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控制小麦条锈病的成株抗性(高温下)基因数量研究

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麦类作物学报 1987年第3期 22-25页

作者： E. A. Milus ,R. f. Line ,宋继学

Gaines,Nugaines和luke冬小麦对条锈病的抗性,是持久性非专化小种抗性的最好例证.自从它们问世以来,在美国沿太平洋西北部地区对小麦条锈菌各生理小种,一直保持着成株期的抗性.1980年试验,对欧洲小种也有抗性.在大田中,这些品种的条锈... 详细信息

Gaines,Nugaines和luke冬小麦对条锈病的抗性,是持久性非专化小种抗性的最好例证.自从它们问世以来,在美国沿太平洋西北部地区对小麦条锈菌各生理小种,一直保持着成株期的抗性.1980年试验,对欧洲小种也有抗性.在大田中,这些品种的条锈病发育缓慢.在低(2-18℃)或高(10-30℃)昼夜温差条件下,Gaines和Nugaines的幼苗对该病菌所有小种都感病,luke幼苗只对最流行的小种是感病的.它们在成熟时,高温差条件下发育的植株变得更抗病,低温差下发育的植株仍然感病.另一研究表明,这些品种的抗性基

关键词：成株抗性冬小麦冬麦感病亲本黄锈病条锈病抗性基因 AUDPC 基因数量高温下

对患有冠心病的高血压患者大幅降压是否有危险?

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世界核心医学期刊文摘（心脏病学分册） 2007年第11期3卷 4-5页

作者： Messerli f.H. Mancia G. Conti C.R. 杜媛 Division of Cardiology St. Luke's-Roosevelt Hospital 1000 Tenth Avenue New York NY 10019 United States Dr.

背景:由于冠状动脉灌注主要发生在心动周期的舒张期,如果舒张压低于临界水平则冠心病(CAD)患者发生冠状动脉事件的风险增高。目的:确定在此类人群中低血压是否与增高的死亡率和发病率有关。

关键词：高血压患者 CAD 冠心病冠状动脉病舒张压全因死亡

Culture, Detection and Identification of Dengue Virus in C6/36 Aedes albopictus, LLC-MK2, MfL and Vero Cell Lines

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Culture, Detection and Identification of Dengue Virus in C6/...

Early Detection of Mild Alzheimer’s Disease in filipino Elderly: Validation of the Montreal Cognitive Assessment-Philippines (MoCA-P)

Third Congress of the Asian-Pacific Organization for Cell Biology

作者： filipinas f. Nalividad Giselle V. Espiritu James L. Dungca Ramil R.Noche Corazon C.Buerano Ronald R,Matias Institute of Biology College of ScienceUniversity of the PhilippinesDilimanQuezon City 1101PhilippinesResearch and Biotechnology DivisionSt. Luke’s Medical Center279 E. Rodriguez Sr. Blvd.Quezon CityPhilippines

four cell lines C6/36 Aedes albopictus, LLC-MK2, MfL and Vero, were used for isolation and culture of dengue virus from serum of patients diagnosed with dengue fever in the Philippines. fifty microliter (50 μl) of se...

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Advances in Alzheimer's Disease 2014年第4期3卷 160-167页

作者： Jacqueline C. Dominguez Jennifer Rose Soriano Cely D. Magpantay Mary Grace S. Orquiza Wynette Marie Solis Macario f. Reandelar Jr. Ma. Lourdes C. Joson Memory Center Institute for Neurosciences St. Luke’s Medical Center Quezon City Philippines

Background: The Montreal Cognitive Assessment (MoCA) is a useful instrument employed by clinicians to detect cognitive impairment and diagnose probable Alzheimer’s Disease (AD) while in its early stages. Methods: A cross-sectional study was conducted to determine the diagnostic validity of the Philippine version of the MoCA (MoCA-P) among 1385 community-dwelling filipino elderly from Marikina City, Metro Manila. Results: 509 controls and 97 elderly with probable AD and a Clinical Dementia Rating (CDR) global score of 0.5 were included in the analysis. Analysis of variance showed that the AD group was older (p fewer years of education (p ff score to differentiate controls from those with probable AD was 20/21, with a sensitivity of 0.835 and a specificity of 0.723, and area under the curve (AUC) of 0.89 (p f scoring for those with ≤7 years of education. Conclusion: The MoCA-P is a valid instrument for the early detection of mild AD among the filipino elderly.

