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Morphological characteristics and evolution model of slope units along loess gully cross section

Frontiers of Earth Science 2024年第1期18卷 17-29页

作者： lulu liu Fayuan LI Xue YANG Jianhua CHENG School of Geography Nanjing Normal UniversityNanjing 210023China Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application Nanjing 210023China Key Laboratory of Virtual Geographic Environment(Ministry of Education) Nanjing Normal UniversityNanjing 210023China

Gully morphology is an important part of loess landform *** with gully development,the variation of its cross section is the most significant,and it can intuitively reflect the characteristics of the lateral widening of the gully ***,in-depth research of the variation of the cross-sectional morphology of the gully is helpful to understanding the development process of the loess *** on the DEMs(Digital Elevation Model)of nine periods of an indoor simulated loess small watershed,this paper studies the evolution model of a complete branch ditch in the watershed using the digital terrain analysis theory and *** show that with the development of the gully,the average gradient of the gully slope continuously decreases,and the slope morphology is mostly a concave slope along the slope *** degree of downward concave first increases and then gradually tends to be *** gully erosion mode is gradually transformed from downward cutting erosion to lateral *** more mature the gully development,the lower the depth of gully bottom cutting is compared with the width of gully ***,the surface cutting depth tends to be stable and the slope is ***,the transformation law of the slope morphology of the gully cross section with the development of the gully is studied,and the prediction model of the transformation of the slope morphology of the gully cross section is established by using the Markov *** Markov model can better reflect the dynamic change of the slope morphology of the gully cross section,which is of great significance to revealing the external performance and internal mechanism of the gully morphology.

关键词： gully cross section slope morphology Markov chain digital elevation model

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Accelerating H^(*)desorption of hollow Mo_(2)C nanoreactor via in-situ grown carbon dots for electrocatalytic hydrogen evolution

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Journal of Energy Chemistry 2024年第9期96卷 464-471页

作者： Mengmeng liu Yuanyuan Jiang Zhuwei Cao lulu liu Hong Chen Sheng Ye School of Materials and Chemistry Anhui Agricultural UniversityHefei 230036AnhuiChina

Molybdenum carbide(Mo_(2)C)is a promising non-noble metal electrocatalyst with electronic structures similar to Pt for hydrogen evolution reaction(HER).However,strong H^(*)adsorption at the Mo sites hinders the improvement of HER ***,we synthesized monodisperse hollow Mo_(2)C nanoreactors,in which the carbon dots(CD)were in situ formed onto the surface of Mo_(2)C through carburization *** to finite element simulation and analysis,the CD@Mo_(2)C possesses better mesoscale diffusion properties than Mo_(2)C *** optimized CD@Mo_(2)C nanoreactor demonstrates superior HER performance in alkaline electrolyte with a low overpotential of 57 mV at 10 mA cm^(−2),which is better than most Mo_(2)C-based ***,CD@Mo_(2)C exhibits excellent electrochemical stability during 240 h,confirmed by operando Raman and X-ray diffraction(XRD).Density functional theory(DFT)calculations show that carbon dots cause the d-band center of CD@Mo_(2)C to shift away from Fermi level,promoting water dissociation and the desorption of H^(*).This study provides a reasonable strategy towards high-activity Mo-based HER eletrocatalysts by modulating the strength of Mo–H bonds.

关键词： Mo_(2)C nanoreactor Carbon dots H^(*)desorption Electrocatalytic hydrogen evolution

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Isolation and characterization of spike S2-specific monoclonal antibodies with reactivity to pan-coronaviruses

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Virologica Sinica 2024年第1期39卷 169-172页

