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Editorial of Special Column“Novel Peptides and Peptidomimetics in Drug Discovery”

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Acta Pharmaceutica Sinica B 2021年第9期11卷 2606-2608页

作者： Jianfeng Cai lulu wei Department of Chemistry University of South Florida

Since insulin,a natural peptide composed of 51 amino acids,was first isolated and commercialized in the 1920s,peptide drugs have greatly reshaped our modern drug discovery area^(1).To date,the total number of approved peptide drugs for human use worldwide has exceeded 60^(2).Popular peptide drugs such as liraglutide(Victoza)^(2) and glucagon-like peptide 1(GLP-1)^(3) are the topselling drugs for type 2 ***,significant hurdles associated with natural peptide sequences as therapeutics,such as metabolic instability and,consequently,have low oral bioavailability and shorter half-life^(4),are still *** overcome the limitations of natural peptides and further optimize their advantages,peptidomimetics emerged as an alternative strategy.

关键词： drugs Popular overcome

One-step synthesis and self-assembly behavior of thermo-responsive star-shaped β-cyclodextrin-（P（M EO2MA-co-PEGMA））21 copolymers

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Frontiers of Materials Science 2017年第3期11卷 223-232页

作者： lulu wei Beibei LU Lei LI Jianning WU Zhiyong LIU Xuhong GUO School of Chemistry and Chemical Engineering Shihezi University/Key Laboratory of Materials-Oriented Chemical Engineering of Xinjiang Uygur Autonomous Region/Engineering Research Center of Materials-Oriented Chemical Engineering of Xinjiang Bingtuan Shihezi 832003 China State Key Laboratory of Chemical Engineering East China University of Science and Technology Shanghai 200237 China

A novel β-cyclodextrin-poly（2-（2-methoxyethoxy）ethyl methacrylate）-co- poly（ethylene glycol） methacrylate （abbreviated as： β-CD-（P（MEO2MA-co-PEGMA））21） was prepared by using the one-step strategy, and then the star-shaped copolymers were used in the atom transfer radical polymerization （ATRP）. The structure of star-shaped β- CD-（P（MEO2MA-co-PEGMA））21 copolymers were studied by FTIR, 1H NMR and gel permeation chromatography （GPC）. The star-shaped copolymers could self-assembled into micelles in aqueous solution owing to the outer amphiphilic β-CD as a core and the hydrophilic P（MEO2MA-co-PEGMA） segments as a shell. These thermo-responsive starshaped copolymers micelles exhibited lower critical solution temperature （LCST） in water, which could be finely tuned by changing the feed ratio of MEO2MA to PEGMA. The LCST of star-shaped β-CD-（P（MEO2MA-co-PEGMA））21 copolymer micelles were increased from 35℃ to 58℃ with the increasing content of PEGMA. The results were investigated by DLS and TEM. When the temperature was higher than corresponding LCSTs, the micelles started to associate and form spherical nanoparticles. Therefore, β- CD-（P（MEO2MA-co-PEGMA））21 star-shaped copolymer micelles could be potentially applied in nano-carrier, nano-reactor, smart materials and biomedical fields.

关键词： star-shaped copolymers thermo-responsive β-cyclodextrin (β-CD) self- assembly atom transfer radical polymerization (ATRP)

Solution-processed all-inorganic lead halide perovskite/layered double hydroxides superlattices

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Science China Chemistry 2024年第9期67卷 2904-2910页

作者： Deyu Li Mingming Zhang lulu wei Shubing Tian Mingze Sun Kang Liu Jixiang Xu Lei Wang Jun Xing Key Laboratory of Eco-chemical Engineering Ministry of EducationCollege of Chemistry and Molecular EngineeringQingdao University of Science&TechnologyQingdao 266042China College of Sino-German Science and Technology Qingdao University of Science&TechnologyQingdao 266042China

Quantum wells and superlattices are key building blocks in the semiconductor industry,normally fabricated using epitaxial growth techniques,such as vapor phase epitaxy,metalorganic chemical vapor deposition and molecular beam ***,these complicated preparation processes,as well as their high cost,limit their extensive *** is essential to develop a simple solution process for building ***,we demonstrate an ion exchange strategy for synthesizing an allinorganic superlattice cesium lead bromide/layered double hydroxides(CsPbBr_3/LDH)in *** room temperature,the perovskite ions diffuse into the interlayer of LDH and assemble into layered perovskite with various *** with traditional organic-inorganic hybrid perovskite superlattice,the all-inorganic perovskite superlattice CsPbBr_(3)/LDH has weak quantum confinement,which exhibits narrow emission line-widths of 20 nm,high quantum yields of 55%,and radiative lifetimes of several *** findings offer a new route to synthesize novel perovskite superlattices and enrich the perovskite supercrystal platform for electronics,photonics and optoelectronics devices.

