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American Journal of Plant Sciences 2014年第24期5卷 3632-3641页

作者： luiz Felipe C. da Motta Pacheco eduardo Uribe Jorge Pino José Troncoso Andrés Quiróz Laboratório de Producción Primaria Facultad de Cienciasdel Mar Universidad Católica del Norte Coquimbo Chile EWOS Innovation Bergen Norway Laboratório de Química Ecológica Instituto de Química Universidad de La Frontera Temuco Chile

Skeletonema costatum was submitted to two experiments using UV lights and CO2with the purpose of observing changes in the lipids profile and the synthesis of polyunsaturated aldehydes (PUA) after cell disruption. When cells receive CO2 supply, it was noticed that the production of PUA was significantly lower. The same was observed when the culture was treated with a dose of 45.9 kJ·m-2 of ultra-violet A/B ray. The premise to all experiments was the production of 2,4-heptadienal compared to the supply of EPA as substrate. As a result, the same synthesis rate was observed both when the CO2 treatment was applied and in the experiment control. On the other hand, the culture subjected to ultraviolet radiation showed a 68% greater demand with the utilization of the substrate. These observations suggested that EPA was consumed before cell disruption and was probably exuded to the surrounding environment as a sign of stress. Changes in cell morphology could be observed by the migration of the chloroplast nearby the cell wall, where PUA was produced, indicating a defense strategy.

关键词： Diatom Physiology Oxilipins Skeletonema costatum Polyunsaturated Aldehyde (PUA)

S53G SNP in Cathepsin B: Can Be Used as a Molecular Biomarker to Breast Cancer?

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Open Journal of Genetics 2022年第4期12卷 43-56页

作者： Letícia Cristina Dalzy Castro Danielle Queiroz Calcagno Carlos eduardo de Melo Amaral luiz Carlos Santana da Silva Programa de Pós-graduaç ã o em Oncologia e Ciências Médicas Universidade Federal do Pará Belém Brasil Laboratório de Erros Inatos do Metabolismo Universidade Federal do Pará Belém Brasil Núcleo de Pesquisa em Oncologia Universidade Federal do Pará Belém Brasil Fundaç ã o Centro de Hematologia e Hemoterapia do Pará Belém Brasil

Cathepsin B (CTS B) is a proteolytic enzyme that participates in several important biological processes. However, when it is altered can be involved in development of breast cancer, a disease with high incidence and mortality rate among women. Many studies have shown a correlation between high CTS B expression and breast tumor. Furthermore, it has been shown that the SNP rs1803250 (S53G) leads to structural and functional changes in protein that can make it pathogenic. The present study aimed to evaluate a possible association of SNP rs1803250 (S53G) with breast cancer. For this, real-time PCR was performed on a sample collected in the State of Pará, with 127 patients and 122 controls. The SNP frequency in this region was 0.12, according to a research project in progress that aims to identify Amerindians molecular alterations. This indicates that the SNP is found in region with a distribution close to worldwide frequency of 0.09. Our results showed that the SNP was in Hardy-Weinberg Equilibrium in collected sample, but C variant allelic frequency was 0.08 in both patients and control groups, which is extremely similar to global average. Moreover, homozygotes CC was not found in the sample and SNP genotypes frequency in patients and control groups was not significantly different. In addition, statistical analysis showed that the SNP did not have to correlate with tumor subtypes nor with tumor staging. Therefore, according to the analyzed sample, the SNP rs1803250 has no association with breast cancer and it cannot be considered a molecular biomarker for breast cancer.

关键词： Cathepsin B Polymorphism Breast Cancer

Uranium Metabolism Associated with Ontogenetic Growth of Birds—Case Studies with Broilers and Ducks

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Advances in Bioscience and Biotechnology 2014年第9期5卷 768-776页

作者： Joao Dias de Toledo Arruda-Neto Guacyara Tenorio Cavalcante Guilherme de Paula Nogueira Tulio eduardo Rodrigues luiz eduardo Correa Fonseca Mitiko Saiki Godofredo Camara Genofre Physics Institute University of Sao PauloSao PauloBrazil CEPESq/UniItalo—Italy-Brazilian University Center Sao PauloBrazil School of Veterinary Medicine Sao Paulo State University/UNESPAracatubaBrazil Institute for Energy and Nuclear Research IPEN/CNEN-SPSao PauloBrazil Institute for Biomedical Sciences University of Sao PauloSao PauloBrazil

Cobb broilers and domestic ducks, both one-day-old, were treated using ration doped with 20 ppm of uranyl nitrate. Uranium concentrations in the tibia (μg-U/g-bone) were measured by neutron activation analysis as function of the animals’ age, from the neonatal period to maturity. Results show that Uranium and Calcium qualitatively follow the same metabolic pathway, and that adult ducks incorporate on average ten times more Uranium than broilers. Data interpretation shows that the Uranium clearance rate in broilers is substantially higher than that in ducks, suggesting that metabolic characteristics favoring Calcium retention in bone may hinder the elimination of Uranium in ducks. The need for further comparative biochemistry studies between Galliformes and Anseriformes is addressed.

