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Expression of multidrug Resistance ATP-Binding Cassette(ABC)Transporters in Canine mammary Tumors

Advances in Breast Cancer Research 2015年第3期4卷 77-85页

作者： Breno S.Salgado Suely Nonogaki luisa m.soares Angela Akamatsu Cristiano R.N.da Silva Thiago P.Anacleto Rodolfo malagó Rafael m.Rocha Fátima Gartner Noeme S.Rocha Departamento de Patologia Faculdade de Medicina de BotucatuUniversidade Estadual PaulistaCampus de BotucatuBotucatuBrazil Instituto de Ciências Biomédicas Abel Salazar Universidade do Porto(Intitute of Biomedical Sciences Abel Salazar of University of Porto)OportoPortugal Fundacao Antonio Prudente Hospital A.C.CamargoSao PauloBrazil Departamento de Clínica Veterinária Faculdade de Medicina Veterinária e ZootecniaUniversidade Estadual PaulistaUNESP.BotucatuBrazil Hospital Escola de medicina Veterinária Fundacao de Ensino e Pesquisa de Itajubá—FEPIItajubáBrazil

mammary neoplasms are the most common tumors in female dogs. They are usually treated using solely surgical mastectomy—which is recognized as unsatisfactory in many cases. Given this, the benefits of chemotherapy in dogs with mammary cancer need to be further explored. Some drugs that can be used for treating canines with mammary tumors may be substrates of uptake and/or efflux transporters such as the ATP-binding cassette (ABC) transporters. Unfortunately, very little is known regarding the pathobiology of such proteins in canine tumors, including mammary cancer. Accordingly, this study was designed to characterize the expression of ABC transporters P-glycoprotein, mRP1, and mRP2 and their relation with clinicopathologic factors in order to allow a better understanding of their influence in canine mammary cancer. P-glycoprotein was expressed in tumors from 55.8% of patients, while mRP1 and mRP2 were expressed in 37.2% and 39.5% of tumors, respectively. P-glycoprotein expression showed to be related with regional lymph node spread (P = 0.0038), as well as with tumor grade (P = 0.0353) and with a shorter survival (P = 0.0245). mRP1 revealed a strong association with a higher histological grade (P mRP1 was determined as prognostic indicator independent of lymph node status using Cox proportional-hazards regression multivariate analysis (P = 0.0216). No relations between mRP2 and clinicopathologic features were observed. We have found that P-glycoprotein and mRP1 are expressed in highly aggressive canine mammary tumors and are related with poor prognosis. Our results suggest that they may play a significant role in the course of canine mammary cancer progression and be promising candidate markers for a validation study on therapy outcome.

关键词： mDR1 P-Gp mRP1 mRP2 ABCC2 mammary Neoplasms Prognosis Dog

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Health Vigilance and Risk Factors for Cervical Cancer: A Study in the State of maranhão, Brazil

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Open Journal of Epidemiology 2024年第1期14卷 75-89页

作者： José márcio soares Leite Carlos Tomaz School of medicine CEUMA University S&#227o Luís Brazil master’s Program in Environment CEUMA University S&#227o Luís Brazil

The purpose of this cross-sectional study was to investigate the importance of health vigilance in the prevention of cervical cancer. The sample consisted of 536 women. To identify which risk factors were associated with cervical cancer or with an increase in the mortality rate of this kind of cancer, a logistic regression model was used. The Odds Ratios (OR) and their respective 95% confidence intervals were also calculated. most of them were at the age of highest incidence of cervical cancer (21 - 59 years old), had an unstable conjugal situation, minimal educational level (78.7%), low income (58.3%), consumed alcoholic beverages (56.4%), had a history of smoking (57.0%) and possessed limited knowledge about the prevention. These results are discussed in terms of a predictive model for cervical cancer that considers the importance of public health vigilance in the screening and precocious diagnosis.

