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Plasma lipidomics reveal systemic changes persistent throughout early life following a childhood burn injury

Burns & Trauma 2023年第1期11卷 814-824页

作者： Eva Kierath Monique Ryan Elaine Holmes Jeremy K.Nicholson Mark W.Fear Fiona M.Wood luke whiley Nicola Gray 无 Australian National Phenome Centre Health Futures InstituteMurdoch UniversityHarry Perkins Institute5 Robin Warren DriveMurdochPerthWA 6150Australia Fiona Wood Foundation Fiona Stanley HospitalFiona Wood FoundationFiona Stanley HospitalLevel 411 Robin Warren DriveMurdochWA 6150Australia Burn injury research unit School of Biomedical SciencesUniversity of Western Australia6 Verdun streetNedlandsWA 6009 Australia Department of Metabolism Digestion and ReproductionFaculty of MedicineImperial College LondonSir Alexander Fleming BuildingSouth KensingtonLondon SW72AZUK Centre for Computational Medicine Health Futures InstituteMurdoch University5 Robin Warren DriveMurdochPerthWA 6150Australia Medical School University of Western AustraliaHarry Perkins InstituteMurdochPerthWA 6150Australia Faculty of Medicine Institute of Global Health InnovationImperial College LondonLevel 1Faculty Building South Kensington CampusLondon SW72AZUK Burns Service of Western Australia WA Department of Health11 Robin Warren driveMurdochWA 6150Australia Perron Institute for Neurological and Translational Science NedlandsWAAustralia

Background:Non-severe paediatric burns can result in poor long-term health *** occurs even in cases with good acute burn-related outcomes,including minimal *** mechanisms that underpin the transition from non-severe burn to sustained negative long-term health impacts are currently ***,sustained metabolic and immune changes have been observed in paediatric burn studies,suggesting these changes may be *** plasma lipidome consists of a rich pool of bioactive metabolites that play critical roles in systemic processes including molecular signalling and *** hypothesised that changes in the plasma lipidome may reflect underlying changes in health status and be linked to long-term health after burn ***:This study analysed the lipidome in children who had previously experienced a non-severe burn,compared to non-injured ***-three participants were recruited between the ages of 5 and 8 years who had experienced a non-severe burn between the ages of 1 and 3 *** samples were also collected from a non-injured,healthy,age and gender matched control group(n=21).Plasma lipids were measured using reversed-phase liquid chromatographymass spectrometery(LC-MS).Results:In total 838 reproducible lipid species from 19 sub-classes passed quality control procedures and progressed to statistical *** of individual lipid metabolites showed significantly higher concentrations of lysophosphatidylethanolamines and phosphatidylethanolamines,and significantly lower concentrations in myristic,palmitic and palmitoleic acids in the plasma of those who had experienced burn injury compared to ***:Long-term changes in the lipid profile may give insight into the mechanisms underlying poor long-term health subsequent to non-severe burn *** work to investigate the relationship between long-term pathology and lipidomic changes may lead to a better understanding of the causes of seconda

关键词： Lipidomics Lipids Burns Trauma Paediatric Children Mass spectrometry

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Strongyloidiasis in Ethiopia:systematic review on risk factors,diagnosis,prevalence and clinical outcomes

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Infectious Diseases of Poverty 2019年第3期8卷 32-42页

作者： Yitagele Terefe Kirstin Ross Harriet whiley College of Veterinary Medicine Haramaya UniversityP.O.Box 138Dire DawaEthiopia Foodborne Pathogen Diagnosis Research Laboratory Haramaya UniversityP.O.Box 138Dire DawaEthiopia Environmental Health College of Science and EngineeringFlinders UniversityGPO Box 2100AdelaideSouth Australia 5001Australia

Background:Strongyloidiasis is a gastrointestinal infection caused by the parasitic nematode Strongyloides *** is estimated to infea up to 370 million people globally and is predominately found in tropical and subtropical areas of socioeconomic *** body:This systematic literature review identified studies published in the last ten years on the risk factors,diagnosis,prevalence and/or clinical outcomes of strongyloidiasis in *** prevalence of *** ranged from 0.2 to 11.1%in adults,0.3%to 20.7%in children,1.5%to 17.3%in HIV positive adults and 5%in HIV positive *** identified studies primarily used microscopy based techniques that potentially underestimated the prevalence four fold compared with serology and *** in children presents a particularly significant issue in Ethiopia as children often presented with anemia,which is associated with impaired mental and cognitive *** most significant risk factor for strongyloidiasis was HIV status and although other risk factors were identified for helminth infections,none were statistically significant for *** *** studies detected *** in dogs and non-biting cyclorrhaphan ***,future research is needed to explore the role of these reservoirs in disease ***:This review demonstrated that strongyloidiasis is an overlooked and neglected disease in *** is a need for a systematic approach using a combination of molecular and serology based diagnostic methods to ascertain the true incidence and burden of strongyloidiasis in *** research is also needed to break the cycle of transmission by identifying environmental reservoirs,risk factors and exploring the potential for zoonotic transfer.

