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How to Ensure Food Supply to the Population of the Medieval Village of Loule (1384-1488)

Journal of Food Science and Engineering 2019年第7期9卷 255-265页

作者： luisa Fernanda Guerreiro martins Interdisciplinary History Cultures and Societies Centre of the University of Evora(UID/HIS/00057/2013POCI-01-0145-FEDER-007702)Largo do Marques de Marialvan. 8Apartado 94Evora 7000-809Portugal

Located in the centre of the Algarve,in the South of Portugal,the ancient village of Louléhas its origins in a Muslim medieval medina(8th Century).After the Christian Conquest of the South and namely of the Louléterritory in 1249,the Christian Administration,based on the city councils meetings,composed of good men,will have to reconcile the social and religious dynamics of the populations who stayed in the territory,formed by Jews,Muslims and *** this social,cultural and religious scenario,local administration will also assure the management of production,distribution and sale of food needed to ensure the survival and the settlement of the populations in the *** of that distribution included cereals,olive oil,wine,meat and fish,all of them representing the Mediterranean food basis of the populations from the South of the Iberian *** is about this daily concern with food distribution and consumption,in a religious and culturally tripartite society that we intend to present this article,focusing the analysis on three types of food:cereals(“bread”),meat and *** intend to demonstrate how the medieval council of Loulémanaged the production of the food and how the population was fed,using the Councillor Minutes of the LouléCity Council in the medieval Christian *** the documentation allows us to propose an interpretation for the consecrated trilogy of bread,olive oil and wine,we choose to underline three fundamental areas of the economy of the Algarve region:cattle raising and the supply of meat to the populations,the shortage of cereals with which the“bread”supply was ensured and the commercialization of *** provision of meat,cereals and fish ensured that the population was well fed,but the most interesting is that,the way the food distribution was made,allows us to understand the capacity to accept a tripartite society between“Christians”,“Moors”and“Jews”.

关键词： Mediterranean food medieval city religious scenario food production distribution.

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Interleukin-1 and TNF-α polymorphisms and Helicobacter pylori in a Brazilian Amazon population

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World Journal of Gastroenterology 2009年第12期15卷 1465-1471页

作者： Hivana Patricia Melo Barbosa luisa Caricio martins Sidney Emanuel Batista dos Santos Samia Demachki Mnica Baraúna Assumpo Charliana Damasceno Arago Tereza Cristina de Oliveira Corvelo Laboratory of Immunogenetics Federal University of Pará66075-110BelémBrazil Nucleus of Tropical Medicine Federal University of Pará66055-240BelémBrazil Laboratory of Human and Medical Genetics Federal University of Pará66075-110BelémBrazil Department of Pathology Joo de Barros Barreto Universitary HospitalFederal University of Pará66073-000BelémBrazil Department of Endoscopy Joo de Barros Barreto Universitary HospitalFederal University of Pará66073-000BelémBrazil

AIM： To study the association between Interleukin-1 （IL-1） and tumor necrosis factor （TNF）-α polymorphisms, infection by Helicobacter pylori （H pylori） and the development of gastrointestinal diseases.METHODS： Genomic DNA was extracted from the peripheral blood of 177 patients with various gastrointestinal diseases and from 100 healthy volunteers. The polymorphisms in IL-1β and TNF-α genes were analyzed using the polymerase chain reactionrestriction fragment length polymorphism method （PCRRFLP） and those from IL-1RN with PCR. The presence of infection due to H pylori and the presence of the CagA toxin were detected by serology. The histopathological parameters in the gastric biopsies of the patients were according to the Sydney classification.RESULTS： A comparison of the frequencies of the different polymorphisms studied among the patients and the control group demonstrated that the allele IL- 1RN＊2 was more frequent among patients with gastric ulcers and adenocarcinoma. Carriers of the allele IL- RN＊2 and those with reactive serology for anti-CagA IgG had a greater risk of developing peptic ulcer and gastric adenocarcinoma, as well as a higher degree of inflammation and neutrophilic activity in the gastricCONCLUSION： Our results indicate a positive association between IL-1RN gene polymorphism and infection by positive H pylori CagA strains and the development of gastric ulcers and adenocarcinoma.