作者： Yabin Hu Jun Chen Jing Yang Zhanpeng liu Xiaoyue Zhang Qian Wu lulu liu Shishan Teng Rongzhang He Bo liu Xingyu Zheng Rui Lu Dong Pan You Wang Liting Peng Hongying chen Yi-Ping Li Wenpei liu Xiaowang Qu College of Basic Medical Sciences Hengyang Medical SchoolUniversity of South China&MOE Key Lab of Rare Pediatric DiseasesHengyang421001China Translational Medicine Institute The First People's Hospital of ChenzhouHengyang Medical SchoolUniversity of South ChinaChenzhou423000China College of Life Sciences Northwest A&F UniversityYangling712100China Institute of Human Virology Department of Pathogen Biology and Biosecurityand Key Laboratory of Tropical Disease Control of Ministry of EducationZhongshan School of MedicineSun Yat-sen UniversityGuangzhou510080China School of Public Health University of South ChinaHengyang421001China

Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),theseventh coronavirus known to jump from intermediate hosts to humans,has resulted in a worldwide pandemic and caused immense economicdamage(Tan et al.,2020;Zhu et al.,2020).It is believed that coronavirus spillover may occur again in the *** exposure to a bat coro-navirus has been serologically confimed in a rural area of China,indi-cating that the coronavirus spillover occurred,although the origin andfrequency of spillovers are unclear(Wang et al.,2018).

关键词： monoclonal acute

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Vaspin alleviates pathological cardiac hypertrophy by regulating autophagy-dependent myocardial senescence

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Emergency and Critical Care Medicine 2024年第1期4卷 4-15页

作者： Haiying Rui Huaxiang Yu Dan Zou Kai Chi Ping Xu Xiaoshuai Song lulu liu Xuting Wu Jinxin Wang Li Xue Department of Emergency Medicine and Chest Pain Center Qilu Hospital of Shandong UniversityJinanShandongChina Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine Institute of Emergency and Critical Care Medicine of Shandong UniversityQilu Hospital of Shandong UniversityJinanShandongChina Key Laboratory of Emergency and Critical Care Medicine of Shandong Province Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong ProvinceShandong Provincial Engineering Laboratory for Emergency and Critical Care MedicineQilu Hospital of Shandong UniversityJinanShandongChina The Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of EducationChinese Ministry of Health and Chinese Academy of Medical SciencesThe State and Shandong Province Joint Key Laboratory of Translational Cardiovascular MedicineQilu Hospital of Shandong UniversityJinanShandongChina.

Background:Visceral adipose tissue-derived serine protease inhibitor(vaspin),a secretory adipokine,protects against insulin *** studies have demonstrated that serum vaspin levels are decreased in patients with coronary artery disease and that vaspin protects against myocardial ischemia-reperfusion injury and ***,it remains unclear whether vaspin exerts specific effects on pathological cardiac ***:An in vivo study was conducted using a cardiac hypertrophy model established by subcutaneous injection of isoproterenol(ISO)in C57BL/6 and vaspin-ko *** was administered intraperitoneally to mice,for further study.H9c2 cells and neonatal rat ventricular myocytes(NRVMs)were treated with ISO to induce *** vaspin fusion protein,the proteasome inhibitor MG132,and chloroquine diphosphate were used for further mechanistic ***:Here,we provide the first evidence that vaspin knockdown results in markedly exaggerated cardiac hypertrophy,fibrosis,and cardiomyocyte senescence in mice treated with ***,the administration of exogenous recombinant human vaspin protected NRVMs in vitro against ISO-induced hypertrophy and ***,vaspin significantly potentiated the ISO-induced decrease in *** rapamycin and chloroquine diphosphate regulated autophagy in vivo and in vitro,respectively,and participated in vaspin-mediated ***,the PI3K-AKT-mTOR pathway plays a critical role in vaspin-mediated autophagy in cardiac tissues and *** data showed that vaspin downregulated the p85 and p110 subunits of PI3K by linking p85 and p110 to NEDD4L-mediated ubiquitination ***:Our results show,for the first time,that vaspin functions as a critical regulator that alleviates pathological cardiac hypertrophy by regulating autophagy-dependent myocardial senescence,providing potential preventive and therapeutic targets for pathological cardiac hyper

关键词： Autophagic flux Myocardial senescence Pathological cardiac hypertrophy Ubiquitination Vaspin

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北欧国家博士生教育改革的动因、举措与逻辑——基于瑞典、挪威、芬兰、丹麦四国的考察

