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Wideband Vertical Patch Antenna

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Wideband Vertical Patch Antenna

2005'全国微波毫米波会议

作者： T.P.Wong ka-lam Lau k.M.luk.k.F.Lee

＜正＞Vertical patch antennas（VPAs） based on koch loop fractal structure[1-6]are *** between koch fractal VPAs in different iterations and a circular VPA with same size and same height are *** a dual koch loop structure,a wideband VPA with 42%bandwidth and 8dBi gain at the center frequency is designed and *** broadside patterns are obtained at the passband.

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α-Synuclein arginylation in the human brain

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Translational Neurodegeneration 2022年第1期11卷 654-666页

作者： Jun Zhao Buyan Pan Marie Fina Yun Huang Marie Shimogawa kelvin C.luk.Elizabeth Rhoades EJames Petersson Dawei W.Dong Anna kashina Department of Biomedical Sciences University of Pennsylvania School of Veterinary MedicinePhiladelphiaPennsylvania 19104USA Department of Chemistry University of Pennsylvania School of Arts and SciencesPhiladelphiaPennsylvania 19104USA Center for Neurodegenerative Disease Research Department of Pathology and Laboratory MedicineUniversity of Pennsylvania Perelman School of MedicinePhiladelphiaPennsylvania 19104USA.

Background: Alpha-synuclein (α-syn) exhibits pathological misfolding in many human neurodegenerative disorders. We previously showed that α-syn is arginylated in the mouse brain and that lack of arginylation leads to neurodegen-eration in mice. Methods: Here, we tested α-syn arginylation in human brain pathology using newly derived antibodies in combina-tion with Western blotting, biochemical assays, and experiments in live neurons. Results: We found that α-syn was arginylated in the human brain on E46 and E83, two sites previously implicated in α-syn pathology and familial cases of Parkinson’s disease. The levels of arginylation in different brain samples ranged between ~ 3% and ~ 50% of the total α-syn pool, and this arginylation nearly exclusively concentrated in the subcellu-lar α-syn fraction that sedimented at low centrifugation speeds and appeared to be simultaneously targeted by multi-ple posttranslational modifications. Arginylated α-syn was less susceptible to S129 phosphorylation and pathological aggregation in neurons. The arginylation level inversely correlated with the overall α-syn levels and with patient age, suggesting a possible causal relationship between arginylation decline and α-syn-dependent neuropathology. Conclusion: We propose that α-syn arginylation constitutes a potential neuroprotective mechanism that prevents its abnormal accumulation during neurodegeneration and aging in the human brain.

关键词： Arginylation Neurodegeneration Aging α-Synuclein

Surgical treatment for scoliosis extending to main thoracic spine by key-vertebral-screws technique (kVST)

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Journal of Medical Colleges of PLA(China) 2007年第2期22卷 115-120页

作者：李明朱晓东 Cheung kM luk.kD Department of Orthopaedic Surgery Changhai Hospital Second Military Medical University Department of Orthopaedic Surgery University of Hong kong

Objective:To introduce a key-vertebral-screws technique(kVST) in the surgical treatment of scoliosis extending to main thoracic levels, and to find the role of fulcrum bending in predicting the result of surgical treatment for scoliosis by this technique. Methods: Seventeen consecutive patients with scoliosis extending to main thoracic spine,who underwent pure posterior fusion without anterior or posterior release by kVST between January 2004 and July 2005 were evaluated for fulcrum bending flexibility, surgical correction rate, fulcrum bending correction index (FBCI) in main thoracic curves. Universal Spine System (USS) instrumentation was used in 15 cases,Monarch in another 2 cases. The severity of the curves was measured by Cobb's method using Rad Work 6. 0 software. Preoperative standing AP radiographs, preoperative fulcrum bending anterioposterior (AP) radiographs, postoperative standing AP radiographs, and most recent follow-up standing AP radiographs for spine were measured and recorded. All the data were analyzed with two-sample paired t-test by Origin 7. 0 software. Results: Infection and neurological complications were not noted. No major complications were found. Just one case had some axial back pain, which got a full recovery from physiotherapy for 2 weeks. In the X-ray, there was an average correction of 71. 5% of the fused main thoracic curves, which had no significant lose of correction in final follow-up. For the whole fused main thoracic curves, the fulcrum bending flexibility were lower to operation correction rate (P = 0. 013). The average FBCI was 123%. From the data, the more rigid curves (especially fulcrum bending flexibility kVST is a good method in the surgical treatment of thoracic scoliosis, which can get satisfying result with lower medical cost. (2) Fulcrum bending flexibility is lower than operative correction rate by kVST in

