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The Role of Nitrogen Fertilizers in Sugarcane Root Biomass under Field Conditions

Agricultural Sciences 2014年第14期5卷 1527-1538页

作者： Rafael Otto Henrique Coutinho Junqueira Franco Carlos eduardo Faroni André Cesar Vitti Emídio Cantidio almeida de Oliveira Renata Alcarde Sermarini Paulo Cesar Ocheuze Trivelin department of Soil Science Luiz de Queiroz College of Agriculture University of Sao Paulo Piracicaba Brazil Brazilian Bioethanol Science and Technology Laboratory (CTBE) Rua Giuseppe Maximo Scolfaro Campinas Brazil Sugarcane Research Center (CTC) Piracicaba Brazil Sao Paulo Agency of Agribusiness and Technology (APTA) Piracicaba Brazil Federal Rural University of Pernambuco (UFRPE) Recife Brazil department of Exact Sciences Luiz de Queiroz College of Agriculture University of Sao Paulo Piracicaba Brazil Center for Nuclear Energy in Agriculture University of Sao Paulo Piracicaba Brazil

Sugarcane is used worldwide for sugar, ethanol and energy production. In Brazil, the shift from burned to unburned harvest systems resulted in increases in nitrogen fertilization rates, which can impact root architecture and biomass. The expectation is also an increase in sugarcane biomass. The study hypothesized that high N rates applied to sugarcane fields increases root growth and N stored in roots, promoting higher biomass and N accumulated in shoots. Two experiments were set up in Southeastern Brazil, on a Typic Kandiudox (TK) and Rhodic Eutrudox (RE). Four treatments were studied 1) N application in the plant-cane (0 and 120 kg·ha-1 N) and 2) N application in the ratoon (0 and 150 kg·ha-1 N). The shoot biomass and the root density (by the core method up to 0.6 m) were evaluated over the first ratoon crop cycle, and the N content in those compartments was also examined. There was no carry over effect on N applied at planting in root and shoot biomass in the ratoon crop cycle. At the RE site, the ratoon N fertilization increased root density in the superficial soil layer (0 - 0.2 m) and close to the plants (der Brazilian field conditions.

关键词： Root System Ratoon Shoot Root: Shoot Ratio

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NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2^(V617F)-positive myeloproliferative neoplasm cells

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2440-2449页

作者： Bruna Alves Fenerich Jaqueline Cristina Fernandes Ana Paula Nunes Rodrigues Alves Juan luiz Coelho-Silva Renata Scopim-Ribeiro Priscila Santos Scheucher Christopher A.Eide Cristina E.Tognon Brian J.Druker eduardo Magalhães Rego João Agostinho Machado-Neto Fabiola Traina department of Medical Images Hematologyand Clinical OncologyUniversity of Sao Paulo at Ribeirao Preto Medical SchoolRibeirao PretoSao PauloBrazil Center for Cell-Based Therapy Sao Paulo Research FoundationRibeirao PretoSao PauloBrazil Knight Cancer Institute Oregon Health&Science UniversityPortlandORUSA Howard Hughes Medical Institute PortlandORUSA department of Internal Medicine University of Sao Paulo Medical SchoolSao PauloBrazil department of Pharmacology Institute of Biomedical Sciences of the University of Sao PauloSao PauloBrazil

Recent data indicate that IGF1R/IRS signaling is a potential therapeutic target in BCR-ABL1-negative myeloproliferative neoplasms(MPN);in this pathway,IRS2 is involved in the malignant transformation induced by JAK2^(V617F),and upregulation of IGF1R signaling induces the MPN ***157,a synthetic compound designed as an IGF1R-IRS1/2 inhibitor,has been shown to induce antineoplastic effects in solid ***,we aimed to characterize the molecular and cellular effects of NT157 in JAK2^(V617F)positive MPN cell lines(HEL and SET2)and primary patient hematopoietic *** JAK2^(V617F)cell lines,NT157 decreased cell viability,clonogenicity,and cell proliferation,resulting in increases in apoptosis and cell cycle arrest in the G2/M phase(pdependent ***157 inhibited erythropoietin-independent colony formation in cells from polycythemia vera patients(p<0.05).These findings further elucidate the mechanism of NT157 action in a MPN context and suggest that targeting IRS1/2 proteins may represent a promising therapeutic strategy for MPN.

