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A chip-scale second-harmonic source via self-injection-locked all-optical poling

Light(Science & Applications) 2023年第12期12卷 2778-2787页

作者： Marco Clementi Edgars nitiss Junqiu Liu Elena durán-Valdeiglesias Sofiane Belahsene Hélène Debrégeas Tobias JKippenberg Camille-Sophie Brès Photonic Systems Laboratory(PHOSL) École Polytechnique Fédérale de Lausanne1015 LausanneSwitzerland Laboratory of Photonics and Quantum Measurements(LPQM) École Polytechnique Fédérale de Lausanne1015 LausanneSwitzerland Almae Technologies Route de Nozay91460 MarcoussisFrance

Second-harmonic generation allows for coherently bridging distant regions of the optical spectrum,with applications ranging from laser technology to self-referencing of frequency ***,accessing the nonlinear response of a medium typically requires high-power bulk sources,specific nonlinear crystals,and complex optical setups,hindering the path toward large-scale *** we address all of these issues by engineering a chip-scale second-harmonic(SH)source based on the frequency doubling of a semiconductor laser self-injection-locked to a silicon nitride *** injection-locking mechanism,combined with a high-Q microresonator,results in an ultra-narrow intrinsic linewidth at the fundamental harmonic frequency as small as 41 *** to the extreme resonant field enhancement,quasi-phase-matched second-order nonlinearity is photoinduced through the coherent photogalvanic effect and the high coherence is mapped on the generated SH *** show how such optical poling technique can be engineered to provide efficient SH generation across the whole C and L telecom bands,in a reconfigurable fashion,overcoming the need for poling *** device operates with milliwatt-level pumping and outputs SH power exceeding 2 mW,for an efficiency as high as 280%/W under electrical *** findings suggest that standalone,highly-coherent,and efficient SH sources can be integrated in current silicon nitride photonics,unlocking the potential of x(2)processes in the next generation of integrated photonic devices.

关键词： resonator harmonic injection

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Site-directed cysteine coupling of disulfide-containing non-antibody carrier proteins(THIOCAPs)

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Science China Materials 2023年第10期66卷 4109-4120页

作者： Ariana Rueda Julian I.Mendoza Lorena Alba-Castellon Eloi Parladé Eric Voltà-durán David Paez Anna Avino Ramon Eritja Esther Vázquez Antonio Villaverde Ramón Mangues Ugutz Unzueta Institut d'Investigació Biomèdica Sant Pau(IIB Sant Pau) Sant Quintí 77-7908041 BarcelonaSpain Josep Carreras Leukaemia Research Institute(IJC Campus Sant Pau) 08041 BarcelonaSpain CIBER de Bioingeniería Biomateriales y NanomedicinaInstituto de Salud Carlos Ⅲ28029 MadridSpain Institut de Biotecnologia i de Biomedicina Universitat Autònoma de Barcelona08193 BellaterraSpain Departament de Genètica i de Microbiologia Universitat Autònoma de Barcelona08193 BellaterraSpain Department of Medical Oncology Hospital de la Santa Creu i Sant Pau.Barcelona08025 BarcelonaSpain CIBER de Enfermedades Raras(CIBERER) Instituto de Salud Carlos Ⅲ28029 MadridSpain Institute for Advanced Chemistry of Catalonia(IQAC) CSIC08034 BarcelonaSpain

The development of a new generation of nonantibody protein drug delivery systems requires site-directed conjugation strategies to produce homogeneous,reproducible and scalable *** that,the genetic addition of cysteine residues into solvent-exposed positions allows the thiol-mediated cysteine coupling of therapeutic drugs into protein-based ***,the high reactivity of unpaired cysteine residues usually reduces protein stability,consequently imposing the use of more methodologically demanding purification *** is especially relevant for disulfide-containing nanocarriers,as previously observed in ***,although many protein scaffolds and targeting ligands are also rich in disulfide bridges,the use of these methodologies over emerging non-antibody carrier proteins has been completely ***,we report the development of a simple and straightforward procedure for a onestep production and site-directed cysteine conjugation of disulfide-containing non-antibody thiolated carrier proteins(THIOCAPs).This method is validated in a fluorescent C-X-C chemokine receptor 4(CXCR4)-targeted multivalent nanocarrier containing two intramolecular disulfide bridges and one reactive cysteine residue strategically placed into a solvent-exposed position(THIO-T22-GFP-H6)for drug conjugation and in a humanized alternative intended for clinical applications(T22-HSnBT-H6).Thus,we produce very stable,homogeneous and fully functional antitumoral nanoconjugates(THIO-T22-GFP-H6-MMAE and T22-HSnBT-H6-MMAE)that selectively eliminate target cancer cells via ***,the developed methodology appears as a powerful tool for the rational engineering of emerging non-antibody,cell-targeted protein nanocarriers that contain disulfide bridges together with a solvent-exposed reactive cysteine(THIOCAP).This should pave the way for the development of a new generation of stable,homogeneous and efficient nanomedicines.

