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Understory seedlings of Quercus mongolica survive by phenological escape

Forest Ecosystems 2024年第2期11卷 236-246页

作者： Shixiong Wu Ying Liu lulu he Wei Zeng Qijing Liu College of Forestry Beijing Forestry UniversityBeijing100083China

Understanding understory seedling regeneration mechanisms is important for the sustainable development of temperate primary forests in the context of increasingly intense climate warming *** poor regeneration of dominant tree species,however,is one of the biggest challenges it faces at the ***,the regeneration of the shade-intolerant Quercus mongolica seedling is difficult in primary forests,which contrasts with the extreme abundance of understory seedlings in secondary *** mechanism behind the interesting phenomenon is still *** study used in-situ monitoring and nursery-controlled experiment to investigate the survival rate,growth performance,as well as nonstructural carbohydrate (NSC) concentrations and pools of various organ tissues of seedlings for two consecutive years,further analyze the understory light availability and simulate the foliage carbon (C) gain in the secondary and primary *** suggested that seedlings in the secondary forest had greater biomass allocation aboveground,height and specific leaf area (SLA) in summer,which allowed the seedling to survive longer in the canopy closure *** light availability and positive C gain in early spring and late autumn are key factors affecting the growth and survival of understory seedlings in the secondary forest,whereas seedlings in the primary forest had annual negative carbon *** the growing season,the total NSC concentrations of seedlings gradually decreased,whereas those of seedlings in the secondary forest increased significantly in autumn,and were mainly stored in roots for winter consumption and the following year's summer shade period,which was verified by the nursery-controlled experiment that simulated autumn enhanced light availability improved seedling survival rate and NSC *** conclusion,our results revealed the survival trade-off strategies of Quercus mongolica seedlings and highlighted the necessity of high light availability d

关键词： Carbon gain Nonstructural carbohydrate Recruitment Trade-off Biomass allocation

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Tumor microenvironment-activatable neuropeptide-drug conjugates enhanced tumor penetration and inhibition via multiple delivery pathways and calcium deposition

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Chinese Chemical Letters 2024年第4期35卷 292-297页

作者： Yi Cao Xiaojiao Ge Yuanyuan Wei lulu he Aiguo Wu Juan Li Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology Zhejiang International Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Sciences(CAS)Key Laboratory of Magnetic Materials and DevicesNingbo Cixi Institute of Biomedical EngineeringZhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China University of Chinese Academy of Sciences Beijing 100049China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China

Peptide-drug conjugates have achieved considerable development and application as a novel strategy for targeted delivery of anticancer drugs. Bioactive peptides induced calcium deposition can irreversibly assist inhibition of tumors. However, active regulation of calcium level through signal transduction of bioactive substances has not been reported yet. In this study, novel neuropeptide-doxorubicin conjugates(NP-DOX) with lysosome-specific acid response were described for neuropeptide Y_1 receptor(Y_1R)-overexpressed triple-negative breast cancer. The delivery mechanism of NP-DOX was clarified that diverse pathways were involved, including intracellular and intercellular transport. Importantly, up-regulation of Y_1 R-mediated intracellular calcium level via second messenger inositol triphosphate was presented in NP-DOX treated MDA-MB-231 cells. In vivo antitumor efficacy demonstrated that NP-DOX showed less organ toxicity and enhanced tumor inhibition benefited from its controlled release and Y_1R-mediated calcium deposition, compared with free DOX. This bioconjugate is a proof-of-concept confirming that neuropeptide-mediated control of signaling responses in neuropeptide-drug conjugates enables great potential for further applications in tumor chemotherapy.

