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Molecular mechanism of different viruses associated with autoimmunity

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Life Research 2022年第1期5卷 9-19页

作者： Arslan Habib Zeeshan Ashraf Irfan Ullah Khan Amjad Ali Dominic Kwesi Quainoo Sajjad Ahmad Qamar Umutumwa Eric Principe dur E Maknoon Razia Laboratory of Molecular Immunology School of Life SciencesFudan UniversityShanghaiChina Department of Fisheries and Aquaculture University of Veterinary&Animal SciencesLahorePakistan Centre of Biotechnology and Microbiology Faculty of Life SciencesUniversity of PeshawarPakistan Department of Biotechnology Faculty of BiosciencesUniversity for Development StudiesGhana Department of Zoology University of OkaraOkaraPakistan School of Biotechnology East China University of Science&TechnologyShanghaiChina Department of Biochemistry Government College University FaisalabadPakistan

Different kinds of human chronic diseases may develop the mechanism of autoimmune *** a group of disorders,in the Western world autoimmunity possess as the third most prevalent morbidity and ***,the mechanism of most autoimmune diseases is still under *** infection is the principal factor involved in the induction of autoimmune diseases other than genetic factors and cytokine *** mechanisms have been proposed by which viral infection might interrupt tolerance to self and induce autoimmune cascade which eventually leads to the destruction of a specific type of cell or a whole-body *** autoimmune attack can be understood through the different immune systems and other possible mechanisms such as molecular mimicry,bystander activation and epitope *** addition to genetic and viral factors,other environmental factors are also involved including bacterial,parasitic and fungal ***,different animal models have been studied which provide strong evidence that viruses induced AIDs as well as accelerated and increased lesions in conditions where self-tolerance is *** the current review,we discussed the virus-induced autoimmunity and the molecular mechanism which is associated with this *** we also discussed the different viruses such as rubella virus,enteroviruses,measles virus,human T-lymphotropic virus type1,human cytomegalovirus,human herpes virus-6,Epstein-Barr virus,rotavirus and some other viruses which modulate the development of AIDs.

关键词： autoimmunity viruses immune tolerance molecular mechanism

Modeling Integrated Coastal Flood Hazard in Hurricane Season

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Journal of Geoscience and Environment Protection 2021年第10期9卷 161-179页

作者： Liber Galbán Rodríguez Lázaro Rodríguez Tamayo Fernando durán Rodríguez Alexis Santiago Perez Figueredo School of Construction Department of Hydraulic Engineering Universidad de Oriente Santiago de Cuba Cuba Department of Topography José Maceo Grajales Higher Institute Santiago de Cuba Cuba School of Construction Multidisciplinary Coastal Zones Study Centre Universidad de Oriente Santiago de Cuba Cuba

The manuscript proposed a procedure designed to determine the hazard of total coastal flooding during the impact of hurricanes, which uses in its formulation the combination of river flooding and that caused by marine upwelling, which n>n>isn>n> multiplied by a density factor of the water that finds an explanation for the effect is shielding and rising of the water level when the currents of both floods collide in the coastal zone. The application of the procedure experimentally in the coastal sector Sevilla, of the municipality Guama province Santiago de Cuba, resultn>n>ingn>n> in the confirmation of areas previously modeled and estimated coastal flooding in the wake of extreme wean style="font-family:Verdana;">ther events in the study area;in addition to other new areas that confirm the actual visual and instrumental observations not included in previous studies.

关键词： Coastal Flood Hurricane Modeling Density Factor GIS Santiago De Cuba

Improved degradation of azo dyes by lignin peroxidase following mutagenesis at two sites near the catalytic pocket and the application of peroxidase-coated yeast cell walls

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Frontiers of Environmental Science & Engineering 2021年第2期15卷 33-42页

作者： Karla IlićĐurđić Raluca Ostafe Olivera Prodanović AleksandraĐurđevićĐelmaš nikolina Popović Rainer Fischer Stefan Schillberg Radivoje Prodanović University of Belgrade-Faculty of Chemistry Studentski trg 12-1611000 BelgradeSerbia Molecular Evolution Protein Engineering and Production facility(MEPEP) Purdue UniversityWest LafayetteIN 47907USA Institute of Molecular Biotechnology RWTH Aachen University52074 AachenGermany Institute for Multidisciplinary Research Kneza Višeslava 111030 BelgradeSerbia Departments of Biological Sciences and Chemistry Purdue UniversityWest LafayetteIN 47907USA Fraunhofer Institute for Molecular Biology and Applied Ecology IME 52074 AachenGermany

