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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 887-898页

作者： Ting wang Zhangzhi Shi Hongyong Zhong Xiangmin Li Jinling Sun Wei Yin Xiaojing Ji Qiang wang Anqi Zhao luning wang School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China

Anterior cruciate ligament(ACL)injuries of the knee are one of the most common and serious athletic injuries.The widely used cortical suspension fixation buttons for ligament reconstruction are permanent implants,particularly those made from conventional steel or titanium alloys.In this study,a biodegradable Zn-0.45Mn-0.2Mg(ZMM42)alloy with the yield strength of 300.4 MPa and tensile strength of 329.8 MPa was prepared through hot extrusion.The use of zinc alloys in the preparation of cortical suspension fixation buttons was proposed for the first time.After 35 d of immersion in simulated body fluids,the ZMM42 alloy fixation buttons were degraded at a rate of 44μm/a,and the fixation strength was retained(379.55 N)in the traction loops.Simultaneously,the ZMM42 alloy fixation buttons exhibited an increase in MC3T3-E1 cell viability and high antibacterial activity against Escherichia coli and Staphylococcus aureus.These results reveal the potential of biodegradable zinc alloys for use as ligament reconstruction materials and for developing diverse zinc alloy cortical suspension fixation devices.

关键词： anterior cruciate ligament reconstruction zinc alloy fixation buttons mechanical property corrosion behavior biocompatibility

New Antibacterial Dihydropyrones Induced by Co-Culture of Penicillium crustosum PRB-2 and Penicillium citrinum HDN11-186

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Journal of Ocean University of China 2024年第1期23卷 216-220页

作者： YU Guihong ZHOU luning WU Guangwei LI Dehai Shandong Province Key Laboratory of Applied Mycology and Qingdao International Center on Microbes Utilizing BiogasSchool of Life SciencesQingdao Agricultural UniversityQingdao 266109China School of Medicine and Pharmacy and Sanya Oceanographic InstitutionOcean University of ChinaQingdao 266003China College of Chemical Engineering Nanjing Forestry UniversityNanjing 210037China Laboratory for Marine Drugs and Bioproducts Laoshan LaboratoryQingdao 266237China

Two new dihydropyrones,rhytismatones C(1)and D(2),and a known compound,penicillenol A1(3),were isolated from the co-culture broth of the deep-sea-derived fungus Penicillium crustosum PRB-2 and Suaeda salsa-derived endophytic fungus Peni-cillium citrinum HDN11-186.Their structures were elucidated through comprehensive analysis of nuclear magnetic resonance(NMR)spectra and mass spectra.The absolute configurations of new compounds were determined by calculating the electronic circular di-chroism(ECD)spectrum.UPLC-MS data showed that compounds 1–3 could only be detected in the media of co-culture,suggesting new biosynthetic pathways were activated in the co-cultured fungi.Compound 1 showed obvious antibacterial activities against Pro-teus sp.MMBC-1002 and Bacillus subtilis MMBC-1004 with minimum inhibitory concentration(MIC)both at 25μmolL^(-1).

关键词： co-culture Penicillium crustosum Penicillium citrinum dihydropyrones antibacterial activity

3D electromagnetic modelling for high-temperature superconducting dynamo flux pumps using T-A formulation

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High Voltage 2024年第2期9卷 367-379页

作者： luning Hao Fangliang Dong Jintao Hu Qi wang Haigening Wei Ismail Patel Adil Shah Yuyang Wu Tim Coombs Department of Engineering University of CambridgeCambridgeUK Plasma Science and Fusion Center Massachusetts Institute of TechnologyCambridgeMassachusettsUSA