关键词： Cobb Broilers Domestic Ducks Uranium-Doped-Ration Uranium-Content in Bones U/Ca Metabolism Uranium Residence Times

Therapeutic and biological activities of Calotropis procera(Ait.) ***.

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Asian Pacific Journal of Tropical Medicine 2010年第4期3卷 332-336页

作者： Marcia Calheiros Chaves Silva Antonio Batista da Silva Fabiano Moura Teixeira Paulo Cesar Pereira de Sousa Regina Maria Macedo Rondon Jose eduardo Ribeiro Honorio Junior luiz Rafael Leite Sampaio Samanda Lima Oliveira Angela Nadyla Martins Holonda Silvania Maria Mendes de Vasconcelos Enfermeira Mestre em Farmacologia/Universidade Federal do Ceara/UFC Farmaceutico Mestre em Patologia Tropical/Universidade Federal do Amazonas/UFAM Biologo Mestre em Bioquimica/Universidade Federal do Ceara/UFC Farmaceutico Mestre em Ciencias Farmaceutica/Universidade Federal do Ceara/UFC Biologa Mestre em Producao Animal/Universidade Estadual do Ceara/UECE Biologo Mestre em Fisiologia da Universidade Estadual do Ceara/UECE Enfermeiro Mestrando em Farmacologia da Universidade Federal do Ceara/UFC Aluna de Farmacia da Universidade Federal do Ceara/UFC Enfermeira Professora Adjunto do Depto.de Fisiologia e Farmacologia da Universidade Federal do Ceara/UFC

Medicinal plants have been used to treat various ailments of the poor population around the world;hence the interest among researchers to know the active ingredients of certain plants has being *** Calotropis procera(***) is a plant original from Africa,commonly found in northeastern *** is well known for their pharmacological properties,since it produces large amounts of *** important role that medicinal plants play in folk medicine has led us to develop this article in order to review the major pharmacological activities of C. procera.

关键词： Calotropis procera Pharmacological activity Medicinal plants

Infrared Spectroscopy of Titania Sol-Gel Coatings on 316L Stainless Steel

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Materials Sciences and Applications 2011年第10期2卷 1375-1382页

作者： Daniela Cordeiro Leite Vasconcelos Vilma Conceicao Costa eduardo Henrique Martins Nunes Antonio Claret Soares Sabioni Massimo Gasparon Wander luiz Vasconcelos Department of Metallurgical and Materials Engineering Federal University of Minas GeraisBelo HorizonteBrasil Department of Physics Federal University of Ouro PretoOuro PretoBrasil School of Earth Sciences The University of QueenslandSt.LuciaAustralia

Sol-gel titania films were deposited on 316L stainless steel using titanium isopropoxide as a chemical precursor. Dip-coating was performed at withdrawal speeds of 6 mm/min, 30 mm/min, and 60 mm/min. Deposited gel films were heat treated in air at 80℃, 100℃, 300℃, and 400℃. The structural evolution of the coatings was evaluated by infrared reflection-absorption spectroscopy. The influence of the withdrawal speed and the heat treatment temperature on the structure of the films was studied by varying the reflectance incidence angle during the infrared experiments and by Glow Discharge Spectrometry. Free functional groups were detected. The results indicate the formation of bidendate bridging coordination of carboxylic acid to titanium. Titanium atoms can also be pentacoordinated according to the processing conditions of the films. We observed a tendency of increasing amounts of OH groups with decreasing reflectance incidence angle. The film hardness was measured via Knoop microindenation hardness test.