关键词： Helicobacter pylori Interleukin 1β gene Interleukin-1 receptor antagonist gene TNF-α gene Cag pathogenicity island

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Helicobacter pylori in dental plaque and stomach of patients from Northern Brazil

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World Journal of Gastroenterology 2010年第24期16卷 3033-3039页

作者： Mnica Baraúna Assumpo luisa Caricio martins Hivana Patricia Melo Barbosa Katarine Antonia dos Santos Barile Sintia Silva de Almeida Paulo Pimentel Assumpo Tereza Cristina de Oliveira Corvelo Endoscopy Department Joo de Barros Barreto University Hospital Immunopathology Laboratory Nucleus of Tropical Medicine Federal University of Pará Immunogenetics Laboratory Federal University of Pará Paulo Pimentel Assumpo Surgery Department Joo de Bar-ros Barreto University Hospital

AIM: To establish whether virulence factor genes vacA and cagA are present in Helicobacter pylori (H. pylori) retrieved from gastric mucosa and dental plaque in pa-tients with dyspepsia. METHODS: Cumulative dental plaque specimens and gastric biopsies were submitted to histological exami-nation, rapid urease test and polymerase chain reac-tion (PCR) assays to detect the presence of cagA and vacA ***: Detection of H. pylori from dental plaque and gastric biopsy samples was greater by PCR com-pared to histological examination and the rapid ure-ase test. DNA from H. pylori was detected in 96% of gastric mucosa samples and in 72% of dental plaque samples. Sixty-three (89%) of 71 dental plaque sam-ples that were H. pylori-positive also exhibited identical vacA and cagA genotypes in gastric mucosa. The most common genotype was vacAs1bm1 and cagA positive, either in dental plaque or gastric mucosa. These viru-lent H. pylori isolates were involved in the severity of clinical ***: These pathogenic strains were found simultaneously in dental plaque and gastric mucosa, which suggests that gastric infection is correlated with the presence of H. pylori in the mouth.

关键词： Helicobacter pylori Gastric mucosa Dental plaque cagA vacA

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Familial Hypercholesterolemia in an Azorean Family:A Novel Mutation in the Low-Density Lipoprotein Receptor Gene

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Advances in Bioscience and Biotechnology 2014年第8期5卷 685-691页

作者： Rita Lourenco luisa martins Joao Anselmo Marina Rita Soares Ana Medeiros Mafalda Bourbon Rui Cesar Fernanda Gomes Department of Pediatrics Hospital do Divino Espírito Santo de Ponta DelgadaAzoresPortugal Department of Endocrinology Hospital do Divino Espirito Santo de Ponta DelgadaAzoresPortugal Instituto Nacional de Saúde Dr.Ricardo Jorge LisbonPortugal

Familial hypercholesterolemia (FH) is one of the most prevalent autosomal dominant inherited disorders. Mutations have been found in at least 3 genes: the low-density lipoprotein receptor (LDLR), apolipoprotein B (APOB), and proprotein convertase subtilisin/kexin type 9 (PCSK9). We report on an Azorean family with FH due to a novel mutation in the LDLR gene across three generations. The index-case was first seen at our endocrinology consultation at 12 years old, because of delayed growth and development. Laboratorial investigations revealed a complete failure of the anterior hypophysis due to a congenital malformation of the sella turcica. A total cholesterol of 313 mg/dL (90 - 190 mg/dL) and low-density lipoprotein cholesterol (LDL-C) of 262 mg/dL ( G) causing a premature termination of transcription (stop codon) was identified.

关键词： Familial Hypercholesterolemia LDL Receptor Gene Pediatric Patients Statins

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Active Alumni in Electrical Engineering Extracurricular Activities： Innovation and Social Responsibility

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Journal of Mechanics Engineering and Automation 2017年第2期7卷 107-112页

作者： Andre Bezerra de Freitas Diniz Bruna luisa martins Barbosa Dennyson Eliseu Araujo Santos, Max Rodrigues Marques Victor Matheus de Camara Silva Department of Electrical Engineering UFRN Natal Brazil

The project analyzes the student＇s participation in complementary activities such as Education Tutorial Program, Junior Company and Academic Center. These organizations have the goal to improve, expand and connect knowledge learned during classes with several practical activities. They can provide a huge integration between the students and the professors in order to achieve better results in the pedagogical, structural and organizational parts of an engineering major degree. Therefore, the project goes through the impact of each entity in the student＇s life and the advantages to professional future, focusing the presence of these organizations in the Electrical Engineering Course of Federal University of Rio Grande do Norte.

