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Hepatic encephalopathy:Lessons from preclinical studies

World Journal of Hepatology 2019年第2期11卷 173-185页

作者： luiza cioglia dias lima Aline Silva Miranda Rodrigo Novaes Ferreira Milene Alvarenga Rachid Ana Cristina Sim?es e Silva Departamento de Patologia Geral Instituto de Ciências BiológicasUniversidade Federal de Minas Gerais(UFMG) Departamento de Morfologia Instituto de Ciências BiológicasUFMG Laboratório Interdisciplinar de Investiga??o Médica Faculdade de MedicinaUFMG

Hepatic encephalopathy(HE) is a major complication that is closely related to the progression of end-stage liver *** changes in advanced liver failure can promote cognition impairment,attention deficits and motor dysfunction that may result in coma and *** can be subdivided according to the type of hepatic injury,namely,type A,which results from acute liver failure,type B,which is associated with a portosystemic shunting without intrinsic liver disease,and type C,which is due to chronic liver *** studies have investigated the pathogenesis of the disease,and most of the mechanisms have been explored using animal *** article aimed to review the use of preclinical models to investigate *** most used animal species are rats and *** models of type A HE include surgical procedures and the administration of hepatotoxic medications,whereas models of types B and C HE are generally surgically induced lesions in liver tissue,which evolve to hepatic *** models have allowed the comprehension of the pathways related to HE.

关键词： Hepatic encephalopathy Acute liver failure Preclinical studies Hepatic cirrhosis Neuroinflammation Hyperammonemia

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First Record in Brazil of Epistylis sp. (Ciliophora) Adhered to Argulus sp. (Argulidae), a Parasite of Hoplias aimara (Eritrhinidae)

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Natural Resources 2016年第6期7卷 331-336页

作者： Lincoln lima Corrêa Marcos Sidney Brito Oliveira luiza Prestes Marcos Tavares-dias Universidade Federal do Oeste do Pará (UFOPA) Instituto de Ciências e Tecnologia das águas (ICTA) Santarém Brasil Programa de Pós-Graduaç ã o em Recursos Aquáticos Continentais Amazô nicos (PPGRACAM) Universidade Federal do Oeste do Pará (UFOPA) Instituto de Ciências e Tecnologia das águas (ICTA) Santarém Brasil Programa de Pós-Graduaç ã o em Ecologia Aquática e Pesca (PPGEAP) Universidade Federal do Pará (UFPA) Belém Brasil Embrapa Amapá Rodovia Juscelino Kubitschek Macapá Brasil

This paper records the first occurrence of Epistylis sp. on the body surface of Argulus sp. parasitizing Hoplias aimara from the upper Araguari River, in the eastern Amazon region, in the north of Brazil. Of the 16 specimens of H. aimara examined, 93.7% had their pelvic, caudal and pectoral fins and tegument infested by Argulus sp. (n = 73), which in turn were infested by Epistylis sp. The specimens of Epistylis sp. from the body surface of Argulus sp. were analyzed using Scanning Electron Microscopy (SEM). The present study also identified a widening of the geographic distribution of these two species of ectoparasites to the eastern Amazon region of Brazil.

关键词： Parasite Ecology Opportunistic Parasite Rio Araguari Eastern Amazon

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