate. There is no definitive and effective method of early diagnosis of cystadenocarcinoma of the pancreas in China and other countries. METHODS: We compared endoscopic ultrasonography-guided (EUS-guided) fine needle aspiration biopsy combined with cyst fluid carcinoembryonic antigen (CEA), CA19-9 examination with computed tomography (CT), B-ultrasonography (B-US) and serum CEA and CA19-9, to explore methods of early diagnosis of cystadenocarcinoma of the pancreas. Retrospective analysis was made on the clinical data of 126 cases of benign pancreatic lesion (90 cases) and cystadenocarcinoma (36). RESULTS: The sensitivity of B-US and CT for cystadenocarcinoma was 52.8% and 77.8%, while the specificity was 78.9% and 86.7%, respectively. When measurement of CEA and CA19-9 of cyst fluid was combined with EUS-guided fine needle aspiration biopsy, the sensitivity was 94.4%, higher than that of B-US and CT (P<0.05). The sensitivity of cyst fluid CEA, CA19-9 examinations was considerably higher than that of serum CEA, CA19-9 (P<0.05). Upper gastrointestinal barium meal and endoscopic retrograde cholangiopancreatography (ERCP) had low sensitivity and specificity. CONCLUSIONS: EUS-guided fine needle aspiration biopsy combined with examination of cyst fluid CEA, CA19-9 is a credible means for early diagnosis of cystadenocarcinoma of the pancreas. B-US, CT and serum CEA, CA19-9 measurements are in common use, their findings are also very important.

关键词： cystadenocarcinoma cystadenoma early diagnosis

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酒精戒断相关睡眠障碍的研究进展

中国药物依赖性杂志 2024年第3期33卷 192-197,203页

作者：唐楚文练宇泽罗颖陈倩罗志红周旭辉湖南中医药大学临床医学院长沙410007 湖南省脑科医院(湖南省第二人民医院) 长沙410007

酒精戒断是睡眠障碍的主要原因之一。酒精戒断相关睡眠障碍是酒精成瘾患者停止饮酒之后出现的入睡困难、睡眠维持困难及早醒症状等一系列的睡眠障碍,与酒精成瘾的发生、进展、恶化及复发相关,其机制涉及氨基丁酸、谷氨酸、褪黑素和食欲... 详细信息

酒精戒断是睡眠障碍的主要原因之一。酒精戒断相关睡眠障碍是酒精成瘾患者停止饮酒之后出现的入睡困难、睡眠维持困难及早醒症状等一系列的睡眠障碍,与酒精成瘾的发生、进展、恶化及复发相关,其机制涉及氨基丁酸、谷氨酸、褪黑素和食欲素神经递质的稳态失衡。本文旨在综述酒精依赖戒断相关睡眠障碍的睡眠周期变化、神经生化机制进展以及治疗方法的更新,包括研发中的药物,以期为酒精依赖戒断相关睡眠障碍的干预提供循证和研究方向。

关键词：酒精成瘾酒精戒断失眠睡眠周期作用机制治疗

Epidermal visualized health monitoring system based on stretchable and washable TPU hybrid conductive microtextiles

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Rare Metals 2024年第7期43卷 3185-3193页

作者： Jing-Bo Yuan zhi-hong Feng Dong-Chan Li Yang luo Yun-Lei Zhou School of Chemical Engineering Hebei University of Technology Engineering Research Center of Chemical Technology for Efficient Utilization of Seawater ResourcesMinistry of EducationTianjin 300401China National Key Laboratory of Application Specific Integrated Circuit Shijiazhuang050000China Department of Materials ETH Zürich8093 ZurichSwitzerland Hangzhou Institute of Technology Xidian UniversityHangzhou 311231China

Electronic textiles,an emerging class of electronic technology,offer exciting opportunities for seamless integration with the human *** applications have been developed based on electronic ***,researches on integrating multiple electronic textilebased devices are still *** this study,we present a system integrated with an electrocardiogram monitoring sensor and an electroluminescence device based on stretchable and washable conductive micro *** signal is acquired by an electrocardiograph amplifier and displayed by a dual-color electroluminescence device based on the processed *** integrated electronic device has excellent moisture permeability and comfort for long-term *** system reported in this study opens a new avenue for the application of electronic textiles in health monitoring,robotic prosthetics,and competitive sports.