关键词： Cancer Cervix Uteri Public Health Surveillance Epidemiology

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Plant growth and metabolism of exotic and native Crotalaria species for mine land rehabilitation in the Amazon

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Journal of Forestry Research 2024年第1期35卷 143-154页

作者： Hemelyn soares das Chagas Rafael Silva Guedes markus Gastauer Paula Godinho Ribeiro Allan Klynger da Silva Lobato Cecílio Frois Caldeira Fabrício William deÁvila AndréRodrigues dos Reis Silvio Junio Ramos Instituto Tecnológico Vale Rua Boaventura da Silva955BelémPA 66055-090Brazil Universidade Federal do Sul e Sudeste do Pará XinguaraPABrazil Núcleo de Pesquisa Vegetal Básica e Aplicada Universidade Federal Rural da AmazôniaParagominasPABrazil Departamento de Engenharia Florestal Universidade Estadual do Centro-Oeste/UNICENTROIratiPRBrazil School of Sciences and Engineering São Paulo State University(UNESP)TupãSP.CEP 17602-496Brazil

Despite its enormous benefits,mining is respon-sible for intense changes to vegetation and soil ***,after extraction,it is necessary to rehabilitate the mined areas,creating better conditions for the establishment of plant species which is *** study evaluated mineral and organic fertilization on the growth,and carbon and nitrogen(N)metabolism of two Crotalaria species[Cro-talaria spectabilis(exotic species)and Crotalaria maypu-rensis(native species from Carajás mineral Province(CmP)]established on a waste pile from an iron mine in CmP.A control(without fertilizer application)and six fertilization mixtures were tested(i=NPK;ii=NPK+micronutrients;iii=NPK+micronutrients+organic compost;iv=PK;v=PK+micronutrients;vi=PK+micronutrients+organic compost).Fertilization contributed to increased growth of both species,and treatments with NPK and micronutrients had the best results(up to 257%***),while organic fertilization did not show *** Crotalaria had a greater number of nodules,higher nodule dry mass,chlorophyll a and b contents and showed free ammonium as the predominant N form,reflecting greater increments in biomass compared to native *** having lower growth,the use of this native species in the rehabilitation of mining areas should be considered,mainly because it has good development and meets current government legislation as an opportunity to restore local biodiversity.

关键词： Biological nitrogen fixation mining Nitrogen metabolism Plant nutrition

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In Silico and in Vitro Analysis of Pyrazolone Derivatives against Zika Virus and Identification of Potential NS5 methyltransferase Inhibitors by molecular Docking

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Journal of Biosciences and medicines 2024年第7期12卷 214-229页

作者： Luciene soares Silva Tiago soares Barbosa maria Leonisa Sanchez-Nuñez Aldenise mont Serrat Rosa da Silva Vitor Won-Held Rabelo Leonardo dos Santos Corrêa Amorim Leonardo Alves miceli Percilene Fazolin Vegi Alice Bernardino Helena Carla Castro Izabel Christina Nunes de Palmer Paixão Science and Biotechnology Graduate Program Department of Cellular and Molecular Biology Institute of Biology Fluminense Federal University Niteri Brazil Science and Biotechnology Graduate Program Department of Cellular and Molecular Biology Institute of Biology Fluminense Federal University Niterói Brazil Laboratory of Antibiotics Biochemistry Teaching and Molecular Modeling Institute of Biology Fluminense Federal University Niterói Brazil Laboratory of Organic Chemistry at the Institute of Chemistry Institute of Biology Fluminense Federal University Niterói Brazil

Zika virus (ZIKV), a mosquito-borne flavivirus, has been associated with benign infections for decades. However, it has become a public health concern due to its association with severe fetal and neurological complications. Although many efforts have been made to control ZIKV infection, approved vaccines or antiviral drugs are still lacking. Consequently, the development of new effective anti-ZIKV agents is urgently needed. In this context, we investigated the antiviral potential of pyrazolone derivatives against ZIKV replication using in silico and in vitro methods. The four pyrazolone derivatives evaluated (1a, 1b, 1c, and 1d) inhibited over 50% of ZIKV replication with low cytotoxicity. Among them, compound 1b exhibited the most potent activity (EC50 = 4.3 μm) and the highest selectivity (SI = 342). mechanism of action studies indicated that these compounds act at early stages of virus replication, and compound 1b can also directly inactivate ZIKV particles. molecular docking studies suggested that these compounds can bind to and block the activity of ZIKV NS5 methyltransferase. Finally, pharmacokinetic and toxicological predictions have reinforced the safety and drug-like profiles of these derivatives. In conclusion, the pyrazolone scaffold proved to be valuable for anti-ZIKV drug development, and the derivatives studied deserve further investigation.

