检索结果-南通市图书馆

Washed microbiota transplantation for Crohn’s disease:A metagenomic,metatranscriptomic,and metabolomic-based study

World Journal of Gastroenterology 2024年第11期30卷 1572-1587页

作者： Shi-Ju Chen Da-Ya Zhang Xia Wu Fa-Ming Zhang Bo-Ta cui Yi-Hao Huang Zu-lun Zhang Rui Wang Fei-Hu Bai Graduate School Hainan Medical UniversityHaikou 571199Hainan ProvinceChina Department of Microbiota Medicine&Medical Center for Digestive Diseases The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011Jiangsu ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Hainan Medical UniversityHaikou 570216Hainan ProvinceChina

BACKGROUND Fecal microbiota transplantation(FMT)is a promising therapeutic approach for treating Crohn’s disease(CD).The new method of FMT,based on the automatic washing process,was named as washed microbiota transplantation(WMT).Most existing studies have focused on observing the clinical ***,the mechanism of action of FMT for the effective management of CD-particularly in-depth multi-omics analysis involving the metagenome,metatranscriptome,and metabolome-has not yet been *** To assess the efficacy of WMT for CD and explore alterations in the microbiome and metabolome in response to *** We conducted a prospective,open-label,single-center clinical *** CD patients underwent *** clinical responses(defined as a decrease in their CD Activity Index score of>100 points)and their microbiome(metagenome,metatranscriptome)and metabolome profiles were evaluated three months after the *** Seven of the 11 patients(63.6%)showed an optimal clinical response three months *** microbiome diversity significantly increased after WMT,consistent with improved clinical *** of the metagenome and metatranscriptome analyses revealed consistent alterations in certain strains,such as Faecalibac-terium prausnitzii,Roseburia intestinalis,and Escherichia *** addition,metabolomics analyses demonstrated that CD patients had elevated levels of various amino acids before treatment compared to the ***,levels of vital amino acids that may be associated with disease progression(e.g.,L-glutamic acid,gamma-glutamyl-leucine,and prolyl-glutamine)were reduced after *** WMT demonstrated therapeutic efficacy in CD treatment,likely due to the effective reconstruction of the patient’s ***-omics techniques can effectively help decipher the potential mechanisms of WMT in treating CD.

关键词： Crohn’s disease Clinical trials Fecal microbiota transplant Metagenome Metatranscriptome Metabolome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Imaging-guided precision oncotherapy mediated by nanoprobes: From seeing to curing

引用

Chinese Chemical Letters 2024年第1期35卷 116-128页

作者： Jie Zheng Shi-Hui Chen biao Huang Mingxi Zhang Quan Yuan Ran cui College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Hubei Jiangxia Laboratory Wuhan 430200China

Malignant tumors are the main diseases threatening human life. Using precise theranostics to diagnose and cure tumors has emerged as a new method to improve patient survival. Based on the current development of precise tumor imaging, image-guided tumor therapy has received widespread attention because it is beneficial for developing precise treatment of tumors, has the potential to improve the efficacy of tumor therapy and reduce the incidence of adverse side effects. Nanoprobes, which are nanomaterial functionalized with specific biomolecules, have intrigued intense interest due to their great potential in monitoring biorecognition and biodetection evens. Benefiting from the unique advantages of nanomaterials, including the easy surface functionalization, the unique imaging performances, and the high drug loading capacity, nanoprobes have become a powerful tool to simultaneously realize tumor precise imaging, diagnosis, and therapy. This review introduces the non-invasive tumor precise imaging and highlights the recent advances of image-guided oncotherapy mediated by nanoprobes in anti-tumor drug delivery, tumor precise surgical navigation, chemodynamic therapy, and phototherapy. Finally, a perspective on the challenge and future direction of nanoprobes in imaging-guided tumor theranostics is also discussed.

关键词： Precise theranostics Imaging-guided Tumor surgical navigation Chemodynamic therapy Phototherapy Nanoprobes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Quantum dynamics within curved thin layers with deviation

引用

Chinese Physics B 2024年第7期33卷 502-507页

作者：程润赵浩罗翠柏周璇王必利李延标王骏 Physics Department of Basic Department Army Engineering University of PLANanjing 211101China National Laboratory of Solid State Microstructure Collaborative Innovation Center of Advanced Microstructuresand School of PhysicsNanjing UniversityNanjing 210093China School of Physics and Electronics Hunan UniversityChangsha 410082China Department of Physics Anhui Normal UniversityWuhu 241002China

Combining the deviation between thin layers' adjacent surfaces with the confining potential method applied to the quantum curved systems,we derive the effective Schr?dinger equation describing the particle constrained within a curved layer,accompanied by a general geometric potential V_(gq) composed of a compression-corrected geometric potential V_(gq)~*and a novel potential V_(gq)~(**) brought by the *** this analysis to the cylindrical layer emerges two types of deviation-induced geometric potential,resulting from the the cases of slant deviation and tangent deviation,respectively,which strongly renormalizes the purely geometric potential and contribute to the energy spectrum based on a very substantial deepening of bound states they offer.

