检索结果-南通市图书馆

Journal of Biomedical Science and Engineering 2009年第4期2卷 210-215页

作者： Ronnie Wirestam Christian Engvall Erik Ryding Stig Holtas Freddy Stahlberg peter Reinstrup Department of Anaesthesiology & Intensive Care Lund University Hospital Lund Sweden Department of Clinical Neurophysiology Lund University Hospital Lund Sweden Department of Diagnostic Radiology Lund University Lund Sweden Department of Medical Radiation Physics Lund University Lund Sweden Department of Medical Radiation Physics Lund University Lund Sweden

Global cerebral perfusion parameters were measured using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) in eight healthy volunteers examined during normal breathing and spontaneous hyperventilation. DSC-MRI-based cerebral blood flow (CBF) de-creased during hyperventilation in all volun-teers (average decrease 29%), and the corre-sponding global CBF estimates were 73±19ml/ (min100g) during normal breathing and 52± 7.9ml/(min100g) during hyperventilation (mean ±SD, n=8). Furthermore, the hypocapnic condi-tions induced by hyperventilation resulted in a prolongation of the global mean transit time (MTT) by on average 14%. The observed CBF estimates appeared to be systematically over-estimated, in accordance with previously pub-lished DSC-MRI results, but reduced to more reasonable levels when a previously retrieved calibration factor was applied.

关键词： Magnetic Resonance Imaging Perfusion Cerebral Blood Flow Mean Transit Time Hypocapnia

How should liver hypertrophy be stimulated?A comparison of upfront associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)and portal vein embolization(PVE)with rescue possibility

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2021年第1期10卷 1-8页

作者： Ernesto Sparrelid Kristina Hasselgren Bård Ingvald Røsok peter Nørgaard Larsen Nicolai Aagaard Schultz Ulrik Carling Eva Fallentin Stefan Gilg Per Sandström Gert Lindell Bergthor Björnsson Department of Clinical Science Intervention and TechnologyDivision of SurgeryKarolinska InstituteKarolinska University HospitalStockholmSweden Department of Surgery and Clinical and Experimental Medicine Linköping UniversityLinköpingSweden Department of Hepato-Pancreato-Biliary Surgery Oslo University HospitalOsloNorway Department of Surgical Gastroenterology and Transplantation RigshospitaletUniversity of CopenhagenDenmark Department of Radiology and Nuclear Medicin RikshospitaletOslo University HospitalOsloNorway Department of Radiology RigshospitaletUniversity of CopenhagenCopenhagenDenmark Department of Surgery Skane University HospitalLundSweden

Background:The role of associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)in comparison to portal vein embolization(PVE)is *** aim of this study was to compare successful resection rates(RR)with upfront ALPPS *** with rescue ALPPS on demand and to compare the hypertrophy of the liver between ALPPS and PVE plus subsequent rescue ***:A retrospective analysis of all patients treated with PVE for colorectal liver metastasis(CRLM)or ALPPS(any diagnosis,rescue ALPPS included)at five Scandinavian university hospitals during the years 2013-2016 was conducted.A Chi-square test and a Mann-Whitney U test were used to assess the difference between the groups.A successful RR was defined as liver resection without a 90-day ***:A total of 189 patients were *** RR was in 84.5%of the patients with ALPPS upfront and in 73.3%of the patients with PVE and rescue ALPPS on demand(P=0.080).The hypertrophy of the future liver remnants(FLRs)with ALPPS upfront was 71%(48-97%)compared to 96%(82-113%)after PVE and rescue ALPPS(P=0.010).Conclusions:Upfront ALPPS offers a somewhat higher successful RR than PVE with rescue ALPPS on *** sequential combination of PVE and ALPPS leads to a higher overall degree of hypertrophy than upfront ALPPS.

关键词： Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS) liver surgery colorectal liver metastases(CRLM) portal vein embolization(PVE)

Effects of Climate Change in the Upper Ordovician of Central Sweden

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

地学前缘 2009年第S1期16卷 113-113页

作者： peter Dahlqvist David A.T.Harper Linda M.Wickstrm Geobiosphere Science Centre Lund University Geological Museum University of Copenhagen Geological Survey of Sweden

Late Ordovician shelly faunas occur at several localities in the(O|¨)stersund area of J(a|¨)mtland,central Sweden,an area that today is included in the Lower Allochton of the Swedish *** Late Ordovician faunas of J(a|¨)mtland have developed against a background of intense and rapid global climate *** faunas are present approximately in the middle of the Kyrk(?)s Quartzite in the east and occur in the uppermost Kogsta Siltstone in the west. Changes in faunas and depositional environments provide regional evidence of these global cooling and regressive *** faunas occur in shale and siltstone facies and are used to effect