关键词： Zika Pyrazolone NS5 methyltransferase Antivirals

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国际护理知识网络建设的调查研究

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International Journal of Nursing Sciences 2024年第3期11卷 374-380,I0004,I0005页

作者： margareth Santos Zanchetta Suzanne Fredericks Kateryna metersky Geraldine martorella Pammla Petrucka Laurie Clune Kelly Graziani Giacchero Vedana Cristina Rosa soares Lavareda Baixinho Cristianne maria Famer Rocha Sara Campagna Sally Zhang He márcia Teles de Oliveira Gouveia marcelo medeiros Denize Bouttelet munari Daniel Gonzalo Eslava Albarracin Carlos Aguilera-Serrano Walterlania Silva Santos Toronto metropolitan University TorontoCanada Florida State University TallahasseeUSA University of Saskatchewan ReginaCanada University of Regina ReginaCanada State of Sao Paulo University Ribeirao PretoBrazil Lisbon Superior School of Nursing LisbonPortugal Federal University of Rio Grande do Sul Porto AlegreBrazil University of Turin TurinItaly Scarborough Health Network ScarboroughCanada Federal University of Piauí TeresinaBrazil Federal University of Goias GoianiaBrazil Fundacion Universitaria Cafam BogotaColombia University of malaga MalagaSpain University of Brasília Ceil^andiaBrazil

本文报告了为创建护理知识网络(Nursing Knowledge Network,NKN)对不同国家护理院校进行环境扫描调查所收集到的信息。采用在线方式(2021年2-10月)进行环境扫描,探索研究领域的确定、现有资源、预期收益、教学研究创新、知识传播障碍及... 详细信息

本文报告了为创建护理知识网络(Nursing Knowledge Network,NKN)对不同国家护理院校进行环境扫描调查所收集到的信息。采用在线方式(2021年2-10月)进行环境扫描,探索研究领域的确定、现有资源、预期收益、教学研究创新、知识传播障碍及网络的预期贡献。目标信息提供者包括来自13个国家63所大学的200名护理教师。要求每所大学有1名参与者回答问卷。共有42所大学(约70%)回复,包括巴西21所,加拿大4所,葡萄牙和西班牙各3所,哥伦比亚、墨西哥、秘鲁和美国各2所,智利、意大利和巴拉圭各1所。其分享了相关信息和见解:通过护理高等教育机构之间的协作和交流,全球可以加强共同创新和研究合作能力;较少被研究的领域是知识网络生成证据、为当地科学实践提供信息的潜在重点。这些信息将为进一步了解护理发展,以及地方、区域和全球护理证据应用和传播相关的政府政策与计划制订提供参考。

关键词：信息网络创新扩散国际教育交流知识管理护理教育护理教师实践护理院校跨文化护理

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Novel insights into the pathogenesis of tendon injury:mechanotransduction and neuroplasticity

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Neural Regeneration Research 2022年第10期17卷 2223-2224页

作者： Suellen Alessandra soares de moraes Faculdade de Fisioterapia e Terapia Ocupacional Universidade Federal do ParáBelémParáBrazil

Tendon pathology is characterized by damage to the tendon structural integrity with disruption of collagen fibers(Nourissat et al.,2015).Acute tendon injuries show a macroscopic discontinuity,ranging from partial to complete tendon *** involve inflammation and lead to loss of *** chronic conditions(or tendinopathy),symptoms include changes in both locomotor and sensorial functions of the tendon(Nourissat et al.,2015;Scott et al.,2020).Inconsistency in terminology for cases of painful tendon disorders is found,but recently the term tendinopathy was established in consensus as preferable for cases with persistent tendon pain and loss of function related to mechanical *** term excludes a problem in clinical practice-i.e.,specification of the presence of a particular pathological or biochemical process(Scott et al.,2020).

关键词： tendon injuries Acute

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O_(3) based advanced oxidation for ibuprofen degradation

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Chinese Journal of Chemical Engineering 2022年第2期35卷 277-284页

作者： Vitória m.Almeida Carla A.Orge m.Fernando R.Pereira O.SaloméG.P.soares Laboratory of Separation and Reaction Engineering-Laboratory of Catalysis and materials (LSRE-LCM)Faculdade de Engenharia da Universidade do PortoRua Dr.Roberto Frias4200-465 PortoPortugal

The degradation of the anti-inflammatory ibuprofen(IBP)was evaluated by several advanced oxidation *** was treated by single ozonation and oxidation with hydrogen peroxide(H_(2)O_(2)),as well as a combination of these *** order to improve the efficiency,the presence of catalysts such as original carbon nanotubes,labelled as CNT,and iron oxide supported on carbon nanotubes,named as Fe/CNT sample,was *** evolution of IBP degradation,mineralization and toxicity of the solutions was *** formation of intermediates was also *** the non-catalytic processes,IBP was faster removed by single ozonation,whereas no significant total organic carbon(TOC)removal was *** with H_(2)O_(2) did not present satisfactory *** ozone and H_(2)O_(2) were combined,a higher mineralization was attained(70%after 180 min of reaction).On the other hand,in the catalytic processes,this combined process allowed the fastest IBP *** terms of mineralization degree,the presence of Fe/CNT increases the removal rate in the first hour of reaction,achieving a TOC removal of 85%.Four compounds were detected as *** treated solutions presented lower toxicity than the initial solution,suggesting that the released intermediates during applied processes are less toxic.

