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Impact of Different Embolic Agents for Transarterial Chemoembolization (TACE) Procedures on Systemic Vascular Endothelial Growth Factor (VEGF) Levels

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Journal of Clinical and Translational Hepatology 2016年第4期4卷 288-292页

作者： Andreas Schicho Claus Hellerbrand kristina krüger lukas P.Beyer Walter Wohlgemuth Christoph Niessen Ernst Hohenstein Christian Stroszczynski Philippe L.Pereira Philipp Wiggermann Department of Radiology University Hospital Regensburg Regensburg Germany Friedrich-Alexander University Erlangen-Nürnberg Institute of Biochemistry(Emil-Fischer Zentrum) Erlangen Germany Clinic for Radiology Minimally-invasive Therapies and Nuclear Medicine SLK Kliniken Heilbronn GmbH Heilbronn Germany

Background and Aims:Intermediate stage hepatocellular carcinoma (HCC) can be treated by transarterial chemoem-bolization (TACE).However,there appear to be side effects,such as induction of proangiogenic factors,*** endothelial growth factor (VEGF),which have been shown to be associated with a poor *** prospective study was designed to compare serum VEGF level response after TACE with different embolic agents in patients with ***:Patients were assigned to one of three different TACE regimens:degradable starch microspheres (DSM) TACE,drugeluting bead (DEBDOX) TACE or Lipiodol TACE (cTACE).All patients received 50 mg doxorubicin/m2 body surface area (BSA) during *** VEGF levels were assessed before TACE treatment,24 h post-treatment and 4 weeks ***:Twenty-two patients with 30 TACE treatments were *** to baseline VEGF levels,a marked increase was observed for 24 h post-TACE (164% of baseline level) and during the 4-week follow-up (170% of baseline level) only for the cTACE arm (p < 0.05).In contrast,the increase of serum VEGF levels were only 114% and 123% for DEBDOX and 121% and 124% for DSM,***:Conventional TACE using Lipiodol shows marked increase in blood levels of the proangiogenic factor VEGF,while DEBDOX and DSM TACE induce only a moderate VEGF response.

关键词： Transarterial chemoembolization Vascular endothelial growth factor Embolic agents Hepatocellular carcinoma Angiogenesis

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Indirect targeting of MYC sensitizes pancreatic cancer cells to mechanistic target of rapamycin (mTOR) inhibition

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Cancer Communications 2022年第4期42卷 360-364页

作者： Christian Schneeweis Zonera HassanKatja Ascherl Matthias Wirth Stella Koutsouli Felix Orben lukas krauß Carolin Schneider Rupert Ollinger Oliver Hkrämer Roland Rad Maximilian Reichert Maria SRobles Dieter Saur Günter Schneider Medical Clinic and Polyclinic II Klinikum rechts der IsarTechnical University MunichMunich 81675Germany Department of Hematology Oncology and Tumor ImmunologyCharite-Universitatsmedizin BerlinCorporate Member of Freie Universitat BerlinHumboldt-Universitat zu Berlin and Berlin Institute of HealthBerlin 12203Germany Institute of Medical Psychology and Biomedical Center(BMC) Faculty of MedicineLMU MunichMunich 80336Germany Institute of Molecular Oncology and Functional Genomics TUM School of MedicineTechnical University MunichMunich 81675Germany Department of Toxicology University of Mainz Medical CenterMainz 55131Germany German Cancer Research Center(DKFZ)and German Cancer Consortium(DKTK) Heidelberg 69120Germany Center for Protein Assemblies(CPA) Technical University of MunichGarching 85747Germany Institute for Translational Cancer Research and Experimental Cancer Therapy Technical University MunichMunich 81675Germany Department of General Visceral and Pediatric SurgeryUniversity Medical Center GottingenGottingen 37075Germany

Dear Editor,Pancreatic ductal adenocarcinoma(PDAC)remains a significant health problem with an increase in the incidence and a five-year survival rate of only 10%[1].The Phosphoinositide 3-kinase-protein kinase-B-mechanistic target of rapamycin(PI3K-AKT-mTOR)pathway is a driver pathway in PDAC and an important therapeutic target[2].We[3]and others[4–6]have demonstrated that the mTOR kinase is a therapeutic target in PDAC,and rationally designed mTOR inhibitor(mTORi)-based combination therapies are emerging[2].

