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Novel management indications for conservative treatment of chylous ascites after gastric cancer surgery

World Journal of Gastroenterology 2022年第42期28卷 6056-6067页

作者： Peng-fei Kong Yong-Hu Xu Zhi-Hua Lai Ming-Zhe Ma Yan-Tao Duan Bo Sun Da-Zhi Xu Department of Gastric Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Department of the General Surgery Suzhou Industrial Park Xinghai HospitalSuzhou 215124Jiangsu ProvinceChina

BACKGROUND Chylous ascites(CA) presents a challenge as a relatively common postoperative complication in gastric cancer(GC). Primary conservative therapy involved total parenteral nutrition, continuous low-pressure drainage, somatostatin, and a lowfat diet. Drainage tube(DT) clamping has been presented as a potential alternative conservative treatment for GC patients with *** To propose novel conservative treatment strategies for CA following GC *** The data of patients with CA after GC surgery performed at the fudan university shanghai Cancer center between 2006 and 2021 were evaluated *** 53 patients underwent surgery for GC and exhibited postoperative CA during the study period. Postoperative hospitalization and time of DT removal showed a significant positive association(R~2 = 0.979, P analysis demonstrated that postoperative infection and antibiotic usage were independent factors for delayed DT ***, DT removal times were shorter in seven patients who underwent DT clamping(clamped DT vs normal group, 11.8 d vs 13.6 d, P = 0.047;clamped DT vs delayed group, 13.6 d vs 27.4 d, P < 0.001). In addition, our results indicated that removal of the DT may be possible after three consecutive days of drainage volumes less than 300 mL in GC patients with *** Infection and antibiotic usage were vital independent factors that influenced delayed DT removal in patients with CA. Appropriate standards for DT removal can significantly reduce the duration of hospitalization. Furthermore, DT clamping might be a recommended

关键词： Gastric cancer Chylous ascites Conservative treatment Drainage tube

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Effect of Sodium Salicylate on Calcium Currents and Exocytosis in Cochlear Inner Hair Cells:Implications for Tinnitus Generation

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Neuroscience Bulletin 2022年第1期38卷 69-80页

作者： Ting Fan Meng-Ya Xiang Ruo-Qiao Zhou Wen Li Li-Qin Wang Peng-fei Guan Geng-Lin Li Yun-Feng Wang Jian Li ENT Institute and Department of Otorhinolaryngology EYE&ENT HospitalFudan UniversityShanghai200031China NHC Key Laboratory of Hearing Medicine Fudan UniversityShanghai200031China Clinical Laboratory center Children’s Hospital of Fudan UniversityShanghai201102China

Sodium salicylate is an anti-inflammatory medication with a side-effect of ***,we used mouse cochlear cultures to explore the effects of salicylate treatment on cochlear inner hair cells(IHCs).We found that IHCs showed significant damage after exposure to a high concentration of ***-cell patch clamp recordings showed that 1–5 mmol/L salicylate did not affect the exocytosis of IHCs,indicating that IHCs are not involved in tinnitus generation by enhancing their neuronal ***,salicylate induced a larger peak amplitude,a more negative half-activation voltage,and a steeper slope factor of Ca^(2+)*** noise analysis of Ca^(2+)tail currents and qRT-PCR,we further found that salicylate increased the number of Ca^(2+)channels along with CaV1.3 *** these changes could act synergistically to enhance the Ca^(2+)influx into *** of intracellular Ca^(2+)overload significantly attenuated IHC death after 10 mmol/L salicylate *** results implicate a cellular mechanism for tinnitus generation in the peripheral auditory system.