关键词： adolescent idiopathic scoliosis spinal fusion radiograph fulcrum-bending flexibility pedicle screw instrumentation segmental instrumentation, spinal deformity coronal collection

Cataract blindness in Hungary

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International Journal of Ophthalmology(English edition) 2020年第3期13卷 438-444页

作者： Gábor L.Sándor Gábor Tóth Dorottya Szabó Irén Szalai Regina luk.cs Anita Pék Georgina Z.Tóth András Papp Zoltán Z.Nagy Hans Limburg János Németh Department of Ophthalmology Semmelweis UniversityBudapest 1085Hungary Department of Ophthalmology Flór Ferenc HospitalKistarcsa 2143Hungary Department of Ophthalmology Petz Aladár HospitalGyor 9024Hungary Faculty of Health Sciences Semmelweis UniversityBudapest 1088Hungary Health Information Services Grootebroek 1613The Netherlands

AIM:To estimate the prevalence of blindness and visual impairment resulting from cataract in the population aged≥50 y in Hungary,and to assess the cataract surgical ***:A rapid assessment of avoidable blindness(RAAB)was conducted.A total of 3523 eligible people were randomly selected and *** participant underwent surgery for cataract was interviewed with regard to the year,place,and costs of the *** with obvious cataract were asked why they had not yet undergone surgery(barriers to surgery).RESULTS:An estimated 12514 people were bilaterally blind;the visual acuity(VA)in 19293 people was<6/60,and the VA in 73962 people was<6/18 in the better eye due to *** estimated 77933 eyes are blind;98067 eyes had a VA of<6/60,and an estimated 277493 eyes had a VA of<6/18 due to *** all cataract surgeries were conducted in government *** age-and sexadjusted cataract surgical coverage with VA<3/60 in eyes was 90.0%.The rate of good visual outcome after surgery was 79.5%.Ocular comorbidity was the main cause of poor outcome(78.1%),followed by late complications(such as posterior capsule opacification)(17.2%),inadequate optical correction(3.1%),and surgical complications(1.6%).The main barrier to surgery in people with bilateral cataract and VA of<6/60 was‘need not felt’.CONCLUSION:The prevalence of visual impairment resulting from cataract is slightly higher than *** quality of the cataract surgical service seems adequate in ***,the number of cataract operations per year should continue to increase due to the increasing patient demands and the aging population.

关键词： cataract prevalence blindness visual impairment rapid assessment of avoidable blindness

Deficiency of Adenomatous Polyposis Coli protein in sporadic colorectal adenomas and its associations with clinical phenotype and histology

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World Journal of Gastroenterology 2006年第24期12卷 3901-3905页

作者： Martin Bortlík Ivana Vítková Martina Pape(z|ˇ)ová Milada kohoutová Ale(s|ˇ) Novotn(y|') Stanislav Adamec Petra Chalupná Milan luk.(s|ˇ) Gastroenterology Center 4th Internal Department General Faculty Hospital1st School of MedicineCharles UniversityPragueCzech Republic Department of Pathology General Faculty Hospital 1st School of MedicineCharles UniversityPragueCzech Republic Institute for Biology and Medical Genetics General Faculty Hospital 1st School of MedicineCharles UniversityPragueCzech Republic

