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M2型肿瘤相关巨噬细胞浸润与食管鳞癌发生、浸润及转移的关系

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郑州大学学报（医学版） 2017年第5期52卷 527-531页

作者：张冰孙淼淼韦娜贺璐璐王正洋张红新陈奎生郑州大学附属肿瘤医院病理科郑州450003 郑州大学第一附属医院病理科河南省肿瘤病理重点实验室郑州450052 中美(河南)荷美尔肿瘤研究院郑州450003

目的:探讨M2型肿瘤相关巨噬细胞(M2型TAM)浸润与食管鳞癌发生、浸润、转移的关系及其可能机制。方法:采用免疫组化SP法分别检测50例食管鳞癌和50例正常食管黏膜组织中CD206(M2型TAM特异性标志物)、IL-8、MCP-1蛋白的表达;应用原位杂交... 详细信息

目的:探讨M2型肿瘤相关巨噬细胞(M2型TAM)浸润与食管鳞癌发生、浸润、转移的关系及其可能机制。方法:采用免疫组化SP法分别检测50例食管鳞癌和50例正常食管黏膜组织中CD206(M2型TAM特异性标志物)、IL-8、MCP-1蛋白的表达;应用原位杂交方法分别检测上述组织中IL-8、MCP-1 mRNA的表达。结果:食管鳞癌组织中M2型TAM的浸润数量多于正常食管黏膜(P=0.032);食管鳞癌间质中IL-8、MCP-1蛋白及mRNA阳性表达率高于正常食管黏膜组织(P0.05);食管鳞癌间质中M2型TAM的浸润数量与IL-8、MCP-1蛋白和mRNA的表达呈正关联(蛋白:rP=0.432、0.315;mRNA:rP=0.373、0.332,P均<0.05)。结论:M2型TAM与食管鳞癌的发生、浸润、转移有关,其机制可能与TAM分泌的趋化因子IL-8和MCP-1有关。

关键词：肿瘤相关巨噬细胞 CD206 IL-8 MCP-1 浸润转移

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儿童组织胞浆菌病1例

实用儿科临床杂志 2009年第9期24卷 652-652,655页

作者：田野陆勤何璐璐于毅游贤慧李立群邱卫娟南京医科大学附属南京儿童医院感染科南京210008 南京医科大学附属南京儿童医院血液科南京210008

组织胞浆菌病是荚膜组织胞浆菌引起的传染性真菌病,好发于6个月～2岁儿童,在我国发病率不高.本院2008年6月收治1例患儿.现报告如下.

关键词：组织胞浆菌病临床表现儿童

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城市地下排水管道隐患评价探索研究

城市勘测 2018年第A1期 290-295页

作者：李晓静胡本刚陈勇何露露张芳国家测绘地理信息局第六地形测量队成都610500

在城市内涝频发、城市水环境恶化的背景下,城市排水管网系统问题不断暴露。本文基于地下管线普查数据成果、基础地理信息数据、城区用地规划数据,结合人口、经济区域面积等社会经济数据探索性地确定了地下排水管道评价指标,并建立了评... 详细信息

在城市内涝频发、城市水环境恶化的背景下,城市排水管网系统问题不断暴露。本文基于地下管线普查数据成果、基础地理信息数据、城区用地规划数据,结合人口、经济区域面积等社会经济数据探索性地确定了地下排水管道评价指标,并建立了评价模型。最后,以渭南市为例,对其排水管网的现状、结构性隐患管道现状进行了评价分析,发现了城区排水不畅的影响因素,为城区排水管网的规划、建设及后期维护改造提供有力的依据。

关键词：管线普查数据排水管网管网现状评价隐患管道结构性评价

小鼠舌癌模型差异基因的筛选及生物信息学分析

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临床医药实践 2019年第1期28卷 31-36页

作者：武媛万晓文王伟蒋琳邵益森何露露江西中医药大学附属医院江西南昌330006 江西中医药大学江西南昌330004

目的:对小鼠舌癌模型差异表达基因进行筛选及基因功能分析,为舌癌发病机制相关的分子标志物及药物靶点提供理论基础。方法:从高通量基因表达(GEO)数据库中选取GSE64271和GSE75421数据包,获取其中小鼠舌癌模型的芯片数据,分为舌癌组和非... 详细信息

