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Diagnosis and treatment of hepatic angiomyolipoma in 26 cases

World Journal of Gastroenterology 2003年第8期9卷 1856-1858页

作者： Ning Ren lun-xiu qin Zhao-You Tang Zhi-Quan Wu Jia Fan, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai 200032, China Liver Cancer Institute Fudan University Shanghai 200032 China. ningren@***

AIM: To summarize the experience of the diagnosis and treatment of hepatic angiomyolipoma (HAML).METHODS: The clinical, imaging and pathological features,and treatment strategies of 26 patients with HAML treated at the authors′institute between October 1998 and January 2003 were retrospectively analyzed. All the patients received liver resection and were followed up till the *** assays were performed with a panel of ***: There was an obvious female predominance (21:5), and most of the patients (18/26) had no *** high echo was found in ultrasonography and punctiform or filiform vascular distribution pattern was found in color Doppler-sonography in most of the lesions (21/26).All of the 5 lesions further enhanced with Levovist showed early and prolonged enhancement. At contrast-enhanced spiral CT, the soft-tissue components of 24 lesions were markedly enhanced in the arterial phase and 18 lesions remained enhanced in the portal venous phase. MRI was performed in 9 patients, and showed hypointensity or hyperintensity on T1-weighted images and heterogeneous hyperintensity on T2-weighted images. Histopathologically,all lesions were composed of adipose tissues, smooth muscle and blood vessels with different proportions. Most lesions showed positive immunohistochemical staining for HMB45(26/26), A103 (24/26) and SMA (24/26). All of the 26 patients showed a benign course with no sign of ***: Preoperative radiological diagnosis of HAML is possible. The demonstration of intratumoral fat and central vessels is helpful in the diagnosis. HMB45, A103 and SMA are promising markers for pathologic diagnosis of HAML,and surgical resection is effective for the treatment of HAML.

关键词：肝血管肌脂瘤肝肿瘤 CT诊断手术治疗

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结合BP神经网络和高阶矩法的渡槽侧墙抗弯时变可靠度分析

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中国农村水利水电 2024年第1期 16-24页

作者：张龙文周伦秀刘倩湖南农业大学水利与土木工程学院湖南长沙410128 湖南农业大学农业高效节水与水利数字建造湖南省普通高等学校重点实验室湖南长沙410128

基于BP神经网络与高阶矩法,结合实测数据,提出了钢筋混凝土渡槽侧墙抗弯时变可靠度分析方法。为评估钢筋锈蚀影响下的渡槽侧墙抗弯时变可靠度,考虑混凝土结构中钢筋有效截面面积损失效应,导出渡槽侧墙承载能力极限状态下的抗弯时变功能... 详细信息

基于BP神经网络与高阶矩法,结合实测数据,提出了钢筋混凝土渡槽侧墙抗弯时变可靠度分析方法。为评估钢筋锈蚀影响下的渡槽侧墙抗弯时变可靠度,考虑混凝土结构中钢筋有效截面面积损失效应,导出渡槽侧墙承载能力极限状态下的抗弯时变功能函数;接着,结合钢筋锈蚀实测数据和BP神经网络原理设计钢筋锈蚀速率预测模型,通过半球形点蚀模型建立混凝土结构中钢筋有效截面面积计算公式;在此基础上,引入点估计-高阶矩可靠度理论发展渡槽结构时变可靠度分析方法,最后将提出的方法应用于某实际渡槽侧墙抗弯时变可靠度分析。结果表明:较之以往的8个实用经验模型,本文所建BP神经网络预测模型可以更准确、综合、简便、快速地预测混凝土结构中的钢筋锈蚀速率;通过与蒙特卡洛模拟法对比验证,本文方法求解时变可靠指标高效准确,可为渡槽时变可靠度评估预测提供一条有效的途径。

关键词：渡槽时变可靠度钢筋锈蚀 BP神经网络高阶矩

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非线性相互作用引起的双模Dicke模型的新奇量子相变

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物理学报 2024年第16期73卷 16-27页

作者：赵秀琴张文慧王红梅太原师范学院物理系晋中030619 太原师范学院计算与应用物理研究所晋中030619 太原师范学院智能优化计算与区块链技术山西省重点实验室晋中030619

