检索结果-南通市图书馆

Immunotherapy for hepatobiliary malignancies:Progress and prospective

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2022年第5期21卷 409-412页

作者： lun-xiu qin Department of General Surgery Huashan HospitalFudan UniversityShanghai 200040China

Hepatobiliary malignancies include hepatocellular carcinoma(HCC)and biliary tract cancers(BTCs).They are characterized by high heterozygosity,rapid progression,and difflcult to treat[1,2].Recent rapid progress in targeted therapeutic agents has brought new hope for those with advanced HCC[3-5].But there are problems such as lower response rate,or drug resistance(primary or acquired),as well as poor tolerance due to their side-effects,which make this treatment alone still face great challenges.

关键词： biliary malignancies prospective

Biomarkers for response to immunotherapy in hepatobiliary malignancies

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2022年第5期21卷 413-419页

作者： Zhi-Fei Lin lun-xiu qin Jin-Hong Chen Department of General Surgery Huashan HospitalCancer Metastasis InstituteFudan UniversityShanghai 200040China

Background:The advent of immune checkpoint inhibitors(ICIs)has revolutionized the therapeutic options of hepatobiliary ***,the clinical benefit provided by immunotherapy seems limited to a small subgroup of patients with hepatobiliary *** identification of reliable predictors of the response to immunotherapy is urgently *** sources:Literature search was conducted in Pub Med for relevant articles published up to May *** of clinical trials was obtained from https://***/.Results:Biomarkers for ICI response of hepatobiliary malignancies remain in the exploration stage and lack compelling *** programmed death-ligand 1(PD-L1)expression is the most widely studied biomarker in hepatocellular carcinoma(HCC)and biliary tract cancers(BTCs),but there are conflicting results on its predictive *** mutational burden(TMB)is generally low both in HCC and BTCs,and the clinical trials of TMB are rare in hepatobiliary ***,mismatch repair deficiency(dMMR)/high microsatellite instability(MSI-H)may be a predictive biomarker of response to antiPD-1 therapy in ***,some emerging biomarkers,such as gut microbiota,show predictive potential in the preliminary *** and liquid-biopsy biomarkers,including circulating tumor cells,circulating tumor DNA(ct DNA)and exosomal PD-L1 provide a quick and non-invasive approach for monitoring the ICI response,showing a new promising ***:Multiple potential biomarkers for predicting ICI response of hepatobiliary malignancies have been explored and tried to apply in *** there is no robust evidence to prove their clinical value in predicting immunotherapeutic response for patients with hepatobiliary *** identification of predictors for response to ICIs is an urgent need and major *** studies are warranted to validate the role of emerging biomarkers in predicting immunotherapeut

关键词： Biomarker Immunotherapy Hepatocellular carcinoma Biliary tract cancers

Expert consensus-promoting clinical excellence and ultimately benefitting patients

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2023年第5期12卷 743-745页

作者： Jin-Hong Chen lun-xiu qin Hepatobiliary Surgery Department of General SurgeryHuashan HospitalFudan UniversityShanghaiChina

Evidence-based medicine serves as the cornerstone of modern *** on current evidence in the field of evidence-based medicine,a team of authoritative experts in the industry engages in comprehensive discussions to develop expert consensus,following standardized *** consensus serves as a foundation for clinical ***,the abundance of expert consensus varies in quality,and some viewpoints even contradict each other,leading to confusion in clinical decision-making.

关键词： Consensus guideline evidence-based medicine

Hepatitis B virus and hepatitis C virus play different prognostic roles in intrahepatic cholangiocarcinoma: A meta-analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第10期22卷 3038-3051页

作者： Zheng Wang Yuan-Yuan Sheng Qiong-Zhu Dong lun-xiu qin Department of Surgery Huashan HospitalFudan University Institute of Biomedical Sciences Fudan University

