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Pharmacology & Pharmacy 2020年第12期11卷 373-401页

作者： Tanja Gmeiner Jasna Grzelj Borut Strukelj luka Stopar Pij Bogomir Marko Faculty of Pharmacy University of Ljubljana Ljubljana Slovenia Krka d. d. Novo Mesto Slovenia Institute Jozef Stefan Ljubljana Slovenia Department of Dermatovenerology University Medical Centre Maribor Maribor Slovenia

Immense changes have been introduced in psoriasis treatment, including successful systemic treatment of inflammation and education of psoriatic patients. The focus of this review is the latest developments in the understanding of the aetiopathogenesis of psoriasis, the significance of its comorbidities, treatment possibilities and long-term management using the latest insight provided by pharmacogenetics and identification of biomarkers. The successful control of the disease leads to reduction of myocardial infarction and long-term cardiovascular risk but is usually achieved after various therapeutic attempts until the best-matched treatment for the individual is identified. There is a high unmet medical need for revealing biomarkers associated with disease prognosis, comorbidities, response to therapy and adverse effects. More studies have to be performed for identification and validation of biomarkers and implementation of personalized medicine into clinical practice.

关键词： Biologicals Psoriasis Pharmacotherapy Dermatology

Identifying subassemblies and understanding their functions during a design review in immersive and non-immersive virtual environments

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Frontiers of Engineering Management 2021年第3期8卷 412-428页

作者： Fanika lukaČEVIĆ StankoŠKEC Peter TÖRLIND MarioŠTORGA Faculty of Mechanical Engineering and Naval Architecture University of ZagrebIvana Lučića 510000 ZagrebCroatia DTU Management Technical University of DenmarkKongens LyngbyDenmark Department of Business Administration Technology and Social SciencesLuleåUniversity of TechnologyLuleåSweden

Design review(DR)is a product development(PD)activity used to inspect the technical characteristics of a design *** virtual reality(IVR)technology enables the presentation of spatial information and interaction with 3D CAD models inside an immersive virtual environment(IVE).Such capabilities have shown the potential to mitigate the cognitive load needed for the visual perception of spatial information and,consequently,enhance design understanding and DR ***,an increasing number of studies have explored the effect of IVR technology on DR activities in different ***,determining when the implementation of IVR technology rather than a conventional user interface for DRs in mechanical engineering PD projects will be beneficial remains ***,a conceptual DR experimental study was conducted to investigate the differences in the ability of engineering students to identify mechanisms and understand their functions when a design solution for a technical system is presented in an IVE by IVR technology and in a non-immersive virtual environment(nIVE)by a conventional user interface(monitor display,keyboard,and mouse).Data were collected by performing DR tasks and having participants complete a prior experience questionnaire,presence questionnaire,and mental rotations *** of the study indicate that IVR does not support an enhanced ability of engineering students to identify mechanisms and understand their functions compared with a conventional user interface.

关键词： design review virtual environment virtual reality mechanism function

Role of sex on psychological distress,quality of life,and coping of patients with advanced colorectal and non-colorectal cancer

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World Journal of Gastrointestinal Oncology 2022年第10期14卷 2025-2037页

作者： Vilma Pacheco-Barcia David Gomez Berta Obispo luka Mihic Gongora Raquel Hernandez San Gil Patricia Cruz-Castellanos Mireia Gil-Raga Vicente Villalba Ismael Ghanem Paula Jimenez-Fonseca Caterina Calderon Department of Medical Oncology School of MedicineAlcala University(UAH)Hospital Central de la Defensa Gómez UllaMadrid 28047Spain Department of Medical Oncology Hospital Universitario de NavarraPamplona 31008Spain Department of Medical Oncology Hospital Universitario Infanta LeonorMadrid 28031Spain Department of Medical Oncology Hospital Universitario Central de AsturiasOviedo 33011Spain Department of Medical Oncology Hospital Universitario de CanariasTenerife 38320Spain Department of Medical Oncology Hospital Universitario La PazMadrid 28046Spain Department of Medical Oncology Hospital General Universitario de ValenciaCIBERONCValencia 46014Spain Department of Clinical Psychology and Psychobiology Faculty of PsychologyUniversity of BarcelonaBarcelona 08007Spain Department of Medical Oncology Hospital Universitario Central de AsturiasISPAOviedo 33007Spain Department of Clinical Psychology and Psychobiology University of BarcelonaBarcelona 08007Spain