关键词： Films Sol-Gel Infrared Spectroscopy Glow Discharge Spectrometry Knoop Hardness

Three Different Doses of Intrathecal Morphine as Part of a Multimodal Regimen for Post-Cesarean Delivery Analgesia: A Randomized Double-Blinded Trial

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Open Journal of Obstetrics and Gynecology 2018年第9期8卷 780-789页

作者： Marcio luiz Benevides Rubens Jardim Nochi Jr. Carlos eduardo Solcia Valter Moreira Xavier Júnior Adalberto Francisco Buss Lima Department of Anesthesiology Hospital Geral Universitário Cuiabá Brazil

Brazil is one of the countries that carry out cesarean delivery in the world. The pain after cesarean delivery (CD) is one of the main concerns of parturient. Intrathecal Morphine (ITM) is widely used for the treatment of pain after CD;however, the optimal dose with minimal side effects is to be established. Objectives: To compare the analgesia and side effects resulted by three different doses of ITM as part of a multimodal regimen for post-cesarean delivery analgesia. Methods: One hundred ninety-four patients were sampled in this randomized, double-blinded, three-arm study (group 0.075: ITM 0.75 mg;group 0.1: ITM 0.1 mg and group 0.15: ITM 0.15 mg). All patients received intravenous dexamethasone, dipyrone and ketoprofen. The primary endpoint was pain intensity measured at rest and on movement, while the secondary endpoint was overall satisfaction with pain relief, the incidence of nausea and vomiting, intensity of pruritus, and the use of additional tramadol, antipruritic and antiemetic use within 24 hours after postoperation. Results: The three groups showed similar pain intensity at rest and on movement. The pain intensity on movement was significantly higher than at rest in the groups (p 0.001). There were no significant differences among the groups regarding secondary endpoint. Conclusions: Our findings suggest that in cases of an elective CD, 0.075 mg of ITM produces postoperative analgesia of similar quality that provided by 0.1 or 0.15 mg ITM. The patients should have a multimodal analgesia approach that includes: ITM, anti-inflammatory agents and access to additional systemic analgesic if necessary.

关键词： Spinal Anesthesia Cesarean Delivery Intrathecal Morphine Postoperative Pain Multimodal Analgesia

Development and Improvement of the Regulation Sieve Svstem Harvester

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Journal of Mechanics Engineering and Automation 2014年第8期4卷 673-687页

作者： Evandro Bertoldi Gil eduardo Guimaraes luiz Carlos da Silva Duarte Patricia Carolina Pedrali ClaudioFernando Rios Nara Liege Barbieri Everton Bertoldi Mechanical Engineering Department UNIJUi-Regional University of Norhtwest of Rio Grande do Sul State Panambi 98280-000Brazil Mechanical Engineering Department FTEC-School of Technology Caxias do Su195012-669 Brazil Agronomy Departament UPF-Passo Fundo University Passo Fundo 99001-970 Brazil Mechanical and Production Engineering Department UPF-Passo Fundo University Carazinho 99500-000 Brazil

Due to high competition of the agriculture machines sector, the auto parts suppliers are investing in research to promote the development and reduce the costs of the products, passing these results to their clients who are the automakers. It was identified the need to redesign the regulation sieve system harvester, which is a compound assembly in the harvester＇s grain cleaning system, with the objective to reduce the costs and improve the ergonomic aspect, keeping the same efficiency from the original project. The improvement was developed by studying the original design and identifying possible project fails, such as components and manufacturing process which could be eliminated. For this, it was needed to do a research about rules and project considerations that must be applied in the products development and ergonomic too, specifically about geometric forms and anthropometric measures. From the redesign of this system, it is verified that it is possible by a study to identify possible improvements, and to develop a new system by a simple project, improving the ergonomic, reducing the cost and keeping the same efficacy from the original project.

关键词： Lower costs ergonomic redesign regulation system harvester.

Fecal microbiota transplantation in patients with metabolic syndrome and obesity:A randomized controlled trial

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World Journal of Clinical Cases 2023年第19期11卷 4612-4624页

作者： Alberto Machado da Ponte Neto Aniele Cristine Ott Clemente Paula Waki Rosa Igor Braga Ribeiro Mateus Pereira Funari Gabriel Cairo Nunes Luana Moreira luiz Gustavo Sparvoli Ramon Cortez Carla Romano Taddei Márcio C Mancini eduardo Guimarães Hourneaux de Moura Departament of Gastroenterology Faculdade de MedicinaUniversidade de Sao PauloServiço de Endoscopia Gastrointestinal do Hospital das Clínicas HCFMUSPSão Paulo 05403-010SPBrazil Department of Endocrinology Hospital das ClínicasUniversity of São Paulo School of MedicineSão Paulo 05403-010SPBrazil Department of Clinical and Toxicology Analysis School of Pharmaceutical SciencesUniversity of São PauloSão Paulo 05403-010SPBrazil School of Arts Science and HumanitiesUniversity of São PauloSão Paulo 05403-010SPBrazil

