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Phylogeny of SARS-CoV as inferred from complete genome comparison

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Chinese Science Bulletin 2003年第2期48卷 1175-1178页

作者： QI Zhen HU Yu LI Wei CHEN Yanjun ZHANG Zhihua SUN Shiwei LU Hongchao ZHANG Jingfen BU Dongbo ling lunjiang CHEN Runsheng Institute of Biophysics Chinese Academy of SciencesBeijing 100101China Institute of Computing Technology Chinese Academy of SciencesBeijing 100080China Beijing Genomics Institute Chinese Academy of SciencesBeijing 101300China

SARS-CoV, as the pathogeny of severe acute respiratory syndrome (SARS), is a mystery that the origin of the virus is still unknown even a few isolates of the virus were completely sequenced. To explore the genesis of SARS-CoV, the FDOD method previously developed by us was applied to comparing complete genomes from 12 SARS-CoV isolates to those from 12 previously identified coronaviruses and an unrooted phylogenetic tree was constructed. Our results show that all SARS-CoV isolates were clustered into a clique and previously identified coronaviruses formed the other clique. Meanwhile, the three groups of coronaviruses depart from each other clearly in our tree that is consistent with the results of prevenient papers. Differently, from the topology of the phylogenetic tree we found that SARS-CoV is more close to group 1 within genus coronavirus. The topology map also shows that the 12 SARS-CoV isolates may be divided into two groups determined by the association with the SARS-CoV from the Hotel M in Hong Kong that may give some information about the infectious relationship of the SARS.

关键词： SARS-associated coronavirus (SARS-CoV) coronavirus phylogeny infection relationship function of degree of disagreement (FDOD).

DISTINCTION BETWEEN TWO POSSIBLE CONFORMATIONS OF INSULIN B4 (Gln) BY CALCULATIONS

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Chinese Science Bulletin 1986年第21期31卷 1493-1497页

作者：石秀凡凌伦奖倪向善陈润生 Institute of Biophysics Academia Sinica Beijing Institute of Biophysics Academia Sinica Beijingt present the most reliable method for determining the structures of macro-biomolecules should be the X-ray diffraction one but it cannot make the structures clear in every detail. For example reported from abroad there all exist two possible conformations for the 4th residue glutamine and the 22nd residue arginine of the insulin B chain. According to the results of the Insulin Group in Beijing for B22 this possibility is really true while for B4 the electron densities possibly representing the second confor-

At present, the most reliable method for determining the structures of macro-biomolecules should be the X-ray diffraction one, but it cannot make the structures clear in every detail. For example, reported from abroad there all exist two possible conformations for the 4th residue glutamine and the 22nd residue arginine of the insulin B chain. According to the results of the Insulin Group in Beijing, for B22, this possibility is really true, while for B4, the electron densities possibly representing the second confor-

关键词： representing Insulin arginine residue possibly possibility really determining glutamine thank

单核细胞与高密度脂蛋白胆固醇比值与超急性期缺血性脑卒中的相关性研究

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黄冈职业技术学院学报 2023年第1期25卷 87-91页

作者：龚玲陈伦江黄冈职业技术学院医药学院湖北黄冈438002 黄冈市中心医院神经内科湖北黄冈438000

目的探讨单核细胞与高密度脂蛋白胆固醇(HDL-C)比值(MHR)与超急性期缺血性卒中(IS)之间的相关性。方法纳入超急性期IS患者123例为观察组,非脑卒中患者83例为对照组。采用Logistic回归分析MHR与超急性期IS之间的相关性。结果观察组MHR水... 详细信息

目的探讨单核细胞与高密度脂蛋白胆固醇(HDL-C)比值(MHR)与超急性期缺血性卒中(IS)之间的相关性。方法纳入超急性期IS患者123例为观察组,非脑卒中患者83例为对照组。采用Logistic回归分析MHR与超急性期IS之间的相关性。结果观察组MHR水平显著高于对照组(P<0.001)。分析结果显示,校正混杂因素后,MHR是超急性期IS发生的独立危险因素(P=0.013)。此外,将MHR分为4个等级,MHR3级和4级的患者发生超急性期IS的风险显著高于MHR1级的患者(P=0.039;P=0.035)。结论MHR的增加与较高的超急性期IS发生风险独立相关。

关键词：单核细胞高密度脂蛋白胆固醇缺血性脑卒中超急性期