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Chiral Separation of N-Benzoyl Phenylalanine Methyl Ester by Nonaqueous Capillary Electrophoresis

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Chinese Chemical Letters 1999年第4期10卷 303-306页

作者： Yi LI lun jia xie Hu Wei LIU Wen Ting HUA(Department of Chemistry, Peking University, Beijing 100871) Department of Chemistry Peking University Beijing 100871 China

A successful chiral separation of N-benzoyl phenylalanine methyl ester has been achieved by nonaqueous capillary electrophoresis (NACE) using P-CD as chiral selector in formamide (FA). Some experimental parameters inf... 详细信息

关键词： nonaqueous capillary electrophoresis chiral separation N-benzoyl phenylalanine methyl ester

Thickness and sp3 bond modulation of（Ti/tetrahedral amorphous carbon）_n multilayer coatings

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Tungsten 2025年第1期7卷 152-160页

作者： Zhi-Jun xie jia-Lin Li Ling Gong Xiang-Li Zhong Hong-jia Song Jin-Bin Wang National-Provincial Laboratory of Special Function Thin Film Materials School of Materials Science and Engineering Xiangtan University

The durability of wear-resistant tetrahedral amorphous carbon（ta-C） coatings is intimately linked to their thickness and the concentration of *** enhance the lifespan of the coatings,we have prepared a multilayer coating consisting of alternating layers of Ti and ta-C,denoted as（Ti/ta-C）_n,using arc ion plating.A multi-layer structure in conjunction with stage cooling is employed to enhance the thickness and promote *** results indicate that the ID/IGvalue,representing the ratio of the intensity of the D peak to that of the G peak in Raman spectroscopy,decreases from 0.85 when no stage cooling is applied to 0.35 when stage cooling is employed,suggesting an enhancement in the fraction of sp3bonds within the *** obtained（Ti/ta-C）_n multilayer coating without peeling off has a maximum thickness of 1.14 μm,which is almost double that of the ta-C coating single layer *** the same time,the coating has a low coefficient of friction,down to 0.069,and maintains excellent friction properties with a wear rate of 3.4×10-6mm3·N-1·*** results conclusively show that the preparation technology can enhance both thickness and sp3bonding in ta-C coatings,significantly expanding their utility across tools,molds,and precision engineering components.

关键词： Arc ion plating Multilayer structure sp3 bond Ta-C coating Wear resistance

Skeletal muscle-specific Bambi deletion induces hypertrophy and oxidative switching coupling with adipocyte thermogenesis against metabolic disorders

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Science China Life Sciences 2025年

作者： Xiangping Yao Xudong Mai Ye Tian Yifan Liu Guanghui Jin Ze Li Shujie Chen Xiaoshuang Dai Liujing Huang Zijing Fan Guihua Pan Xiaohan Pan Xiangmin Li Michael C Yu jia Sun Jingxing Ou Hong Chen Liwei xie College of Life and Health Sciences Guangdong Industry Polytechnic Department of Endocrinology and Metabolism Zhujiang Hospital Southern Medical University State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application Guangdong Open Laboratory of Applied MicrobiologyInstitute of Microbiology Guangdong Academy of Sciences Institute of Aging Research Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics School of Medical Technology Guangdong Medical University Department of Hepatic Surgery and Liver transplantation Center of the Third Affiliated Hospital Organ Transplantation Institute Sun Yat-sen University Organ Transplantation Research Center of Guangdong ProvinceGuangdong province engineering laboratory for transplantation medicine Guangdong Provincial Key Laboratory of Liver Disease Research School of Public Health Xinxiang Medical University BGI Institute of Applied Agriculture BGI-Shenzhen Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Department of Biological Sciences State University of New York at Buffalo Department of Internal Medicine Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan) Guangdong Medical University