BACKGROUNDPatients with advanced gastrointestinal cancer must cope with the negative effects of cancer and *** To evaluate psychological distress,quality of life,and coping strategies in patients with advanced colorectal cancer compared to non-colorectal cancer based on *** A prospective,transversal,multicenter study was conducted in 203 patients;101(50%)had a colorectal and 102(50%)had digestive,non-colorectal advanced *** completed questionnaires evaluating psychological distress(Brief Symptom Inventory-18),quality of life(EORTC QLQ-C30),and coping strategies(Mini-Mental Adjustment to Cancer)before starting systemic cancer *** The study included 42.4%*** exhibited more depressive symptoms,anxiety,functional limitations,and anxious preoccupation than *** with non-colorectal digestive cancer and women showed more somatization and physical symptoms than subjects with colorectal cancer and *** with colorectal cancer reported the best health *** The degree of disease acceptance in gastrointestinal malignancies may depend on sex and location of the primary digestive *** interventions should specifically address sex and tumor site differences in individuals with advanced digestive cancer.

关键词： Anxiety Colorectal cancer Depression Gastrointestinal cancer Sex

Relations between mercury fractions and microbial community components in seawater under the presence and absence of probable phosphorus limitation conditions

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Journal of Environmental Sciences 2019年第1期31卷 145-162页

作者： Igor ?ivkovi? Vesna Fajon Jo?e Kotnik Yaroslav Shlyapnikov Kristina Obu Vazner Ermira Begu Stefanija ?estanovi? Danijela ?anti? Ana Vrdoljak Slaven Jozi? Mladen ?oli? Jelena Lu?i? Jere Ve?a Grozdan Ku?pili? Marin Ordulj Frano Mati? Branka Grbec Natalia Bojani? ?ivana Nin?evi? Gladan Milena Horvat Department of Environmental Sciences Jo?ef Stefan Institute Jo?ef Stefan International Postgraduate School Ecological Engineering Institute Maribor 2000 Slovenia Laboratory of Marine Microbiology Institute of Oceanography and FisheriesSplit 21000 Croatia Laboratory of Chemical Oceanography and Sedimentology of the Sea Institute of Oceanography and FisheriesSplit 21000 Croatia Laboratory of Chemical Oceanography and Sedimentology of the Sea Institute of Oceanography and Fisheries Department of Marine Studies University of SplitSplit 21000 Croatia Laboratory of Physical Oceanography Institute of Oceanography and FisheriesSplit 21000 Croatia Laboratory of Plankton and Shellfish Toxicity Institute of Oceanography and FisheriesSplit 21000 Croatia

Microbial transformations of toxic monomethylmercury(MMHg) and dissolved gaseous mercury(DGM) at the lower levels of the marine food web are not well understood, especially in oligotrophic and phosphorus-limited seas. To examine the effects of probable phosphorus limitation(~PP-limitation) on relations between mercury(Hg) fractions and microorganisms, we determined the total mercury(THg), total methylated mercury(MeHg), DGM, and microbiological and chemical parameters in the Central Adriatic Sea. Using statistical analysis, we assessed the potential microbial effects on Hg transformations and bioaccumulation. Only in the absence of ~PP-limitation conditions(^(NO–P)P-limitation) is MeHg significantly related to most chemical and microbial parameters, indicating metabolism-dependent Hg *** heterotrophic activity of low nucleic acid bacteria(abundant in oligotrophic regions)seems responsible for most of Hg methylation under ^(NO–P)P-limitation. Under these conditions,DGM is strongly related to microbial fractions and chlorophyll a, indicating biological DGM production, which is probably not metabolically induced, as most of these relations are also observed underPP-limitation. MMHg biomagnification was observed through an increased bioaccumulation factor from microseston to mesozooplankton. Our results indicate that Hgtransformations and uptake might be enhanced under ^(NO–P)P-limitation conditions, emphasizing their impact on the transfer of Hg to higher trophic levels.