关键词： Neuropeptide-drug conjugate Tumor penetration Calcium deposition Tumor inhibition Triple-negative breast cancer

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D-type neuropeptide decorated AIEgen/RENP hybrid nanoprobes with light-driven ROS generation ability for NIR-Ⅱ fluorescence imaging-guided through-skull photodynamic therapy of gliomas

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Aggregate 2024年第1期5卷 185-195页

作者： Xuelu he Yuan Luo Yanying Li Yuanbo Pan Ryan T.K.Kwok lulu he Xiaolin Duan Pengfei Zhang Aiguo Wu Ben Zhong Tang Juan Li Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology Zhejiang International Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Sciences(CAS)Key Laboratory of Magnetic Materials and DevicesNingbo Cixi Institute of Biomedical EngineeringZhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboP.R.China Guangdong Key Laboratory of Nanomedicine Shenzhen Engineering Laboratory of Nanomedicine and NanoformulationsCAS-HK Joint Lab for BiomaterialsResearch Laboratory for Biomedical Optics and Molecular ImagingShenzhen Key Laboratory for Molecular ImagingCAS Key Lab for Health InformaticsShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenP.R.China Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced StudyThe Hong Kong University of Science and Technology(HKUST)KowloonP.R.China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhenP.R.China

Glioma is one of the most common malignant tumors of the central nervous system,leading high mortality rates in ***-induced emission(AIE)photosensitizers-based photodynamic therapy(PDT)has emerged as a promising therapeutic strategy for least-invasive treatment of glioma,which involves local irradiation of the tumor using an external near-infrared(NIR)***,most AIE photosensitizers suffered from poorly penetration of the visible light excitation,bad spatiotemporal resolution in deep tissues and low efficient blood-brain barrier(BBB)crossing ability,which greatly limited the clinical practice of AIE photosensitizers for especially deep-seated brain tumor *** this work,we developed a multifunctional NIR-driven theranostic agent through hybrid of AIE photosensitizers TIND with rare-earth doping nanoparticles(RENPs)NaGdF4:Nd/Yb/Tm with up/down dual-mode conversion *** theranostic agent was further decorated with D-type neuropeptide DNPY for crossing BBB and targeting *** the 808-nm light irradiation,the down-conversion NIR-II luminescence could indicate the position glioma and the upconversion NIR-I luminescence could trigger the AIE photosensitizers producing reactive oxygen species to inhibit orthotopic glioma tumor growth in *** results demonstrate that the integration of Dtype neuropeptide,AIE photosensitizers and RENPs could be promising candidates for in vivo NIR-II fluorescence image-guided through-skull PDT treatments of brain tumors.

关键词： aggregation-induced emission D-type neuropeptide glioma photodynamic therapy rare-earth doping nanoparticles

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菌糠预腐解与蚯蚓对苏打盐碱土改良效果的研究

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农业资源与环境学报 2024年第3期41卷 614-622页

作者：何露露马利民张春燕李明堂吉林农业大学资源与环境学院长春130118 潍坊市安丘生态环境监控中心山东潍坊262199

为实现高添加量菌糠与蚯蚓对苏打盐碱土的快速改良,本研究利用预腐解菌糠与蚯蚓对苏打盐碱土进行改良,探究了在苏打盐碱土中添加大量菌糠预腐解后再接种蚯蚓对蚯蚓的影响,以及二者共同作用对苏打盐碱土水稳性团聚体分布、盐碱化程度、... 详细信息

为实现高添加量菌糠与蚯蚓对苏打盐碱土的快速改良,本研究利用预腐解菌糠与蚯蚓对苏打盐碱土进行改良,探究了在苏打盐碱土中添加大量菌糠预腐解后再接种蚯蚓对蚯蚓的影响,以及二者共同作用对苏打盐碱土水稳性团聚体分布、盐碱化程度、土壤养分及有机碳和水溶性有机碳的影响。结果表明:将15%、20%、25%、30%的菌糠添加到苏打盐碱土中先进行预腐解再接种蚯蚓,可以显著增加蚯蚓的存活率和日增重倍数,使蚯蚓的存活率基本保持在90%以上。在苏打盐碱土中添加15%~30%的菌糠预腐解后再接种蚯蚓显著增加了>2mm的水稳性团聚体数量,降低了土壤pH,提高了土壤电导率,增加了苏打盐碱土中的阳离子交换量(增加量为4.8~10.2 cmol·kg^(-1)),降低了苏打盐碱土的碱化度(下降2.7~4.0个百分点),显著增加了土壤速效氮磷钾含量,显著提高了土壤有机碳含量、水溶性有机碳含量及芳香度,促进了类腐植酸物质的生成。研究表明,大量菌糠预腐解后再接种蚯蚓能够快速高效地改良苏打盐碱土。