目的:对小鼠舌癌模型差异表达基因进行筛选及基因功能分析,为舌癌发病机制相关的分子标志物及药物靶点提供理论基础。方法:从高通量基因表达(GEO)数据库中选取GSE64271和GSE75421数据包,获取其中小鼠舌癌模型的芯片数据,分为舌癌组和非舌癌组,利用R语言的limma包分析筛选差异基因。利用DAVID和STRING数据库对差异表达基因进行基因本体论(GO)及京都基因与基因组百科全书(KEGG)基因功能分析、蛋白相互作用分析。结果:对差异基因筛选后,将两个数据集的数据取交集后最终得到303个基因,其中31个基因上调与细胞周期(Cell Cycle)和卵母细胞分裂有关,说明在肿瘤发生发展的过程中,通过上调这些基因促进肿瘤增殖。而其余基因的KEGG分析结果则表明这些基因与代谢过程密切相关。通过蛋白互作网络(PPI)筛选出cross-talk基因:整合素a1(Itga1)和整合素a6(Itga6)。结论:筛选出的差异基因可能在舌癌的分子层面发挥了重要的作用,为舌癌发生、发展的机制、肿瘤标志物的筛选等提供了理论依据。

关键词：生物信息学分析差异表达基因舌癌

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正畸牵引力对牙釉质层微观结构的影响

南方医科大学学报 2020年第8期40卷 1165-1171页

作者：李祉欣张凯亮李瑞萍许龄丹何璐璐庞晓婵卢纪元曹宝成张宝平兰州大学口腔医学院甘肃兰州730000 兰州大学口腔医院修复科甘肃兰州730000 兰州大学口腔医院正畸科甘肃兰州730000 兰州大学口腔医院颌面外科甘肃兰州730000

目的探讨正畸牵引力对牙釉质层微观结构的影响,为口腔正畸临床实践提供力学依据。方法选取48颗离体前磨牙,随机分为6组,8颗/组。A组为空白对照组,仅使用光固化粘接法粘接正畸托槽,不加任何力。B1、B2、B3组均使用光固化粘接法粘接正畸托... 详细信息

目的探讨正畸牵引力对牙釉质层微观结构的影响,为口腔正畸临床实践提供力学依据。方法选取48颗离体前磨牙,随机分为6组,8颗/组。A组为空白对照组,仅使用光固化粘接法粘接正畸托槽,不加任何力。B1、B2、B3组均使用光固化粘接法粘接正畸托槽,分别加载50 g力持续6月,200 g力持续6月和200 g力持续1月。C1、C2组分别使用光固化粘接和化学固化粘接技术粘接托槽。对试样组的牙齿进行不脱钙环氧树脂包埋,经硬组织切片机切片后,使用扫描电子显微镜(SEM)、原子力显微镜(AFM)及能谱仪(EDS)对断裂界面形态和元素组成进行分析。结果实验组离体牙相比对照组粘合剂残余指数较大,SEM观察到牙釉质表面出现微裂纹和空隙结构,AFM显示不同粘接方式釉质表面形成与打磨方向呈角度的微裂纹。实验组随托槽上加的力值增大,牙釉质界面微裂隙越多。界面粗糙度方面A与C2组具有差异(P<0.05);峰-谷距离方面,A、C1和C2组三者具有显著差异(P<0.05)。结论正畸牵引力改变了正常牙釉质层的微观结构。

关键词：正畸力牙釉质层微结构釉质脱矿

Recent progress in polymer dielectrics containing boron nitride nanosheets for high energy density capacitors

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High Voltage 2020年第4期5卷 365-376页

作者： he Li lulu Ren Yao Zhou Bin Yao Qing Wang Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA

hexagonal boron nitride nanosheets(BNNSs)are two-dimensional nanomaterials with graphitic-like layered nanostructures,high surface areas,and large aspect *** to their excellent thermal conductivity,electrical and mechanical strengths,BNNSs are emerging as multifunctional fillers in polymer *** this article,the authors review the recent progress in the BN-containing polymer nanocomposites designed for high-performance film *** general synthetic approaches to BNNSs and polymer/BNNS nanocomposites are summarized,particular attention is placed on structure-property correlation and rational structural design of the composites with optimized dielectric properties and capacitive *** stark contrast to the polymer composites employing high dielectric constant fillers to enhance the electric displacement,a new design concept based on the utilization of BNNSs with a wide bandgap to impede electrical conduction and consequently improve breakdown strength and charge-discharge efficiency of the polymer composites,is *** significance of developing dielectric capacitors with desirable thermal conductivity and thermal stability to ensure their robust and efficient operation is *** merits and challenges regarding the existing polymer dielectrics containing BNNSs for energy storage are *** outlook for future research opportunities and engineering applications is also presented in this review.