关键词： confining potential method quantum mechanics curved thin layer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Epidemiological Characteristics of Human Parainfluenza Viruses Infections-China,2019-2023

引用

China CDC weekly 2024年第12期6卷 235-241,I0003,I0004页

作者： Yixuan Gao Yingwei Ma Daxing Feng Feng Zhang biao Wang Xiaoqing Liu Bing Zhu Hui Xie Linqing Zhao Xiaoru Long Ying Chen Bing Wang Jie Jiang Zhen Zhu Yan Zhang Aili cui Baicheng Xia Naiying Mao National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Precision Medicine Research Center Children’s Hospital of ChangchunChangchun CityJilin ProvinceChina Henan Provincial Center for Disease Control and Prevention Zhengzhou CityHenan ProvinceChina Laboratory of Viral Diseases Qingdao Municipal Centre for Disease Control and PreventionQingdao CityShandong ProvinceChina Virus Laboratory Gansu Provincial Center for Disease Control and PreventionLanzhou CityGansu ProvinceChina Jiangxi Provincial Center for Disease Control and Prevention Nanchang CityGansu ProvinceChina Virus Laboratory Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou CityGuangdong ProvinceChina Institute for Immunization and Prevention Beijing Center for Disease Prevention and ControlAcademy for Preventive MedicineInstitute of Tuberculosis Control Research and PreventionBeijingChina Laboratory of Virology Beijing Key Laboratory of Etiology of Viral Diseases in ChildrenCapital Institute of PediatricsBeijingChina Department of Infection Children’s Hospital of Chongqing Medical UniversityChongqingChina Inner Mongolia Autonomous Region Comprehensive Center for Disease Control and Prevention Hohhot CityInner Mongolia Autonomous RegionChina Shenyang Prefecture Center for Disease Control and Prevention Shenyang CityLiaoning ProvinceChina

Introduction:A retrospective study based on sentinel surveillance was conducted in 10 provinciallevel administrative divisions(PLADs)in China to enhance the understanding of the epidemiological characteristics of human parainfluenza viruses(HPIVs).Methods:From January 2019 to June 2023,respiratory specimens were collected from individuals with acute respiratory infections(ARIs)and screened for four HPIVs serotypes and other common respiratory viruses using multiplex real-time polymerase chain reaction(PCR).This study analyzed the association of HPIVs infections with seasonal patterns,geographical distribution,demographic profiles,clinical features,and co-infection ***:During the study period,a total of 12,866 ARIs were *** overall detection rate of HPIVs was 6.15%,varying from 5.04%in 2022 to 9.70%in *** median age of HPIVs-infected patients was 3 ***2 was more prevalent among individuals aged 5–17 years(42.57%),while HPIV4 was more common in those over 65 years(12.24%).HPIV3(54.16%)and HPIV1(27.18%)were the predominant serotypes,and their prevalence exhibited significant seasonal fluctuations postcoronavirus disease 2019(COVID-19)*** peak of HPIV3 shifted three months later in 2020 compared to 2019 and returned to a summer peak *** peaks of HPIV1 were observed in 2021 following the peak of ***,coinfections were frequent in HPIVs cases(overall rate:22.12%),with human rhinovirus being the most common co-infecting ***:The prevalence of HPIVs in China was predominantly due to HPIV3 and HPIV1,and their seasonal patterns were altered by pandemic ***,continuous surveillance of HPIVs is essential.

关键词： prevalence seasonal Human

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integrin α6:a potential target for cancer molecular imaging and targeting therapy

引用

Malignancy Spectrum 2024年第1期1卷 30-45页

作者： Xin-Ling Li Zhuo-lun Shen Qiao-Li Wang Jia-Cong Ye Wen-biao Zhang Ying-He Li Guo-Kai Feng Mu-Sheng Zeng State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhouGuangdongChina

As a major kind of cell surface adhesion molecules with signal transduction function,integrins play a major role in tumorigenesis and tumor *** role of integrins in tumor cells and the tumor microenvironment has been extensively *** the integrin family,integrinαvβ3 is the most studied integrin in the past 20 *** of preclinical and clinical studies have been conducted,which showed clinical benefits of targeting integrinαvβ3 in tumor imaging and ***,the focus of interest is gradually shifting from integrinαvβ3 toward other integrin ***α6 is expressed in many malignant tumors,such as colorectal cancer,head and neck squamous cell carcinoma,breast cancer,pancreatic cancer,and liver cancer,and its expression is correlated with poor survival of the *** studies have shown that tumor molecular imaging agents and therapeutic drugs targeting integrinα6 have excellent safety and efficacy in preclinical mouse models,encouraging clinical translation of this promising *** this review,we briefly overview the physiological and pathological function of integrinα6 and highlight the recent advances in integrinα6-targeted imaging and therapeutics in tumors.