关键词： JAK2 IGF1R neoplasms STAT3

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Early Failure detection in Power Transformers

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Journal of Power and Energy Engineering 2013年第5期1卷 30-40页

作者： luiz eduardo Borges da Silva Erik Leandro Bonaldi Levy Ely de Lacerda de Oliveira Germano Lambert-Torres Giscard F. C. Veloso Ismael Noronha Felipe dos Santos Moreira José Nielze Caminha Itajuba Federal University Itajuba Brazil 2PS Solutions Itajuba Brazil 3Termopernambuco Thermal Power Plant Recife Brazil.

This paper presents equipment for early detection of failures in the insulation of power transformers, checking existing partial discharges inside. The equipment involves hardware, control and signal acquisition software, and signal analysis software. This equipment has a set of algorithms that were made with intelligent extraction techniques and interpretation of data. The degradation diagnosis of the equipment insulation is based on digital signal processing algorithms for extraction of features and also in artificial intelligence algorithms that allies a mining involving all the data linked to the equipment throughout its operating life can make an assessment of the operating conditions of the equipment and suggest interventions and provide an estimated time so that they have to be made.

关键词： Transformers Measuring System Signal Processing Partial Discharges Predictive Maintenance

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Statistical data driven approach of COVID-19 in Ecuador: R_(0) and R_(t) estimation via new method

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Infectious Disease Modelling 2021年第1期6卷 232-243页

作者： Raúl Patricio Fernandez-Naranjo MSc eduardo Vasconez-Gonzalez MD Katherine Simbana-RiveraMD,MSc Lenin Gomez-Barreno MD Juan S.Izquierdo-Condoy MD Domenica Cevallos-RobalinoMD,MPH(c) Esteban Ortiz-prado MD,MSc,MPH One Health Research Group Faculty of MedicineUniversidad de las AmericasQuitoEcuador Resident of Intensive Care Unit Hospital Quito Sur IESSQuitoEcuador

The growth of COVID-19 pandemic throughout more than 213 countries around the world have put a lot of pressures on governments and health services to try to stop the rapid expansion of the *** 2009,H1N1 Influenza pandemic,statistical and mathematical methods were used to track how the virus spreads around *** of these models that were developed at the beginning of the XXI century are based on the classical susceptible-infected-recovered(SIR)model developed almost a hundred years *** evolution of this model allows us to forecast and compute basic and effective reproduction numbers(R_(t) and R_(0)),measures that quantify the epidemic potential of a pathogen and estimates different *** this study,we present a traditional estimation technique for R_(0) with statistical distributions by best fitting and a Bayesian approach based on continuous feed of prior distributions to obtain posterior distributions and computing real time R_(t).We use data from COVID-19 officially reported cases in Ecuador since the first confirmed case on February *** of the lack of data,in the case of R_(0) we compare two methods for the estimation of these parameters below exponential growth and maximum likelihood *** do not make any assumption about the evolution of cases due to limited information and we use previous methods to compare scenarios about R_(0) and in the case of R_(t) we used Bayesian inference to model uncertainty in contagious proposing a new modification to the well-known model of Bettencourt and Ribeiro based on a time window of m days to improve *** R_(0) with exponential growth criteria was 3.45 and with the maximum likelihood estimation method was *** results show that Guayas,Pichincha and Manabíwere the provinces with the highest number of cases due to *** reasons explain the increased transmissibility in these localities:massive events,population density,cities dispersion patterns,and

关键词： Bayesian inference R0 COVID-19 Real time reproduction factor Basic reproduction factor Ecuador