关键词： Alzheimer Disease filipino MoCA-P Validation

洛杉矶社区相关性耐甲氧西林金黄色葡萄球菌感染所致的坏死性筋膜炎

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世界核心医学期刊文摘（皮肤病学分册） 2005年第8期1卷 2-3页

作者： Miller L.G. Perdreau- Remington f. Rieg G. 惠海英 Dr.Division of Infectious Diseases Harbor- UCLA Medical Center L. A. Biomed. Inst. At Harbor- UCLA Torrance CA United States

BACKGROUND: Necrotizing fasciitis is a life- threatening infection requiring urgent surgical and medical therapy. Staphylococcus aureus has been a very uncommon cause of necrotizing fasciitis, but we have recently noted an alarming number of these infections caused by community- associated methicillin- resistant S. aureus (MRSA). METHODS: We reviewed the records of 843 patients whose wound cultures grew MRSA at our center from January 15,2003, to April 15,2004. Among this cohort, 14 were identified as patients presenting from the community with clinical and intraoperative findings of necrotizing fasciitis, necrotizing myositis, or both. RESULTS: The median age of the patients was 46 years (range, 28 to 68), and 71 percent were men. Coexisting conditions or risk factors included current or past injection- drug use (43 percent); previous MRSA infection, diabetes, and chronic hepatitis C (21 percent each); and cancer and human immunodeficiency virus infection or the acquired immunodeficiency syndrome (7 percent each). four patients (29 percent) had no serious coexisting conditions or risk factors. All patients received combined medical and surgical therapy, and none died, but they had serious complications, including the need for reconstructive surgery and prolonged stay in the intensive care unit. Wound cultures were monomicrobial for MRSA in 86 percent, and 40 percent of patients (4 of 10) for whom blood cultures were obtained had positive results. All MRSA isolates were susceptible in vitro to clindamycin, trimethoprim- sulfamethoxazole, and rifampin. All recovered isolates belonged to the same genotype (multilocus sequence type ST8, pulsed- field type USA300, and staphylococcal cassette chromosome mec type IV [SCCmecIV]) and carried the Panton- Valentine leukocidin (pvl), lukD, and luke genes, but no other toxin genes were detected. CONCLUSIONS: Necrotizing fasciitis caused by community- associated MRSA is an emerging clinical entity. In areas in which community- a

关键词：坏死性筋膜炎金黄色葡萄球菌血培养阳性体外药敏试验慢性丙型肝炎整形外科手术吸毒史肌炎经验性治疗药物治疗

肺分支动脉留置导管内生物制剂灌注治疗晚期肺癌

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上海生物医学工程 1997年第1期18卷 39-41页

作者：茅爱武徐志明高中度钱锡桂孙嘉珍邵维城上海同仁医院上海200050

探讨IL—2/LAK细胞在介入式局部应用中的抗肿瘤作用,寻求疗效确切、操作可行的晚期肺癌生物治疗的应用途径。我们对60例晚期肺癌随机分为治疗组对照1组和对照2组。治疗组采用经皮颈外静脉穿刺肺分支动脉插管留置、IL—2、LAK细胞及化疗... 详细信息

探讨IL—2/LAK细胞在介入式局部应用中的抗肿瘤作用,寻求疗效确切、操作可行的晚期肺癌生物治疗的应用途径。我们对60例晚期肺癌随机分为治疗组对照1组和对照2组。治疗组采用经皮颈外静脉穿刺肺分支动脉插管留置、IL—2、LAK细胞及化疗药物联合滴注治疗;对照1组以相同生物制剂及化疗药物外周静脉应用;对照2组采用单纯静脉化疗。三组化疗药物剂量及疗程均相同。结果:三组有效率(CR+PR)分别为:治疗组53.3％,对照1组39.9％,对照2组33.3％。结论:IL—2、LAK细胞与化疗药物联合应用能起到抗肿瘤的协同作用。IL—2、LAK细胞介入式局部应用弥补了其在体内半衰期短的缺陷,使肿瘤靶组织获得大剂量免疫细胞成为可能,从而提高其抗肿瘤作用。

关键词：肺癌白介素Ⅲ LAK细胞肺肿瘤生物制剂

关于大麻素-1受体阻断剂利莫那班对超重或肥胖患者体重和心脏代谢危险因素影响的随机对照试验:RIO-北美研究

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世界核心医学期刊文摘（心脏病学分册） 2006年第6期2卷 6-7页

作者： Pi-Sunyer f.X. Aronne L.J. Heshmati H.M. 任付先 Obesity Research Center St. Luke's- Roosevelt Hospital WH1020 1111 Amsterdam Ave New York NY 10025 United States Dr.

Context: Rimonabant, a selective cannabinoid- 1 receptor blocker, may reduce body weight and improve cardiometabolic risk factors in patients who are overweight or obese. Objective: To compare the efficacy and safety of rimonabant with placebo each in conjunction with diet and exercise for sustained changes in weight and cardiometabolic risk factors over 2 years. Design, Setting, and Participants: Randomized, double- blind, placebo- controlled trial of 3045 obese(body mass index ≥ 30) or overweight(body mass index >27 and treated or untreated hypertension or dyslipidemia) adult patients at 64 US and 8 Canadian clinical research centers from August 2001 to April 2004. Intervention: After a 4- week single- blind placebo plus diet(600 kcal/d deficit) run- in period, patients were randomized to receive placebo, 5 mg/d of rimonabant, or 20 mg/d of rimonabant for 1 year. Rimonabant- treated patients were rerandomized to receive placebo or continued to receive the same rimonabant dose while the placebo group continued to receive placebo during year 2. Main Outcome Measures: Body weight change over year 1 and prevention of weight regain during year 2. Additional efficacy measures included changes in waist circumference, plasma lipid levels, and other cardiometabolic risk factors. Results: At year 1, the completion rate was 309(51% ) patients in the placebo group, 620(51% ) patients in the 5 mg of rimonabant group, and 673(55% ) patients in the 20 mg of rimonabant group. Compared with the placebo group, the 20 mg of rimonabant group produced greater mean(SEM) reductions in weight(- 6.3 [0.2] kg vs - 1.6[0.2] kg; Pference(- 6.1 [0.2] cm vs- 2.5[0.3] cm; Pf triglycerides(percentage change,- 5.3[1.2] vs 7.9 [2.0]; Pf high- density lipoprotein cholesterol(percentage change, 12.6 [0.5] vs 5.4 [0.7]; Pfrom the 20 mg of rimonabant group to the placebo group during y