关键词： Mercury speciation Methylmercury Probable phosphorus limitation Microbial community

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克罗地亚Grand Park酒店

现代装饰 2020年第5期 20-27页

作者： Jure ?ivkovi? 刘印梅

克罗地亚Grand Park酒店处于欣赏亚得里亚海(Adriatic)美景的绝佳位置。无论在酒店的哪个位置,都能够给客人留下这样的印象:人们仿佛住在一个公园里,俯瞰着罗维尼优美的城市及海岛景观。酒店位于海岸边,靠近码头及海滨长廊,将市中心区... 详细信息

克罗地亚Grand Park酒店处于欣赏亚得里亚海(Adriatic)美景的绝佳位置。无论在酒店的哪个位置,都能够给客人留下这样的印象:人们仿佛住在一个公园里,俯瞰着罗维尼优美的城市及海岛景观。酒店位于海岸边,靠近码头及海滨长廊,将市中心区与蒙特穆利尼(Monte Mulini)地带的旅游景点连接起来。为了融合到现有的森林中,酒店地面跟随场地的坡度后退,形成阶梯状的大尺度露台、地中海花园、游泳池和日光浴平台。带有露台的酒吧和餐厅位于大堂的接待区,接待区通过中央楼梯与主餐厅相连。已经有超过半个世纪

关键词：克罗地亚 Grand Park 罗维尼

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厨房的色调

家饰 2002年第6期 108-110页

作者： luka

笔记本电脑的核心不仅是一个CPU而是一个平台

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网络与信息 2007年第11期21卷 24-25页

作者： luka

在笔记本用户里面，几乎没有人没有听说过迅驰（Centrino）这一名词。而当迅驰刚发布时，很多人对迅驰技术都存在疑问：“真的有看上去那么好吗？”事实上，在经过近四年半的发展后，迅驰已经得到了消费者以及厂商的认可，当初的疑虑已... 详细信息

在笔记本用户里面，几乎没有人没有听说过迅驰（Centrino）这一名词。而当迅驰刚发布时，很多人对迅驰技术都存在疑问：“真的有看上去那么好吗？”事实上，在经过近四年半的发展后，迅驰已经得到了消费者以及厂商的认可，当初的疑虑已经抛诸脑后。在笔记本电脑上迅驰早已深入人心，提起笔记本电脑必言之迅驰。正是由于迅驰这一名词的大红大紫，很多消费者在购买笔记本的时候都会选择迅驰平台，但也有不少消费者由于缺乏对笔记本市场的关心而欠缺对迅驰的基本认识，

关键词：笔记本电脑平台 CPU 迅驰技术消费者名词

Malaria stratification in a malarious area,a field exercise

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Asian Pacific Journal of Tropical Medicine 2010年第10期3卷 807-811页

作者： Vatandoost Hassan Akbarzadeh Kamran Hanafi- Bojd Ahniad Ali Mashayekhi Minoo Saffari Mohammad Malik Elfatih M Kenyi luka Abakar John Baptist Busaq Alikhan Esmailpour Mohammad Hassen Abuelgasim Oshaghi Mohamad Ali Department of Medical Entomology & Vector Control School of Public Health & National Institute of Health ResearchTehran University of Medical Sciences Kerman University of Medical Sciences PHC and Preventive Medicine Ministry of Health Baghlan province Urmieh University of Medical Sciences Northern State Ministry of Health Malaria Control Programme