A high-temperature superconducting(HTS)dynamo flux pump can inject DC currents into closed-loop HTS magnets without contact.It enables the realisation of current-lead-free or even through-wall charging systems for high-field applications such as nuclear magnetic resonance/magnetic resonance imaging(MRI)magnets,fusion reactors and accelerators.Researchers have proposed many simulation models to understand the working principle of HTS dynamos,few of which are in 3D because of converging problems.Therefore,the influences of many key 3D parameters in the HTS dynamo are scarcely reported.The authors propose an efficient 3D modelling method of the HTS dynamo based on the T-A formulation.The rotating magnets are modelled by a ring-shaped permanent magnet with space-time-variant remanent flux density to avoid moving meshes.This,together with the T-A formulation,makes the 3D model efficient and universal.The accuracy of the model is verified by the experimental instantaneous and time-integrated dynamic voltages.Using this model,the authors present systematic case studies to thoroughly explore the influences of the key parameters of a dynamo flux pump on the dynamic voltage and losses.The proposed modelling method and results could significantly benefit the design and optimisation of HTS dynamos for high-field magnets.

关键词： formulation magnets pump

Comparative analysis of DNA-SIP and magnetic-nanoparticle mediated isolation (MMI) on unraveling dimethoate degraders

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Frontiers of Environmental Science & Engineering 2024年第1期18卷 59-69页

作者： luning Lian Yi Xing Dayi Zhang Longfei Jiang Mengke Song Bo Jiang School of Energy and Environmental Engineering University of Science&Technology BeijingBeijing 100083China Beijing Key Laboratory of Resource-oriented Treatment of Industrial Pollutants University of Science&Technology BeijingBeijing 100083China National Environmental and Energy Science and Technology International Cooperation Base University of Science&Technology BeijingBeijing 100083China College of New Energy and Environment Jilin UniversityChangchun 130021China Guangzhou Institute of Geochemistry Chinese Academy of SciencesGuangzhou 510640China College of Natural Resources and Environment South China Agricultural UniversityGuangzhou 510642China National Engineering Laboratory for Site Remediation Technologies Beijing 100015China

Microorganisms are crucial in the bioremediation of organophosphorus pesticides. However, most functional microorganisms (> 99%) are yet to be cultivated. This study applied two cultivation-independent approaches, DNA-SIP and magnetic-nanoparticle mediated isolation (MMI), to identify the functional microorganisms in degrading dimethoate in agricultural soils. MMI identified five dimethoate degraders: Pseudomonas, Bacillus, Ramlibacter, Arthrobacter, and Rhodococcus, whereas DNA-SIP identified three dimethoate degraders: Ramlibacter, Arthrobacter, and Rhodococcus. Also, MMI showed higher resolution than DNA-SIP in identifying functional microorganisms. Two organic phosphohydrolase (OPH) genes: ophC2 and ophB, were involved in dimethoate metabolism, as revealed by DNA-SIP and MMI. The degradation products of dimethoate include omethoate, O,O,S-trimethyl thiophosphorothioate, N-methyl-2-sulfanylacetamide, O,O-diethyl S-hydrogen phosphorodithioate, O,O,O-trimethyl thiophosphate, O,O,S-trimethyl thiophosphorodithioate, and O,O,O-trimethyl phosphoric. This study emphasizes the feasibility of using SIP and MMI to explore the functional dimethoate degraders, expanding our knowledge of microbial resources with cultivation-independent approaches.

关键词： Stable isotope probing(SIP) Magnetic-nanoparticle mediated isolation(MMI) Dimethoate Biodegradation Cultivation-independent approach

Second phase refining induced optimization of Fe alloying in Zn:Significantly enhanced strengthening effect and corrosion uniformity

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International Journal of Minerals,Metallurgy and Materials 2022年第4期29卷 796-806页

作者： Zhangzhi Shi Changheng Li Meng Li Xiangmin Li luning wang Beijing Advanced Innovation Center for Materials Genome Engineering Key Laboratory for Advanced Materials Processing of Ministry of EducationBeijing Laboratory of Metallic Materials and Processing for Modern TransportationSchool of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China

Many non-toxic alloying elements,such as Fe,Ca,and Sr,have negligible solid solubilities in Zn matrix,leading to formation of coarse second phase particles.They exhibit low strengthening effects but highly detrimental to ductility.So refining second phase is a common pursuit for Zn alloys.The present paper takes Zn-0.3Fe alloy suffered from coarse FeZn_(13) second phase particles as a touchstone to testify microstructure refining effect through solidification with an accelerated speed and multi-pass rolling.FeZn_(13) particles are refined from 24 to 2μm,and Zn grains are refined to 5μm.As a result,the strengthening effect of Fe is enhanced significantly,with yield strength and the ultimate tensile strength of the alloy increased from 132 to 218 MPa and from 159 to 264 MPa,respectively.Furthermore,corrosion non-uniformity and penetration are much alleviated.These results show that microstructure refinement,especially on coarse intermetallic second phases,has a great potential to improve mechanical and degradation properties of biodegradable Zn alloys.