关键词： Neglected tropical disease Soil transmitted helminth Public health Strongyloides stercoralis AIDS HIV Anemia

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温度对芒果生长、干物质产量和淀粉积累的影响

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世界热带农业信息 1991年第5期 27-35页

作者： A.W.whiley 陈里林

10个芒果品种嫁接在Kensington的实生苗砧木上,在日/夜温为15/10℃、20/15℃、25/20℃或30/25℃下生长20周。营养生长随温度的提高而增强。在25/20℃和30/25℃下所有品种都进行营养生长。在20/15℃下,Carabao、Kensington和Dashehari停... 详细信息

10个芒果品种嫁接在Kensington的实生苗砧木上,在日/夜温为15/10℃、20/15℃、25/20℃或30/25℃下生长20周。营养生长随温度的提高而增强。在25/20℃和30/25℃下所有品种都进行营养生长。在20/15℃下,Carabao、Kensington和Dashehari停止生长。在15/10℃下,Kensington、Nam Dok Mai、Alphonso、Florigon、Glenn、Irwin、Haden和Sensation产生花序。温度从15/10℃升到30/25℃时,平均生长梢数(敏感品种)从0.48提高到3.21,每条生长梢的叶数从1.22提高到13.63。新梢的干物质,在最低温(15/10℃)下绝大部分分配到根系(95％),在30/25℃下则大部分分配到叶片(58％)。计算出的零营养生长日平均温度为15℃。温度和相对生长活性也影响砧木树干木质组织在20周末的淀粉积累(淀粉含量在15/10℃时为15.9％,30/25℃时为4.8％)。Irwin在两种较高温度下的淀粉含量最高(30/25℃时为其它品种的两倍),而Kensington在25/20℃下的淀粉含量却最低,约为其它大部分品种的50％。

关键词：干物质产量淀粉积累营养生长品种间干物质分配淀粉浓度芒果树芒果品种淀粉含量温度处理

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开花中期喷施多效唑对油梨果实增大和增产的效应

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世界热带农业信息 1993年第4期 35-39页

作者： A.W.whiley 陈里林

开花中期叶面喷施多效唑(Paclobutrazol)2.5、1.25和0.62克/升(指有效成分克数,下同),抑制了哈斯(Hass)油梨(Persea americana Mill.)植株的春季生长,改变了座果春梢的干物质分配。干物质分配到营养生长的比例下降,分配到果实的比例提... 详细信息

开花中期叶面喷施多效唑(Paclobutrazol)2.5、1.25和0.62克/升(指有效成分克数,下同),抑制了哈斯(Hass)油梨(Persea americana Mill.)植株的春季生长,改变了座果春梢的干物质分配。干物质分配到营养生长的比例下降,分配到果实的比例提高。与其它处理相比,2.5克/升处理植株春梢的木质部淀粉浓度提高约70％。开花中期叶面喷施多效唑还降低了植株夏梢生长(约20％)。在春梢老熟时以每平方米树冠覆盖面积茎干注射0.2克多效唑,开花中期叶面再加喷1次1.25克/升浓度的多效唑,夏梢长度比对照树降低36％。开花中期叶面喷施2.5和1.25克/升多效唑的处理提高了收获时的平均果个(分别增大16％和11％)。多效唑对果实年产量无显著影响,但以两年累计产量看,1.25和0.62克/升的处理增产显著,约为63％。茎干注射对当年和下一年的果实产量均无显著影响。

关键词：喷施处理多效春梢树冠覆盖面干物质分配淀粉浓度夏梢座果茎干哈斯

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油梨疫霉根腐病的杀菌防治及其对植株水分、产量和环颈病的影响

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热带农业科技 1988年第4期 43-46页

作者： A·W·whiley 李维锐澳

通过叶面喷酒乙磷铝或土壤施用瑞毒霉,防治由肉桂疫霉引起的油梨根腐病。处理树的木质部水势较高,在夜间水分亏缺比未处理病树恢复得快而完全。被保护树的产量较高。生理性病害——油梨环颈病的发病率,与树体木质部水势相关。

关键词：根腐病有效成份腐烂病瑞毒霉疫霉菌基模势乙磷铝油梨鳄梨水分亏缺植株水分产量

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芒果树的抚育管理

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云南热作科技 1990年第2期13卷 42-45,41页

作者： A.W.whiley 李国华

一、对气候因子的控制 1温度:选择适宜芒果生产的立地环境,温度和雨量最为重要。据报道,尽管在某些地区温度高达48℃,芒果生长茂盛,但其最适生长温度为24—27℃。在大多数情况下,零下低温时芒果发生寒害或死亡,成龄树比幼年树更能忍受... 详细信息