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外国教育研究 2024年第8期51卷 51-69页

作者：刘璐璐西北工业大学高等教育研究中心陕西西安710072

在全球化和知识经济时代,博士生教育越来越成为促进和引领国家经济社会发展、提升与强化国家发展可持续能力的重要引擎。许多国家都在积极推进博士生教育改革,以提升自身全球竞争力和国家发展韧性。在提升国家创新能力、融入博洛尼亚进... 详细信息

在全球化和知识经济时代,博士生教育越来越成为促进和引领国家经济社会发展、提升与强化国家发展可持续能力的重要引擎。许多国家都在积极推进博士生教育改革,以提升自身全球竞争力和国家发展韧性。在提升国家创新能力、融入博洛尼亚进程和回应博士教育内部挑战的多重驱动下,瑞典、挪威、芬兰、丹麦进行了广泛而深刻的博士生教育改革。北欧国家博士生教育改革的举措包括博士生培养模式的结构化、培养导向的多元化、培养过程的国际化、培养资源的集成化、培养机制的协同化,遵循了提升过程质量、优化培养效率、增强发展韧性的内在逻辑,以应对全球化背景和知识经济时代的多重挑战,实现可持续发展。

关键词：北欧博士生教育改革过程质量效率韧性

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The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing Xue Yuejia Ma Ke Ye Xue Zhao Fangliang Ge Feifei Zheng lulu liu Xu Gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

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新时代我国青少年体育政策协同的变迁及其效果评价

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体育科学 2024年第6期44卷 89-96,F0003页

作者：王涛陈尧刘璐路福建师范大学体育科学学院福建福州350117 衡阳师范学院体育科学学院湖南衡阳421002

我国青少年体育工作的复杂性决定了政策协同的必要性。基于政策目标与政策措施协同创新视角,对2012—2022年我国青少年体育政策协同的变迁及效果进行分析。研究发现,新时代以来我国青少年体育政策总协同不断提高,是政策目标与政策措施... 详细信息

我国青少年体育工作的复杂性决定了政策协同的必要性。基于政策目标与政策措施协同创新视角,对2012—2022年我国青少年体育政策协同的变迁及效果进行分析。研究发现,新时代以来我国青少年体育政策总协同不断提高,是政策目标与政策措施共同作用的结果。随着我国青少年体育工作的大力开展,青少年体育各个政策目标与各个政策措施之间的协同度也逐渐增强,这些组合各异的协同关系对促进青少年体育组织建设和场地设施两个政策目标方面产生显著正影响,但对促进青少年体育活动开展的影响不显著。命令型政策措施对青少年体育组织建设及场地设施的协同效果最好,但并没有因此减弱其他政策工具的协同效果;能力建设政策措施协同在各个政策目标的达成上发挥着稳定作用,正成为我国青少年体育高质量发展的内生动力;学习型政策措施协同在促进青少年体育场地设施面积达标率方面的效果较好,我国青少年体育事业发展的特殊性日益受到重视;激励型政策措施协同呈现出高使用度低效率的特点,其与各个政策目标的协同效果均不佳。综上所述,青少年体育政策制定无须夸大任何一项政策措施协同的积极作用,未来需进一步探索如何发挥政策措施协同的整体效益。

关键词：青少年体育政策政策协同政策变迁政策效果

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农户庭院型创业影响因素的实证研究

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云南财经大学学报 2024年第1期40卷 97-110页

作者：庄晋财刘露露江苏大学管理学院江苏镇江212013

鼓励和引导农户在符合用地政策前提下,利用自有院落空间及资源资产,高质量发展庭院经济,是促进就地就近就业创业、发展乡村特色产业、拓展增收来源的有效途径。以农户家庭为研究对象,运用实际调查数据,从农户家庭资源禀赋、庭院型创业... 详细信息