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Massive Thromboembolism from an Abdominal Aortic Aneurysm after Successful Thrombolysis for an Acute Myocardial Infarction

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Case Reports in Clinical Medicine 2015年第2期4卷 45-49页

作者： Fernando luiz de Melo Bernardi Paulo Cury Rezende Cibele Larrosa Garzillo eduardo Gomes Lima Diogo Arantes Behling Pereira da Luz Vera demarchi Aiello Whady Hueb department of Atherosclerosis Heart Institute of the University of Sao Paulo Sao Paulo Brazil department of Pathology Heart Institute of the University of Sao Paulo Sao Paulo Brazil

Thrombolytic therapy is indicated to the treatment of patients with ST-elevation myocardial infarction or pulmonary embolism. Its indication should especially consider the risk of bleeding, but other complications might pose harm to patients. Although rarely reported, fibrinolysis can trigger thromboembolic phenomena from emboligenic sources such as aortic aneurysms. Clinicians should be aware of this life-threatening complication. In this case report, we present one patient admitted due to a ST-segment elevation acute myocardial infarction successfully treated with fibrinolytic treatment, but who evolved with a massive microembolism from an abdominal aortic aneurysm. despite intensive medical care, the patient evolved with multiorganic failure due to distal microembolism to the guts and lower limbs, severe rhabdomyolysis and ultimately to death. In this challenging case, clinical, anatomical and histopathologic features are presented and discussed.

关键词： Thromboembolism Abdominal Aortic Aneurysm Fibrinolysis Myocardial Infarction

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The Effect of UV Light and CO<sub>2</sub>in the Production of Polyunsaturated Aldehydes in <i>Skeletonema costatum</i>(Bacillariophycea)

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American Journal of Plant Sciences 2014年第24期5卷 3632-3641页

作者： luiz Felipe C. da Motta Pacheco eduardo Uribe Jorge Pino José Troncoso Andrés Quiróz Laboratório de Producción Primaria Facultad de Cienciasdel Mar Universidad Católica del Norte Coquimbo Chile EWOS Innovation Bergen Norway Laboratório de Química Ecológica Instituto de Química Universidad de La Frontera Temuco Chile

Skeletonema costatum was submitted to two experiments using UV lights and CO2with the purpose of observing changes in the lipids profile and the synthesis of polyunsaturated aldehydes (PUA) after cell disruption. When cells receive CO2 supply, it was noticed that the production of PUA was significantly lower. The same was observed when the culture was treated with a dose of 45.9 kJ·m-2 of ultra-violet A/B ray. The premise to all experiments was the production of 2,4-heptadienal compared to the supply of EPA as substrate. As a result, the same synthesis rate was observed both when the CO2 treatment was applied and in the experiment control. On the other hand, the culture subjected to ultraviolet radiation showed a 68% greater demand with the utilization of the substrate. These observations suggested that EPA was consumed before cell disruption and was probably exuded to the surrounding environment as a sign of stress. Changes in cell morphology could be observed by the migration of the chloroplast nearby the cell wall, where PUA was produced, indicating a defense strategy.

关键词： Diatom Physiology Oxilipins Skeletonema costatum Polyunsaturated Aldehyde (PUA)

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Prevalence of Helicobacter pylori vacA,cagA,dupA and oipA Genotypes in Patients with Gastric Disease

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Advances in Microbiology 2017年第1期7卷 1-9页

作者： Mayara Luciana Sallas Jessica Lima Melchiades Luanna Munhoz Zabaglia Juliana Ribeiro do prado Moreno Wilson Aparecido Orcini Elizabeth Suchi Chen Marilia de Arruda Cardoso Smith Spencer luiz Marques Payao Lucas Trevizani Rasmussen Sagrado Coracao University(USC) BauruBrazil Federal University of Sao Paulo(UNIFESP) Sao PauloBrazil