关键词： Salicylate Tinnitus Inner hair cell Calcium current Exocytosis Whole-cell patch clamp CaV1.3 channel

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Environmental noise beside an elevated box girder bridge for urban rail transit

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Journal of Zhejiang university-Science A(Applied Physics & Engineering) 2021年第1期22卷 53-69页

作者： Yun-fei ZHANG Li LI Zhen-yu LEI Long-bo YU Zheng BU Institute of Rail Transit Tongji UniversityShanghai 201804China shanghai Key Laboratory of Rail Infrastructure Durability and System Safety Shanghai 201804China

Noise generated by trains running on elevated lines creates many disturbances to the normal lives of surrounding residents. Investigations have shown that people living along elevated lines complain that the noise is sometimes unbearable. To better control the noise and optimize the acoustic environment, noise spectrum characteristics were analyzed and compared with a field test and a numerical simulation. Through an energy analysis of the noise on the bridge side, the energy distribution characteristics of the noise at specific measuring points in different frequency bands were obtained. The influence of the Doppler effect on frequency shift was analyzed. Based on the partial coherence theory, a multi-input and single-output program was compiled to calculate the correlation and contribution degree of the bridge structure-borne noise and wheel/rail noise at the one-third octave center frequency. The results show that the peak noises of the bridge and the wheel/rail are concentrated at 31.5–63 Hz and 400–800 Hz, respectively. For environmental noise on the bridge side, the frequency band above 250 Hz is mainly affected by the wheel/rail noise. In areas of noise source strength, the relative ratio of noise energy above 250 Hz can reach 83.4%. Noise in the near ground and far bridge area is mainly low-frequency, and the relative energy ratio is about 8.9%. The Doppler effect has an influence of less than 6% on the frequency shift with a speed of 67.9 km/h. In the low-frequency band below 250 Hz, the noise in the acoustic shadow area near the bridge and the ground is mainly contributed to by the vibration-radiated noise of the bridge, of which the contribution of the bottom panel is the most prominent. The noise in the comprehensive noise area of the far bridge is mainly caused by the structure-borne noise of the bridge, and the contribution of each bridge panel is different. This study can provide a reference for finding the source of elevated rail noise in some challe

关键词： Urban rail transit Elevated line Environmental noise Box girder bridge Field measurement Acoustic model Doppler effect

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Twenty years of ocean observations with China Argo

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Acta Oceanologica Sinica 2023年第2期42卷 1-16页

作者： Zenghong Liu Xiaogang Xing Zhaohui Chen Shaolei Lu Xiaofen Wu Hong Li Chunling Zhang Lijing Cheng Zhaoqin Li Chaohui Sun Jianping Xu Dake Chen fei Chai State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou310012China Observation and Research Station of Global Ocean Argo System(Hangzhou) Ministry of Natural ResourcesHangzhou310012China Frontier Science center for Deep Ocean Multispheres and Earth System/Key Laboratory of Physical Oceanography Ocean University of ChinaQingdao266100China Department of Atmospheric and Oceanic Sciences/Institute of Atmospheric Sciences Fudan UniversityShanghai200438China College of Marine Sciences Shanghai Ocean UniversityShanghai201306China International center for Climate and Environment Sciences Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing100029China

The international Argo program,a global observational array of nearly 4000 autonomous profiling floats initiated in the late 1990s,which measures the water temperature and salinity of the upper 2000 m of the global ocean,has revolutionized *** has been recognized one of the most successful ocean observation systems in the ***,the proposed decade action“OneArgo”for building an integrated global,full-depth,and multidisciplinary ocean observing array for beyond 2020 has been *** the past two decades since 2002,with more than 500 Argo deployments and 80 operational floats currently,China has become an important partner of the Argo *** DACs have been established to process the data reported from all Chinese floats and deliver these data to the GDACs in real time,adhering to the unified quality control procedures proposed by the Argo Data Management *** Argo products have been developed and released,allowing accurate estimations of global ocean warming,sea level change and the hydrological cycle,at interannual to decadal *** addition,Deep and BGC-Argo floats have been deployed,and time series observations from these floats have proven to be extremely useful,particularly in the analysis of synoptic-scale to decadal-scale *** future aim of China Argo is to build and maintain a regional Argo fleet comprising approximately 400 floats in the northwestern Pacific,South China Sea,and Indian Ocean,accounting for 9%of the global fleet,in addition to maintaining 300 Deep Argo floats in the global ocean(25%of the global Deep Argo fleet).A regional BGC-Argo array in the western Pacific also needs to be established and maintained.