关键词： Hirnantia Sweden Ordovician climate change

在线全文

学校读者我要写书评

暂无评论

帕金森病的细胞移植治疗

中国现代神经疾病杂志 2005年第5期5卷 319-324页

作者： Olle Lindvall peter Hagell 刘暌只达石 Section of Restorative Neurology.Wallenberg Neuroscience Center University HospitalLundSweden 300060 天津市环湖医院神经外科天津医科大学总医院

帕金森病(Parkinson disease,PD)的细胞替代策略基于这样一个思想,即移植的细胞可以重建纹状体的多巴胺能神经传导,尽管该病呈慢性进展过程并累及大脑的其他部位和功能,但是重建的神经环路至少可以在相当长的时间维持一定的神经功能.20... 详细信息

帕金森病(Parkinson disease,PD)的细胞替代策略基于这样一个思想,即移植的细胞可以重建纹状体的多巴胺能神经传导,尽管该病呈慢性进展过程并累及大脑的其他部位和功能,但是重建的神经环路至少可以在相当长的时间维持一定的神经功能.20年以前的实验业已证明在大鼠帕金森病模型移植富含多巴胺能神经元的胚胎中脑组织可以促进发生退变的纹状体内神经再生并促使某些神经功能改善.更进一步的动物实验结果表明,移植的多巴胺能神经元表现出内源性神经元的形态和功能特征--重建退变的纹状体、释放多巴胺并与宿主神经元建立有效的突触联系,而且能接受宿主的传入冲动[1].移植后的神经再生可以部分(并非全部)改善啮齿类动物和猴的多巴胺缺失症状[1,2].

关键词：细胞移植治疗帕金森病模型多巴胺能神经元神经功能改善 disease 动物实验神经再生啮齿类动物细胞替代

SARS-CoV-2 spike protein as a bacterial lipopolysaccharide delivery system in an overzealous inflammatory cascade

在线全文

学校读者我要写书评

暂无评论

Journal of Molecular Cell Biology 2022年第9期14卷 26-39页

作者： Firdaus Samsudin Palur Raghuvamsi Ganna Petruk Manoj Puthia Jitka Petrlova Paul MacAry Ganesh S.Anand peter J.Bond Artur Schmidtchen Bioinformatics Institute(BIl) Agency for ScienceTechnology and Research(A*STAR)Singapore 138671Singapore Department of Biological Sciences National University of SingaporeSingapore 117543Singapore Division of Dermatology and Venereology Department of Clinical SciencesLund UniversitySE-22184 LundSweden Life Sciences Institute Centre for Life SciencesNational University of SingaporeSingapore 117546Singapore Department of Chemistry The Pennsylvania State UniversityPA 16801USA Copenhagen Wound Healing Center Bispebjerg HospitalDepartment of Biomedical SciencesUniversity of CopenhagenDK-2400 CopenhagenDenmark

Accumulating evidence indicates a potential role for bacterial lipopolysaccharide(LPs)in the overactivation of the immune response during SARS-CoV-2 *** is recognized by Toll-like receptor 4,mediating proinflammatory *** previously reported that LPS directly interacts with SARS-CoV-2 spike(S)protein and enhances proinflammatory *** native gel electrophoresis and hydrogen-deuterium exchange mass spectrometry,we showed that LPS binds to multiple hydrophobic pockets spanning both the S1 and S2 subunits of the S *** simulations validated by a microscale thermophoresis binding assay revealed that LPS binds to the S2 pocket with a lower affinity compared to S1,suggesting a role as an intermediate in LPS ***,nuclear factor-kappa B(NF-kB)activation in monocytic THP-1 cells is strongly boosted by *** NF-kB reporter mice followed by bioimaging,a boosting effect was observed for both S1 and S2,with the former potentially facilitated by *** Omicron S variant binds to LPS,but with reduced affinity and LPS boosting in vitro and in *** together,the data provide a molecular mechanism by which S protein augments LPS-mediated hyperinflammation.