量子相变是量子光学和凝聚态物理领域的一个重要课题.本文在标准双模Dicke模型的基础上引入原子-光的非线性相互作用,研究其所引起的量子相变.利用自旋相干态变分法从理论上给出有两个参量的基态能量泛函.两模光场采用四种不同的比例关... 详细信息

量子相变是量子光学和凝聚态物理领域的一个重要课题.本文在标准双模Dicke模型的基础上引入原子-光的非线性相互作用,研究其所引起的量子相变.利用自旋相干态变分法从理论上给出有两个参量的基态能量泛函.两模光场采用四种不同的比例关系进行研究,并且在实验参数下,通过可调的原子-光的非线性相互作用参量,给出了宏观多粒子量子态的丰富结构.本文主要呈现了在蓝失谐和红失谐下,双稳的正常相、共存的正常-超辐射相和原子数反转态等丰富的基态特性.原子-光的非线性相互作用在蓝失谐可以引起标准的双模Dicke模型的正常相到超辐射相的二级量子相变.在红失谐时引起新奇的基态特性,新奇的量子相变,即反转的超辐射相到反转的正常相的二级逆量子相变.原子-光的非线性相互作用和两模光场比例不同时,对量子相变的相边界和基态物理量的值有较大影响.

关键词：双模Dicke模型原子-光的非线性相互作用量子相变自旋相干态法

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Clinical and genetic characteristics of a child with Sotos syndrome and attention-deficit/hyperactivity disorder:A case report

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World Journal of Clinical Cases 2024年第22期12卷 5131-5139页

作者： Ya-Jing Yang Bei-Yi Li Ke-Xin Gan Jing Liu xiu-qin Lv Dong-Mei Zhang Hui-Juan Ma Department of Internal Medicine North China University of Science and TechnologyTangshan 063000Hebei ProvinceChina Department of Internal Medicine Hebei Medical UniversityShijiazhuang 050017Hebei ProvinceChina Department of Endocrinology Hebei General HospitalShijiazhuang 050000Hebei ProvinceChina Department of Endocrinology The First Hospital of Hebei Medical UniversityShijiazhuang 050023Hebei ProvinceChina

BACKGROUND Sotos syndrome is an autosomal dominant disorder,whereas attention-deficit/hyperactivity disorder(ADHD)is a neurodevelopmental *** report aimed to summarize the clinical and genetic features of a pediatric case of Soros syndrome and ADHD in a child exhibiting precocious *** SUMMARY The patient presented with accelerated growth and advanced skeletal maturation;however,she lacked any distinct facial characteristics related to specific genetic *** analyses revealed a paternally inherited heterozygous synonymous mutation[c.4605C>T(***1535Arg)].Functional analyses suggested that this mutation may disrupt splicing,and bioinformatics analyses predicted that this mutation was likely *** an initial diagnosis of Sotos syndrome,the patient was diagnosed with ADHD during the follow-up period at the age of 8 years and 7 *** The potential for comorbid ADHD in Sotos syndrome patients should be considered to avoid the risk of a missed diagnosis.

关键词： Sotos syndrome Attention-deficit/hyperactivity disorder Nuclear receptor binding SET domain protein 1 Case report Developmental disabilities Diagnosis Como rbidity Management

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明清回儒人性概念阐释与伊儒会通

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青海民族研究 2024年第1期35卷 213-219页

作者：马晓琴张伦恺南京理工大学江苏南京210094

明清时期中国社会涌现出一批“学通四教”的回儒学者,他们积极介入中国传统思想和伊斯兰哲学议题的讨论,生产出了一套风格独特的社会知识体系。就人性的内涵而言,明清回儒学者将人性界定为人生而为人的本质,这一本质体现为人所具有的智... 详细信息

明清时期中国社会涌现出一批“学通四教”的回儒学者,他们积极介入中国传统思想和伊斯兰哲学议题的讨论,生产出了一套风格独特的社会知识体系。就人性的内涵而言,明清回儒学者将人性界定为人生而为人的本质,这一本质体现为人所具有的智慧、理智之性;在人性的类型上,回儒们认为人性具有丰富的外延,除人之特性,还有人之物性。在人性概念的讨论上,明清回儒学者既有对伊斯兰灵魂观和儒学人性观的借鉴吸收,也有与二者的不同创新,体现出当时中国社会不同文化的融会贯通,以及文化融会贯通中的和而不同。