关键词： tumor imaging tumor therapy tumor microenvironment molecular imaging integrin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

片层纤维V_(2)O_(5)·1.6H_(2)O干凝胶提升水系锌离子电池循环性能

引用

工程科学学报 2024年第3期46卷 438-446页

作者：刘丹崔月裴彪高海燕赵永男天津工业大学材料科学与工程学院天津300387 天津市先进纤维与储能技术重点实验室天津300387

水系锌离子电池凭借低成本和环境友好的特点具有极大的发展和应用前景.具有高比表面、分层、或快速离子导体结构的钒基材料是锌离子电池最具有前景的正极材料之一.如何改善钒基材料的长循环性能是亟待解决的问题之一.本文采用溶胶凝胶... 详细信息

水系锌离子电池凭借低成本和环境友好的特点具有极大的发展和应用前景.具有高比表面、分层、或快速离子导体结构的钒基材料是锌离子电池最具有前景的正极材料之一.如何改善钒基材料的长循环性能是亟待解决的问题之一.本文采用溶胶凝胶法并冷冻干燥成功制备了V_(2)O_(5)·1.6H_(2)O干凝胶,利用X射线衍射仪、扫描电子显微镜对其物相和形貌进行了表征,发现制备的材料为V_(2)O_(5)·1.6H_(2)O,结晶相良好,且成片状纤维大孔结构.电化学测试表明,在0.1 A·g^(–1)电流密度下,首次放电比容量为388.4 mA·h·g^(–1),循环1000次后容量仍保持为129.7 mA·h·g^(–1),具有良好的长循环稳定性.在0.1、0.2、0.5、1、2和3 A·g^(-1)电流密度下,纤维状V2O5干凝胶表现出良好的倍率性能,放电比容量分别为388.4、338.5、282.9、239.1、194.4和165.9 mA·h·g^(–1),远高于商业化V2O5 (279.5、251.0、205.5、174.5、144.6和125.1 mA·h·g^(–1)).良好的电化学性能主要归功于结合水的支撑作用增大了层间距,在循环过程中材料具有良好的结构稳定性,避免了放电容量衰减;同时纤维片状结构缩短了锌离子的迁移路径.对充放电机理研究发现,在锌离子的嵌入脱出过程中伴随有碱式硫酸锌的生成与消失,且该过程可逆.

关键词：锌离子电池 V_(2)O_(5)·1.6H_(2)O 正极材料长循环性能机理探究

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

用非线性磁场梯度方法对空间磁结构模型的重构研究

引用

地球物理学报 2024年第10期67卷 3641-3654页

作者：崔博傅绥燕濮祖荫谢伦张驰北京大学地球与空间科学学院北京100871 中国科学院地质与地球物理研究所北京100029

空间等离子体中的各种磁结构的形成是空间物理过程发展的产物,理解磁结构的拓扑形态对于认识空间物理过程有着重要作用.由于磁结构的三维(Three-dimensional, 3D)图像无法直接被观测到,因此通过卫星的局地观测来重建磁结构就成为一种很... 详细信息

空间等离子体中的各种磁结构的形成是空间物理过程发展的产物,理解磁结构的拓扑形态对于认识空间物理过程有着重要作用.由于磁结构的三维(Three-dimensional, 3D)图像无法直接被观测到,因此通过卫星的局地观测来重建磁结构就成为一种很重要的研究途径.迄今已发展出多种空间磁结构的重构方法,其中“非线性磁场梯度”(Nonlinear Magnetic Gradients, NMG)方法(Shen et al., 2021)能够完备地利用四颗卫星星座的磁场与电流的局地观测和物理原理来计算星座质心处磁场的一阶梯度和二阶梯度以重构出星座附近磁场的近似形态.本文采用NMG方法重构了四种与磁层磁重联相关的动理学尺度磁结构模型:(i)一维(One-dimensional, 1D)Harris电流片与地球偶极磁场的叠加,星座质心位于赤道面X=-20R_E(地球半径)和Y=0;(ii) X线重联模型,星座质心位于X点(r=0);(iii)离子尺度轴对称的磁通量绳模型,星座质心位于通量绳轴线上;(iv) 3D分形线(separator)重联模型,星座质心位于正、负零点连线的中心.本工作重点对重构结果进行细致的误差分析及检验.结果表明,在距离星座质心显著大于10倍卫星平均间距空间范围内,用NMG方法获得的这四种磁场拓扑形态均与模型磁场相符.进而,对于前三个不存在磁零点的磁结构,NMG方法可以近似重现星座周边~10倍卫星平均间距空间范围内磁场模型的数值和方向,重构结果与模型磁场基本一致.对于存在两个磁零点的分形线重联模型,在接近与两个磁零点扇形(fan)面平行的方向上,NMG方法可以近似重现星座周边~5倍卫星平均间距空间范围内的磁场,在其他方向上NMG方法仍可以近似重现星座周边~10倍卫星平均间距范围内的磁场.由此可见,NMG方法为重构空间磁结构提供了一种有效的途径.但是必须注意,对于有磁零点的磁结构,扇形面的存在,会导致重构精度降低.