关键词： zinc alloys microstructure mechanical properties corrosion uniformity

Drug-nanoencapsulated PLGA microspheres prepared by emulsion electrospray with controlled release behavior

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Regenerative Biomaterials 2016年第5期3卷 309-317页

作者： Shenglian Yao Huiying Liu Shukui Yu Yuanyuan Li Xiumei wang luning wang School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Department of Oral and Maxillofacial Surgery School of StomatologyDalian Medical UniversityDalian 116044China Institute for Neuroscience Capital Medical UniversityBeijing 100069China

The development of modern therapeutics has raised the requirement for controlled drug delivery system which is able to efficiently encapsulate bioactive agents and achieve their release at a desired rate satisfying the need of the practical system.In this study,two kind of aqueous model drugs with different molecule weight,Congo red and albumin from bovine serum(BSA)were nanoencapsulated in poly(DL-lactic-co-glycolic acid)(PLGA)microspheres by emulsion electrospray.In the preparation process,the aqueous phase of drugs was added into the PLGA chloroform solution to form the emulsion solution.The emulsion was then electrosprayed to fabricate drugnanoencapsulated PLGA microspheres.The morphology of the PLGA microspheres was affected by the volume ratio of aqueous drug phase and organic PLGA phase(V_(w)/V_(o))and the molecule weight of model drugs.Confocal laser scanning microcopy showed the nanodroplets of drug phase were scattered in the PLGA microspheres homogenously with different distribution patterns related to V_(w)/V_(o).With the increase of the volume ratio of aqueous drug phase,the number of nanodroplets increased forming continuous phase gradually that could accelerate drug release rate.Moreover,BSA showed a slower release rate from PLGA microspheres comparing to Congo red,which indicated the drug release rate could be affected by not only V_(w)/V_(o)but also the molecule weight of model drug.In brief,the PLGA microspheres prepared using emulsion electrospray provided an efficient and simple systemto achieve controlled drug release at a desired rate satisfying the need of the practices.

关键词： PLGA microspheres drug nanoencapsulation emulsion electrospray controlled drug release

Associations of particulate matter with dementia and mild cognitive impairment in China: A multicenter cross-sectional study

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The Innovation 2021年第3期2卷 118-125页

作者： Jiping Tan Nan Li Xiaoxiao wang Gongbo Chen Lailai Yan luning wang Yiming Zhao Shanshan Li Yuming Guo Geriatric Neurology Department of The Second Medical Center&National Clinical Research Center for Geriatric Diseases Chinese PLA General HospitalBeijing 100039China Research Center of Clinical Epidemiology Peking University Third HospitalBeijing 100191China Guangdong Provincial Engineering Technology Research Center of Environmental and Health risk Assessment Department of Occupational and Environmental Health School of Public HealthSun Yat-sen UniversityGuangzhou 510080China Department of Laboratorial Science and Technology School of Public HealthPeking UniversityBeijing 100191China Department of Epidemiology and Preventive Medicine School of Public Health and Preventive MedicineMonash UniversityMelbourneAustralia