AIM: To identify the prognostic value of hepatitis B virus(HBV) and hepatitis C virus(HCV) infections in patients with intrahepatic ***: A search was performed for relevant publications in Pub Med, EMBASE and Web of Science databases. The pooled effects were calculated from the available information to identify the relationship between HBV or HCV infection and the prognosis and clinicopathological features. The χ2 and I2 tests were used to evaluate heterogeneity between studies. Pooled hazard ratios(HRs) with 95% confidence intervals(CIs) were calculated by a fixed-effects model, if no heterogeneity existed. If there was heterogeneity, a random-effects model was ***: In total, 14 studies involving 2842 cases were enrolled in this meta-analysis. The patients with HBV infection presented better overall and diseasefree survival, and the pooled HRs were significant at 0.76(95%CI: 0.70-0.83) and 0.78(95%CI: 0.66-0.94), respectively. Additionally, our study revealed that HCV infection was correlated with shortened overall survival in comparison with the control group(HR = 2.64, 95%CI: 1.77-3.93). We also found that HBV infection occurred more frequently in male patients [odds ratio(OR) = 1.91, 95%CI: 1.06-3.44] and was correlated with higher levels of serum aspartate transaminase(AST) and alpha-fetoprotein(AFP)(OR = 1.93, 95%CI: 1.11-3.35; OR = 3.86, 95%CI: 2.58-5.78) and a lower level of serum carbohydrate antigen 19-9(CA19-9)(OR = 0.47, 95%CI: 0.34-0.65). Moreover, HBV infection was associated with cirrhosis(OR = 6.44, 95%CI: 4.33-9.56), a higher proportion of capsule formation(OR = 6.04, 95%CI: 3.56-10.26), and a lower rate of lymph node metastasis(OR = 0.39, 95%CI: 0.25-0.58). No significant publication bias was seen in any of the enrolled ***: HBV infection may indicate a favorable prognosis in patients with intrahepatic cholangiocarcinoma, while HCV infection suggests a poor prognosis.

关键词： Hepatitis B virus Hepatitis C virus Clinical features Intrahepatic cholangiocarcinoma Prognosis

A Prognostic Nomogram for Hepatocellular Carcinoma Based on Wound Healing and Immune Checkpoint Genes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2022年第5期10卷 891-900页

作者： Beiyuan Hu Xiaotian Shen Wei qin Lan Zhang Tiantian Zou Qiongzhu Dong lun-xiu qin Department of General Surgery Huashan Hospital&Cancer Metastasis InstituteInstitutes of Biomedical SciencesFudan UniversityShanghaiChina

Background and Aims:Wound healing and tumor progression share some common biological features;however,how variations in wound healing patterns affect hepatocellular carcinoma(HCC)prognosis remains ***:We analyzed the wound healing patterns of 594 HCC samples from The Cancer Genome Atlas(TCGA)and the International Cancer Genome Consortium(ICGC)and correlated them with immune infiltration and the expression levels of immune checkpoint genes.A risk score,which we named the“***”score,was established via stepwise Cox *** constructed a nomogram based on age,sex,TNM stage,and *** score and explored its predictive value for HCC ***-four clinical patients were enrolled in this study,and all were from Huashan Hospital of Fudan University between 2015 and 2017 to serve as an independent validation ***:We identified two distinct wound healing patterns in *** biological processes of healing cluster 1(C1)are related to metabolism,while those of healing cluster 2(C2)are related to the inflammatory response and immune cell accumulation.A total of 565 wound healing-related genes(based on Gene Ontology)and 25 immune checkpoint genes were *** analyzing differentially expressed genes and implementing a stepwise Cox estimation analysis,six genes with p values less than 0.02 in a multivariate Cox estimation were chosen as the“***”gene set(FCER1G,PLAT,ITGA5,CCNB1,CD86 and CD40).The“***”gene set,as an OS risk factor,was further validated in Fudan *** constructed a nomogram to predict the 1-,3-and 5-year overall survival(OS)in the TCGA *** area under curve vales of the receiver characteristic operator curves were 0.82,0.76 and 0.73 in the training group and 0.84,0.76 and 0.72 in the test ***:We established a prognostic nomogram based on the *** gene signature,which includes six wound healing-and immunity-related *** nomogram accurately predicts the OS of HCC

关键词： Hepatocellular carcinoma Bioinformatics Immune checkpoint Wound healing Prognosis

Serum vascular endothelial growth factor is a potential biomarker of metastatic recurrence after curative resection of hepatocellular carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2000年第4期6卷 565-568页

作者： Qi Niu Zhao You Tang Zeng Chen Ma lun xiu qin Lian Hai Zhang Liver Cancer Institute&Zhongshan Hospital Shanghai Medical UniversityShanghai 200032China

Hepatocellular carcinoma (HCC) is one of the most common malignancies in China. To date, surgery is still the best solution to it. However, metastatic recurrences after curative hepatic resections are very common. Tang et al have reported that recurrence rate within 5 years of curative hepatic resection is 61.5% [1]. As curative hepatic resection has a high tendency for metastatic recurrence, therapeutic interventions such as transarterial embolization and antiangiogenesis have been tried to further improve prognosis of HCC patients. Therefore, establishing a dependable, sensitive, easy, and economical method to predict metastatic recurrence following curative hepatic resection is of clinical urgency.