关键词： rapamycin therapeutic adenocarcinoma

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奥地利私有土地滞洪工程补偿机制:洪灾风险管理中的多中心治理探索

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景观设计学（中英文） 2019年第3期7卷 32-45页

作者：卢卡斯·拉什纳拉尔夫·诺德贝克亚瑟·辛德艾格沃尔特·塞赫肖杰(译) 奥地利维也纳自然资源与生命科学大学景观、空间与基础设施科学系空间、环境与土地规划研究院奥地利维也纳自然资源与生命科学大学经济学与社会科学系森林、环境与自然资源政策研究院奥地利维也纳工业大学空间规划系土地政策与管理研究院不详

在洪涝风险管理战略中,滞蓄洪水,尤其是调控滞洪正发挥着愈加突出的作用。滞洪工程虽然能够有效降低洪涝高发地区的洪水风险,但也会占用大量土地,侵犯其所有者的财产权益。因此,此类工程在实施过程中,往往会面临可用土地不足以及越发高... 详细信息

在洪涝风险管理战略中,滞蓄洪水,尤其是调控滞洪正发挥着愈加突出的作用。滞洪工程虽然能够有效降低洪涝高发地区的洪水风险,但也会占用大量土地,侵犯其所有者的财产权益。因此,此类工程在实施过程中,往往会面临可用土地不足以及越发高昂的(农业)土地补偿费等阻碍。滞洪工程的大规模推广不仅会改变滨河土地的用途,也会使相关权力及机构向低层政府机关下沉,甚至转移到提供滞洪用地的私人土地所有者、滞洪工程受益者等非政府行为主体。本文以奥地利山地城市阿尔滕马克特市的调控滞洪工程补偿方案为例,通过多中心视角探索了一系列新型治理路径;同时以多中心理论的五大命题为依据,辨析了"治理"在奥地利滞洪工程补偿机制中的含义,并分析了滞洪工程在提高滨河地区景观韧性方面的潜力和局限性。

关键词：调控滞洪多中心治理补偿景观韧性

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Association of mineral and bone biomarkers with adverse cardiovascular outcomes and mortality in the German Chronic Kidney Disease(GCKD)cohort

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Bone Research 2023年第4期11卷 764-771页

作者： Katharina Charlotte Reimer Jennifer Nadal Heike Meiselbach Matthias Schmid Ulla T.Schultheiss Fruzsina Kotsis Helena Stockmann Nele Friedrich Matthias Nauck Vera krane Kai-Uwe Eckardt Markus P.Schneider Rafael kramann Jürgen Floege Turgay Saritas Department of Nephrology Rheumatologyand Clinical ImmunologyUniversity Hospital RWTH AachenAachenGermany Institute of Experimental Medicine and Systems Biology RWTH Aachen UniversityAachenGermany Institute for Cell and Tumor Biology RWTH Aachen UniversityAachenGermany Institute of Medical Biometry Informatics and EpidemiologyUniversity Hospital of BonnBonnGermany Department of Nephrology and Hypertension University of Erlangen-NürnbergErlangenGermany Institute of Genetic Epidemiology Faculty of Medicine and Medical Center-University of FreiburgFreiburgGermany Department of Medicine IV-Nephrology and Primary Care Faculty of Medicine and Medical Center-University of FreiburgFreiburgGermany Department of Nephrology and Medical Intensive Care Charité-Universitätsmedizin BerlinBerlinGermany Department of Nephrology University Medical Center RegensburgRegensburgGermany Institute of Clinical Chemistry and Laboratory Medicine University Medicine GreifswaldGreifswaldGermany DZHK(German Centre for Cardiovascular Research) Partner Site GreifswaldUniversity MedicineGreifswaldGermany Department of Medicine I Division of NephrologyUniversity Hospital WürzburgWürzburgGermany

Mineral and bone disorder(MBD)in chronic kidney disease(CKD)is tightly linked to cardiovascular disease(CVD).In this study,we aimed to compare the prognostic value of nine MBD biomarkers to determine those associated best with adverse cardiovascular(CV)outcomes and *** 5217 participants of the German CKD(GCKD)study enrolled with an estimated glomerular filtration rate(eG FR)between 30–60 mL·min-1 per 1.73 m2 or overt proteinuria,serum osteoprotegerin(OPG),C-terminal fibroblast growth factor-23(FGF23),intact parathyroid hormone(iP TH),bone alkaline phosphatase(BAP),cross-linked C-telopeptide of type 1 collagen(CTX1),procollagen 1intact N-terminal propeptide(P1NP),phosphate,calcium,and 25-OH vitamin D were measured at *** with missing values among these parameters(n=971)were excluded,leaving a total of 4246 participants for *** a median follow-up of6.5 years,387 non-CV deaths,173 CV deaths,645 nonfatal major adverse CV events(MACEs)and 368 hospitalizations for congestive heart failure(CHF)were *** and FGF23 were associated with all outcomes,with the highest hazard ratios(HRs)for *** the final Cox regression model,adjusted for CV risk factors,including kidney function and all other investigated biomarkers,each standard deviation increase in OPG was associated with non-CV death(HR 1.76,95%CI:1.35–2.30),CV death(HR 2.18,95%CI:1.50–3.16),MACE(HR 1.38,95%CI:1.12–1.71)and hospitalization for CHF(HR 2.05,95%CI:1.56–2.69).Out of the nine biomarkers examined,stratification based on serum OPG best identified the CKD patients who were at the highest risk for any adverse CV outcome and mortality.

关键词： Kidney cardiovascular vitamin

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