关键词：苏打盐碱土菌糠预腐解蚯蚓土壤改良

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论习近平文化思想的四个来源

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社科纵横 2024年第1期39卷 1-5页

作者：饶旭鹏何露露兰州理工大学马克思主义学院兰州730050

习近平文化思想是习近平新时代中国特色社会主义思想的文化篇,是马克思主义中国化时代化最新理论成果。习近平文化思想以中华优秀传统文化为历史根基,实现了传统文化的生命更新;以马克思主义经典作家文化思想为精神魂魄,开辟了马克思主... 详细信息

习近平文化思想是习近平新时代中国特色社会主义思想的文化篇,是马克思主义中国化时代化最新理论成果。习近平文化思想以中华优秀传统文化为历史根基,实现了传统文化的生命更新;以马克思主义经典作家文化思想为精神魂魄,开辟了马克思主义在中国发展的新思路;以中国共产党的百年文化建设经验为历史主线,一脉相承回答新时代建设社会主义文化强国的时代之需;以人类优秀文明成果为理论借鉴,引领人类文明新境界。习近平文化思想是指导中国特色社会主义文化建设的强大精神武器.

关键词：习近平文化思想四个来源

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大学生多层面自我控制能力的培养及应用探究

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大学（研究与管理） 2024年第6期 117-120页

作者：贺璐璐杨广柱佳木斯大学教育科学学院黑龙江佳木斯154007

大学生通常面临着学习压力大、时间管理困难、人际关系紧张以及情绪调节不稳定等问题,解决这些问题要求学生具备良好的自我控制能力,塑造积极的行为习惯和健康的生活方式,切实改善在行为、情绪、思维等方面存在的不利因素,加强个体的决... 详细信息

大学生通常面临着学习压力大、时间管理困难、人际关系紧张以及情绪调节不稳定等问题,解决这些问题要求学生具备良好的自我控制能力,塑造积极的行为习惯和健康的生活方式,切实改善在行为、情绪、思维等方面存在的不利因素,加强个体的决策能力、注意力以及认知灵活性。鉴于其重要意义,学校和社会应给予高度重视,提供多种沟通渠道,不断完善现有的培养机制,以促进学生的全面发展和实现自己的人生目标。

关键词：大学生自我控制能力身心健康培养机制

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Improving Catalytic Stability and Coke Resistance of Ni/Al_(2)O_(3) Catalysts with Ce Promoter for Relatively Low Temperature Dry Reforming of Methane Reaction

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Chemical Research in Chinese Universities 2022年第4期38卷 1032-1040页

作者： he lulu CheN Xin REN Yuanhang YUE Bin TSANG Shik Chi Edman he heyong Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Fudan UniversityShanghai200438P.R.China Wolfson Catalysis Centre Department of ChemistryUniversity of OxfordOxfordOX13QRUK