关键词： COVID-19 SARS-CoV-2 spike protein lipopolysaccharide TLR4 hyperinflammation

The Global Stratotype Section and Point （GSSP） for the base of the Holocene Series/Epoch （Quaternary System/Period） in the NGRIP ice core

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Episodes 2008年第2期31卷 264-267页

作者： Mike Walker Sigfus Johnsen Sune Olander Rasmussen Jorgen-Peder Steffensen Trevor Popp Philip Gibbard Wim Hoek John Lowe John Andrews Svante Bjorck Les Cwynar Konrad Hughen peter Kershaw Bernd Kromer Thomas Litt David J. Lowe Takeshi Nakagawa Rewi Newnham Jakob Schwander Department of Archaeology and Anthropology University of Wales Lampeter Wales SA48 7ED UK. Centre for Ice and Climatel The Niels Bohr Institute University of Copenhagen Juliane Maries Vej 30 DK2100 Copenhagen Denmark. Stable Isotope Laboratory Institute of Arctic and Alpine Research University of Colorado Boulder Co 80302 USA. Department of Geography University of Cambridge Downing Place Cambridge CB2 3EN UK. Department-of Physical Geography University of Utrecht Heidelberglaan 2 3508 TC Utrecht The Netherlands. Department of Geography Royal Holloway University of London Egham Surrey TW20 0EX UK. Institute for Arctic and Alpine Research University of Colorado Campus Box 450 Boulder Co 80309 USA. GeoBiosphere Science Centre Quaternary Sciences Lund University S/51veg 12 SE-223 62 Lund Sweden. Department of Biology University of New Brunswick Fredericton New Brunswick Canada E3B 6E1. Department of Marine Chemistry and Geochemistry Woods Hole Oceanographic Institution Woods Hole MA 02543 USA. School of Geography and Environmental Science Monash University Victoria 3800 Australia. Heidelberg Academy of Sciences University of Heidelberg 1NF 229 D-69120 Heidelberg Germany. Institute for Palaeontology University of Bonn Nussallee 8 D-53115 Bonn Germany. Department of Earth and Ocean Sciences University of Waikato Private Bag 3105 Hamilton New Zealand. Department of Geography University of Newcastle Newcastle-upon-Tyne NE 1 7RU UK. School of Geography University of Plymouth Drake Circus Plymouth PIA 8AA UK. Climate and Environmental Physics Physics Institute University of Bern Sidlerstrasse 5 CH-3012 Bern Switzerland.

The Greenland ice core from NorthGRIP （NGRIP） contains a proxy climate record across the Pleistocene-Holocene boundary of unprecedented clarity and resolution. Analysis of an array of physical and chemical parameters within the ice enables the base of the Holocene, as reflected in the first signs of climatic warming at the end of the Younger Dryas/Greenland Stadial 1 cold phase, to be located with a high degree of precision.

关键词：地球全新世第四纪地质时代周期

CIK细胞治疗老年人中晚期胃癌的副反应分析

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

肿瘤 2006年第10期26卷 950-952页

作者：蒋敬庭吴昌平 Ning Xu peter Nilsson-Ehle 邓海峰陆明洋李敏苏州大学附属第三医院肿瘤生物诊疗中心常州213003 Section of Clinical Chemistry ＆ Pharmacology Lund UniversityLund S-221 85Sweden

目的:探讨使用细胞因子诱导的杀伤细胞(cytokine-induced killer cells,CIK细胞)免疫治疗老年中晚期胃癌的副反应及其处理方法。方法:采用生物技术诱导培养CIK细胞,经培养后的CIK细胞回输给老年中晚期胃癌患者,同时观察输注后的临床反... 详细信息

目的:探讨使用细胞因子诱导的杀伤细胞(cytokine-induced killer cells,CIK细胞)免疫治疗老年中晚期胃癌的副反应及其处理方法。方法:采用生物技术诱导培养CIK细胞,经培养后的CIK细胞回输给老年中晚期胃癌患者,同时观察输注后的临床反应。结果:在回输后29例老年中晚期胃癌患者中PR 8例,MR 9例,sD 7例,PD 5例,总缓解率为58．6％。患者的全身反应及局部反应包括寒战13例,发热9例,恶心呕吐1例,全身不适3例,经对症处理后无一例患者出现休克、毛细血管渗漏综合征、皮疹与血尿常规、肝肾功能异常。结论:用自体CIK细胞治疗老年中晚期胃癌,可使老年中晚期胃癌患者的临床症状和体征得到改善,治疗中的副反应经对症处理可以缓解。

关键词：胃肿瘤杀伤细胞,细胞因子诱导免疫疗法,过继性治疗结果,副反应

在线全文

学校读者我要写书评

暂无评论

ACTH短期治疗肾移植术后高脂血症

实用临床医学（江西） 2004年第1期5卷 10-12页

作者：曹赟杰何小舟 peter Nilsson Ehle Ning Xu 苏州大学第三附属医院江苏常州213003 Department of Clinical Chemistry Institute of Laboratory MedicineUniversity Hospital of LundS-221 85 LundSweden

目的 :观察促肾上腺皮质激素 (ACTH)对肾移植受者血脂代谢的影响。方法 :将 30例肾移植术后高血脂患者随机分为ACTH治疗组 (n =15 )和对照组 (n =15 )。对照组不给予任何降脂治疗 ,治疗组接受连续 5d的ACTH治疗 (2 5U/d)。分别检测并比... 详细信息