Ambient air pollution has been shown to be associated with the pathogenesis of dementia and mild cognitive impairment(MCI).However,few studies have examined these associations in well-characterized populations with low residential mobility,similar living habits,and a standardized assessment of both air pollution exposure and clinical outcome.This study examined the associations of long-term exposure to particulate matter(PM)air pollution with dementia and MCI,using data from the Chinese Veteran Clinical Research Platform.The cognitive function of elderly veterans from 277 communities in 18 Chinese cities was examined.Participants’daily exposures to aerodynamic diameters%2.5 mm(PM2.5)and%10 mm(PM10)during the 3 years prior to the survey were estimated using a satellite-based prediction.The adjusted odds ratios(ORs)and 95%confidence intervals of MCI associated with each 10 mg/m^(3) increase in PM2.5 and PM10 were 1.52(1.39,1.67)and 1.04(1.00,1.08),and those of dementia associated with PM2.5 and PM10 were 1.27(1.11,1.46)and 1.13(1.05,1.21),respectively.This demonstrates that long-term exposure to PM2.5 and PM10 can increase the prevalence of dementia/MCI among veterans in China.Higher ORs were observed for those with%9 years of educational attainment,those who actively attended physical activities,those who never smoked,former drinkers,and those who did not suffer from cerebral infarction.Improvement of ambient air quality,especially decreasing levels of PM2.5,may help to decrease the risk of dementia/MCI.Given the statistically significant association between PM and cognitive impairment demonstrated here,future studies should focus on examining the causal effect of PM pollution on dementia and MCI.

关键词： particulate matter dementia MCI air pollution

天津市2010—2016年恶性肿瘤生存分析

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中华肿瘤杂志 2024年第4期46卷 319-325页

作者：王冲沈成凤寻鲁宁张爽张辉郑文龙王德征天津市疾病预防控制中心非传染性疾病预防控制所肿瘤登记科天津300011 天津市疾病预防控制中心非传染性疾病预防控制所生命统计科天津300011

目的对天津市2010—2016年新发恶性肿瘤进行生存分析,为评估区域肿瘤防治状况、制定健康政策提供依据。方法收集2010年1月1日至2016年12月31日天津市户籍居民肿瘤登记数据,随访截至2021年12月31日。使用寿命表法估计观察生存率(OSR),Ede... 详细信息

目的对天津市2010—2016年新发恶性肿瘤进行生存分析,为评估区域肿瘤防治状况、制定健康政策提供依据。方法收集2010年1月1日至2016年12月31日天津市户籍居民肿瘤登记数据,随访截至2021年12月31日。使用寿命表法估计观察生存率(OSR),EderedⅡ法估计相对生存率(RSR),并对不同年份、性别、年龄、地区和肿瘤分类进行亚组分析。采用Kaplan-Meier法和Log rank检验比较生存曲线组间差异,Joinpoint回归模型分析趋势变化。结果天津市恶性肿瘤5年RSR从2010年的41.92%提高至2016年的53.65%,呈上升趋势(t=4.81,P=0.005)。2010—2016年总体5年RSR为48.56%,女性(57.71%)高于男性(39.20%),城区(49.38%)高于郊区(47.24%),0~14岁、15~44岁、45~64岁和≥65岁年龄组5年RSR分别为63.14%、78.39%、58.25%和32.67%。恶性肿瘤相对中位生存时间从2010年的2.34年提高至2016年的6.00年,呈上升趋势(t=3.86,P=0.012)。2010—2016年总体中位相对生存时间为4.11年,女性(11.99年)高于男性(2.03年),城区(4.60年)高于郊区(3.43年),15~44岁、45~64岁和≥65岁年龄组相对中位生存时间分别为12.07、11.92和1.34年。结论天津市2010—2016年恶性肿瘤5年生存率持续升高,总体肿瘤防治效果明显,应重点关注男性、郊区和高年龄组人群,进一步加强肺癌、食管癌、肝癌、胆囊癌和胰腺癌防治。

关键词：恶性肿瘤生存分析观察生存率相对生存率天津

Grey-matter volume as a potential feature for the classification of Alzheimer's disease and mild cognitive impairment: an exploratory study

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Neuroscience Bulletin 2014年第3期30卷 477-489页