关键词： halide perovskite superlattice layered double hydroxides 2D

Folate-conjugated pH-responsive nanocarrier designed for active tumor targeting and controlled release of doxorubicin

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Frontiers of Materials Science 2017年第4期11卷 328-343页

作者： lulu wei Beibei LU Lin CUI Xueying PENG Jianning wu Deqiang LI Zhiyong LIU Xuhong GUO School of Chemistry & Chemical Engineering Shihezi University/Key Laboratory of Green Processing for Chemical Engineering/Key Laboratory of Materials-Oriented Chemical Engineering of Xinjiang Uygur Autonomous Region/Engineering Research Center of Materials-Oriented Chemical Engineering of Xinjiang Bingtuan Shihezi 832003 China School of Medicine Shihezi University Shihezi 832003 China College of Chemistry and Chemical Engineering Xinjiang Agricultural University Urumqi 830001 China State Key Laboratory of Chemical Engineering East China Universityof Science and Technologyl Shanghai 200237 China

A novel type of amphiphilic pH-responsive folate-poly（ε-caprolactone）- block-poly（ 2-hydroxyethylmethacrylate ）-co-poly（ 2-（ dimethylamino ）-ethylmethacrylate ）（FA-PCL-b-P（HEMA-co-DMAEMA））（MFP） block copolymers were designed and synthe- sized via atom transfer radical polymerization （ATRP） and ring opening polymerization （ROP） techniques. The molecular structures of the copolymers were confirmed with IH NMR, FTIR and GPC measurements. The critical micelle concentration （CMC） of MFP in aqueous solution was extremely low （about 6.54 mglL）. The in vitro release behavior of DOX-Ioaded micelles was significantly accelerated when the pH value of solution decreased from 7.4 to 5.0. In vitro antitumor efficiency was evaluated by incubating DOX- loaded micelles with Hela cells. The results demonstrated that this copolymer possessed excellent biocompatibility, and FA-decorated micelles MFP showed higher cellular uptake than those micelles without the FA moiety, indicating their unique targetability. These folate-conjugated biodegradable micelles are highly promising for targeted cancer chemothe-rapy.

关键词： amphiphilic polymer pH-sensitive active targeting drug delivery system folic acid

CSN6 promotes tumorigenesis of gastric cancer by ubiquitin-independent proteasomal degradation of p16INK4a

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Cancer Biology & Medicine 2019年第3期16卷 514-529页

作者： Wenqi Du Zongxiang Liu Wentao Zhu Tongtong Li Zhiman Zhu lulu wei Jun Song Dongsheng Pei Department of Pathology Xuzhou Medical UniversityXuzhou221004China Department of Anatomy Xuzhou MedicalUniversityXuzhou221004China Department of Periodontal Mucosal Diseases the Affiliated Xuzhou StomatologicalHospital of Xuzhou Medical UniversityXuzhou221002China Department of General Surgery the Affiliated Hospital ofXuzhou Medical UniversityXuzhou221002China Institute of Digestive Diseases Xuzhou Medical UniversityXuzhou221002China

Objective: CSN6 is a vital subunit of the constitutive photomorphogenesis 9(COP9) signalosome(CSN), which is responsible for development disorders and promotes ubiquitin-26 S proteasome-dependent degradation in vitro and *** role in the tumor development of gastric cancer remains *** this study, we investigated the role of CSN6 in gastric cancer ***: Human gastric cancer samples were collected and immunohistochemistry was performed to identify the role of CSN6 in gastric *** cell proliferation was measured by CCK-8 and the EdU incorporation *** localization and a co-immunoprecipitation study were used to show the interaction between the protein CSN6 and *** assay was performed to validate whether ubiquitination is involved in CSN6-mediated p16 ***/c nude mice were used to produce a tumor model in order to test the effect of CSN6 on cancer growth in ***: CSN6 expression was dramatically increased in gastric cancer tissues compared with paired adjacent non-tumor tissues and CSN6 was correlated with worse overall and disease-specific ***, we also found that CSN6 downregulated p16 protein expression, thereby promoting gastric cancer cell growth and ***, CSN6 interacted with p16 and a proteasome activator REGγ(PA28γ), thereby facilitating ubiquitin-independent degradation of ***: CSN6 promoted the loss of p16-mediated tumor progression and played an important role in regulating ubiquitin-independent proteasomal degradation of p16.

