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Blood compatible heteratom-doped carbon dots for bio-imaging of human umbilical vein endothelial cells

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Chinese Chemical Letters 2020年第3期31卷 769-773页

作者： Jian Zhong Xinmian Chen Miaoran Zhang Chaoxin Xiao lulu Cai Waleed Ali Khan Kaixuan Yu Jiayi cui Lin He Personalized Drug Therapy Key Laboratory of Sichuan Province Department of PharmacySichuan Provincial People's HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610072China State Key Laboratory of Heavy Oil Processing Beijing Key Laboratory of Biogas Upgrading UtilizationCollege of New Energy and MaterialsChina University of Petroleum(Beijing)Beijing 102249China State Key Laboratory of Biotherapy and Cancer West China HospitalSichuan University and Collaborative Innovation CenterChengdu 610041China

Carbon dots have unique advantages in biological applications owing to their excellent optical prope ***,the biosafety evaluation of carbon dots has limitations owing to cytotoxicity in vitro,and the re is little pre-safety evaluation before in vivo and clinical *** the carbon dots are or not suitable for applications in vivo,evaluation analysis can be made based on hemolysis and changes in erythrocyte *** this work,a green fluorescent N,S-doped carbon dots(N,S-CDs)were obtained by hydrothermal method,tobias acid,and m-phenylenediamine as precursors.N,S-CDs not only possessed excellent dispersibility,uniform particle size,high quantum yield(37.2%)and stable photoluminescence property but also retain their photostability and stro ng fluorescence intensity in the acid/alkaline solutions,different ionic strengths(NaCl)and under 365 nm UV *** r,the N,S-CDs displayed low cytotoxicity and high cellular uptake efficiency in human umbilical vein endothelial cells(HUVEC)and excellent blood compatibility to the *** is foreseeable that N,S-CDs could be further studied as a promising biological imaging agent in vivo.

关键词： Carbon dots Fluorescent Cell imaging Erythrocyte Blood compatibility

Ultrathin origami accordion-like structure of vacancy-rich graphitized carbon nitride for enhancing CO_(2) photoreduction

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Carbon Energy 2023年第4期5卷 94-104页

作者： Guangri Jia Zhongxu Wang Ming Gong Ying Wang Lu Hua Li Yilong Dong lulu Liu Lei Zhang Jingxiang Zhao Weitao Zheng Xiaoqiang cui State Key Laboratory of Automotive Simulation and Control Key Laboratory of Automobile Materials of MOESchool of Materials Science and EngineeringJilin UniversityChangchunJilinChina Key Laboratory of Photonic and Electronic Bandgap Materials Ministry of EducationCollege of Chemistry and Chemical EngineeringHarbin Normal UniversityHarbinHeilongjiangChina Institute for Frontier Materials Deakin UniversityWaurn PondsVictoriaAustralia College of Chemistry Jilin UniversityChangchunJilinChina

Retaining the ultrathin structure of two-dimensional materials is very important for stabilizing their catalytic ***,aggregation and restacking are unavoidable,to some extent,due to the van der Waals interlayer interaction of two-dimensional ***,we address this challenge by preparing an origami accordion structure of ultrathin twodimensional graphitized carbon nitride(oa-C_(3)N_(4))with rich *** novel structured oa-C_(3)N_(4) shows exceptional photocatalytic activity for the CO_(2) reduction reaction,which is 8.1 times that of the pristine C_(3)N_(4).The unique structure not only prevents restacking but also increases light harvesting and the density of vacancy defects,which leads to modification of the electronic structure,regulation of the CO_(2) adsorption energy,and a decrease in the energy barrier of the carbon dioxide to carboxylic acid intermediate *** study provides a new avenue for the development of stable highperformance two-dimensional catalytic materials.

关键词： C_(3)N_(4) CO_(2)photoreduction molecular modification photocatalysts solar energy conversion two-dimensional materials

Targeted drug delivery strategies for the treatment of rheumatoid arthritis

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Science China(Life Sciences) 2021年第7期64卷 1187-1189页

作者： Jinxia Zhang Ling Jiang Lihong Sun Ping Wang Suhui Sun Menghong Xu lulu zhang Shumin Wang Xiaolong Liang Ligang cui Department of Ultrasound Peking University Third HospitalBeijing 100191China

A chronic autoimmune disease named rheumatoid arthritis(RA)is characterized mainly by synovitis,which has high morbidity,disability and mortality *** addition,the aetiology and pathogenesis of RA have not been fully *** is usually accompanied by persistent arthritic pain,swelling,stiffness,and functional disorders;in severe cases,it may result in cardiovascular,pulmonary,psychological and skeletal diseases(Scott et al.,2010).