BACKGROUND Metabolic syndrome is a multifactorial disease,and the gut microbiota may play a role in its ***,especially abdominal obesity,is associated with insulin resistance,often increasing the risk of type two diabetes mellitus,vascular endothelial dysfunction,an abnormal lipid profile,hypertension,and vascular inflammation,all of which promote the development of atherosclerotic cardiovascular *** To evaluate the outcomes of fecal microbiota transplantation(FMT)in patients with metabolic *** This was a randomized,single-blind placebo-controlled trial comparing FMT and a sham procedure in patients with metabolic *** selected 32 female patients,who were divided into eight groups of four patients *** of the patients were submitted to upper gastrointestinal *** each group,two patients were randomly allocated to undergo FMT,and the other two patients received saline *** patients were followed for one year after the procedures,during which time anthropometric,bioimpedance,and biochemical data were *** patients also had periodic consultations with a nutritionist and an *** primary end point was a change in the gut *** There was evidence of a postprocedural change in microbiota composition in the patients who underwent FMT in relation to that observed in those who underwent the sham ***,we found no difference between the two groups in terms of the clinical parameters *** There were no significant differences in biochemical or anthropometric parameters,between the two groups ***,there were significant postprocedural differences in the microbiota composition between the placebo *** date,clinical outcomes related to FMT remain uncertain.

关键词： Fecal microbiota transplantation Metabolic syndrome Obesity Endoscopy Diabetes mellitus Endocrinology

Variability of Air-Sea CO_(2) Fluxes and Dissolved Inorganic Carbon Distribution in the Atlantic Basin:A Coupled Model Analysis

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International Journal of Geosciences 2013年第1期4卷 249-258页

作者： eduardo G.G.de Farias Paulo Nobre Joao A.Lorenzzetti Roberto A.F.de Almeida luiz C.I.Junior National Institute for Space Research Center for Weather Forecasts and Climate StudiesCachoeira PaulistaBrazil National Institute for Space Research Remote Sensing DivisionSao Jose dos CamposBrazil

The biogeochemical dynamics of carbon in the ocean is a subject of fundamental interest to environmental studies. In this context, we have implemented a ten year run of the Brazilian Earth System Coupled Ocean-Atmosphere Model (BESM-OA2.3) integrated with TOPAZ biogeochemical model for the Atlantic basin. The modeled ΔpCO2 for the tropical Atlantic shows very clearly a high dominance of positive fluxes, that is, the CO2 fluxes are sea-to-air throughout the tropical region and for both winter and summer periods. In the mid-latitudes regions negatives fluxes (air-to-sea) were observed for both seasons. An exception to this pattern is an extensive negative tongue on the latitude 10N. The occurrence of this negative ΔpCO2 tongue region in the Tropical Atlantic is highly correlated to negative Evaporation-Precipitation values during this season. In the northern hemisphere (NH) summer the negative values of ΔpCO2 in the tropical Atlantic region are concentrated in the adjacent zone of the Amazon river mouth due to the North Equatorial Counter Current intensification. This process favors the formation of a carbon sink in the adjacent region of the Amazon river mouth. Model results show lowest values of dissolved inorganic carbon (DIC) in a surface layer (100 - 150 m). Highest DIC values are observed in deeper layers and concentrated in an equatorial band. The chlorophyll bloom in equatorial zones was well represented by the model. These blooms are the result of equatorial upwelling that brings the high concentration tongues of DIC present in the equatorial band towards the euphotic zone. This is the first published paper about the BESM-OA2.3 integrated with TOPAZ. The presented results suggest that this modeling system is able to reproduce the main regional carbon dynamics features of the mid-latitude/tropical Atlantic.

关键词： Carbon Cycle Atlantic Basin Coupled Model Climatological Analysis

Brain Abscess after COVID-19: Case Report

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Advances in Infectious Diseases 2023年第1期13卷 77-80页

作者： Natalia Chilinque Zambão da Silva Patrícia Yvonne Maciel Pinheiro Joao Gabriel Dib Farinhas luiz eduardo Dalmeida Machado Sampaio Fluminense Federal University Rio de Janeiro Brazil Antonio Pedro University Hospital Fluminense Federal University Rio de Janeiro Brazil Pasteur Hospital Rio de Janeiro Brazil

As the COVID-19 pandemic progresses, complications and unusual presentations of the disease have been described. Among them, the involvement of distinct parts of the neuroaxis. We report a rare case of brain abscess in elderly after SARS-Cov-2 infection readmitted in our health unit. Patient was treated with ceftriaxone, metronidazole and vancomycin with good clinical and therapeutic response. The satisfactory conduct of the case was only possible by the involvement of a multiprofessional team, which sought early diagnosis, surgical intervention and adequate duration of treatment.

关键词： Brain Abscess Biopsy COVID-19