关键词： Argo program China Argo ocean observation core Argo Deep Argo BGC-Argo

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如何用锚点情境法降低自评健康的回答偏误?——一项基于CFPS2012数据的实证分析

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人口与发展 2019年第2期25卷 117-128页

作者：吴菲复旦大学社会学系上海200433

健康不平等是人口学研究中的核心议题之一。然而,以自评健康为代表的主观健康测量因受回答异质性问题的困扰,可能会对研究结论的可信性造成威胁。锚点情境法(anchoring vignette method)作为一项有效处理回答异质性的方法在西方学术界... 详细信息

健康不平等是人口学研究中的核心议题之一。然而,以自评健康为代表的主观健康测量因受回答异质性问题的困扰,可能会对研究结论的可信性造成威胁。锚点情境法(anchoring vignette method)作为一项有效处理回答异质性的方法在西方学术界已被广泛使用。介绍了该方法的基本原理、核心假设及其验证方法。使用2012年中国家庭追踪调查(CFPS2012)数据,应用锚点情境法对自评健康(self-rated health)进行调整,发现不同群体在面对同样的自评健康选项时,的确存在回答异质性的问题,如未加调整,所得的年龄、迁移状态以及社会经济地位对于自评健康的影响会产生实质性的偏误。

关键词：锚点情境法自评健康回答异质性情境等价性假设回答一致性假设

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Criteria-specific long-term survival prediction model for hepatocellular carcinoma patients after liver transplantation

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World Journal of Gastroenterology 2014年第31期20卷 10900-10907页

作者： fei Teng Gui-Hua Wang Yi-Feng Tao Wen-Yuan Guo Zheng-Xin Wang Guo-Shan Ding Xiao-Min Shi Zhi-Ren Fu Organ Transplantation Institute of Changzheng Hospital Second Military Medical University

AIM: To establish a model to predict long-term survival of hepatocellular carcinoma (HCC) patients after liver transplantation (MHCAT).

关键词： Criteria Hepatocellular carcinoma Liver transplantation MHCAT Survival model

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Coupled electrophysiological recording and single cell transcriptome analyses revealed molecular mechanisms underlying neuronal maturation

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Protein & Cell 2016年第3期7卷 175-186页

作者： Xiaoying Chen Kunshan Zhang Liqiang Zhou Xinpei Gao Junbang Wang Yinan Yao fei He Yuping Luo Yongchun Yu Siguang Li Liming Cheng Yi E. Sun Stem Cell Translational Research center Tongji Hospital Tongji University School of Medicine Shanghai 200065 China Department of Psychiatry and Biobehavioral Sciences David Geffen School of Medicine University of California Los Angeles CA 90095 USA Institute of Neurobiology Institute of Brain Science and State Key Laboratory of Medical Neurobiology Fudan University Shanghai 200032 China Collaborative Innovation center for Brain Science Tongji University Shanghai 200092 China

The mammalian brain is heterogeneous, containing billions of neurons and trillions of synapses forming vari- ous neural circuitries, through which sense, movement, thought, and emotion arise. The cellular heterogeneity of the brain has made it difficult to study the molecular logic of neural circuitry wiring, pruning, activation, and plasticity, until recently, transcriptome analyses with single cell resolution makes decoding of gene regulatory networks underlying aforementioned circuitry properties possible. Here we report success in per- forming both electrophysiological and whole-genome transcriptome analyses on single human neurons in culture. Using Weighted Gene Coexpression Network Analyses （WGCNA）, we identified gene clusters highly correlated with neuronal maturation judged by electrophysiological characteristics. A tight link between neu- ronal maturation and genes involved in ubiquitination and mitochondrial function was revealed. Moreover, we identified a list of candidate genes, which could potentially serve as biomarkers for neuronal maturation. Coupled electrophysiological recording and single cell transcriptome analysis will serve as powerful tools in the future to unveil molecular logics for neural circuitry functions.