Objective:To conducted a spatial analysis for stratification of priority malaria control areas in Kahnuj County,as part of field ***:Information of Health Centers of Kahnuj County has been used for stratification retrospectively.A knowledge,attitudes and practices(KAP) study was arranged to provide preliminary information about the knowledge,attitude and practice related to malaria in the ***:Numbers of malaria cases has been decreased in year *** were five important vectors of malaria in this region including:Anopheles stephensi (***),Anopheles dthali(***).Anopheles superpictus(***),Anophels culicifacies(***),and Anopheles Jluviatilis(***),but majority of malaria cases in this county was related to Plasmodium vivax(***).Educational levels of community were 38% ,20% ,10% and 32% for illiterate,primary,secondary and university levels,respectively. KAP study revealed that about 37% of people have got malaria at least once and only 27% of people knew that mosquito is the vector of ***:Malaria in Kahnuj represents a real *** occurs in city *** can be suspected for the first peak of malaria cases in late spring in Kahnuj *** has a relatively high density in autumn while two malaria cases due to *** were reported in *** on KAP study,the knowledge of respondents seems good but the attitude and practice is *** to the data such as API,main malaria vector,transmission rate,and foreign migrants,the Kahnuj County has been spatially divided into three strata based on various *** authorities should implement all the interventions based on stratification.

关键词： Malaria Kahnuj Stratification Iran

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如何切入少儿市场？

国际品牌观察 2021年第16期 42-43页

作者： luka Radunovic 岳璐

在掘金少儿市场时,品牌需要遵守哪些规则?尽管世界各地均有许多旨在对广告业加强管控的举措和行动,但不可否认的是,截至目前,广告业的管控几乎仍然以行业自律和自我监管为主。少儿是最容易受外界影响且缺少辨别力的群体,研究显示,在8岁... 详细信息

在掘金少儿市场时,品牌需要遵守哪些规则?尽管世界各地均有许多旨在对广告业加强管控的举措和行动,但不可否认的是,截至目前,广告业的管控几乎仍然以行业自律和自我监管为主。少儿是最容易受外界影响且缺少辨别力的群体,研究显示,在8岁之前,大多数孩子甚至无法区分广告与电视节目内容,也无法弄明白网络上的滑稽漫画与针对他们的在线横幅广告之间的区别。

关键词：少儿市场广告商烟草广告

照射后TGF-α、EGF及其受体EGF-R表达在小鼠小肠上皮细胞再增殖过程中的作用

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中华放射肿瘤学杂志 1998年第1期7卷 22-24页

作者：姚伟强 lukaMilas 上海医科大学肿瘤医院

目的探讨ＴＧＦα、ＥＧＦ及其受体ＥＧＦＲ在小鼠小肠上皮受照射后再增殖中的作用。材料与方法雄性Ｃ３Ｈｆ／Ｋａｍ小鼠５Ｇｙ全身一次性照射后，不同时间杀死小鼠取出空肠，常规ＨＥ染色高倍下计数隐窝细胞数和分裂相；并以免疫... 详细信息

目的探讨ＴＧＦα、ＥＧＦ及其受体ＥＧＦＲ在小鼠小肠上皮受照射后再增殖中的作用。材料与方法雄性Ｃ３Ｈｆ／Ｋａｍ小鼠５Ｇｙ全身一次性照射后，不同时间杀死小鼠取出空肠，常规ＨＥ染色高倍下计数隐窝细胞数和分裂相；并以免疫组化法定量测定隐窝区和绒毛区ＴＧＦα、ＥＧＦ和ＥＧＦＲ的表达。结果照射后３～４天小鼠小肠上皮隐窝细胞及分裂相均达到高峰；而ＴＧＦα、ＥＧＦ和ＥＧＦＲ在照射后第１天即在隐窝区达到高峰，随之下降，其表达变化时间上领先于细胞分裂。结论ＴＧＦα、ＥＧＦ和ＥＧＦＲ的表达可能在小鼠小肠上皮受照射后的再增殖过程中起着重要的作用。

关键词：小鼠小肠上皮细胞照射 TGF-α EGF EGF-α