Skeletal muscle plays a significant role in both local and systemic energy metabolism. The current investigation aims to explore the role of the Bambi gene in skeletal muscle, focusing on its implications for muscle hypertrophy and systemic metabolism. We hypothesize that skeletal muscle-specific deletion of Bambi induces muscle hypertrophy, improves metabolic performance, and activates thermogenic adipocytes via the reprogramming of progenitor of i WAT, offering potential therapeutic strategies for metabolic syndromes. Leveraging the Chromatin immunoprecipitation(ChIP)-seq and bioinformatics analysis, Bambi gene is shown to be a direct target of HIF2α, which is further confirmed by ChIP-qPCR and promoter luciferase assay. Skeletal muscle-specific Bambi deletion led to significant muscle hypertrophy and improved metabolic parameters, even under high-fat diet conditions. This deletion induced metabolic reprogramming of stromal vascular fractions(SVFs) into thermogenic adipocytes, contributing to systemic metabolic improvements, potentially through the secretory ***, mice with skeletal muscle-specific Bambi deletion demonstrate resistance to high-fat diet-induced metabolic disorders, highlighting a potential therapeutic pathway for metabolic syndrome management. Thus, skeletal muscle-specific deletion of Bambi triggers muscle growth, enhances metabolic performance, and activates thermogenic adipocytes. These findings suggest Bambi as a novel therapeutic target for metabolic syndromes, providing new insights into the interaction between muscle hypertrophy and systemic metabolic improvement. The study underscores the potential of manipulating muscle physiology to regulate whole-body metabolism, offering a novel perspective on treating metabolic disorders.

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Multiple magnetic topologies in flux transfer events: THEMIS measurements

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Science China(Technological Sciences) 2016年第8期59卷 1283-1293页

作者： LV LeiQi PU ZuYin xie lun School of Earth and Space Science Peking University Beijing 100871 China PKU/UCLA Joint Research Institute in Science and Engineering Peking University Beijing 100871 China

Flux transfer events （FTEs） are local transient magnetic reconnections at the magnetopause （MP） that provide channels for transport of solar wind energy and plasma into the magnetosphere （MSP）. All current theoretical models suggest that FTEs are open-flux ropes; however, global simulations show that they contain both open and closed magnetic fields. To clarify this to- pology, we analyzed 441 events observed by THEMIS and investigated their magnetic topologies. Only one type of open field line was detected in most magnetosheath （MSH） FTEs, independent of the polarity of the Bn bipolar signatures. Newly formed MSH field lines were also observed. In the all MP boundary layers FTEs and most MSP FTEs, multiple types of topologies were observed, irrelevant to the Bn bipolar polarity. Closed field lines were found in all MP boundary layers and MSP FTEs. Meanwhile very few boundary FTEs contained the newly formed MSH flux. In some situations, only closed field lines were seen in MSP FTEs, which are referred to as the fossil FTEs. These results, which largely differ from the traditional view, demonstrate the existence of complex magnetic topologies in FTEs. Based on these results, we propose a new 3D FTE picture to modify the current FTE models.

关键词： flux transfer events magnetic flux rope magnetic field topology magnetopause

Empathizing with Emotional Robot Based on Cognition Reappraisal

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China Communications 2017年第9期14卷 100-113页

作者： Xin Liu lun xie Zhiliang Wang School of Computer and Communication Engineering University of Science and Technology Beijing

This paper proposes a continuous cognitive emotional regulation model for robot in the case of external emotional stimulus from interactive person's expressions. It integrates a guiding cognitive reappraisal strategy into the HMM(Hidden Markov Model) emotional interactive model for empathizing between robot and person. The emotion is considered as a source in the 3D space(Arousal, Valence, and Stance). State transition and emotion intensity can be quantitatively analyzed in the continuous space. This cognition-emotion interactive model have been verified by the expression and behavior robot. Empathizing is the main distinguishing feature of our work, and it is realized by the emotional regulation which operated in a continuous 3D emotional space enabling a wide range of intermediate emotions. The experiment results provide evidence with acceptability, accuracy, richness, fluency, interestingness, friendliness and exaggeration that the robot with cognition and emotional control ability could be better accepted in the human-robot interaction(HRI).