关键词：伊儒会通明清回儒伊斯兰人性概念

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Metastatic human hepatocellular carcinoma models in nude mice and cell line with metastatic potential

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World Journal of Gastroenterology 2001年第5期7卷 597-601页

作者： Zhao-You Tang Fan-Xian Sun Jian Tian Sheng-Long Ye Yin-Kun Liu Kang-Da Liu Qiong Xue Jie Chen Jing-Lin Xia lun-xiu qin Hui-Chuan Sun Lu Wang Jian Zhou Yan Li Zeng-Chen Ma Xin-Da Zhou Zhi-Quan Wu Zhi-Ying Lin Bing-Hui Yang Liver Cancer Institute of Fudan University and Zhongshan Hospital,Shanghai 200032,China Liver Cancer Institute of Fudan University (previous Liver Cancer Institute of Shanghai Medical University)136 Yixueyuan Road Zhongshan Hospital Shanghai 200032China. zytang@***

Metastatic human HCC model is needed for the studies on mechanism and intervention of metastatic recurrence. By using orthotopic implantation of histologically intact tissues of 30 surgical specimens, a patient like metastatic model of human HCC in nude mice (LCI-D20)and a Iow metastatic model of human HCC in nude mice LCI-D35 ) have been established. All mice with transplanted LCI-D20 tumors exhibited extremely high metastatic ability including spontaneous metastasis to liver, lungs, lymph nodes and peritoneal *** difference was also found in expression of some of the invasiveness related genes and growth factors between the LCI-D20 and LCI-D35 tumors. PAI-Iincreased gradually following tumor progression in LCID20 model, and correlated with tumor size and AFP level,Phasic expression of tissue intercellular adhesion molecule-I in this model was also observed. Using corneal micropocket model, it was demonstrated that the vascular response induced by LCI-D20 tumor was stronger than that induced by LCI-D35 tumor. Similar report on metastatic human HCC model in nude mice and human HCC cell line with metastatic potential was rarely found in the literature. This LCI-D20 model has been widely used for the studies on intervention of metastasis, including antiangiogenesis, antisense approach, metalloproteinase inhibitor, differentiation inducer, etc. It is concluded that the establishment of metastatic human HCC model in nude mice and human HCC cell line with metastatic potential will provide important models for the in vivo and in vitro study of HCC invasiveness, angiogenesis as well as intervention of HCC recurrence.

关键词： hepatocellular carcinoma metastasis metastatic model nude mice cell line experimental intervention angiogenesis

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系统性红斑狼疮合并细菌性感染患者STAT1、STAT3、IL-1β表达与Th1/Th2平衡的相关性

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中华医院感染学杂志 2024年第9期34卷 1313-1316页

作者：杜坤李秀琴杨友琴北大医疗海洋石油医院检验科天津300000

目的探讨系统性红斑狼疮合并细菌性感染患者信号转导激活因子(STAT)1、STAT3、白细胞介素(IL)-1βmRNA相对表达量及其与辅助性T细胞亚群1/2(Th1/Th2)平衡的关系。方法选取2020年1月-2023年6月北大医疗海洋石油医院收治的30例系统性红斑... 详细信息

目的探讨系统性红斑狼疮合并细菌性感染患者信号转导激活因子(STAT)1、STAT3、白细胞介素(IL)-1βmRNA相对表达量及其与辅助性T细胞亚群1/2(Th1/Th2)平衡的关系。方法选取2020年1月-2023年6月北大医疗海洋石油医院收治的30例系统性红斑狼疮合并细菌性感染患者和35例系统性红斑狼疮未合并细菌性感染患者,分别为感染组和非感染组,比较两组患者外周血Th1、Th2及STAT1、STAT3、IL-1β表达水平,分析STAT1、STAT3、IL-1β与Th1、Th2的相关性,受试者工作特征(ROC)曲线分析STAT1、STAT3、IL-1β对系统性红斑狼疮合并细菌性感染的诊断价值。结果感染组Th1、Th1/Th2表达水平低于非感染组(P<0.05),而Th2、STAT1、STAT3、IL-1β表达水平高于非感染组(P<0.05);STAT1、STAT3、IL-1β与Th1、Th1/Th2呈负相关(P<0.05),与Th2呈正相关(P<0.05);STAT1、STAT3、IL-1β诊断系统性红斑狼疮合并细菌性感染的曲线下面积(AUC)为0.950,敏感度为86.67%,特异度为94.29%。结论系统性红斑狼疮患者合并细菌性感染后,外周血Th1、Th1/Th2表达水平降低,Th2、STAT1、STAT3、IL-1β表达水平升高;STAT1、STAT3、IL-1β与Th1、Th1/Th2呈负相关,与Th2呈正相关;STAT1、STAT3、IL-1β联合对系统性红斑狼疮合并细菌性感染的诊断价值较高。