关键词： CSN6 gastric cancer proliferation p16 REGγ

Purification and anti-inflammatory effect of selenium-containing protein fraction from selenium-enriched Spirulina platensis

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Food Bioscience 2022年第1期45卷 197-203页

作者： Pingyingzi Jiang Jinhao Meng Lifei Zhang Li Huang lulu wei Yunxia Bai Xiaoling Liu Shubo Li College of Light Industry and Food Engineering Guangxi UniversityNanning530004China

Spirulina platensis is an excellent carrier of Se,and thus widely used in medical fields and as well as in the food ***,there is little information about the characteristics and bioactivity of selenium-containing *** proteins(Se-SP).In this study,Se-SP with different molecular weights were isolated from selenium-enriched ***,and the bioactivities(such as antioxidant and anti-inflammatory activities)of Se-SP were ***-SP3(with a molecular weight range of 20-48 kDa)showed better free radical scavenging ability(ABTS)than the other *** addition,Se-SP3 suppressed inflammatory cytokines,in which decreased by 74% interleukin 6(IL-6),42.28% tumor necrosis factor-α(TNF-α),69.07% content of malondialdehyde(MDA),40.45% interleukin-1β(IL-1β)relative to the LPS ***,Se-SP3 decreased the nitric oxide(NO)production by 64.84% compared with the LPS group and increased the activities of superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px),indicating that Se-SP3 has excellent antioxidant and anti-inflammatory activities,and could be used as a functional food ingredient or natural medicine.

关键词： Selenium Spirulina platensis protein Purification Bioactivities Inflammatory cytokines

Peptidomimetic-based antibody surrogate for HER2

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Acta Pharmaceutica Sinica B 2021年第9期11卷 2645-2654页

作者： Mengmeng Zheng Chunpu Li Mi Zhou Ru Jia Fengyu She lulu wei Feng Cheng Qi Li Jianfeng Cai Yan Wang Department of Chemistry University of South FloridaTampaFL 33620USA Department of Medical Oncology&Cancer Institute of Medicine Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China Academy of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Pharmaceutical Science College of PharmacyUniversity of South FloridaTampaFL 33612USA

Inhibition of human epidermal growth factor receptor 2 mediated cell signaling pathway is an important therapeutic strategy for HER2-positive *** monoclonal antibodies are currently used as marketed drugs,their large molecular weight,high cost of production and susceptibility to proteolysis could be a hurdle for long-term *** this study,we reported a strategy for the development of artificial antibody based on y-AApeptides to target HER2 extracellular domain(ECD).To achieve this,we synthesized a one-bead-two-compound(OBTC)library containing 320,000 cyclic y-AApeptides,from which we identified a y-AApeptide,M-3-6,that tightly binds to HER2 ***,we designed an antibody-like dimer of M-3-6,named M-3-6-D,which showed excellent binding affinity toward HER2 comparable to monoclonal ***,M-3-6-D was completely resistant toward enzymatic *** addition,it could effectively inhibit the phosphorylation of HER2,as well as the downstream signaling pathways of AKT and ***,M-3-6-D also efficiently inhibited cell proliferation in vitro,and suppressed tumor growth in SKBR3 xenograft model in vivo,implying its therapeutic potential for the treatment of *** small molecular weight,antibody-like property,resistance to proteolysis,may enable it a new generation of artificial antibody ***,our strategy of artificial antibody surrogate based on dimers of cyclicγ-AApeptides could be applied to a myriad of disease-related receptor targets in future.

关键词： HER2 Anti-cancer Peptidomimetics γ-AApeptides Antibody-surrogate

Editor Profiles: Guest Editors of Special Column “Novel Peptides and Peptidomimetics in Drug Discovery”

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Acta Pharmaceutica Sinica B 2021年第9期11卷 2605-2605页

作者： Cai, Jianfeng wei, lulu USF Tampa FL 33620 USA USF Chem Tampa FL 33620 USA Univ S Florida Dept Chem Tampa FL 33620 USA

*** Cai obtained *** *** chemistry from the Nanjing University in 1997 and 2000,*** received his *** bioorganic chemistry from the University of Washington in ***(USA) *** he joined USF in 2009 as an assistant professor,he did his postdoctoral research in bioorganic chemistry at Yale University in Andrew *** group from 2007 to 2009.

关键词： Profiles Guest chemistry

BnVIR:bridging the genotype-phenotype gap to accelerate mining of candidate variations underlying agronomic traits in Brassica napus

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Molecular Plant 2022年第5期15卷 779-782页

作者： Zhiquan Yang Congyuan Liang lulu wei Shengbo Wang Feifan Yin Dongxu Liu Liang Guo Yongming Zhou Qing-Yong Yang National Key Laboratory of Crop Genetic Improvement College of InformaticsHuazhong Agricultural UniversityWuhan 430070China Hubei Key Laboratory of Agricultural Bioinformatics College of InformaticsHuazhong Agricultural UniversityWuhan 430070China

Dear Editor,Genetic variations,which range from single nucleotide polymor-phisms(SNPs)and short insertion/deletions(InDels)to large-scale structural variations(SVs),are the basis of phenotypic *** the effect of geneti... 详细信息

关键词： agronomic traits InDel