关键词： Complementary activities education tutorial program junior course academic center electrical engineering

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Treatment of spinal cord injury with biomaterials and stem cell therapy in non-human primates and humans

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Neural Regeneration Research 2025年第2期20卷 343-353页

作者： Ana Milena Silva Olaya Fernanda martins Almeida Ana Maria Blanco Martinez Suelen Adriani Marques PhD Program in Pathological Anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Biomedical Science Institute Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate Program in Pathological Anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate Program in Pathological Anatomy(PPGAP/UFRJ) Department of Neurobiology/Institute of BiologyCampus do GragoatáNiteróiRio de JaneiroBrazil

Spinal cord injury results in the loss of sensory,motor,and autonomic functions,which almost always produces permanent physical ***,in the search for more effective treatments than those already applied for years,which are not entirely efficient,researches have been able to demonstrate the potential of biological strategies using biomaterials to tissue manufacturing through bioengineering and stem cell therapy as a neuroregenerative approach,seeking to promote neuronal recovery after spinal cord *** of these strategies has been developed and meticulously evaluated in several animal models with the aim of analyzing the potential of interventions for neuronal repair and,consequently,boosting functional *** the majority of experimental research has been conducted in rodents,there is increasing recognition of the importance,and need,of evaluating the safety and efficacy of these interventions in non-human primates before moving to clinical trials involving therapies potentially promising in *** article is a literature review from databases(PubMed,Science Direct,Elsevier,Scielo,Redalyc,Cochrane,and NCBI)from 10 years ago to date,using keywords(spinal cord injury,cell therapy,non-human primates,humans,and bioengineering in spinal cord injury).From 110 retrieved articles,after two selection rounds based on inclusion and exclusion criteria,21 articles were ***,this review arises from the need to recognize the experimental therapeutic advances applied in non-human primates and even humans,aimed at deepening these strategies and identifying the advantages and influence of the results on extrapolation for clinical applicability in humans.

关键词： bioengineering biomaterials cell therapy humans non-human primates spinal cord injury stem cell therapy

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Effects of natural mineral-rich water consumption on the expression of sirtuin 1 and angiogenic factors in the erectile tissue of rats with fructose-induced metabolic syndrome

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Asian Journal of Andrology 2014年第4期16卷 631-638页

作者： Cidalia D Pereira Milton Severo luisa Rafael Maria Joao martins Delminda Neves Department of Biochemistry Faculty of Medicine University of Porto Department of Clinical Epidemiology Predictive Medicine and Public Health Faculty of Medicine University of Porto Department of Clinical Pathology Sao Joao Hospital Centre EPE Department of Experimental Biology Faculty of Medicine and Institute for Molecular and Cell Biology (IBMC) University of Porto Portugal.

Consuming a high-fructose diet induces metabolic syndrome （MS）-Iike features, including endothelial dysfunction. Erectile dysfunction is an early manifestation of endothelial dysfunction and systemic vascular disease. Because mineral deficiency intensifies the deleterious effects of fructose consumption and mineral ingestion is protective against MS, we aimed to characterize the effects of 8weeks of natural mineral-rich water consumption on the structural organization and expression of vascular growth factors and receptors on the corpus cavernosum （CC） in 10% fructose-fed Sprague-Dawley rats （FRUCT）. Differences were not observed in the organization of the CC either on the expression of vascular endothelial growth factor （VEGF） or the components of the angiopoietins/Tie2 system. However, opposing expression patterns were observed for VEGF receptors （an increase and a decrease for VEGFR1 and VEGFR2, respectively） in FRUCT animals, with these patterns being strengthened by mineral-rich water ingestion. Mineral-rich water ingestion （FRUCTMIN） increased the proportion of smooth muscle cells compared with FRUCT rats and induced an upregulatory tendency of sirtuin I expression compared with the control and FRUCT groups. Western blot results were consistent with the dual immunofluorescence evaluation. Plasma oxidized low-density lipoprotein and plasma testosterone levels were similar among the experimental groups, although a tendency for an increase in the former was observed in the FRUCTMIN group. The mineral-rich water-treated rats presented changes similar to those observed in rats treated with MS-protective polyphenol-rich beverages or subjected to energy restriction, which led us to hypothesize that the effects of mineral-rich water consumption may be more vast than those directly observed in this study.