关键词： mortality cardiovascular diseases

LPS-induced mitochondrial DNA synthesis and release facilitate RAD50-dependent acute lung injury

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Signal Transduction and Targeted Therapy 2021年第4期6卷 1104-1106页

作者： Xueqin Zhan Rui cui Xinwei Geng Jiaqian Li Yunlian Zhou lulu He Chao Cao Chao Zhang Zhimin Chen Songmin Ying Department of Pulmonology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthNational Children's Regional Medical CenterHangzhouZhejiangChina International Institutes of Medicine the Fourth Affiliated Hospital of Zhejiang University School of MedicineYiwuChina Department of Pharmacology and Department of Respiratory and Critical Care Medicine of the Second Affiliated Hospital Zhejiang University School of MedicineKey Laboratory of Respiratory Disease of Zhejiang ProvinceHangzhouZhejiangChina

Dear Editor,ATP-binding cassette(ABC)-ATPase(RAD50),together with meiotic recombination 11 homolog 1(MRE11)subunits,to form MRE11-RAD50 complex,plays important roles in recognition of double-stranded DNA(dsDNA)and initiation of consequent inflammatory *** lung injury(ALI)and acute respiratory destress syndrome(ARDS)are systemic uncontrolled inflammation and ***,the function of the DNA sensor in ALI/ARDS remains poorly *** we investigated functions of RAD50 using mouse primary macrophages and conditionally RAD50 knockout mice in vitro and in a lipopolysaccharide(LPS)-induced lung injury model.

关键词： RAD50 acute lung

Comparative transcriptional analysis and identification of hub genes associated with wing differentiation of male in Aphis gossypii

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Journal of Cotton Research 2022年第3期5卷 243-260页

作者： HUANGFU Ningbo SHI Qingyu CHEN lulu MA Xiaoyan ZHANG Kaixin LI Dongyang WANG Li ZHU Xiangzhen JI Jichao LUO Junyu cui Jinjie Zhengzhou Research Base State Key Laboratory of Cotton BiologyZhengzhou UniversityZhengzhou 450001China State Key Laboratory of Cotton Biology Institute of Cotton ResearchChinese Academy of Agricultural SciencesAnyangHenan 455000China College of Agronomy Xinjiang Agricultural UniversityUrumqi 830052China.

Background:Aphis gossypii Glover(Hemiptera:Aphididae),a worldwide polyphagous phloem-feeding agricultural pest,has three wing morphs(winged parthenogenetic female,gynopara,and male)in the life *** exclusive males could fly from summer hosts to winter hosts,which are essential for gene exchanges of cotton aphid populations from different hosts or ***,the molecular mechanism of wing differentiation of male in *** remains ***:Morphological observation of male *** showed that there is no distinct difference in the external morphologies of the 1st and 2nd instar *** obvious differentiation of wing buds started in the 3rd instar nymph and was visible via naked eyes in the 4th instar nymphal stage,then adult male emerged with full *** to morphological dynamic changes,the development of wings in males were divided into four stages:preliminary stage(the 1st instar to 2nd instar),prophase(the 3rd instar),metaphase(the 4th instar),anaphase(the 5th instar).Results of feeding behavior monitoring via EPG(electrical penetration graph)technology indicated that although the male cotton aphids had strong desire to feed(longer duration of C 55.24%,F 5.05%and Pd waves 2.56%),its feeding efficiency to summer host cotton was low(shorter E13.56%and E2 waves 2.63%).Dynamic transcriptome analysis of male aphid at 5 different developmental periods showed that in the 3rd instar nymph,the number of up-regulated DEGs was significant increased,and time-course gene transcriptional pattern analyses results also showed that numerous genes categorized in clusters 3,5,and 8 had the highest expressed levels,which were consistent with morphological changes of wing *** results indicate that the 3rd instar nymph is the critical stage of wing bud differentiation in ***,through pathway enrichment analysis of DEGs and WGCNA,it revealed that the neuroactive ligand-receptor interaction,Ras signaling pathway,dopaminergic synaps

关键词： Aphis gossypii EPG Wing bud differentiation Dynamic transcriptome WGCNA

Paternally imprinted LATE-FLOWERING2 transcription factor contributes to paternal-excess interploidy hybridization barriers in wheat∞

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Journal of Integrative Plant Biology 2023年第12期65卷 2587-2603页

作者： Guanghui Yang Man Feng Kuohai Yu Guangxian cui Yan Zhou Lv Sun lulu Gao Yumei Zhang Huiru Peng Yingyin Yao Zhaorong Hu Vincenzo Rossi Ive De Smet Zhongfu Ni Qixin Sun Mingming Xin State Key Laboratory for Agrobiotechnology Key Laboratory of Crop Heterosis Utilization(MOE)Beijing Key Laboratory of Crop Genetic ImprovementChina Agricultural UniversityBeijing 100193China Qingdao Agricultural University Qingdao 266109China Council for Agricultural Research and Economics Research Centre for Cereal and Industrial CropsBergamo 24126Italy Department of Plant Biotechnology and Bioinformatics Ghent UniversityGhent B‐9052Belgium VIB Center for Plant Systems Biology Ghent B‐9052Belgium

