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Prenatal and pubertal testosterone exposure imprint permanent modifications in the prostate that predispose to the development of lesions in old Mongolian gerbils

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Asian Journal of Andrology 2017年第2期19卷 160-167页

作者： Manoel F Biancardi Ana PS Perez Cassia rS Caires luiz r falleiros jr rejane M Goes Patricia SL Vilamaior Diogenes r Freitas jr Fernanda CA Santos Sebastiao r Taboga Department of Structural and Functional State University of Campinas Av. Bertrand Russel s/n Campinas Sao Paulo 13084864 Brazil 2Department of Histology Embryology and Cell BiologyFederal University of Goias Samambaia II Goiania Goias 74001970 Brazil University Estadual Paulista - UNESP Department of Biology Laboratory of Microscopy and Microanalysis Rua Cristovao Colombo 2265 Sao Jose do Rio Preto Sao Paulo 15054000 Brazil Medical School Federal University of Goias Colemar Natal e Silva Goiania Goias 74001970 Brazil

The prostate is an accessory sex gland that develops under precise androgenic control. It is known that hormonal imbalance may disrupt its development predisposing this gland to develop diseases during aging. Although the hypothesis regarding earlier origins of prostate diseases was proposed many years ago, the mechanisms underlying this complex phenomenon are poorly understood. Therefore, the aim of this study was to evaluate the prostates of old male gerbils exposed to testosterone during intrauterine and postnatal life using morphological, biometrical, stereological, Kariometric, immunohistochemical, and immunofluorescence analyses. Our findings demonstrate that prenatal and pubertal exposure to testosterone increases the susceptibility to the development of prostate diseases during aging. The presence of a more proliferative gland associated with foci of adenomatous hyperplasia in animals exposed to testosterone during the prenatal and pubertal phase show that the utero life and the pubertal period are important phases for prostatic morphophysiology establishment, which is a determinant for the health of the gland during aging. Therefore, these findings reinforce the idea that prostate disease may result from hormonal disruptions in early events during prostate development, which imprint permanently on the gland predisposing it to develop lesions in later stages of life.

关键词： adenomatous hyperplasia endocrine-disrupting chemicals gerbil prostate development testosterone

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Extreme drought triggers parallel shifts in wood anatomical and physiological traits in upper treeline of the Mediterranean Andes

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Ecological Processes 2024年第01期13卷 132-143页

作者： luiz Santini jr. Dylan Craven Daigard ricardo Ortega rodriguez Manolo Trindade Quintilhan Stephanie Gibson-Carpintero Cristina Aravena Torres Fidel A.roig Ariel A.Mu?oz Alejandro Venegas-Gonzalez Hémera Centro de Observación de la Tierra Universidad Mayor GEMA Center for Genomics Ecology and Environment Universidad Mayor Data Observatory Foundation ANID Technology Center Depart-ment of Forest Sciences ESALQ-University of Sao Paulo Department of Plant Biology Institute of Biology University of Campinas Instituto de Geografía Universidad Nacional Autónoma de México (UNAM) Argentine Institute of Nivology Glaciology and Environmental Sciences(IANIGLA CONICET ) Institute of Geography Pontificia Universidad Católica de Valparaíso Instituto de Ciencias Agroalimentarias Animales y Ambientales (ICA3) Universidad de O'Higgins

Background Treeline ecotones of Mediterranean ecoregions have been affected by the increasing intensity and severity of droughts. Even though the effect of droughts on forest dynamics has been widely documented, knowledge is relatively scarce of how extreme climate episodes affect the hydraulic structure and, therefore, the phys-iology of woody plants. The Mediterranean Andes have experienced an uninterrupted period of drought since 2010, including an extremely dry year in 2019 with approximately 80% rainfall deficit. Here, we investigated shifts in wood anatomical and physiological traits of Kageneckia angustifolia, an endemic treeline species, in response to this drought *** We evaluated the xylem plasticity of three K. angustifolia populations across their natural distribution(31–35° SL) based on anatomical(vessel structure and distribution) and physiological(intrinsic water-use efficiency) variables in the tree rings. We focused on the period 2000–2020 that corresponds to before the megadrought(2000–2007),(ii) megadrought(2008–2018) and(iii) hyperdrought(2019–2020). The variables were annualized and analyzed by linear mixed-effects *** Our results provide insights to the anatomical and physiological mechanisms underlying the resilience of treeline forests to persistent droughts in central Chile. We found that the extreme drought in 2019–2020 triggered shifts in vessel size and frequency that increased hydraulic safety. These significant shifts in vessel traits occurred in parallel with a decrease in pit aperture area and an increase in water-use efficiency, further increasing the resilience of K. angustifolia to extreme drought *** Our results revealed coordinated shifts in vessel size and frequency and water-use efficiency in response to the megadrought, thereby reducing vulnerability to hydraulic failure. The apparent resilience of K. angustifolia to extreme droughts suggests that this adaptation to drought stress may incre