关键词：系统性红斑狼疮细菌性感染信号转导激活因子白细胞介素-1β 受试者工作特征

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The microcell mediated transfer of human chromosome 8 into highly metastatic rat liver cancer cell line C5F

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World Journal of Gastroenterology 2003年第3期9卷 449-453页

作者： Hu Liu Sheng-Long Ye Jinng Yang Zhao-You Tang Yin-Kun Liu lun-xiu qin Shuang-Jian Qiu Rui-Xia Sun Liver Cancer Institute, Zhong Shan Hospital, Fudan University, Shanghai 200032, China Liver Cancer Institute Zhong Shan Hospital Fudan University Shanghai 200032 China.

AIM: Our previous research on the surgical samples of primary liver cancer with CGH showed that the loss of human chromosome 8p had correlation with the metastatic phenotype of liver cancer. In order to seek the functional evidence that there could be a metastatsis suppressor gene (s) for liver cancer on human chromosome 8, we tried to transfer normal human chromosome 8 into rat liver cancer cell line C5F, which had high metastatic potential to ***: Human chromosome 8 randomly marked with neo gene was introduced into C5F cell line by MMCT and positive microcell hybrids were screened by double selections of G418 and HAT. Single cell isolation cloning was applied to clone microcell hybrids. Finally, STS-PCR and WCP-FISH were used to confirm the ***: Microcell hybrids resistant to HAT and G418 were obtained and 15 clones were obtained by single-cell isolation cloning. STS-PCR and WCP-FISH proved that human chromosome 8 had been successfully introduced into rat liver cancer cell line C5F. STS-PCR detected a random loss in the chromosome introduced and WCP-FISH found a consistent recombination of the introduced human chromosome with the rat ***: The successful introduction of human chromosome 8 into highly metastatic rat liver cancer cell line builds the basis for seeking functional evidence of a metastasis suppressor gene for liver cancer harboring on human chromosome 8 and its subsequent cloning.

关键词： C5F细胞系肝癌动物模型微细胞调节转换器人染色体8 肿瘤转移

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A model of five genes of tumor microenvironment predicts prognosis in Cholangiocarcinoma

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Cancer Advances 2024年第2期7卷 1-12页

作者： Jin-Shan Yang Chuan-Xin Wu Kai Li Ling-Xiang Xu Xing-Lang Wu qin-Bo Wang lun-Wei Chen Na Wang Hang Sun Department of Hepatobiliary Surgery The Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China Department of Hepatobiliary Surgery The Third People’s Hospital of Sichuan ProvinceChengdu 610100China Key Laboratory of Molecular Biology for Infectious Diseases(Ministry of Education) Institute for Viral HepatitisDepartment of Infectious DiseasesThe Second Affiliated HospitalChongqing Medical UniversityChongqing 400010China

Background:Cholangiocarcinoma(CCA)is highly malignant and has a poor prognosis has a high malignant degree and poor *** purpose of this study is to develop a new prognostic model based on genes related to the tumor microenvironment(TME).Methods:Derived from the discerned differentially expressed genes within The Cancer Genome Atlas(TCGA)dataset,this investigation employed the methodology of weighted gene co-expression network analysis(WGCNA)to ascertain gene co-expressed modules intricately linked to the Tumor Microenvironment(TME)among Cholangiocarcinoma(CCA)*** genes associated with prognosis,as identified through Cox regression analysis,were employed in the formulation of a predictive *** model underwent validation,leading to the development of a risk score formula and ***,we validated the model’s reliability using data from CCA patients in the Gene Expression Omnibus(GEO)database(accession:GSE107943).Results:6139 DEGs were divided into 10 co-expressed gene modules using *** these,two modules(blue module with 832 genes and brown module with 1379 genes)showed high correlation with the *** prognostic genes(BNIP3,COL4A3,SPRED3,CEBPB,PLOD2)were identified through Cox regression analysis,and a prognostic model and risk score formula were developed based on these *** score formula:Risk score=BNIP3×1.70520-COL4A3×2.39815+SPRED3×1.17936+CEBPB×0.40456+PLOD2×***-Meier survival analysis revealed that the survival probabilities of the low-risk group were significantly higher than those of the high-risk ***,the related evaluation indexes suggested that the model exhibited strong predictive ***:The prognostic model,based on five TME-related genes(BNIP3,COL4A3,SPRED3,CEBPB,PLOD2),could accurately assess the prognosis of CCA patients to aid in guiding clinical decisions.