A series of Ni catalysts supported on alumina with different Ce contents(1.0%–6.0%,mass fraction)was prepared by the impregnation method and used for dry reforming of methane(DRM)at a relatively low temperature of 650°*** promotion effect of Ce with different loading amounts on the physicochemical properties of the catalysts was systematically characterized by transmission electron microscopy(TEM),X-ray diffraction(XRD),N_(2) adsorption-desorption,thermo elemental IRIS Intrepid inductively coupled plasma atomic emission spectrometer(ICP-AES),UV-visible diffuse reflectance spectroscopy(UV-Vis DRS),Fourier transformation infrared(FTIR)spectra,H_(2)-temperature programmed reduction(H_(2)-TPR)analysis,H_(2)-temperature programmed desorption(H_(2)-TPD),and The X-ray photoelectron spectroscopy(XPS)*** results indicate that all the catalysts mainly exist in the NiAl_(2)O_(4) phase after being calcined at 750°C with small Ni particle sizes due to the strong metal-support interaction derived from the reduction of the NiAl_(2)O_(4) *** Ce-promoted catalysts show better catalytic performance as well as the resistance against sintering of Ni particles and deposition of carbon compared to the Ni/Al_(2)O_(3) *** Ni-6Ce/Al_(2)O_(3) exhibits the best catalytic stability and coke resistance among the four catalysts studied,which is due to its small Ni nanoparticles sizes,excellent reducibility as well as high amount of active oxygen *** a 400 h stability test for DRM reaction at 650°C,Ni-6Ce/Al_(2)O_(3) exhibits less coke deposition and small growth of Ni *** work provides a simple way to preparing the Ni-Ce/Al_(2)O_(3) catalyst with enhanced catalytic performance in *** Ni-6Ce/Al_(2)O_(3) catalyst has great potential for industrial application due to its anti-sintering ability and resistance to carbon deposition.

关键词： Dry reforming of methane(DRM) Cerium oxide Ni-based catalyst Coke resistance

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基于多维感性工学的产品造型设计研究

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设计 2024年第3期37卷 112-115页

作者：何露露孙宁娜曾汐江苏大学艺术学院

消费者的购买欲是由产品整体属性共同性激发的,获取产品形、色、质以及相关关系构建的多维KE模型能更加精准地预测消费者情感需求。通过近20年来国内外相关文献,归纳出多维感性工学在产品造型设计中文的献设计流程,并总结多维感性工学... 详细信息

消费者的购买欲是由产品整体属性共同性激发的,获取产品形、色、质以及相关关系构建的多维KE模型能更加精准地预测消费者情感需求。通过近20年来国内外相关文献,归纳出多维感性工学在产品造型设计中文的献设计流程,并总结多维感性工学在产品造型设计研究中的5个关键设计步骤。基于前人研究成果分析各个阶段运用的方法以及优劣势,最后,从研究对象和方法两个方面展望多维感性工学在产品造型设计未来的研究趋势。

关键词：感性工学产品造型设计产品特征设计流程设计方法

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盐度对中华绒螯蟹繁殖性能的影响

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海洋渔业 2024年第3期46卷 343-352页

作者：贺露露耿智黄晓荣冯广朋庄平赵峰张涛杜楠李春波上海海洋大学水产与生命学院上海201306 中国水产科学研究院东海水产研究所农业部东海与远洋渔业资源开发利用重点实验室上海200090 上海长江口渔业资源增殖和生态修复工程技术研究中心上海200090 南京农业大学无锡渔业学院江苏无锡214081

为研究盐度对中华绒螯蟹(Eriocheir sinensis)繁殖性能的影响,开展了不同盐度梯度下亲蟹的交配(盐度0、2、4、6、8,后续补充盐度1、3、5)、产卵(盐度0、3、6、9、12、15、18、21)及其胚胎孵化(盐度0、3、6、9、12、15、18、21)实验。测... 详细信息