关键词： Advanced oxidation processes Catalysts Emerging pollutants Ibuprofen

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实现星际文件系统并更进一步

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科技纵览 2022年第11期 38-43,5页

作者： Yiannis Psaras Jorge m.soares David Dias Carl De Torres(插图) 伦敦协议实验室不详

2020年初新冠疫情暴发,全世界史无前例地转向了远程办公。一些互联网服务提供商则采取了预防措施,暂时缩减了服务规模,不过这对于亚洲、欧洲和北美国家来说可能并非必需的措施,这些地区通常能够应对远程办公(以及疯狂观看网飞节目)带来... 详细信息

2020年初新冠疫情暴发,全世界史无前例地转向了远程办公。一些互联网服务提供商则采取了预防措施,暂时缩减了服务规模,不过这对于亚洲、欧洲和北美国家来说可能并非必需的措施,这些地区通常能够应对远程办公(以及疯狂观看网飞节目)带来的需求激增。因为其网络大多过度配置,容量超过了通常所需。

关键词：文件系统远程办公互联网服务提供商需求激增预防措施

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Joint Return Value Estimation of Significant Wave Heights and Wind Speeds with Bivariate Copulas

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中国海洋大学学报:英文版 2023年第5期22卷 1181-1192页

作者： TAO Shanshan DONG Sheng LIN Yifan GUEDES soares Carlos College of Engineering Ocean University of ChinaQingdao 266100China Huadian Heavy Industries Co. Ltd.Beijing 100070China Instituto Superior Técnico Universidade de LisboaLisboa 1049-001Portugal

The joint design criteria of significant wave heights and wind speeds are quite important for the structural reliability of fixed offshore ***,the design method that regards different ocean environmental variables as independent is *** the present study,we introduce a bivariate sample consisting of the maximum wave heights and concomitant wind speeds of the threshold by using the peak-over-threshold and declustering *** selecting the appropriate bivariate copulas and univariate distributions and blocking the sample into years,the bivariate compound distribution of annual extreme wave heights and concomitant wind speeds is *** joint design criteria,namely,the joint probability density method and the conditional probability method,are applied to obtain the joint return values of significant wave heights and wind *** show that(28.5±0.5)m s^(-1)is the frequently obtained wind speed based on the Atlantic dataset,and these joint design values are more appropriate than those calculated by univariate analysis in the fatigue design.

关键词： joint design wave height wind speed compound distribution copula

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Thermal Annealing Characteristics of Detrital Zircon Fission Track Obtained from Natural Borehole Samples

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Journal of Earth Science 2022年第1期33卷 45-56页

作者： Chang'e Cai Nansheng Qiu Jian Chang Cleber Jose soares Hong Chen Chongqing Key Laboratory of Complex Oil and Gas Field Exploration and Development Chongqing University of Science and TechnologyChongqing 401331China State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing 102249China ChronusCamp Research-Thermochronology Analyses LTD Itapira 13974Brazil

Previous studies proposed thermal simulation experiment to investigate the annealing characteristics of fission tracks in igneous zircon ***,basic research about detrital zircon fission track was relatively *** study discussed the initial track length,annealing temperature and annealing model of zircon fission track by using the measured track lengths obtained from natural borehole samples in the sedimentary basins with different thermal *** results show that the initial track length of zircon fission track is 12.97 μ*** total annealing temperature(Ttotal) of zircon fission track derived from the evolutionary curve of the mean track lengths is approximately 400 ℃.The temperature ranges of 120-230 ℃ corresponds to the partial annealing zone(PAZ),and is lower than the range obtained through thermal annealing *** annealing model is modified based on the measured track *** addition,a functional formula about the mean track length,annealing temperature,and geological time is proposed,and the fitted values of track lengths consist with the measured track lengths in this *** properly understanding the initial track length and annealing behavior of zircon fission track can provide a significant guidance for the study of hydrocarbon accumulation in sedimentary basins.

关键词： zircon detrital zircon fission track initial track length annealing temperature annealing model natural borehole sample

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