关键词： Conductive microtextile Textile composite Electronic textile Electroluminescent displays

Combination of diketone and PAO to achieve macroscale oil-based superlubricity at relative high contact pressures

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Friction 2024年第5期12卷 869-883页

作者： Shaonan DU Chenhui ZHANG zhi luo State Key Laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing100084China Beijing National Laboratory of Molecular Sciences CAS Key Laboratory of Engineering PlasticsInstitute of ChemistryChinese Academy of SciencesBeijing100190China

1-(4-ethylphenyl)-nonane-1,3-dione(0206)is an oil-soluble liquid molecule with rod-like *** this study,the chelate(0206-Fe)with octahedral structure was prepared by the reaction of ferric chloride and 1,*** experimental results show that when using 0206 and a mixed solution containing 60%0206-Fe and 40%0206(0206-Fe(60%))as lubricants of the steel friction pairs,superlubricity can be achieved(0.007,0.006).But their wear scar diameters(WSD)were very large(532µm,370µm),which resulted in the pressure of only 44.3 and 61.8 MPa in the contact areas of the friction *** 0206-Fe(60%)was mixed with PAO6,it was found that the friction coefficient(COF)decreased with increase of 0206-Fe(60%)in the *** the ratio of 0206-Fe(60%)to PAO6 was 8:2(PAO6(20%)),it exhibited better comprehensive tribological properties(232.3 MPa).Subsequent studies have shown that reducing the viscosity of the base oil in the mixed solution helped to reduce COF and increased *** the COF,contact pressure,and running-in time,it was found that the mixed lubricant(Oil3(20%))prepared by the base oil with a viscosity of 19.7 mPa·s(Oil3)and 0206-Fe(60%)exhibited the best tribological properties(0.007,161.4 MPa,3,100 s).

关键词： diketone oil-based lubricants chelate superlubricity

Quasi-in-situ Observation and SKPFM Studies on Phosphate Protective Film and Surface Micro-Galvanic Corrosion in Biological Mg-3Zn-xNd Alloys

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Acta Metallurgica Sinica(English Letters) 2024年第4期37卷 648-664页

作者： Zhaochen Yu Kaixuan Feng Shuyun Deng Yang Chen hong Yan honggun Song Chao luo zhi Hu School of Advanced Manufacturing Nanchang UniversityNanchang330031China Institute for Advanced Study Nanchang UniversityNanchang330031China

The phosphate protective film and micro-galvanic corrosion of biological Mg-3Zn-xNd (x = 0, 0.6, 1.2) alloys were investigated by scanning and transmission electron microscopy, quasi-in-situ observation, scanning Kelvin probe force microscopy (SKPFM) and electrochemical tests. The results revealed the Mg-Zn-Nd phases formed in Mg-3Zn alloy contained with Nd. Adding Nd resulted in a significant decline in the cracks of the phosphate protective film and micro-galvanic corrosion of alloys, which were recorded by quasi-in-situ observation. In addition, the Volta potential difference of Mg-Zn-Nd/α-Mg (~ 188 mV) was lower than MgZn/α-Mg (~ 419 mV) and Zn-rich/α-Mg (~ 260 mV), and the corrosion rates of alloys markedly decreased after the addition of 0.6 wt% Nd. The improvement in corrosion resistance of Nd-containing alloys was mainly attributed to the following: (i) the addition of Nd reduced the Volta potential difference (second phases/α-Mg);(ii) the phosphate protective film containing Nd_(2)O_(3) deposited on the surface of the alloys, effectively preventing the penetration of harmful anions.

关键词： Magnesium alloys Quasi-in-situ observation Phosphate protective film Scanning Kelvin probe force microscopy(SKPFM) Micro-galvanic corrosion

Study on the tribological properties of metal rolling bearing under lubrication with diketone lubricants

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Science China(Technological Sciences) 2024年第7期67卷 2003-2017页

作者： DU ShaoNan ZHANG ChenHui luo zhi State Key Laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing 100084China Beijing National Laboratory of Molecular Sciences CAS Key Laboratory of Engineering PlasticsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China

In this article, 1-(4-ethylphenyl)-nonane-1,3-dione(0206) was prepared by Claisen condensation. By mixing 0206, chelate, and base oil in a ratio of 3.2:4.8:2, a diketone lubricant(PAO=14(20%)) that can achieve superlubricity was prepared and applied to bearing lubrication experiments. The experimental results show that when the bearing was lubricated by base oil, the friction coefficient(COF) and temperature rise decreased with the decrease of the viscosity of PAO. When PAO=14(20%) was used as the lubricant, the COF of the bearing was the lowest(0.001), and the wear morphology was comparable to that of the bearing lubricated with commercial lubricant. Compared with the base oil with the same viscosity, it is found that the COF and temperature rise of the bearing lubricated by PAO=14(20%) were lower under any experimental conditions. And when the amount of lubricant added was 10 μL, the COF of the bearing lubricated by PAO=14(20%) reached a very low value(0.0004).Bearing ball surface analysis identified the formation of diketone adsorption films. Combined with the previous PAO=14(20%)superlubricity mechanism, it was considered that the occurrence of tribochemical reaction and the bearing effect of chelates were the main reasons for the existence of ultra-low friction coefficient and low wear. In addition, when there were polar molecules in the lubricant, they were adsorbed on the metal surface through tribochemical reactions, resulting in many irregular pits on the surface.