关键词：磁结构磁场重构磁重联磁场拓扑形态

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

基于羟醛缩合反应构建电中性中空纤维疏松纳滤分离层及染料去除的研究

引用

膜科学与技术 2024年第2期44卷 125-133页

作者：汤申艺武彪崔振宇天津工业大学材料科学与工程学院天津300387 天津天一爱拓科技有限公司天津300382

以聚偏氟乙烯(PVDF)/苯乙烯-马来酸酐(SMA)中空纤维超滤膜为基膜,在膜表面依次引入三乙二醇(TEG)、戊二醛(GA)、聚乙烯醇(PVA)3种亲水有机物,基于羟醛缩合反应在膜表面构建了稳定致密的电中性疏松纳滤(LNF)分离层.研究了膜的微结构特征... 详细信息

以聚偏氟乙烯(PVDF)/苯乙烯-马来酸酐(SMA)中空纤维超滤膜为基膜,在膜表面依次引入三乙二醇(TEG)、戊二醛(GA)、聚乙烯醇(PVA)3种亲水有机物,基于羟醛缩合反应在膜表面构建了稳定致密的电中性疏松纳滤(LNF)分离层.研究了膜的微结构特征和分离性能.结果表明,随着接枝反应的发生,膜亲水性逐渐提高,表面接近中性.带负电荷的日落黄(SY)和正电荷的结晶紫(CV)染料均可被完全去除,并保持较高的渗透通量[27.8 L/(m^(2)·h),28.9 L/(m^(2)·h)].此外,膜还表现出优异的化学稳定性和长期运行稳定性.本工作为制备具有高分离性能的电中性中空纤维纳滤膜提供了一种新的途径.

关键词：电中性化学交联中空纤维膜疏松纳滤染料脱除

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于对称的破解“1+1”与“3N+1”猜想的新思路

引用

北华航天工业学院学报 2024年第4期34卷 1-4页

作者：崔岩崔朝栋申彪北华航天工业学院计算机学院河北廊坊065000 中国建筑科学研究院建筑机械化研究分院河北廊坊065000 北京航天自动控制研究所北京100854

本文所探讨的哥德巴赫猜想(“1+1”)与Collatz猜想(“3N+1”)是数论中的著名未解问题。经研究发现破解“1+1”与“3N+1”猜想有三个关键点:分解素数、构造对称、内特兰定理及其推广的应用。在此基础上本文提出六种证明方法,希望通过这... 详细信息

本文所探讨的哥德巴赫猜想(“1+1”)与Collatz猜想(“3N+1”)是数论中的著名未解问题。经研究发现破解“1+1”与“3N+1”猜想有三个关键点:分解素数、构造对称、内特兰定理及其推广的应用。在此基础上本文提出六种证明方法,希望通过这些方法的探索和验证,能够为数学界带来新的启示和突破。

关键词：对称素数共轭素数哥德巴赫猜想 Collatz猜想贝特兰定理推广诺特定理素数线

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于真实业务数据的软件质量自动校验方法

引用

电信科学 2024年第3期40卷 174-186页

作者：田标崔伟黄慧冯小龙天翼数字生活科技有限公司广东广州510630 中国矿业大学信息与控制工程学院江苏徐州221116

软件性能校验结果有助于检验业务集群能否满足访问规模需求,但当前工具存在需要估算参数值、手工输入数据较多、性能偏低、应用复杂等不足。深入分析了JMeter并发机制设计的不足,提出了一种具有一般性的量化访问速度控制机制及基于协程... 详细信息

软件性能校验结果有助于检验业务集群能否满足访问规模需求,但当前工具存在需要估算参数值、手工输入数据较多、性能偏低、应用复杂等不足。深入分析了JMeter并发机制设计的不足,提出了一种具有一般性的量化访问速度控制机制及基于协程的并发设计方案,给出了相应的测试即服务(TaaS)的架构设计和分布式自动性能测试方案,具有更高的并发性能,能使用真实业务数据并自动调整访问速度或调度更多服务器执行,自动汇总分析全量响应,有助于提高软件质量校验的效果及结果的直观性。

关键词：性能测试量化速度控制自动校验

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：