The enzymatic degradation of azo dyes is a promising alternative to ineffective chemical and physical remediation *** peroxidase(LiP)from Phanerochaete chrysosporium is a hemecontaining lignin-degrading oxidoreductase that catalyzes the peroxide-dependent oxidation of diverse molecules,including industrial *** enzyme is therefore ideal as a starting point for protein ***,we subjected two positions(165 and 264)in the environment of the catalytic Trp171 residue to saturation mutagenesis,and the resulting library of 104 independent clones was expressed on the surface of yeast *** yeast display library was used for the selection of variants with the ability to break down structurally-distinct azo dyes more *** identified mutants with up to 10-fold greater affinity than wild-type LiP for three diverse azo dyes(Evans blue,amido black 10B and Guinea green)and up to 13-fold higher catalytic ***,cell wall fragments displaying mutant LiP enzymes were prepared by toluene-induced cell lysis,achieving significant increases in both enzyme activity and stability compared to a whole-cell *** cell wall fragments retained their initial dye degradation activity after 10 reaction cycles each lasting 8 *** best-performing mutants removed up to 2.5-fold more of each dye than the wild-type LiP in multiple reaction cycles.

关键词： Bioremediation Enzyme immobilization Protein engineering Yeast surface display

Anti-porcine circovirus type 2(PCV2) antibody placental barrier leakage from sow to fetus: impact on the diagnosis of intra-uterine PCV2 infection

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Virologica Sinica 2014年第2期29卷 136-138页

作者： Dipongkor Saha Rubén Del Pozo Sacristán nicolaas Van Renne Liping Huang Ruben Decaluwe Annelies Michiels Alfonso Lopez Rodriguez Maria José Rodrí-guez Margarita García durán Ilse Declerk Dominiek Maes Hans J. nauwynck Laboratory of Virology Faculty of Veterinary Medicine Ghent University Brain Tumor Research Center Department of Molecular Neurosurgery Harvard Medical School and Massachusetts General Hospital Department of Obstetrics Reproduction and Herd Health Faculty of Veterinary Medicine Ghent University Ingenasa Hermanos García Noblejas

Dear Editor,Fetuses develop antibodies when they are infectedwith porcine circovirus type 2(PCV2).At abortion orbirth,both PCV2 and/or anti-PCV2 antibodies can thenbe *** anti-PCV2 antibodies in aborted fe-tuses or stillborn piglets is generally used as evidence ofan intra-uterine PCV2 ***,a recent anal-ysis of fetuses sent in for PCV2 diagnosis and caesare-an-derived,colostrum-deprived pigs revealed that

关键词：猪圆环病毒2型 PCV2 流产胎儿胎盘屏障母猪感染子宫诊断

Epigenetic mechanisms in non-alcoholic fatty liver disease:An emerging field

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World Journal of Hepatology 2015年第24期7卷 2497-2502页

作者： Rocío Gallego-durán Manuel Romero-Gómez Inter-Centre Unit of Digestive Diseases and CIBERehd Virgen Macarena-Virgen del Rocío University Hospitals Instituto de Biomedicina de Sevilla University of Sevilla

non-alcoholic fatty liver disease(nAFLD) is an emerging health concern in both developed and non-developed world, encompassing from simple steatosis to nonalcoholic steatohepatitis(nASH), cirrhosis and liver cancer. Incidence and prevalence of this disease are increasing due to the socioeconomic transition and change to harmful diet. Currently, gold standard method in nAFLD diagnosis is liver biopsy, despite complications and lack of accuracy due to sampling error. Further, pathogenesis of nAFLD is not fully understood, but is well-known that obesity, diabetes and metabolic derangements played a major role in disease development and progression. Besides, gut microbioma and host genetic and epigenetic background could explain considerable interindividual variability. Knowledge that epigenetics, heritable events not caused by changes in DnA sequence, contribute to development of diseases has been a revolution in the last few years. Recently, evidences are accumulating revealing the important role of epigenetics in nAFLD pathogenesis and in nASH genesis. Histone modifications, changes in DnA methylation and aberrant profiles or micro RnAs could boost development of nAFLD and transition into clinical relevant status. PnPLA3 genotype GG has been associated with a more progressive disease and epigenetics could modulate this effect. The impact of epigenetic on nAFLD progression could deserve further applications on therapeutic targets together with future non-invasive methods useful for the diagnosis and staging of nAFLD.