Gastric diseases such as chronic gastritis and gastric cancer are most commonly caused by virulence factors of Helicobacter pylori (H. pylori), such as the vacA, cagA, dupA and oipA genes. Therefore, this study investigated the prevalence and the combination of these virulence factors from patients with gastric diseases. The endoscopic biopsies were obtained from 516 patients with gastric symptoms, 101 of which were from patients with normal gastric tissue, 365 of which were from patients with chronic gastritis, and 50 of which were from patients with gastric cancer. H. pylori and the virulence factors were detected by PCR. The oipA gene exhibited an increased risk for chronic gastritis (p = 0.0296), and the vacA gene demonstrated a risk for gastric cancer from chronic gastritis (p = 0.0002). Based on the combination of the virulence factors, cagA, vacA, dupA and oipA genes exhibited a high prevalence in patients with chronic gastritis and gastric cancer. The cagA+/dupA+ genotype demonstrated a significant correlation in patients with normal gastric mucosa (p = 0.0278). In the chronic gastritis group, a significant association was observed between the cagA+ and the vacA s1m1 genotypes (p cagA+/dupA+ genotypes (p = 0.0183), the dupA+/oipA+ genotypes (p cagA, vacA, dupA, and oipA genes, which contributed to the risk of developing gastroduodenal diseases. Furthermore, this is the first study to reveal a high prevalence of the oipA gene in H. pylori isolates in Brazil.

关键词： Helicobacter pylori Virulence Factors cagA dupA oipA vacA

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Influence of Water Content on the Quality of Pigeonpea Seeds

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American Journal of Plant Sciences 2017年第10期8卷 2397-2406页

作者： Cristiane Fernandes Lisboa Rodrigo Starnek Lopes de Araújo Itamar Rosa Teixeira José Hortêncio Mota Alessandro Guerra Da Silva Marcos eduardo Viana de Araújo deyner Damas Aguiar Silva Edgar Estevam Franca Isneider luiz Silva Fernando Ribeiro Teles de Camargo department of Agricultural Engineering Sate University of Goiás Anápolís Brazil department of Agricultural University of Rio Verde Rio Verde Brazil department of Agricultural Federal University of Goiás Jataí Brazil

The species Cajanus cajan L. where pigeonpea is from presents a harvest potential in tropical regions for it is used as human and animal feed, besides being used as green fertilizer. However, the harvest area of this Fabaceae is still insignificant, due to especially the lack of quality seeds. In this context, it is possible to affirm that drying and store are portrayed as important steps for obtaining superior quality seeds. The aim of this study is to evaluate the physiologic quality of dwarf pigeonpea seeds, with different water content during storage. A factorial scheme 3 × 6 was adopted in the delimitation completely randomized, with four replications. Treatments were constituted by the combination of lots of seeds containing three different water contents (11%, 14% and 16%), submitted to a 10-month storage period, with evaluations every two months (0, 2, 4, 6, 8 and 10). Seeds were stocked in a bag type kraft under normal lab conditions, that is, no control. Physiologic quality of the seeds was evaluated through the following tests: Germination Pattern Test—GPT, first count of germination, accelerated aging and electric conductivity. It can be concluded that pigeonpea with hard seeds containing water content at 11% existing superior physiologic quality throughout the 10-month storage, under no controlled condition, certainly promoted by the less intense breathing from the reserves cumulated in the seed lot. Pigeonpea seeds storage with water content superior to 14% promotes a sharp decrease of physiologic quality, due to an increase in metabolic activity.