关键词： endothelium vascular endothelial growth factor carcinoma hepatocellular enzyme-linked immunosorbent assay liver neoplasms liver cirrhosis immunohistochemistry

The fuel and engine: The roles of reprogrammed metabolism in metastasis of primary liver cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2020年第3期7卷 299-307页

作者： Wen-Wei Zhu Ming Lu Xiang-Yu Wang Xu Zhou Chao Gao lun-xiu qin Department of General Surgery Huashan HospitalCancer Metastasis InstituteFudan University12 Urumqi Road(M)Shanghai200040China

Metastasis and metabolism reprogramming are two major hallmarks of *** the initiation and progression of cancer,tumor cells are known to undergo fundamental metabolic changes to sustain their development and *** recent years,much more attentions have been drawn to their important roles in facilitating cancer metastasis through regulating the biological *** this review,we summarized the recent progresses in the studies of metabolism reprogramming of cancer metastasis,particularly of primary liver cancer,and highlight their potential applications.

关键词： Amino acid Cancer metastasis Cholesterol Fatty acid Glucose Primary liver cancer Tumor microenvironment

Ex vivo liver resection and auto-transplantation as an alternative for the treatment of liver malignancies: Progress and challenges

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 117-122页

作者： Xin Yang Lu Lu Wen-Wei Zhu Yi-Feng Tao Cong-Huan Shen Jin-Hong Chen Zheng-Xin Wang lun-xiu qin Hepatobiliary Surgery and Liver Transplantation Centers Department of General SurgeryHuashan Hospital&Cancer Metastasis InstituteFudan UniversityShanghai 200040China

Hepatectomy is still the major curative treatment for patients with liver ***,it is still a big challenge to remove the tumors in the central posterior area,especially if their location involves the retrohepatic inferior vena cava and hepatic *** vivo liver resection and auto-transplantation(ELRA),a hybrid technique of the traditional liver resection and transplantation,has brought new hope to these patients and therefore becomes a valid alternative to liver *** to its technical difficulty,ELRA is still concentrated in a few hepatobiliary centers that have experienced surgeons in both liver resection and liver *** efficacy and safety of this technique has already been demonstrated in the treatment of benign liver diseases,especially in the advanced alveolar ***,the application of ELRA for liver malignances has gained more ***,standardization of clinical practice norms and international consensus are still *** prognostic impact in these oncologic patients also needs further *** this review,we summarized the principles and recent progresses on ELRA.

关键词： Ex vivo liver resection Liver auto-transplantation Oncology Liver malignancies

Alpha5 nicotine acetylcholine receptor subunit promotes intrahepatic cholangiocarcinoma metastasis

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第4期9卷 1690-1705页

作者： Yan Fu Keyu Shen Hao Wang Shun Wang Xufeng Wang Le Zhu Yan Zheng Tiantian Zou Hongfei Ci Qiongzhu Dong lun-xiu qin Hepatobiliary Surgery Department of General SurgeryHuashan Hospital&Cancer Metastasis InstituteFudan University200040 ShanghaiChina Center of Interventional Radiology and Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast University87 Dingjiaqiao Road210009 NanjingChina institutes of Biomedical Sciences Fudan University200032 ShanghaiChina Key Laboratory of Whole-period Monitoring and Precise Intervention of Digestive Cancer Shanghai Municipal Health CommissionMinhang HospitalFudan UniversityShanghaiChina

Neurotransmitter-initiated signaling pathway were reported to play an important role in regulating the malignant phenotype of tumor *** cells could exhibit a"neural addiction"property and build up local nerve networks to achieve an enhanced neurotransmitter-initiated signaling through nerve growth factor-mediated *** the dysregulated nervous systems might represent a novel strategy for cancer ***,whether intrahepatic cholangiocarcinoma(ICC)could build its own nerve networks and the role of neurotransmitters in the progression ICC remains largely *** staining and Enzyme-linked immunosorbent assay suggested that IcC cells and the infiltrated nerves could generate a tumor microenvironment rich in acetylcholine that promotes IcC metastasis by inducing epithelial-mesenchymal transition(EMT).Acetylcholine promoted iCC metastasis through interacting with its receptor,alpha 5 nicotine acetylcholine receptor subunits(CHRNA5).Furthermore,acetylcholine/CHRNA5 axis activated GSK3β/β-catenin signaling pathway partially through the influx of Ca^(2+)-mediated activation of Ca/calmodulin-dependent protein kinases(CAMKll).In addition,acetylcholine signaling activation also expanded nerve infiltration through increasing the expression of Brain-Derived Neurotrophic Factor(BDNF),which formed a feedforward acetylcholine-BDNF axis to promote ICC ***93,a small-molecule inhibitor of CAMKIll,significantly inhibited the migration and enhanced the sensitivity to gemcitabine of ICC *** all,Acetylcholine/CHRNA5 axis increased the expression ofβ-catenin to promote the metastasis and resistance to gemcitabine of ICC via CAMKIl/GSK3βsignaling,and the CAMKIl inhibitor KN93 may be an effective therapeutic strategy for combating ICC metastasis.

关键词： GSK3β metastasis Alpha