关键词： superlubricity diketone chelate tribochemical recations bearing lubrication

Clinicopathological characteristics of 15 patients with combined hepatocellular carcinoma and cholangiocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2007年第2期6卷 161-165页

作者： Zuo, Huai-Quan Yan, Lu-Nan Zeng, Yong Yang, Jia-Ying luo, hong-zhi Liu, Jiang-Wen Zhou, Li-Xin Sichuan Univ Dept Gen Surg W China Hosp Chengdu 610041 Peoples R China

BACKGROUND: Combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC) is a rare subtype of primary liver cancer, and clinicopathological features of cHCC-CC have seldom been reported in detail. This study was undertaken to explore the diagnosis and clinicopathological characteristics of cHCC-CC in comparison with hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC), respectively. METHODS: The clinical data from 15 patients with cHCC-CC, 132 patients with HCC and 44 patients with CC who had undergone hepatic resection were analyzed retrospectively. Clinicopathological characteristics of cHCC-CC, HCC and CC such as hepatitis B viral infection, serum hepatitis C virus (HCV) antibody, serum alpha-fetoprotein (AFP) level, cirrhosis, vascular invasion, lymph node metastasis, surgical procedure and adjuvant treatment were also analyzed. Follow up was carried out in the patients, and their 1-, 3-, and 5-year survival rates were calculated. RESULTS: Two patients with cHCC-CC were correctly diagnosed by enhanced CT before operation, the other 13 patients were diagnosed by histology and immunohistochemistry after operation. Radical (8/15) and conservative hepatectomy (7/15) for cHCC-CC was similar to that for HCC and CC (P > 0.05). Pathologically cHCC-CC showed more significantly vascular invasion and lymph node metastasis than HCC (P 0.05). Hepatitis B viral infection, serum HCV antibody, cirrhosis, and serum AFP level of cHCC-CC patients were similar to those of HCC patients (P > 0.05) but different from CC patients (P < 0.05). The cumulative 1-, 3-, and 5-year survival rates in patients with cHCC-CC were poorer than in patients with HCC or CC (P < 0.05). CONCLUSIONS: Patients with cHCC-CC are seldom diagnosed before operation. The progression of cHCC-CC is more rapid than that of HCC or CC. Survival rate of patients with cHCC-CC after hepatic resection is poorer than that of patients with HCC or CC.

关键词： clinicopathological characteristics combined hepatocellular carcinoma and cholangiocarcinoma

Reduction of dinitrogen to ammonia on doped three-atom clusters Nb_(2)M(M=Sc to Cu & Y to Ag)

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Rare Metals 2024年第8期43卷 3810-3818页

作者： Ran Cheng Chao-Nan Cui zhi-Xun luo Beijing National Laboratory for Molecular Science(BNLMS) State Key Laboratory for Structural Chemistry of Unstable and Stable SpeciesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China School of Chemical Science University of Chinese Academy of SciencesBeijing 100049China

Catalytic reduction of dinitrogen to ammonia under mild conditions remains an attractive topic for the purpose of lowering energy ***-atom metal clusters have been proved an ideal model to explore highly efficient catalysts taking advantage of unique geometric/electronic structures and cooperative active *** a study of N2 activation and reduction on seventeen bimetallic Nb_2M(M=Sc to Cu,and Y to Ag) clusters was *** key processes for ammonia fixation(namely nitrogen activation,hydrogenation,and ammonia desorption) are fully studied,and three preferred systems(Nb_2Ni,Nb_2Rh and Nb_2Pd) are highlighted with outstanding catalytic *** d-σ and d-π~* orbital hybridizations between these metal clusters and N_(2) were demonstrated and the internal association with the N≡N bond activation was *** examining the ammonia synthesis on four chosen Nb_(2)M clusters(M=Fe,Ni,Rh and Pd),it can be elucidated that the distal pathway is more favorable than the alternative pathway in these *** work not only clarifies the N_(2) reduction on the bimetallic Nb_(2)M clusters,but also guides efficient bimetallic catalyst design.

关键词： Three-atom cluster catalysis Three-criteria strategy Nitrogen fixation Ammonia synthesis Theoretical calculations