关键词： disulfide directed bridges

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COVID‑19 and tourism sector stock price in Spain:medium‑term relationship through dynamic regression models

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Financial Innovation 2023年第1期9卷 257-280页

作者： Isabel Carrillo‑Hidalgo Juan Ignacio Pulido‑Fernández JoséLuis durán‑Román Jairo Casado‑Montilla Laboratory of Analysis and Innovation in Tourism University of JaénParaje Las Lagunillas S/ND3‑13423071 JaénSpain Laboratory of Analysis and Innovation in Tourism University of JaénParaje Las Lagunillas S/ND3‑27323071 JaénSpain Laboratory of Analysis and Innovation in Tourism University of JaénParaje Las Lagunillas S/ND3‑21723071 JaénSpain

The global pandemic,coronavirus disease 2019(COVID-19),has significantly affected tourism,especially in Spain,as it was among the first countries to be affected by the pandemic and is among the world’s biggest tourist *** market values are responding to the evolution of the pandemic,especially in the case of tourist ***,being able to quantify this relationship allows us to predict the effect of the pandemic on shares in the tourism sector,thereby improving the response to the crisis by policymakers and ***,a dynamic regression model was developed to predict the behavior of shares in the Spanish tourism sector according to the evolution of the COVID-19 pandemic in the medium *** has been confirmed that both the number of deaths and cases are good predictors of abnormal stock prices in the tourism sector.

关键词： COVID-19 Stock exchange Tourism stock Dynamic regression models Spain

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An Algorithm to Reduce Compression Ratio in Multimedia Applications

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Computers, Materials & Continua 2023年第1期74卷 539-557页

作者： dur-e-Jabeen Tahmina Khan Rumaisa Iftikhar Ali Akbar Siddique Samiya Asghar Department of Electronic Engineering Sir Syed University of Engineering&TechnologyKarachiPakistan Department of Information&Computer Science Sir Syed University of Engineering&TechnologyKarachiPakistan

In recent years,it has been evident that internet is the most effective means of transmitting information in the form of documents,photographs,or videos around the *** purpose of an image compression method is to encode a picture with fewer bits while retaining the decompressed image’s visual *** transmission,this massive data necessitates a lot of channel *** order to overcome this problem,an effective visual compression approach is required to resize this large amount of *** work is based on lossy image compression and is offered for static color *** quantization procedure determines the compressed data quality *** images are converted from RGB to International Commission on Illumination CIE La^(∗)b^(∗);and YCbCr color spaces before being *** the transform domain,the color planes are encoded using the proposed quantization *** improve the efficiency and quality of the compressed image,the standard quantization matrix is updated with the respective image *** used seven discrete orthogonal transforms,including five variations of the Complex Hadamard Transform,Discrete Fourier Transform and Discrete Cosine Transform,as well as thresholding,quantization,de-quantization and inverse discrete orthogonal transforms with CIE La^(∗)b^(∗);and YCbCr to RGB *** to signal noise ratio,signal to noise ratio,picture similarity index and compression ratio are all used to assess the quality of compressed *** the relevant transforms,the image size and bits per pixel are also *** the(n,n)block of transform,adaptive scanning is used to acquire the best feasible compression *** of these characteristics,multimedia systems and services have a wide range of possible applications.

关键词： Color image compression color spaces discrete orthogonal transforms(DOTs) peak-to-signal noise ratio(PSnR) similarity index

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Stem cell-based approaches: Possible route to hearing restoration?

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World Journal of Stem Cells 2020年第6期12卷 422-437页

作者： María Beatriz durán-Alonso Institute of Biology and Molecular Genetics University of ValladolidValladolid 47003Spain

Disabling hearing loss is the most common sensorineural disability *** affects around 466 million people and its incidence is expected to rise to around 900 million people by 2050,according to World Health Organization *** cases of hearing impairment are due to the degeneration of hair cells(HCs)in the cochlea,mechano-receptors that transduce incoming sound information into electrical signals that are sent to the *** to these cells is mainly caused by exposure to aminoglycoside antibiotics and to some anti-cancer drugs such as cisplatin,loud sounds,age,infections and genetic *** deficits may also result from damage to the spiral ganglion neurons that innervate cochlear *** from what is observed in avian and nonmammalian species,there is no regeneration of missing sensory cell types in the adult mammalian cochlea,what makes hearing loss an irreversible *** review summarizes the research that has been conducted with the aim of developing cell-based strategies that lead to sensory cell replacement in the adult cochlea and,ultimately,to hearing *** main lines of research are discussed,one directed toward the transplantation of exogenous replacement cells into the damaged tissue,and another that aims at reactivating the regenerative potential of putative progenitor cells in the adult inner *** from some of the studies that have been conducted are presented and the advantages and drawbacks of the various approaches discussed.