关键词： emotional robot human-robot in-teraction guiding cognitive reappraisal emo-tional regulation active field emotion space

Improving microwave brightness temperature predictions based on Bayesian model averaging ensemble approach

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Applied Mathematics and Mechanics(English Edition) 2016年第11期37卷 1501-1516页

作者： Binghao jia Zhenghui xie State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics (LASG) Institute of Atmospheric PhysicsChinese Academy of Sciences

The choices of the parameterizations for each component in a microwave emission model have significant effects on the quality of brightness temperature （Tb） sim- ulation. How to reduce the uncertainty in the Tb simulation is investigated by adopting a statistical post-processing procedure with the Bayesian model averaging （BMA） ensemble approach. The simulations by the community microwave emission model （CMEM） cou- pled with the community land model version 4.5 （CLM4.5） over China's Mainland are con- ducted by the 24 configurations from four vegetation opacity parameterizations （VOPs）, three soil dielectric constant parameterizations （SDCPs）, and two soil roughness param- eterizations （SRPs）. Compared with the simple arithmetical averaging （SAA） method, the BMA reconstructions have a higher spatial correlation coefficient （larger than 0.99） than the C-band satellite observations of the advanced microwave scanning radiometer on the Earth observing system （AMSR-E） at the vertical polarization. Moreover, the BMA product performs the best among the ensemble members for all vegetation classes, with a mean root-mean-square difference （RMSD） of 4 K and a temporal correlation coefficient of 0.64.

关键词： Bayesian model averaging (BMA) microwave brightness temperature com-munity microwave emission model (CMEM) community land model version 4.5 (CLM4.5)

Optimal redundancy allocation for reliability systems with imperfect switching

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Journal of Systems Engineering and Electronics 2014年第2期25卷 332-339页

作者： lun Ran Jinlin Li Xujie jia Hongrui Chu School of Management and Economics Beijing Institute of Technology College of Science Minzu University of China

The problem of stochastically allocating redundant com- ponents to increase the system lifetime is an important topic of reliability. An optimal redundancy allocation is proposed, which maximizes the expected lifetime of a reliability system with sub- systems consisting of components in parallel. The constraints are minimizing the total resources and the sizes of subsystems. In this system, each switching is independent with each other and works with probability p. Two optimization problems are studied by an incremental algorithm and dynamic programming technique respectively. The incremental algorithm proposed could obtain an approximate optimal solution, and the dynamic programming method could generate the optimal solution,

关键词： optimal redundancy allocation parallel imperfectswitching incremental algorithm dynamic programming.

Vacuum Susceptibility Calculation

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Communications in Theoretical Physics 2005年第3X期44卷 514-518页

作者： SHI Yuan-Mei PING jia-lun Department of Physics Nanjing Normal University Nanjing 210097 China School of Physics and Microelectronics Shandong University Jinan 250100 China

The vector susceptibility is investigated numerically in the Dyson-Schwinger approach. The results agree with those obtained analytically previously by using a simple gluon propagator.

关键词： Dyson-Schwinger equation vacuum susceptibility full gluon propagator

Experimental study of osthole on treatment of hyperlipidemic and alcoholic fatty liver in animals

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World Journal of Gastroenterology 2006年第27期12卷 4359-4363页

作者： Fang Song Mei-Lin xie Lu-jia Zhu Ke-Ping Zhang Jie Xue Zhen-lun Gu Department of Pharmacology Medical School of Soochow University Suzhou 215123 Jiangsu Province China Suzhou Institute of Chinese Marteria Medica Suzhou 215123 Jiangsu Province China

AIM： To evaluate the effects of osthole on fatty liver, and investigate the possible mechanism. METHODS： A quail model with hyperlipidemic fatty liver and rat model with alcoholic fatty liver were set up by feeding high fat diet and alcohol, respectively. These experimental animals were then treated with osthole 5-20 mg/kg for 6 wk, respectively. Whereafter, the lipid in serum and hepatic tissue, and coefficient of hepatic weight were measured. RESULTS： After treatment with osthole the levels of serum total cholesterol （TC）, triglyceride （TG）, lower density lipoprotein-cholesterol （LDL-C）, coefficient of hepatic weight, and the hepatic tissue contents of TC and TG were significantly decreased. The activity of superoxide dismutase （SOD） in liver was improved. In alcohol-induced fatty liver rats, the level of malondialdehyde （MDA） in liver was decreased. In high fat-induced fatty liver quails, glutathione peroxidase （GSH-PX） in liver was significantly improved. The histological evaluation of liver specimens demonstrated that the osthole dramatically decreased lipid accumulation. CONCLUSION： These results suggested that osthole had therapeutic effects on both alcohol and high fatinduced fatty liver. The mechanism might be associated with its antioxidation.

关键词： Hyperlipidemic fatty liver Alcoholic fatty liver Osthole Quails Rats