Interploidy hybridization between hexaploid and tetraploid genotypes occurred repeatedly during genomic introgression events throughout wheat evolution,and is commonly employed in wheat breeding *** wheat usually serves as maternal parent because the reciprocal cross generates progeny with severe defects and poor seed germination,but the underlying mechanism is poorly ***,we performed detailed analysis of phenotypic variation in endosperm between two interploidy reciprocal crosses arising from tetraploid(Triticum durum,AABB)and hexaploid wheat(Triticum aestivum,AABBDD).In the paternal‐versus the maternal‐excess cross,the timing of endosperm cellularization was delayed and starch granule accumulation in the endosperm was repressed,causing reduced germination *** expression profiles of genes involved in nutrient metabolism differed strongly between these endosperm ***,expression patterns of parental alleles were dramatically disturbed in interploidy versus intraploidy crosses,leading to increased number of imprinted *** endosperm‐specific TaLFL2 showed a paternally imprinted expression pattern in interploidy crosses partially due to allele‐specific DNA *** TaLFL2 binds to and represses a nutrient accumulation regulator TaNAC019,leading to reduced storage protein and starch accumulation during endosperm development in paternal‐excess cross,as confirmed by interploidy crosses between tetraploid wild‐type and clustered regularly interspaced palindromic repeats(CRISPR)–CRISPR‐associated protein 9 generated hexaploid *** findings reveal a contribution of genomic imprinting to paternal‐excess interploidy hybridization barriers during wheat evolution history and explains why experienced breeders preferentially exploit maternal‐excess interploidy crosses in wheat breeding programs.

关键词： imprinting interploidy cross wheat

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不同低聚多元醇软段结构水性聚氨酯膜的制备

高分子材料科学与工程 2018年第5期34卷 143-148页

作者：姚路路席涛崔鹏合肥工业大学化学与化工学院安徽合肥230009

分别以相对分子质量均为2000的聚丙二醇(PPG)、聚四氢呋喃醚二醇(PTMG)、聚己二酸己二醇酯二醇(PHA)和聚己二酸乙二醇酯二醇(PEA)为软段原料,以异佛尔酮二异氰酸酯(IPDI)和小分子多元醇、小分子多元胺为硬段原料制备了系列水性聚氨脂(W... 详细信息

分别以相对分子质量均为2000的聚丙二醇(PPG)、聚四氢呋喃醚二醇(PTMG)、聚己二酸己二醇酯二醇(PHA)和聚己二酸乙二醇酯二醇(PEA)为软段原料,以异佛尔酮二异氰酸酯(IPDI)和小分子多元醇、小分子多元胺为硬段原料制备了系列水性聚氨脂(WPU)膜。通过红外光谱、动态力学热分析,以及溶胀和溶解选择因子、渗透汽化分离苯/环己烷测试对膜的结构和性能进行了表征。研究表明,WPU-PTMG膜硬段结合紧密,WPU-PPG膜溶胀率和渗透汽化通量较大;WPU-PEA膜的酯基密度较大,微相分离程度较高,对苯的亲和性最好;WPU-PHA膜的酯基密度小于WPU-PEA膜,其溶胀率和渗透汽化通量大于WPU-PEA。

关键词：水性聚氨酯软段结构渗透汽化

Effect of hydrogen content on dielectric strength of the silicon nitride film deposited by ICP-CVD

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Chinese Physics B 2021年第4期30卷 550-554页

作者： Yudong Zhang Jiale Tang Yongjie Hu Jie Yuan lulu Guan Xingyu Li Hushan cui Guanghui Ding Xinying Shi Kaidong Xu Shiwei Zhuang School of Physics and Electronic Engineering Jiangsu Normal UniversityXuzhou 221116China Jiangsu Leuven Instruments Co.Ltd Xuzhou 221300China

The inductively coupled plasma chemical vapor deposition(ICP-CVD) deposited silicon nitride(SiN_(x)) thin film was evaluated for its application as the electrical insulating film for a capacitor *** order to achieve highest possible dielectric strength of SiN_(x),the process parameters of ICP-CVD were carefully tuned to control hydrogen in SiN_(x) films by means of tuning N_(2)/SiH_(4) ratio and radio frequency(RF) *** electrical measurements,the hydrogen content in the films was measured by dynamic secondary ion mass spectrometry(D-SIMS).Fourier transform infrared spectroscopy(FTIR) and micro Raman spectroscopy were used to characterize the SiN_(x) films by measuring Si-H and N-H bonds’ *** was found that the more Si-H bonds lead to the higher dielectric strength.

关键词： dielectric strength silicon nitride film inductively coupled plasma chemical vapor deposition(ICP-CVD) hydrogen content

Carbetocin for the prevention of postpartum hemorrhage:a systematic review and meta-analysis of randomized controlled trials

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Carbetocin for the prevention of postpartum hemorrhage:a sys...