关键词： Cajanus cajan L. Physiologic deterioration Seed Quality Viability and Vigour

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Adrenal Insufficiency by Adrenoleukodystrophy

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Health 2020年第1期12卷 1-13页

作者： Elda Cristinne Mattos Botelho eduardo Romero Sampaio Botelho Luciana Correa de Souza Rodrigues Tatiana prado Wanderley Fernanda Navarini Queiroz Pollyana Cirino Gomes Borges Sabrina Arrais Rolim Aragao Ximenes Cruz Janete Pacheco da Silva Larissa Bianca Cunha de Sa Alberto Krayyem Arbex IPEMED Medical School AFYA EducationalBrasíliaBrazil Medical Clinic in Endocrinology and Diabetology Schleswig-FlensburgGermany

The X-linked adrenoleukodystrophy (ALD) is a severe neurodegenerative disorder due to mutations in the ABCD1 gene. Objective: To report a case of a 19-year-old man with adrenal insufficiency due to adrenoleukodystrophy. Method: Case report and literature review. Result: A previously healthy 19-year-old male patient was admitted to the emergency room with nausea and vomiting for 5 days, who progressed to abdominal pain, severe asthenia, and fever (38.5°C). He referred progressive darkening of the skin, oral mucosa, tongue and nail bed of the hands and feet, observed in the last 6 years. Emergency laboratory evaluation showed severe hyponatremia and hyperkalemia, which, together with decreased plasma cortisol, directed the investigation to causes of adrenal insufficiency. High ACTH (Adrenocorticotropic hormone) and very long chain fatty acid levels closed the diagnosis. Discussion: ALD is characterized by progressive demyelination in the central and peripheral nervous system and adrenal insufficiency consequence to the accumulation of very long chain fatty acids (VLCFA) in the adrenal. The overall incidence of ALD is 1:17,000. Adrenal insufficiency may be the first symptom of ALD in boys and adults. The diagnosis is based on the measurement of VLCFA plasma levels. Allogeneic bone marrow transplantation is the only treatment that provides a permanent cure when the procedure is performed at an early stage of brain demyelination, i.e. when patients are asymptomatic, although brain magnetic resonance imaging (MRI) is abnormal. Treatment of Addison’s disease is obligatory, but does not change the course of neurological symptoms.

关键词： Adrenoleukodystrophy Adrenomyeloneuropathy Adrenal Insufficiency Addison’s Disease

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Three Different Doses of Intrathecal Morphine as Part of a Multimodal Regimen for Post-Cesarean delivery Analgesia: A Randomized Double-Blinded Trial

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Open Journal of Obstetrics and Gynecology 2018年第9期8卷 780-789页

作者： Marcio luiz Benevides Rubens Jardim Nochi Jr. Carlos eduardo Solcia Valter Moreira Xavier Júnior Adalberto Francisco Buss Lima department of Anesthesiology Hospital Geral Universitário Cuiabá Brazil

Brazil is one of the countries that carry out cesarean delivery in the world. The pain after cesarean delivery (CD) is one of the main concerns of parturient. Intrathecal Morphine (ITM) is widely used for the treatment of pain after CD;however, the optimal dose with minimal side effects is to be established. Objectives: To compare the analgesia and side effects resulted by three different doses of ITM as part of a multimodal regimen for post-cesarean delivery analgesia. Methods: One hundred ninety-four patients were sampled in this randomized, double-blinded, three-arm study (group 0.075: ITM 0.75 mg;group 0.1: ITM 0.1 mg and group 0.15: ITM 0.15 mg). All patients received intravenous dexamethasone, dipyrone and ketoprofen. The primary endpoint was pain intensity measured at rest and on movement, while the secondary endpoint was overall satisfaction with pain relief, the incidence of nausea and vomiting, intensity of pruritus, and the use of additional tramadol, antipruritic and antiemetic use within 24 hours after postoperation. Results: The three groups showed similar pain intensity at rest and on movement. The pain intensity on movement was significantly higher than at rest in the groups (p 0.001). There were no significant differences among the groups regarding secondary endpoint. Conclusions: Our findings suggest that in cases of an elective CD, 0.075 mg of ITM produces postoperative analgesia of similar quality that provided by 0.1 or 0.15 mg ITM. The patients should have a multimodal analgesia approach that includes: ITM, anti-inflammatory agents and access to additional systemic analgesic if necessary.

关键词： Spinal Anesthesia Cesarean delivery Intrathecal Morphine Postoperative Pain Multimodal Analgesia

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