作者： Yane Guo Zengqiang Zhang Bo Zhou Pan wang Hongxiang Yao Minshao Yuan Ningyu An Haitao Dai luning wang Xi Zhang Yong Liu Department of Neurology Institute of Geriatrics and Gerontology Chinese PLA General Hospital Hainan Branch of Chinese PLA General Hospital Department of Radiology Chinese PLA General Hospital Department of Neurology the People's Hospital of Jimo Brainnetome Center Institute of Automation Chinese Academy of Sciences National Laboratory of Pattern Recognition Institute of Automation Chinese Academy of Sciences

Specific patterns of brain atrophy may be helpful in the diagnosis of Alzheimer＇s disease （AD）. In the present study, we set out to evaluate the utility of grey-matter volume in the classification of AD and amnestic mild cognitive impairment （aMCI） compared to normal control （NC）individuals. Voxel-based morphometric analyses were performed on structural MRIs from 35 AD patients, 27 aMCI patients, and 27 NC participants. A two-sample two-tailed t-test was computed between the NC and AD groups to create a map of abnormal grey matter in AD. The brain areas with significant differences were extracted as regions of interest （ROIs）, and the grey-matter volumes in the ROIs of the aMCI patients were included to evaluate the patterns of change across different disease severities. Next, correlation analyses between the grey-matter volumes in the ROIs and all clinical variables were performed in aMCI and AD patients to determine whether they varied with disease progression. The results revealed significantly decreased grey matter in the bilateral hippocampus/ parahippocampus, the bilateral superior/middle temporal gyri, and the right precuneus in AD patients.The grey-matter volumes with clinical variables were positively correlated Finally, we performed exploratory linear discriminative analyses to assess the classifying capacity of grey-matter volumes in the bilateral hippocampus and parahippocampus among AD, aMCI, and NC. Leave-one-out cross- validation analyses demonstrated that grey-matter volumes in hippocampus and parahippocampus accurately distinguished AD from NC. These findings indicate that grey-matter volumes are useful in the classification of AD.

关键词： Alzheimer＇s disease mild cognitive impairment voxel-based morphometry grey matter volume classification

Microstructure, wear resistance, and corrosion performance of Ti35Zr28Nb alloy fabricated by powder metallurgy for orthopedic applications

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Journal of Materials Science & Technology 2020年第6期41卷 191-198页

作者： Wei Xu Xin Lu Jingjing Tian Chao Huang Miao Chen Yu Yan luning wang Xuanhui Qu Cuie Wen Beijing Advanced Innovation Center for Materials Genome Engineering Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing100083China Central Laboratory Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijing100730China School of Engineering RMIT UniversityMelbourne3001Australia

A ternary Ti35Zr28Nb alloy was fabricated by powder metallurgy(PM)from pre-alloyed powder.The microstructure,hardness,corrosion behavior,and wear response of the produced alloy were investigated systematically.The results show that nearly full dense Ti35Zr28Nb alloy(relative density is 98.1±1.2%)can be fabricated by PM.The microstructure was dominated with uniform phase.The Ti35Zr28Nb alloy displayed spontaneous passivity in a naturally aerated simulated body fluid(SBF)solution at 37±0.5°C.The Ti35Zr28Nb alloy exhibited the highest corrosion resistance as compared to as-cast Ti6Al4V and pure Ti because of the formation of a protective passive film containing TiO2,Nb2O5,and ZrO2,including the highest corrosion potential(-0.22±0.01 V),the lowest corrosion current density(57.45±1.88 nA),the lowest passive potential(0.05±0.01 V)and the widest passivation range(1.29±0.09 V).Under the same wear condition,the wear rate of the Ti35Zr28Nb alloy(0.0021±0.0002 mm3/m·N)was lower than that of the CP Ti(0.0029±0.0004 mm3/m·N)and close to that of the Ti6Al4V(0.0020±0.0003 mm3/m·N).The wear mechanism of the Ti35Zr28Nb alloy was mainly dominated by abrasive wear,accompanied by adhesive wear.The highest corrosion resistance together with the adequate wear resistance makes the PM-fabricated Ti35Zr28Nb alloy an attractive candidate for orthopedic implant materials.

关键词： Ti35Zr28Nb Powder metallurgy Microstructure Wear behavior Corrosion resistance