目的 :观察促肾上腺皮质激素 (ACTH)对肾移植受者血脂代谢的影响。方法 :将 30例肾移植术后高血脂患者随机分为ACTH治疗组 (n =15 )和对照组 (n =15 )。对照组不给予任何降脂治疗 ,治疗组接受连续 5d的ACTH治疗 (2 5U/d)。分别检测并比较两组血脂变化。结果 :治疗组所有患者经ACTH治疗后均有明显的血脂变化 ,其中TC、TG、LDL、apoB、LP(a)分别减少了 11%～ 2 6 %不等 ,HDL胆固醇 (HDL c)和apoA1增加了 10 %～ 12 %。对照组血脂水平无显著变化。结论 :ACTH可显著改善肾移植受者的高脂血症 ,疗效显著 ,安全可靠 ,其长期效果有待于进一步观察。

关键词： ACTH 高脂血症肾移植

冠心病患者血浆载脂蛋白M水平及其相关性研究

在线全文

学校读者我要写书评

暂无评论

现代医学 2004年第1期32卷 22-25页

作者：焦国庆张晓膺董选 peter Nilsson-Ehle NING Xu 苏州大学附属第三医院胸外科江苏常州213003 Department of Clinical Chemistry Institute of Laboratory MedicineUniversity Hospital of LundS-221 85 LundSweden

目的　监测冠心病患者血浆中载脂蛋白M (ApoM )的水平 ,了解ApoM与其他脂蛋白或载脂蛋白的关系。方法　应用Dot Blotting技术检测 70例冠心病患者及 85例健康志愿者血浆中ApoM的水平 ,酶法及比浊法检测冠心病患者血浆中载脂蛋白AI(ApoAI... 详细信息

目的　监测冠心病患者血浆中载脂蛋白M (ApoM )的水平 ,了解ApoM与其他脂蛋白或载脂蛋白的关系。方法　应用Dot Blotting技术检测 70例冠心病患者及 85例健康志愿者血浆中ApoM的水平 ,酶法及比浊法检测冠心病患者血浆中载脂蛋白AI(ApoAI)、载脂蛋白B(ApoB)、脂蛋白a(Lpa)、总三酸甘油酯 (TG)、高密度脂蛋白胆固醇 (HDL C)、低密度脂蛋白胆固醇 (LDL C)以及空腹血糖 (Glu) ;比较冠心病患者和健康志愿者血浆中ApoM的水平 ,对ApoM与其他脂蛋白的关系进行相关性分析。结果　冠心病患者血浆中ApoM的水平为 (3 .3 55± 0 .12 2 2 )ODu·mm- 2 ,明显高于健康志愿者 (2 .0 97± 0 .0 5988)ODu·mm- 2 (P <0 .0 1) ,与ApoAI(r=-0 .2 42 3 ,P =0 .0 43 3 )、LDL C ApoB(r =-0 .2 481,P =0 .0 3 83 )、LDL C(r =-0 .2 60 8,P =0 .0 2 92 )相关。健康志愿组血浆ApoM与HDL C (r =0 .3 4 69,P =0 .0 0 95)、HDL C ApoAI(r =0 .414 6,P =0 .0 0 16)相关。结论　ApoM可能参与了体内的胆固醇代谢。

关键词：冠心病血浆载脂蛋白M 相关性研究血脂脂蛋白a

在线全文

学校读者我要写书评

暂无评论

城市感知与可持续城市设计

景观设计学（中英文） 2016年第4期4卷 64-71页

作者：彼得·斯约斯特洛姆王颖（译）瑞典隆德大学工学院可持续城市设计系不详

随着全球化与城镇化进程的不断加速,城市空间在日常生活中扮演着越来越重要的角色。科学技术的发展使得人们与世界的联通更加密切,但以身体感官去体验真实世界的需求却并未因此而减弱。瑞典隆德大学工学院十余年来始终致力于可持续城市... 详细信息

随着全球化与城镇化进程的不断加速,城市空间在日常生活中扮演着越来越重要的角色。科学技术的发展使得人们与世界的联通更加密切,但以身体感官去体验真实世界的需求却并未因此而减弱。瑞典隆德大学工学院十余年来始终致力于可持续城市设计的研究与应用,在本次采访中,彼得·斯约斯特洛姆副教授对城市感知在可持续城市设计中的作用进行了解析,就城市的身份特征、城市意象等概念展开了讨论,并分析了大数据等技术应用对于城市设计的影响,同时也对景观设计行业的发展前景做出了展望。

关键词：城市感知可持续城市设计身份特征大数据教育