关键词： Patch-Seq hESC/hiPSC-derived neuron WGCNA Biomarkers for neuronal maturation Ubiquitination and mitochondrial function

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上海市居民社区爱国卫生服务满意度现状及影响因素分析

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上海医药 2024年第18期45卷 12-15,62页

作者：于慧敏王伟姜综敏史晓誉刘梦婷魏晓敏严非付朝伟复旦大学公共卫生学院(国家卫生健康委员会卫生技术评估重点实验室) 上海200032 上海市健康促进中心爱国卫生和健康促进指导部上海200040

目的:通过调查上海市居民对社区爱国卫生服务的满意度,从居民视角探究上海市爱国卫生服务开展情况。方法:将上海市划分为中心城市A区、B区和非中心城区C区、D区,于2022年9-12月采用分层整群随机抽样方法分别从4个区域各抽取5个街道,共... 详细信息

目的:通过调查上海市居民对社区爱国卫生服务的满意度,从居民视角探究上海市爱国卫生服务开展情况。方法:将上海市划分为中心城市A区、B区和非中心城区C区、D区,于2022年9-12月采用分层整群随机抽样方法分别从4个区域各抽取5个街道,共计20个街道的社区居民开展问卷调查。问卷内容包括居民一般资料、对近一年社区爱国卫生相关服务满意度、对四害防治效果的感知度和对各类场所卫生情况的感知度。结果:4122名(81.8%)居民对近一年社区爱国卫生服务表示满意,其中城区居民2529名(90.3%),郊区居民1593名(71.2%)。两水平方差成分模型分析结果显示,所在区域、老鼠出现情况、小区垃圾处置点卫生情况和小区周边环境卫生情况是对居民社区爱国卫生服务满意度具有统计学意义的影响因素(P<0.05)。结论:应进一步关注非中心城区爱国卫生服务开展情况,建立健全基层爱国卫生服务体系,以政府为主导、多部门协作、全社会动员,持续推进上海市社区爱国卫生服务的持续发展。

关键词：社区爱国卫生服务四害场所卫生满意度影响因素

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Small balloon strategy associated with low pacemaker implantation rate after self-expanding transcatheter valve implantation

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World Journal of Emergency Medicine 2021年第1期12卷 48-53页

作者： Yuan Zhang Wen-zhi Pan Li-hua Guan Xiao-chun Zhang Sha-sha Chen Li-fan Yang Lei Zhang Ming-fei Li Dan-dan Chen Da-xin Zhou Jun-bo Ge Department of Cardiology Shanghai Institute of Cardiovascular DiseaseZhongshan HospitalFudan UniversityShanghai 200032China

BACKGROUND: This study aims to investigate whether small balloon aortic valvuloplasty(BAV) reduces the need for permanent pacemaker implantation (PPMI) after transcatheter aortic valveimplantation (TAVI).METHODS: This was a retrospective analysis using data from our local TAVI database. SmallBAV was defined as a small balloon size (=18 mm) pre-dilatation. Normal BAV was defined as aballoon size >18 mm. The primary endpoint was the incidence of new ***: Of 99 consecutive TAVI patients, five patients were excluded due to pre-existingpermanent pacemaker. Patients in the small BAV group (n=57) had a signifi cantly lower PPMI ratecompared with the normal BAV group (n=37) (3.5% vs. 18.9%, P=0.026). Moderate or severe aorticvalve regurgitation post-procedure was similar between the small BAV and normal BAV groups (5.3%vs. 8.1%, P=0.480);likewise, the mean aortic gradient post-procedure did not differ significantly(11.5±5.2 mmHg vs. 12.2±7.3 mmHg, 1 mmHg=0.133 kPa, P=0.580) between the groups. Devicesuccess rates were also similar (94.7% vs. 91.8%, P=0.680). In multivariable analysis, small BAV(P=0.027), the ratio of prosthesis diameter to annulus diameter (P=0.048), and mean aortic gradientby echo in the basement (P=0.021) were independent predictors of ***: The small BAV strategy is associated with a low rate of permanentpacemaker implantation after transcatheter self-expanding valve implantation in this single-centerobservational study.