关键词：随机对照试验肥胖患者受体阻断剂危险因素心脏代谢大麻素体重超重北美限制饮食

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戈佐岛的家族性假性脱皮

世界核心医学期刊文摘（眼科学分册） 2006年第5期2卷 27-28页

作者： Hardie J.G. Mercieca f. fenech T. Cuschieri A. 王海燕 Department of Ophthalmology St. Luke'sHospital G'Mangia Malta

Aims: To describe the occurrence of pseudoexfoliation in three Gozitan families. Methods: Three families with a high incidence of pseudoexfoliation were identified. All members of the three families who agreed to participate were interviewed and underwent a full ophthalmologic examination. The pseudoex-foliation status was classified as present, absent, or unknown. Results: A total of 55 individuals from three separate family probands and with a male:female sex ratio of 5:4 were examined. In all, 18 had definite evidence of pseudoexfoliation, 17 of them bilaterally and one showing only unilateral signs. Age was the main risk factor, with 18 out of the 20 individuals who were over the age of 60 years having pseudoexfoliation, while none of the 35 who were below the age of 60 years had pseudoexfoliation. The ophthalmological findings varied in different families. family I had a high incidence of both cataract and glaucoma, family II had mainly glaucoma, while in family III all individuals had cataract but none had evidence of glaucoma. The first generation of these three families were deceased but their hospital and clinical records revealed that in all three families the father was affected and there was no evidence of maternal involvement. Conclusions: In all three families, pseudoexfoliation appeared to be genetically transmitted as a late onset autosomal dominant trait of variable expression. Maternal transmission could not be confirmed in these families.

关键词：家族性脱皮假性眼部检查高发家族危险因素家族成员眼部表现 60岁先证者

红曲对中度血脂升高美国人调节血脂作用的临床研究

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上海预防医学 2013年第9期25卷 501-506页

作者：陆继红 Kermit Bonovich Harry Colfer Michael Davidson Carlos A.Dujovne David L.fried Mitchell Greenspan Ronald P.Karlsberg Stephen P.King Craig f.Laforce Marc Litt J.Robert McGhee 曾润海朱佳石谈宁芝华茂北京临床药理研究中心北京100088 Healthy Options Burns Clinic Rush-Presbyterian-St. luke's Medical Center Kansas University Medical Center and Kansas foundation for Clinical Pharmacology Omega Medical Research Lifemark Medical Center Cardiovascular Research Institute of So. CA future Scripts North Carolina Clinical Research Jacksonville Heart Center Mediquest Research Group Nu Skin Center for Anti-aging Research 香港理工大学

[目的]评价在饮食控制的情况下红曲（RYRCholestin）对美国高血脂人群的降脂作用和安全性。[方法]开放标记，自身对照，多中心临床试验。187名美国高血脂人群入选（血清低密度脂蛋白胆固醇3．50—4．92mmol／L，总胆固醇5．18—7．25mmo... 详细信息

[目的]评价在饮食控制的情况下红曲（RYRCholestin）对美国高血脂人群的降脂作用和安全性。[方法]开放标记，自身对照，多中心临床试验。187名美国高血脂人群入选（血清低密度脂蛋白胆固醇3．50—4．92mmol／L，总胆固醇5．18—7．25mmol／L；男116人，女71人），162入完成试验。在整个试验中受试者遵照美国国家胆固醇教育计划的饮食要求。试验的前4周仅控制饮食，第5周至第12周连续服用8周RYRCholestin（每日2．4g）。[结果]经前4周饮食控制，血清脂质各指标无显著变化。口服RYRCholestin8周后，血清总胆固醇、低密度脂蛋白胆固醇和三酰甘油分别降低16．6％，24．O％和25．2％，高密度脂蛋白胆固醇升高14．3％（P〈0．001）。显效率为79．0％，有效率为97．5％。停服14d（2周）后，血脂各指标回到试验前水平。试验中共发现可能与服用产品相关的、轻度的29项不良反应。[结论]RYRCholestin的耐受性良好，它可降低血清总胆固醇、低密度脂蛋白胆固醇和三酰甘油，升高血清高密度脂蛋白胆固醇。停服2用后受试者的血脂各项指标均恢复到试验前水平。

关键词：红曲高脂血症低密度脂蛋白胆固醇三酰甘油高密度脂蛋白胆固醇