关键词： non-alcoholic steatohepatitis Epigenetics Diagnosi

Role of Electromagnetic Stimulation in the Treatment of Osteonecrosis of the Femoral Head in Early Stages

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Journal of Biomedical Science and Engineering 2014年第5期7卷 252-257页

作者： Juan L. Cebrián Guillermo L. Milano Alberto Francés Yaiza Lopiz Fernando Marco Luis López-durán Department of Orthopaedic Surgery Hospital Clínico San Carlos Madrid Spain

Osteonecrosis of the femoral head is a disorder that leads to collapse and osteoarthritis in young patients. This study examines the effectiveness of pulsed electromagnetic fields [PEMF] in the treatment of osteonecrosis of the head in precollapse bone stages. A retrospective evaluation was done of 51 patients including 70 hips with symptomatic osteonecrosis of the hip treated with pulsed electromagnetic fields. Criteria for inclusion in the study group were evidence of osteonecrosis and absence of collapse of the femoral head. The average follow-up was 26 months (range, 18 - 90). Etiologies included idiopathic (40 cases), steroid use (26) and alcohol (4). To demonstrate the existence of osteonecrosis and its evolution, magnetic resonance imaging [MRI] and plain radiography techniques were used. Results: Procedures were radiological success in 80% of cases, and no progression to collapse in 88.57% of hips. Eight of the 70 hips had radiographic progression to collapse. This study suggests that selected PEMF reduce the incidence of progression of osteonecrosis of femoral head in early stage.

关键词： Osteonecrosis Collapse Pulsed Electromagnetic Fields Magnetic Resonance Imaging

Solvent- and Catalyst-Free Microwave-Assisted Decarboxylation of Malonic Acid Derivatives

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Green and Sustainable Chemistry 2017年第4期7卷 270-280页

作者： Fanny Araceli Cabrera-Rivera Luis Gabriel Hernández-Vázquez Patricia Flores-Sánchez Maria durán-Galván Jaime Escalante The Center of Chemical Research UAEM Cuernavaca México SIGnA Civac S. A. de C. V. Jiutepec México

It has been found that microwave assisted decarboxylation of malonic acid derivatives can be achieved under solvent-free and catalyst free conditions. This new method produces the corresponding carboxylic acid in a pure manner and with a high yield in a very short reaction time: 3 - 10 min. In general terms, the condition under which this reaction is carried out accelerates the decarboxylation significantly of a series of disubstituted malonic acid derivatives, and makes this new process efficient, easy and environmentally friendly.

关键词： Microwave Decarboxylation Malonic Acid Derivatives Solvent-Free Catalyst-Free Green Chemistry

A Synopsis of Pterostemon (Iteaceae), a Group Endemic to Mexico

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American Journal of Plant Sciences 2013年第12期4卷 1-9页

作者： Judith Márquez Guzmán Martha Martínez Gordillo Ramiro Cruz durán Jaime Jiménez Ramírez María Cristina Pérez-Amador Departamento de Biología Comparada Facultad de Ciencias Universidad Nacional Autónoma de México México D.F. México Laboratorio de Desarrollo en Plantas Facultad de Ciencias Universidad Nacional Autónoma de México México D. F. México Laboratorio de Química Facultad de Ciencias Universidad Nacional Autónoma de México México D. F. México

The genus Pterostemon Schauer (Iteaceae), is a group of three species restricted in distribution to Mexico. It includes: Pterostemon mexicanus Schauer, P. rotundifolius Ramírez, and P. bravoanus J. Jiménez-Ram. & Martínez Gordillo. On the basis of field observations and herbarium specimens, we review the morphology (vegetative and reproductive), and distribution to give an updated taxonomic treatment for the genus. Additionally the utility of morphological characters is evaluated for taxomic use, and detailed taxonomic descriptions and ecological associations are given for each species.

关键词： Endemic Mexico Pterostemon Iteaceae

The Social Conditions in the Genesis of Preeclampsia

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Open Journal of Epidemiology 2014年第3期4卷 115-121页

作者： Jaime Salvador-Moysén Yolanda Martínez-López José M. Ramírez-Aranda Marisela Aguilar-durán Miguel A. Reyes-Romero Department of Family Medicine University Hospital Dr. José Eleuterio González Universidad Autónoma de Nuevo León Monterrey México Faculty of Medicine and nutrition Universidad Juárezdel Estado de Durango Durango México Scientific Research Institute Universidad Juárez del Estado de Durango Durango México

This article highlights the importance of preeclampsia as a global public health problem and the lack of a satisfactory model to explain its genesis. Scientific advances relevant to the placental pathophysiology, which have resulted in a deeper understanding of the immunological mechanisms associated to preeclampsia and have been translated into better treatment options, are also highlighted, although to date these approaches cannot explain the origin of the disease. From a theoretical approach underpinned by the concepts related to the social determinants of the health, and specifically from current psychosocial epidemiology, an alternative approach that gives account for the genesis of preeclampsia is proposed. The proposal is based in the scientific literature as well as in the work of the authors;it takes as references unfavorable socioeconomic and psychosocial conditions in pregnant women, linking these conditions to a series of failed adaptive biological processes closely related to an ineffective allostatic response by the body, which ultimately determines the occurrence of the disease.

关键词： Preeclampsia Psychosocial Epidemiology Social Inequality Allostasis neighborhood