关键词： Transcatheter aortic valve implantation Balloon aortic valvuloplasty Balloon size Permanent pacemaker implantation

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Association of β-cell function and insulin resistance with pediatric type 2 diabetes among Chinese children

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World Journal of Diabetes 2021年第8期12卷 1292-1303页

作者： Zhen-Ran Xu Hong-Wei Du Lan-Wei Cui Rong-Xiu Zheng Gui-Mei Li Hai-Yan Wei fei-Yu Lu Li-Li Chen Chu-Shan Wu Shu-Xin Zhang Shu-Le Zhang Fang Liu Miao-Ying Zhang Zhou Pei Cheng-Jun Sun Jing Wu fei-Hong Luo Department of Pediatric Endocrinology and Inherited Metabolic Diseases National Children’s Medical CenterChildren’s Hospital of Fudan UniversityShanghai 201102China Department of Pediatric Endocrinology and Inherited Metabolic Diseases The First Bethune Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Pediatrics The First Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina Department of Pediatrics Tianjin Medical University General HospitalTianjin 300052China Department of Pediatric Endocrinology and Inherited Metabolic Diseases Shandong Provincial Hospital Affiliated to Shandong UniversityJinan 250021Shandong ProvinceChina Department of Endocrinology Henan Children's HospitalZhengzhou 450052Henan ProvinceChina

BACKGROUND In addition to insulin resistance,impaired insulin secretion has recently been identified as a crucial factor in the pathogenesis of type 2 diabetes mellitus(T2DM).Scarce clinical data exist for pediatric *** To investigate the association ofβ-cell function and insulin resistance with pediatric T2DM in the first Chinese multicenter *** This multicenter cross-sectional study included 161 newly diagnosed T2DM children and adolescents between January 2017 and October *** with normal glycemic levels(n=1935)were included as healthy control *** homeostasis models(HOMAs)were used to assess theβ-cell function(HOMA2-%B)and insulin resistance(HOMA2-IR)*** HOMA index was standardized by sex and *** performed logistic regression analysis to obtain odds ratios(ORs)for T2DM risk using the standardized HOMA index,adjusted for confounding factors including sex,Tanner stage,T2DM family history,body mass index z-score,and lipid *** The male-female ratio of newly diagnosed T2DM patients was 1.37:1(OR=2.20,P=0.011),and the mean ages of onset for boys and girls were 12.5±1.9 years and 12.3±1.7 years,*** prevalence of related comorbidities including obesity,elevated blood pressure,and dyslipidemia was 58.2%,53.2%,and 80.0%,*** T2DM group had lower HOMA2-%B levels(P<0.001)and higher HOMA2-IR levels(P<0.001)than the control *** the decrease in HOMA2-%B z-score(OR=8.40,95%CI:6.40-11.02,P<0.001)and the increase in HOMA2-IR z-score(OR=1.79,95%CI:1.60-2.02,P<0.001)were associated with a higher risk of T2DM,and the decrease in HOMA2-%B z-score always had higher ORs than the increase in HOMA2-IR z-score after adjusting for confounding *** Besides insulin resistance,β-cell function impairment is also strongly associated with Chinese pediatric *** difference in susceptibility and high comorbidities warrant specific T2DM screening and prevention strategies in Chinese children.

关键词： Diabetes mellitus Type 2 β-cell dysfunction Insulin resistance Adolescent Homeostasis models

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