关键词： Dendro-anatomy Kageneckia angustifolia Xylem vulnerability Drought Climate change

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Proactive reconciliation as a tool for integrating mining and milling operations

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International Journal of Mining Science and Technology 2019年第2期29卷 239-244页

作者： Ana Carolina Chieregati luiz Eduardo Campos Pignatari Francis Fernand Pitard Homero Delboni jr Department of Mining and Petroleum Engineering University of Sao Paulo EDEM Engenharia Mineral Francis Pitard Sampling Consultants

Historically, reconciliation has been viewed as a quality test of model estimates as well as a powerful tool for detecting and correcting problems in all stages of mine operations from resource estimation to metal production. If used correctly, reconciliation helps to better predict the life of mine(LOM), improves the adherence of production plans to the respective budget, and allows for effective control of the mining and milling processes. However, the accuracy of reconciliation results requires that all input data must be generated in accordance with the principles of sampling correctness. Furthermore, complete reconciliation systems can become extremely complex and must be carefully analyzed in order to provide realistic and helpful conclusions. Based on these concepts, this paper presents a successful proactive reconciliation system applied to a copper and gold mine in Brazil for monitoring and integrating mining and milling operations.

关键词： reconciliation Prognostication Sampling Gold Copper

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Cardiovascular autonomic neuropathy in diabetes:Pathophysiology,clinical assessment and implications

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World Journal of Diabetes 2021年第6期12卷 855-867页

作者： Alice Duque Mauro Felippe Felix Mediano Andrea De Lorenzo luiz Fernando rodrigues jr Education and research Department Instituto Nacional de CardiologiaRio de Janeiro 22240006RJBrazil Laboratory of Clinical research on Chagas Disease Evandro Chagas National Institute of Infectious DiseasesOswaldo Cruz FoundationRio de Janeiro 21040360RJBrazil Department of Physiological Sciences Biomedical InstituteFederal University of the State of Rio de JaneiroRio de Janeiro 22240006RJBrazil

Cardiovascular autonomic neuropathy(CAN)is a debilitating condition that mainly occurs in long-standing type 2 diabetes patients but can manifest earlier,even before diabetes is *** is a microvascular complication that results from lesions of the sympathetic and parasympathetic nerve fibers,which innervate the heart and blood vessels and promote alterations in cardiovascular autonomic *** entire mechanism is still not elucidated,but several aspects of the pathophysiology of CAN have already been described,such as the production of advanced glycation end products,reactive oxygen species,nuclear factor kappa B,and pro-inflammatory *** microvascular complication is an important risk factor for silent myocardial ischemia,chronic kidney disease,myocardial dysfunction,major cardiovascular events,cardiac arrhythmias,and sudden *** has also been suggested that,compared to other traditional cardiovascular risk factors,CAN progression may have a greater impact on cardiovascular disease ***,CAN might be subclinical for several years,and a late diagnosis increases the mortality *** duration of the transition period from the subclinical to clinical stage remains unknown,but the progression of CAN is associated with a poor *** tests can be used for CAN diagnosis,such as heart rate variability(HrV),cardiovascular autonomic reflex tests,and myocardial ***,it has already been described that CAN could be detected even during the subclinical stage through a reduction in HrV,which is a non-invasive test with a lower operating ***,considering that diabetes mellitus is a global epidemic and that diabetic neuropathy is the most common chronic complication of diabetes,the early identification and treatment of CAN could be a key point to mitigate the morbidity and mortality associated with this long-lasting condition.