AIM： To evaluate the frequency of the loss of the Adenomatous Polyposis Coil （APC） protein and to compare the APC status with the characteristics of colorectal adenomas. METHODS： Immunohistochemical analysis of the APC protein was performed on 118 adenomas and the results were compared with parameters of malignant potential, location of adenomas, macroscopic appearance and age of the patients. RESULTS： A complete loss of the APC protein was found in 28 （24%） adenomas, while 90 （76%） were APC positive. The mean size of adenomas was 13.5± 14.2 mm （95% CI 10.5-16.5） in APC-positive, and 13.8 ±15.5 mm （95% CI 7.8-19.8） in APC-negative adenomas （P = 0.364）. Statistical analysis revealed no difference between APC-positive and negative adenomas as to the histological type （P = 0.327） and grade of dysplasia （P =0.494）. We found that even advanced adenomas did not differ in their APC status from the non-advanced tumors （P = 0.414）. Finally, no difference was found when the location （P = 0.157）, macroscopic appearance （P = 0.571） and age of patients （P = 0.438） were analysed and compared between both APC positive and negative adenomas. CONCLUSION： Most adenomas expressed full-length APC protein, suggesting that protein expression is not a reliable marker for assessment of APC gene mutation. Complete loss of APC protein did not influence morphology, location, or appearance of adenomas, nor was it affected by the patient＇s age.

关键词： Adenomatous Polyposis Coli protein Adeno-ma Immunohistochemistry Histology

甘草次酸靶向肝星状细胞治疗肝纤维化的体内研究

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中华肝脏病杂志 2005年第9期13卷 664-667页

作者：张其胜 John M luk.张健田庚元上海市第一人民医院分院消化科 200081 香港大学医学院玛丽医院外科中国科学院上海有机化学研究所

目的观察以6-磷酸甘露糖修饰的白蛋白(M6P26-HSA)作为特异性载体,将甘草次酸(GA) 靶向释放到肝星状细胞治疗肝纤维化的效果。方法用125I记由M6P26-HSA和GA在体外合成新的偶合物GA-HSA-M6P26,观察其在体内的器官分布情况,用双重免疫组织... 详细信息

目的观察以6-磷酸甘露糖修饰的白蛋白(M6P26-HSA)作为特异性载体,将甘草次酸(GA) 靶向释放到肝星状细胞治疗肝纤维化的效果。方法用125I记由M6P26-HSA和GA在体外合成新的偶合物GA-HSA-M6P26,观察其在体内的器官分布情况,用双重免疫组织化学的方法观察星状细胞对GA- HSA-M6P26的选择性摄取;选用Sirius红染色观察GA-HSA-M6P26对肝纤维化时胶原沉积的影响,用定量聚合酶链反应检测GA-HSA-M6P26对Ⅰ型前胶原mRNA表达的影响。结果静脉注射后10min,GA-HSA- M6P26选择性地分布于肝脏,摄取高峰可达(5 5.093±5.404)%。双重免疫组织化学染色证实GA-HSA- M6P26主要被星状细胞选择性摄取,GA-HSA-M6P26治疗后肝脏胶原沉积明显减少,Ⅰ型前胶原和α-平滑肌肌动蛋白mRNA表达明显降低。结论GA-HSA-M6P26可以选择性地分布于肝脏星状细胞,有显著的抗肝纤维化作用。

关键词：甘草次酸肝纤维化 6-磷酸甘露糖肝星状细胞甘草次酸(GA) 抗肝纤维化作用体内研究细胞治疗靶向释放双重免疫组织化学染色

Broadband Antenna with EBG Cells

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Broadband Antenna with EBG Cells

2005'全国微波毫米波会议

作者： Lam SIU kwai-Man luk Department of Electronic Engineering City University of Hong Kong 83 Tat Chee Avenue

＜正＞A wideband and low back radiation patch antenna is presented in this *** antenna is fed by an L-shaped probe and is designed to operate at *** cells are constructed and surrounded the L-probe antenna,through the special arrangement of the EBG cells;a reduction of back radiation can be *** antenna finds the front to back ratio around 36.6dB at -180 degree and yields the impedance bandwidth of 20.2% （SWR＜2） from 10.39GHz to 12.73GHz.