一、对气候因子的控制 1温度:选择适宜芒果生产的立地环境,温度和雨量最为重要。据报道,尽管在某些地区温度高达48℃,芒果生长茂盛,但其最适生长温度为24—27℃。在大多数情况下,零下低温时芒果发生寒害或死亡,成龄树比幼年树更能忍受临界低温。

关键词：芒果树抚育管理

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用树干注射法矫正油梨缺锌缺硼及防治疫霉菌根腐病

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世界热带农业信息 1993年第3期 32-35页

作者： A.W.whiley 莫治雄

将3种浓度(7.5％、10％和20％)的膦酸酯溶液注入油梨树干,可改善疫霉菌根腐病引起的树冠衰萎症状。所有膦酸酯和膦酸钾注射液,包括低浓度(7.5％和10％)注射液,都能成功地防治根腐病。改善树体的健康状况。7.5％膦酸酯处理可采用化学上... 详细信息

将3种浓度(7.5％、10％和20％)的膦酸酯溶液注入油梨树干,可改善疫霉菌根腐病引起的树冠衰萎症状。所有膦酸酯和膦酸钾注射液,包括低浓度(7.5％和10％)注射液,都能成功地防治根腐病。改善树体的健康状况。7.5％膦酸酯处理可采用化学上相容的含锌和硼的混合液配方,树干注射后可以提高这些养分在夏季抽生的老熟叶中的浓度。在生长季节中,用含螯合锌17％或硝酸锌10％的膦酸酯溶液注射两次(15毫升/米冠径),可使叶片锌浓度提高到临界水平(30毫克/公斤干物质重)以上。但是,含有螯合锌的注射液的吸收时间远比含硝酸锌的长。在生长季节中,用含硼0.9％的膦酸酯溶液注射两次(15毫升/米冠径),可使叶硼浓度提高,但未达到临界水平(50毫克/公斤干重)。

关键词：疫霉菌根腐膦酸酯冠径干物质重临界水平硝酸锌疫霉根腐病生长季节吸收时间

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Immunophenotyping identifies distinct cellular signatures for systemic lupus erythematosus and lupus nephritis

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Rheumatology & Autoimmunity 2023年第1期3卷 15-25页

作者： Yi Tong V.Aw Phillip J.whiley Ayla May Lorenzo Tom Lea-Henry Somasundhari Shanmuganandam Maurice Stanley Sonia N.Babu Vicki Athanasopoulos Jean Cappello Julia I.Ellyard Matthew Cook Carola Vinuesa Giles Walters David A.Fulcher Simon H.Jiang Division of Medicine The Canberra HospitalGarranAustralian Capital TerritoryAustralia The Australian National University Medical School GarranAustralian Capital TerritoryAustralia Department of General Surgery The Canberra HospitalGarranAustralian Capital TerritoryAustralia Department of Immunology and Infectious Disease John Curtin School of Medical ResearchGarranAustralian Capital TerritoryAustralia Centre for Personalized Immunology NHMRC Centre for Research ExcellenceCanberraAustralia Department of Renal Medicine The Canberra HospitalGarranAustralian Capital TerritoryAustralia Department of Immunology The Canberra HospitalCanberraAustralian Capital TerritoryAustralia

Background:Systemic lupus erythematosus(SLE)is a complex systemic autoimmune disease characterized by development of autoantibodies and multiorgan *** involvement,termed lupus nephritis,has major impact on life *** is increasingly recognized that SLE is likely a common clinical manifestation of pathophysiologically diverse processes,and lupus nephritis has similarly been associated with several distinct immunological *** compared the immune cell phenotypes of individuals with SLE in the presence or absence of ***:Cryopreserved peripheral blood mononuclear cells from SLE patients with and without kidney involvement underwent flow cytometric analysis to identify major populations in T cells,B cells and myeloid ***:We compared the frequencies of lymphocyte populations in 69 SLE patients without nephritis,20 SLE patients with nephritis,and 92 healthy blood *** with SLE and lupus nephritis(LN)had reduced marginal zone B cells(P<0.0001 in SLE;P=0.001 in LN),memory B cells(P=0.002 in SLE;P=0.001 in LN)and circulating T follicular helper(Tfh)memory cells(P<0.0001 in SLE and LN)compared to healthy *** with lupus nephritis had increase Th2(P<0.0001)and T regulatory cells(P<0.0001)compared to both SLE patients without nephritis and healthy ***:SLE patients with and without lupus nephritis have distinct immunologic differences that may reflect the unique pathophysiological processes contributing to disease manifestations.

关键词： immunoprofiling lupus nephritis systemic lupus erythematosus

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