为研究盐度对中华绒螯蟹(Eriocheir sinensis)繁殖性能的影响,开展了不同盐度梯度下亲蟹的交配(盐度0、2、4、6、8,后续补充盐度1、3、5)、产卵(盐度0、3、6、9、12、15、18、21)及其胚胎孵化(盐度0、3、6、9、12、15、18、21)实验。测定并分析不同盐度下亲蟹的交配率、产卵率、胚胎孵化率、性腺成熟系数(GSI)、肝胰腺指数(HSI)、产卵量、生殖指数和生殖力等指标。结果表明:1)中华绒螯蟹可交配的最低盐度为1,在此盐度下雌蟹的平均交配率为(6.67±5.77)%,适宜交配的盐度范围为4~21;能够正常产卵的最低盐度为6,适宜产卵的盐度范围为9~21;2)在盐度0~21环境下,当盐度为0时,中华绒螯蟹胚胎虽可继续发育,但不能孵化出膜,其他盐度下的孵化率均随着培养时间的延长逐渐升高。当盐度为15时,胚胎的孵化率最高,盐度15中第15天时平均孵化率达到了(70.00±5.23)%;3)在盐度0~8范围内,雌雄蟹交配后各盐度组间HSI均无显著差异(P>0.05),雌蟹GSI随盐度升高表现出先上升后下降的趋势,雄蟹GSI则先下降后上升;4)在盐度6~21范围内,随盐度的升高,雌蟹的产卵量、生殖力及生殖指数均呈现先上升后下降的变化趋势。当盐度为6时,雌蟹的产卵量和生殖指数均为最低(P<0.05),分别为(13.26±2.99)万粒和(5.47±1.70)%。当盐度升至18时,雌蟹的产卵量、生殖指数和生殖力均达到峰值,分别为(31.83±2.61)万粒、(11.45±1.70)%和(0.51±0.05)万粒·g^(-1),且与其他各盐度组间有显著性差异(P<0.05)。综上所述,中华绒螯蟹交配、产卵的盐度下限阈值分别为为1和6,适宜交配的盐度范围为4~21,适宜产卵的盐度范围为9~21;从原肠期开始,胚胎最佳孵化盐度为15,适宜孵化的盐度范围为12~18;中华绒螯蟹在盐度18时繁殖性能最佳。研究表明,水体盐度对中华绒螯蟹亲蟹交配、产卵及胚胎孵化等具有一定影响。研究确立了中华绒螯蟹交配、产卵和胚胎孵化的最低盐度值及适宜盐度范围,可以为中华绒螯蟹的繁育生物学研究提供基础资料,也可为合理划分长江口中华绒螯蟹繁育场提供科学依据和参考。

关键词：中华绒螯蟹盐度繁殖性能交配产卵胚胎孵化

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Numerical study of shoreline changes by emergency beach nourishment project at the Middle Beach of Beidaihe, China

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Acta Oceanologica Sinica 2012年第1期31卷 125-133页

作者： ZHANG Yu he lulu KUANG Cuiping PAN Yi GU Jie YANG Yanxiong ZHANG Jiabo College of Geoscience and Surveying Engineering China University of Mining and TechnologyBeijing 100083China Department of Hydraulic Engineering College of Civil EngineeringTongji UniversityShanghai 200092China College of Marine Science Shanghai Ocean UniversityShanghai 201306China Qinhuangdao Mineral Resource and Hydrogeological Brigade Hebei Geological Prospecting BureauQinhuangdao 066003China

Beach nourishment is a common coastal management strategy used to protect beach from erosion along the sandy coastlines. This method has been successfully applied to an emergency project at the West Beach of Beidaihe in the summer of 2008 and the full West Beach nourishment project in 2009-2010, which is the direct base of this study. Some basic information about the emergency engineering area at the Middle Beach is firstly described. The shoreline change of this area, including the analysis of beach width in five monitoring profiles in the bathing places of Middle Beach, is then discussed. After that a numerical modal based on one-line theory is established and the numerical results agree well with the measured shorelines, which indicates that the model is appropriate and is qualified to predict the shoreline change of the Middle Beach. With the same model and parameters, long-term performance of the project is predicted, and the result shows that without follow-up nourishment and project, the bathing places can remain suitable for bathing for about 10 a. It is suggested to nourish the beach in time and carry out the beach nourishment project for the full Middle Beach in Beidaihe.

关键词： one-line model numerical model shoreline change beach nourishmentl Middle Beach in Beidaihe

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