关键词： Cardiovascular autonomic neuropathy Cardiac autonomic neuropathy Diabetes mellitus Heart rate variability Sympathetic autonomic nervous system Parasym-pathetic autonomic nervous system

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Successful liver allograft inflow reconstruction with the right gastroepiploic vein

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Hepatobiliary & Pancreatic Diseases International 2016年第1期15卷 106-110页

作者： rafael S Pinheiro ruy J Cruz jr Lucas S Nacif Matheus F Vane luiz AC D'Albuquerque Liver Transplant Division Department of GastroenterologyUniversity of S?o Paulo School of Medicine Department of Anesthesiology University of S?o Paulo School of Medicine

Portal vein thrombosis is a common complica- tion in cirrhotic patients. When portal vein thrombectomy is not a suitable option, a large collateral vessel can be used for allograft venous inflow reconstruction. We describe an unusu- al case of successful portal revascularization using the right gastroepiploic vein. The patient underwent a cadaveric or- thotropic liver transplantation with end-to-end anastomosis of the portal vein to the right gastroepiploic vein. Six months after liver transplantation the patient is well with good liver function. The use of the right gastroepiploic vein for allograft venous reconstruction is feasible and safe, with a great advan- tage of avoiding the need of venous jump graft.

关键词： liver transplantation vascular grafting portal vein, cavernous transformation of varicose veins hypertension, portal

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Spectral Model for Soybean Yield Estimate Using MODIS/EVI Data

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International Journal of Geosciences 2013年第9期4卷 1233-1241页

作者： Anibal Gusso Jorge ricardo Ducati Mauricio roberto Veronez Damien Arvor luiz Gonzaga da Silveira jr. Environmental Engineering UNISINOSSao LeopoldoBrazil remote Sensing Center and Astronomy Department UFRGSPorto AlegreBrazil Graduate Program in Geology UNISINOSSao LeopoldoBrazil Institut de recherche Pour le Developpement(IrD) MontpellierFrance Graduate Program in Applied Computing UNISINOSSao LeopoldoBrazil

Attaining reliable and timely agricultural estimates is very important everywhere, and in Brazil, due to its characteristics, this is especially true. In this study, estimations of crop production were made based on the temporal profiles of the Enhanced Vegetation Index (EVI) obtained from Moderate resolution Imaging Spectroradiometer (MODIS) images. The objective was to evaluate the coupled model (CM) performance of crop area and crop yield estimates based solely on MODIS/EVI as input data in rio Grande do Sul State, which is characterized by high variability in seasonal soybean yields, due to different crop development conditions. The resulting production estimates from CM were compared to official agricultural statistics of Brazilian Institute of Geography and Statistics (IBGE) and the National Company of Food Supply (CONAB) at different levels from 2000/2001 to 2010/2011 crop years. results obtained with CM indicate that its application is able to generate timely production estimates for soybean both at municipality and local levels. Validation estimates with CM at State level obtained r2 = 0.95. Combining all cropping years at municipality level, estimates were highly correlated to official statistics from IBGE, with r2 = 0.91 and rMSD = 10,840 tons. Spatially interpolated comparisons of yield maps obtained from the CM estimates and IBGE data also showed visual similarity in their spatial distribution. Local level comparisons were performed and presented r2 = 0.95. Implications of this work point out that time-series analysis of production estimates are able to provide anticipated spatial information prior to the soybean harvest.

关键词： remote Sensing Coupled Model Soy Yield Forecast Satellite Images

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Leukocyte-technetium-99m uptake in Crohn's disease:Does it show subclinical disease?