关键词： composites polymer boron

低氧诱导因子与肝脏脂质代谢异常的相关性研究进展

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心血管病学进展 2017年第1期38卷 91-94页

作者：甘露路杨文慧何燕王勤刘师节张帆杨莉昆明医科大学附属延安医院老年医学科云南昆明650051

低氧诱导因子通过调控其下游靶基因表达对脂肪肝引起的脂质代谢紊乱产生适应性反应,同时介导阻塞性睡眠呼吸暂停相关肝脏脂质沉积,阻塞性睡眠呼吸暂停常与肥胖协同加重组织缺氧,导致严重的肝细胞脂肪变性及炎症。目前,国内外已有大量基... 详细信息

低氧诱导因子通过调控其下游靶基因表达对脂肪肝引起的脂质代谢紊乱产生适应性反应,同时介导阻塞性睡眠呼吸暂停相关肝脏脂质沉积,阻塞性睡眠呼吸暂停常与肥胖协同加重组织缺氧,导致严重的肝细胞脂肪变性及炎症。目前,国内外已有大量基础研究旨在探究低氧诱导因子在脂肪肝的发生发展过程中起着保护性作用还是有害的作用,但仍无定论。因而阐明低氧诱导因子调控肝脏脂质代谢的分子机制,将有利于利用低氧诱导因子这个有效靶点,在脂肪肝及其相关疾病中发挥治疗作用。

关键词：低氧诱导因子脂肪肝脂质代谢阻塞性睡眠呼吸暂停

Full mode flight dynamics modelling and control of stopped-rotor UAV

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Chinese Journal of Aeronautics 2022年第10期35卷 95-105页

作者： Ao he Honggang GAO Shanshan ZHANG Zhenghong GAO Bodi MA lulu CheN Wei DAI School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China School of Civil Aviation Northwestern Polytechnical UniversityXi'an 710072China

The Stopped-Rotor(SR)UAV combines the advantages of vertical take-off and landing of helicopter and high-speed cruise of fixed-wing *** the same time,it also has a unique aerodynamic layout,which leads to great differences in the control and aerodynamic characteristics of various flight modes,and brings great challenges to the flight dynamics modelling and control in full-mode *** this paper,the flight dynamics modelling and control method of SR UAV in full-mode flight is ***,based on the typical flight profile of SR UAV when performing missions,using the theory and method of fuzzy mathematics,the T-S flight dynamics model of SR UAV in full-mode flight is established by synthesizing the flight dynamics model of each flight ***,an explicit model tracking and parameter adjusting control system based on fuzzy theory is designed to enhance the stability of the inner loop of SR UAV in full-mode flight,which effectively reduces the coupling between axes and improves the control quality of the ***,the outer loop control system is designed by using classical control method,and the control law of SR UAV in full-mode automatic flight is *** simulation results show that the proposed control system design method is feasible and effective,which lays a solid foundation for the subsequent engineering implementation of the SR UAV.

关键词： Full-mode control High-speed helicopter Model building Stopped-rotor aircraft Variable parameter stabilization

A critical review of on-site inorganic arsenic screening methods

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Journal of Environmental Sciences 2023年第3期125卷 453-469页

作者： Yi he Jingyu Liu Yanhua Duan Xiaofei Yuan lulu Ma Ratan Dhar Yan Zheng Department of Sciences John Jay College and the Graduate CenterThe City University of New YorkNY 10019USA State Environmental Protection Key Laboratory of Integrated Surface Water-Groundwater Pollution Control School of Environmental Science and EngineeringSouthern University of Science and TechnologyShenzhen 518055China Guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control School of Environmental Science and EngineeringSouthern University of Science and TechnologyShenzhen 518055China Queensland Alliance for Environmental health Sciences(QAEHS) The University of QueenslandQLD 4102Australia Department of Earth and Physical Sciences York CollegeThe City University of New YorkNY 11451USA

Approximately 94 to 220 million people worldwide are at risk of drinking well water containing arsenic > 10 μg/L, the WHO guideline value. To identify non-compliant domestic wells, assess health risks and reduce exposure, accurate and rapid on-site inorganic arsenic screening methods are desirable because all domestic wells worldwide need to be ***, the principles, advantages and limitations of commonly used colorimetry, electrochemistry, and biosensing methods are critically reviewed, with the performance compared with laboratory-based benchmark methods. Most commercial kits are based on the classic Gutzeit reaction. Despite being semi-quantitative, the more recent and more expensive products display improved and acceptable accuracy and shorter testing time (~10 min). Carried out by trained professionals, electrochemical methods are also feasible for on-site analysis, although miniaturization is desirable yet challenging. Biosensing using whole bacterial cells or bio-engineered materials such as aptamers is promising, if incorporated with function specific nanomaterials and biomaterials. Since arsenic is frequently found as arsenite in reducing groundwater and subject to oxidation during sampling, transportation and storage, on-site separation and sample preservation are feasible but the specific methods should be chosen based on sample matrix and tested before use. To eliminate arsenic exposure among hundreds of millions of mostly rural residents worldwide, we call for concerted efforts in research community and regulatory authority to develop accurate, rapid, and affordable tests for on-site screening and monitoring of arsenic in drinking water. Access to affordable testing will benefit people who are socioeconomically disadvantaged.

关键词： Inorganic arsenic On-site analysis Drinking water Groundwater Field test