关键词： Cholangiocarcinoma tumor microenvironment prognostic prediction model nomogram

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基于AMPK信号通路探讨黄芪甲苷对db/db小鼠2型糖尿病合并非酒精性脂肪肝病的作用机制

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中国实验方剂学杂志 2024年第5期30卷 72-79页

作者：周敏刘秀吴勇军向琴喻嵘湖南中医药大学长沙410208

目的:基于网络药理学和实验验证研究黄芪甲苷(ASⅣ)对db/db小鼠2型糖尿病(T2DM)合并非酒精性脂肪肝病(NAFLD)的作用机制。方法:通过随机将24只db/db小鼠分为4组:模型组、二甲双胍组、黄芪甲苷低、高剂量组。采用6只C57小鼠作为空白组。... 详细信息

目的:基于网络药理学和实验验证研究黄芪甲苷(ASⅣ)对db/db小鼠2型糖尿病(T2DM)合并非酒精性脂肪肝病(NAFLD)的作用机制。方法:通过随机将24只db/db小鼠分为4组:模型组、二甲双胍组、黄芪甲苷低、高剂量组。采用6只C57小鼠作为空白组。黄芪甲苷低、高剂量组分别予黄芪甲苷0.015、0.030 g·kg^(-1)灌胃,二甲双胍组予0.067 g·kg^(-1)灌胃,空白组和模型组予等体积蒸馏水灌胃。灌胃结束后,检测小鼠空腹血糖(FBG),进行口服葡萄糖耐量试验,检测血清血脂水平及肝组织病理情况。通过网络药理学预测黄芪甲苷治疗T2DM合并NAFLD的作用靶点及富集通路,并采用分子生物学技术验证其主要相关富集通路;蛋白免疫印迹法(Western blot)检测肝组织AMPK、p-AMPK、甾醇调节元件结合蛋白-1(SREBP-1)、脂肪酸合成酶(FAS)蛋白表达。结果:与空白组比较,经ASⅣ治疗的小鼠体质量、肝质量系数、空腹血糖、血清总胆固醇、甘油三酯和低密度脂蛋白胆固醇水平降低(P<0.05,P<0.01)。肝组织的病理学显示脂质蓄积情况明显改善,影像学结果显示经黄芪甲苷治疗后,脂肪肝的程度减轻。网络药理学预测结果表明血管内皮生长因子α(VEGFA),半乳糖凝集素3(LGALS3),蛋白激酶B2(Akt2),含Rho相关卷曲螺旋蛋白激酶1(ROCK1),蛋白激酶B1(Akt1),信号传导及转录激活蛋白(STAT3),间质表皮转化因子(MET)是“药物-疾病”中的关键靶点,京都基因与基因组百科全书(KEGG)富集的结果显示AMP依赖的蛋白激酶(AMPK)信号通路与T2DM合并NAFLD密切相关。Western blot结果显示,与空白组比较,模型组中p-AMPK/AMPK表达水平明显下调,SREBP-1、FAS蛋白表达水平明显上调(P<0.01);与模型组比较,二甲双胍组、黄芪甲苷高剂量组p-AMPK/AMPK表达水平明显上调,SREBP-1、FAS蛋白表达水平明显下调(P<0.05,P<0.01)。结论:黄芪甲苷通过激活AMPK信号通路来调控脂质类蛋白的表达,从而改善脂质代谢。

关键词：黄芪甲苷 2型糖尿病非酒精性脂肪性肝病 db/db小鼠网络药理学

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