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World Journal of Gastroenterology 2010年第3期16卷 365-371页

作者： Luciene G Mota luiz GV Coelho Carlos jr Simal Maria LA Ferrari Clodomiro Toledo Josep Martin-Comin Simone OF Diniz Valbert N Cardoso Nuclear Engineering Department Federal University of Minas Gerais Gastro-enterology ALFA Institute Clinical HospitalFederal University of Minas Gerais Nuclear Medicine Felício Rocho HospitalMedicine FacultyFederal University of Minas Gerais Medicine Nuclear Center Bellvitge Hospital radioisotope Laboratory Pharmacy FacultyFederal University of Minas Gerais

AIM:To evaluate inflammatory activity in patients with Crohn's disease (CD) using technetium-99m-hexamethylpropyleneamine oxime (99mTc-HMPAO) granulocyte ***: Twenty patients (7 male and 13 female) with CD and five healthy volunteers were selected for 99mTc-HMPAO granulocyte scintigraphy. The Crohn's Disease Activity Index (CDAI), blood tests and C-reactive protein (CrP) of each patient were performed 7 d before the scintigraphic images. The leukocytes were labeled according to the International Society of radiolabeled Blood Elements (ISOrBE) consensus protocol and the scintigraphic images, including single photon emission computed tomography, were obtained 30 min and 2 h after injection of the radiolabeled ***:The labeling yield of the leukocytes with the lipophilic complex 99mTc-HMPAO was 55.0%±10%. Six of the 20 patients (30%) presented congruent results for the three parameters investigated (CDAI, Scintigraphic Index and CrP). On the other hand, 14 patients (70%) did not show congruent results. There was no significant correlation between the indices analyzed according to the Spearman test (P>0.05,n=20).CONCLUSION: The results suggest that 99mTc-HMPAO-labeled leukocyte scintigraphy could be important for determining inflammatory activity in CD even in the absence of clinical symptoms.

关键词： Technetium-99m Hexamethylpropyleneamine oxime Leukocytes Inflammatory bowel disease Scintigraphy

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Lafoensia pacari alleviates intestinal damage by modulating cyclooxygenase-2:In silico and in vivo evaluation in a colitis model

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World Journal of Gastroenterology 2023年第17期29卷 2628-2641页

作者： Gabrielle Caroline Peiter Thayene Kamyli Moesch Queiroz Edson luiz Michalkiewicz jr raphael Henrique Chappuis Jennefer Sousa Luz luiz Henrique Casagrande Piovezani Cleison Ferreira Silva Matheus Nozomi Tsutumi Augusto Fernandes Chaves rafael Messias luiz Cinthia Façanha Wendel Ana Carla Zarpelon-Schutz Kádima Nayara Teixeira Programa Multicêntrico de Pós-graduação em Biquímica e Biologia Molecular-Setor Palotina Universidade Federal do ParanáPalotina 85.950-000ParanáBrazil Programa de Pós-graduação em Biotecnologia-Setor Palotina Universidade Federal do ParanáPalotina 85.950-000ParanáBrazil Campus Toledo Universidade Federal do ParanáToledo 85.919-899ParanáBrazil

BACKGrOUND Inflammatory bowel diseases(IBD)are a worldwide health problem and mainly affect young people,consequently affecting the *** treatments are often associated with side effects,and new therapeutic options are *** centuries,plants have represented important substrates in the field of drug *** pacari(***)is a plant whose pharmaceutical potential has been described,and may have biological activity relevant to the treatment of IBD *** To investigate the activity of keto-alcoholic extracts of *** with respect to ameliorating the inflammatory and nociceptive symptoms of acute experimental colitis in *** Keto-alcoholic extracts of *** leaves and bark were administered to male andfemale Swiss mice weighing 25 g to 30 g(n=8 male mice and n=8 female mice).The effect of these extracts was observed in an acetic acid-induced acute experimental model of colitis with regard to antinociception/analgesia and inflammatory tissue *** macroscopic indices included the Wallace score and the colon weight obtained using a precision *** hyperalgesia was determined using an electronic *** related to overt pain was determined by quantifying the number of writhing instances within 20 min of administration of acetic *** docking was performed using human and murine cyclooxygenase-2(COX-2)with 3 flavonoids(ellagic acid,kaempferol,and quercetin)on the AutoDock Vina *** of variance followed by Tukey’s posttest was used with Prine model of colitis,administration of extracts from *** ameliorated acetic acidinduced writhing and colitis-associated inflammatory *** improvements may be attributable to the reduction in edema,inflammation(e.g.,ulcers,hyperemia,and bowel wall damage),and the intensity of abdominal *** keto-alcoholic extracts of *** leaves and bark administered at a