关键词： angiopoietins erectile tissue hypersaline sodium-rich naturally sparkling mineral water receptors sirtuin 1 vascularendothelial growth factor

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Colorectal cancer screening:A review of current knowledge and progress in research

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1119-1133页

作者： Sara Ramos Lopes Claudio martins Inês Costa Santos Madalena Teixeira Élia Gamito Ana luisa Alves Department of Gastroenterology Centro Hospitalar de SetúbalSetúbal 2910-446Portugal

Colorectal cancer(CRC)is one of the most prevalent malignancies worldwide,being the third most commonly diagnosed malignancy and the second leading cause of cancer-related deaths *** the progress in screening,early diagnosis,and treatment,approximately 20%-25%of CRC patients still present with metastatic disease at the time of their initial ***,the burden of disease is still expected to increase,especially in individuals younger than 50 years old,among whom early-onset CRC incidence has been *** and early detection are pivotal to improve CRC-related *** is well established that CRC screening not only reduces incidence,but also decreases deaths from *** screening strategies have proven effective in decreasing both CRC incidence and mortality,though variations in efficacy have been reported across the ***,uncertainties persist regarding the optimal screening method,age intervals and ***,adherence to CRC screening remains globally *** recent years,emerging technologies,notably artificial intelligence,and non-invasive biomarkers,have been developed to overcome these ***,controversy exists over the actual impact of some of the new discoveries on CRC-related outcomes and how to effectively integrate them into daily *** this review,we aim to cover the current evidence surrounding CRC *** will further critically assess novel approaches under investigation,in an effort to differentiate promising inno-vations from mere novelties.

关键词： Colorectal cancer Screening Review Oncology Artificial intelligence

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Materials as activator of future global science and technology challenges

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Progress in Natural Science:Materials International 2021年第6期31卷 785-791页

作者： Rodrigo martins Full Professor at FCT-NOVA President of the International Union of Materials Research Societies President of the European Academy of Sciences

The aim of this statement is to give a contribution towards the future, where for all, materials are the driven force for the transformations we aim to reach and for which a global common house is imperative to be established, as the International Union of Materials Research Societies, IUMRS aims to be the central vehicle for such, aiming to boost innovation to its maxima, without compromising vital global principles of opening science to the *** is consolidated by 4 main principles: Circular Economy; Trans disciplinarity; Horizontal cross cutting synergy(the introduced Metro Station concept); look always to the Big Picture and not to silos. This means that the traditional vertical thematic topics that were essential to define so far, the so-called road maps for something should be revisited and reconverted towards much larger horizontal scenarios.

关键词： Materials science and engineering Green technologies and products Materials activator Materials accelerator of progress changes

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The Involvement of Lipids in Alzheimer's Disease

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Journal of Genetics and Genomics 2014年第5期41卷 261-274页

作者： Wei Ling Florence Lim Ian James martins Ralph Nigel martins School of Medical Sciences Edith Cowan University Centre of Excellence in Alzheimer's Disease Research and Care McCusker Foundation for Alzheimer's Disease Research Inc. Suite 22 Hollywood Medical Centre School of Psychiatry and Clinical Neurosciences The University of Western Australia

It has been estimated that Alzheimer＇s disease （AD）, the most common form of dementia, will affect approximately 81 million individuals by 2040. To date, the actual cause and cascade of events in the progression of this disease have not been fully determined. Furthermore, there is currently no definitive blood test or simple diagnostic method for AD. Considerable efforts have been put into proteomic approaches to develop a diagnostic blood test, but to date these efforts have not been successful. More recently, there has been a stronger focus on lipidomic studies in the hope of increasing our understanding of the underlying mechanisms leading to AD and developing an AD blood test. It is well known that the strongest genetic risk factor for AD is the e4 variant of apolipoprotein E （APOE）. Evidence suggests that the ApoE protein, a major lipid transporter, plays a key role in the pathogenesis of AD, and its role in both normal and aberrant lipid metabolism warrants further extensive investigation. Here, we review ApoE-lipid interactions, as well as the roles that lipids may play in the pathogenesis of AD.

关键词： Alzheimer's disease Lipids ApoE Oxysterols Inflammation

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