鼓励和引导农户在符合用地政策前提下,利用自有院落空间及资源资产,高质量发展庭院经济,是促进就地就近就业创业、发展乡村特色产业、拓展增收来源的有效途径。以农户家庭为研究对象,运用实际调查数据,从农户家庭资源禀赋、庭院型创业项目特征和乡村创业环境三个方面分析农户庭院型创业的影响因素。结果表明,农户家庭年收入水平、闲置住房数量、承包土地规模均对农户庭院型创业产生显著正向影响;农户家庭劳动力人数、家庭成员的受教育程度对农户庭院型创业的影响显著为正;创业项目的实施难度和利益前景均对农户庭院型创业产生显著正向影响;农村制度环境对农户庭院型创业有显著正向影响;农户家庭的村庄关系对农户庭院型创业的影响未通过显著性检验。为促进农户庭院创业的高质量发展,政府政策应该着力帮助农户家庭提升资源能力,向村庄引入适合农户家庭的创业项目,以及加大对农户家庭在创业贷款、税收减免优惠、创业技能培训和信息咨询等方面的支持力度。

关键词：庭院型创业影响因素家庭创业

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新时代教育评价改革的“兼容-中心”识别:分析框架与制度逻辑

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教育研究与实验 2024年第3期 111-121页

作者：朱德全刘璐璐西南大学教育学部重庆400715

新时代,教育评价改革关乎我国人才培养质量的提升、教育现代化的建设和教育强国的建成。为更好地深化教育评价改革,亟需厘清场域内为数众多的相关主体的制度逻辑,并识别多重制度逻辑的兼容性与中心性,以期呈现出教育评价改革实践中的组... 详细信息

新时代,教育评价改革关乎我国人才培养质量的提升、教育现代化的建设和教育强国的建成。为更好地深化教育评价改革,亟需厘清场域内为数众多的相关主体的制度逻辑,并识别多重制度逻辑的兼容性与中心性,以期呈现出教育评价改革实践中的组织样态。新时代教育评价改革的多重制度逻辑属于高兼容性-低中心性的“主导型”关系类型。据此,以维稳兼容性和提升中心性为总体思路,提出维系兼容互利状态、形塑共生演进模式,建立多中心化组织,重塑立体网状结构的发展新路向。

关键词：教育评价改革多重制度逻辑中心性兼容性

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ZnO掺杂对钛酸锶基陶瓷储能性能的影响

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硅酸盐学报 2024年第4期52卷 1183-1191页

作者：王佳蕊刘洋刘璐璐王娣王超郝继功李伟聊城大学材料科学与工程学院山东省教育厅敏感材料与器件实验室山东聊城252059

采用传统固相合成工艺制备了(Sr_(0.42)Na_(0.15)Bi_(0.29)Ca_(0.07)□_(0.07))TiO_(3)-x%ZnO(□表示空位,化学式简写为SNBCT-x%ZnO,质量分数)储能陶瓷,并研究了ZnO掺杂对SNBCT陶瓷结构和储能性能的影响。结果表明:所用组分样品均具有... 详细信息

采用传统固相合成工艺制备了(Sr_(0.42)Na_(0.15)Bi_(0.29)Ca_(0.07)□_(0.07))TiO_(3)-x%ZnO(□表示空位,化学式简写为SNBCT-x%ZnO,质量分数)储能陶瓷,并研究了ZnO掺杂对SNBCT陶瓷结构和储能性能的影响。结果表明:所用组分样品均具有以立方相为主相的钙钛矿结构,并表现出细长的电滞回线。ZnO掺杂有效提高了SNBCT陶瓷的击穿强度,并促进了其储能性能的提升。当ZnO掺杂量为0.5%时,样品在468 kV/cm电场下的有效储能密度(W_(rec))达5.16 J/cm^(3),储能效率(η)为88.2%。通过有限元分析建立了该组分陶瓷的晶粒/晶界模型,模拟了电场作用下样品击穿裂纹的扩展,分析了样品高耐击穿行为的内在机理。此外,样品还具有良好的充放电性能,放电能量密度(Wd)和放电速率(t_(0.9))在280 kV/cm电场下分别为2.61 J/cm^(3)和227 ns,同时样品表现出良好的温度稳定性,在脉冲功率系统中展示出良好的应用潜力。

关键词：电介质陶瓷钛酸锶储能性能脉冲充放电

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