关键词： Antinociceptive activity Anti-inflammatory activity Cyclooxygenase-2 Flavonoids Inflammatory bowel disease Lafoensia pacari

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A methodology for coffee price forecasting based on extreme learning machines

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Information Processing in Agriculture 2022年第4期9卷 556-565页

作者： Carolina Deina Matheus Henrique do Amaral Prates Carlos Henrique rodrigues Alves Marcella Scoczynski ribeiro Martins Flavio Trojan Sergio luiz Stevan jr Hugo Valadares Siqueira Department of Production Engineering Federal University of Rio Grande do Sul90.035-190Brazil Department of Electronics Federal University of TechnologyParana 84017-220Brazil Graduate Program in Production Engineering Federal University of TechnologyParana 84017-220Brazil

This work introduces a methodology to estimate coffee prices based on the use of Extreme Learning *** process is initiated by identifying the presence of nonstationary components,like seasonality and *** components are withdrawn if they are ***,the temporal lags are selected based on the response of the Partial Autocorre-lation Function *** predictors,we address the following models:Exponential Smooth-ing(ES),Autoregressive(Ar)and Autoregressive Integrated and Moving Average(ArIMA)models,Multilayer Perceptron(MLP)and Extreme Learning Machines(ELMs)neural *** computational results based on three error metrics and two coffee types(Ara-bica and robusta)showed that the neural networks,especially the ELM,can reach higher performance levels than the other *** methodology,which presents preprocess-ing stages,lag selection,and use of ELM,is a novelty that contributes to the coffee prices forecasting field.

关键词： Coffee price forecasting Linear models Artificial neural networks Computational intelligence

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Testosterone replacement maintains smooth muscle content in the corpus cavernosum of orchiectomized rats

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Asian Journal of Urology 2017年第4期4卷 223-229页

作者： Graziele Halmenschlager Ernani Luis rhoden Gabriela Almeida Motta Lucas Sagrillo Fagundes Jorge luiz Medeiros jr rosalva Meurer Claudia ramos rhoden Centro Universitario ritter dos reis(Uniritter)and Universidade Federal de Cieˆncias da Sau´de de Porto Alegre(UFCSPA)e PPG Cieˆncias da Sau´de Porto AlegreRSBrazil Department of Urology at Universidade Federal de Cieˆncias da Sau´de de Porto Alegre(UFCSPA) Urologist at Irmandade Santa Casa de Miserico´rdia de Porto Alegre(ISCMPA)and Hospital Moinhos de Vento de Porto Alegre(HMV)Porto AlegreRSBrazil Universidade Federal de Cieˆncias da Sau´de de Porto Alegre(UFCSPA)e PPG Cieˆncias da Sau´de-Porto Alegre RSBrazil INrS Institut Armand Frappier(Universit.du Que´bec)and BioMed research Center Laval QuebecCanada Laboratory of Morphometry Metabolismand Cardiovascular DiseaseBiomedical CenterInstitute of BiologyState University of Rio de JaneiroRio de JaneiroBrazil Laboratory of Multidisciplinary of Sciences Biomedical CenterMedical School of Valenc¸aValenc¸a/Rio de JaneiroBrazil

Objective:To evaluate the effects of testosterone(T)on the maintenance of corpus cavernosum(CC)structure and ***:Animals were divided into three groups:sham operation group(n Z 8)underwent sham operation;Orchiectomized(Orchiec)t oily vehicle group(n Z 8)underwent bilateral orchiectomy and received a single dose of oily vehicle by intramuscular injection(i.m.)30 days after orchiectomy;and Orchiec t T group(n Z 8)underwent bilateral orchiectomy and received a single dose of T undecanoate 100 mg/kg i.m.30 days after the *** were euthanized 60 days after the beginning of the experiment with an anesthetic overdose of ketamine and *** samples and penile tissue were collected on euthanasia.

关键词： Testosterone replacement Histomorphometry Androgen deprivation Hypogonadism Corpus cavernosum

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