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Headword Percolation in a Multi-Parser Architecture for Natural Language Understanding

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Headword Percolation in a Multi-Parser Architecture for Natu...

第一届自然语言处理联合学术会议

作者： Po Chui luk.Helen Meng Human-Computer Communications Laboratory Department of Systems Engineering ＆ Engineering Management The Chinese University of Hong kong Hong Kong SAR Human-Computer Communications Laboratory Department of Systems Engineering ＆ Engineering Management The Chinese University of Hong kong Hong Kong SAR

＜正＞This paper describes an approach for identifying the information goal（s） of informationseeking queries, such as those in the ATIS domain （Price, 1990）. The approach is based the Multi-Parser Architecture （MPA） extended with a headword percolation procedure. MPA can generate full and robust parses for input natural language queries. Headword percolation identifies the prime constituent（s） in the parse trees. These constituents are incorporated in goal identification rules derived from training parse trees using an automatic, data-driven technique. The rules are then evaluated with a test set in terms of in single goal identification, multiple goal identification and out-of-domain rejection. We compare the current approach with a previous one based on Belief Networks （BN）（Meng et al. 1999）. Results show that the former gave statistically significant improvements. This is indicative of the merits of rich semantic/syntactic analysis in the parse structures for goal identification.

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Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer

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World Journal of Gastroenterology 2018年第7期24卷 810-818页

作者： Daniel Brungs David Lynch Alison WS luk.Elahe Minaei Marie Ranson Morteza Aghmesheh kara L Vine Martin Carolan Mouhannad Jaber Paul de Souza Therese M Becker Illawarra Health and Medical Research Institute University of WollongongWollongong 2500Australia School of Biological Sciences University of WollongongWollongong 2500Australia Illawarra Cancer Centre Wollongong HospitalWollongong 2500Australia CONCERT-Translational Cancer Research Centre New South Wales 2000Australia Centre for Circulating Tumor Cell Diagnostics and Research Ingham Institute for Applied Medical ResearchLiverpool HospitalSydney 2170Australia School of Medicine University of Western SydneySydney 2170Australia South Western Medical School University of New South WalesSydney 2170Australia

AIM To demonstrate the feasibility of cryopreservation of peripheral blood mononuclear cells(PBMCs) for prognostic circulating tumor cell(CTC) detection in gastroesophageal *** Using 7.5 m L blood samples collected in EDTA tubes from patients with gastroesopheagal adenocarcinoma, CTCs were isolated by epithelial cell adhesion molecule based immunomagnetic capture using the Iso Flux platform. Paired specimens taken during the same blood draw(n = 15) were used to compare number of CTCs isolated from fresh and cryopreserved PBMCs. Blood samples were processed within 24 h to recover the PBMC fraction, with PBMCs used for fresh analysis immediately processed for CTC isolation. Cryopreservation of PBMCs lasted from 2 wk to 25.2 mo(median 14.6 mo). CTCs isolated from pre-treatment cryopreserved PBMCs(n = 43) were examined for associations with clinicopathological variables and survival *** While there was a significant trend to a decrease in CTC numbers associated with cryopreserved specimens(mean number of CTCs 34.4 vs 51.5, P = 0.04), this was predominately in samples with a total CTC count of > 50, with low CTC count samples less affected(P = 0.06). There was no significant association between the duration of cryopreservation and number of CTCs. In cryopreserved PBMCs from patient samples prior to treatment, a high CTC count(> 17) was associated with poorer overall survival(OS)(n = 43, HR = 4.4, 95%CI: 1.7-11.7, P = 0.0013). In multivariate analysis, after controlling for sex, age, stage, ECOG performance status, and primary tumor location, a high CTC count remained significantly associated with a poorer OS(HR = 3.7, 95%CI: 1.2-12.4, P = 0.03). CONCLUSION PBMC cryopreservation for delayed CTC isolation is a valid strategy to assist with sample collection, transporting and processing.

关键词： Cryopreservation Circulating tumor cells Liquid biopsy Gastroesophageal cancer Gastric cancer