关键词： Hearing loss Cochlear hair cells Spiral ganglion neurons Cell regeneration Adult stem cells Cell transplantation

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Do plant histone variants stand idly by while DnA viruses invade the nucleus?

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Stress Biology 2023年第1期3卷 507-510页

作者： Zhihao Jiang Rosa Lozano-durán Department of Plant Biochemistry Center for Molecular Plant Biology(ZMBP)Eberhard-Karls University of TübingenTübingenGermany

Main text,In the eukaryotic nucleus,the cellular DnA is always wrapped around protein octamers containing two molecules each of histone H2A,H2B,H3,and H4,forming the nucleosome to compact,protect,organize,and control the *** histone H1 binds to DnA at the entry and exit sites of the core *** n-terminal tails of these histones protrude from the nucleosomes and are the sites of various post-translational modifications,such as methylation,acetylation,phosphorylation,and ubiquitination,all of which jointly modulate gene expression,DnA replication,and DnA repair,among other processes(Foroozani et al.2022).

关键词： DnA nucleosome plant

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The spectrum of building block conformers sustains the biophysical properties of clinically-oriented self-assembling protein nanoparticles

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Science China Materials 2022年第6期65卷 1662-1670页

作者： Eric Voltà-durán Julieta M Sánchez Hèctor-López-Laguna Eloi Parladé Laura Sánchez-García Alejandro Sánchez-Chardi Ario de Marco Ugutz Unzueta Esther Vázquez Antonio Villaverde Institut de Biotecnologia i de Biomedicina Universitat Autònoma de BarcelonaBellaterra 08193BarcelonaSpain Departament de Genètica i de Microbiologia Universitat Autònoma de BarcelonaBellaterra 08193BarcelonaSpain CIBER de Bioingeniería Biomateriales y nanomedicina(CIBER-BBn) Bellaterra 08193BarcelonaSpain Instituto de Investigaciones Biológicas y Tecnológicas(IIBYT)(COnICET-Universidad nacional de Córdoba) ICTA&Cátedra de Química BiológicaDepartamento de QuímicaFCEFyNUNC.Av.Velez Sarsfield 1611X 5016GCA CórdobaArgentina Servei de Microscòpia Universitat Autònoma de BarcelonaBellaterra 08193BarcelonaSpain Departament de Biologia Evolutiva Ecologia i Ciències AmbientalsFacultat de BiologiaUniversitat de Barcelona08028 BarcelonaSpain Laboratory for Environmental and Life Sciences University of Nova GoricaNova Gorica 5000Slovenia Biomedical Research Institute Sant Pau(IIB Sant Pau) Sant Antoni Ma Claret 16708025 BarcelonaSpain

Histidine-rich peptides confer self-assembling properties to recombinant proteins through the supramolecular coordination with divalent *** fact allows the cost-effective,large-scale generation of microscopic and macroscopic protein materials with intriguing biomedical *** such materials,resulting from the simple bioproduction of protein building blocks,homomeric nanoparticles are of special value as multivalent interactors and drug ***,we have here identified that the assembly of a given His-tagged protein might render distinguishable categories of self-assembling protein *** fact has been scrutinized through the nanobody-containing fusion proteins EM1-GFP-H6 and A3C8-GFP-H6,whose biosynthesis results in two distinguishable populations of building *** one of them,the assembling and disassembling is controllable by ***,a second population immediately self-assembles upon purification through a non-regulatable pathway,rendering larger nanoparticles with specific biological *** structural analyses of both model proteins and nanoparticles revealed important conformational variability in the building *** fact renders different structural and functional categories of the final soft materials resulting from the participation of energetically unstable intermediates in the oligomerization *** data illustrate the complexity of the Hismediated protein assembling in recombinant proteins but they also offer clues for a better design and refinement of protein-based nanomedicines,which,resulting from biological fabrication,show an architectonic flexibility unusual among biomaterials.

关键词： recombinant proteins self-assembling protein materials nanoparticles biomaterials

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The influence of CEO’s financial literacy on SMEs technological innovation:the mediating effects of MCS and risk‑taking

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Financial Innovation 2023年第1期9卷 371-396页

作者： Antonio duréndez Julio Dieguez‑Soto Antonia Madrid‑Guijarro Department of Economics Accounting and FinanceUniversidad Politécnica de CartagenaCalle Real330201 CartagenaSpain Finance and Accounting Department Universidad de MálagaCalle El Ejido29071 MalagaSpain Cátedra de Emprendimiento Santander‑UPCT Department of EconomicsAccounting and FinanceUniversidad Politécnica de CartagenaCalle Real330201 CartagenaSpain

Previous literature showed mixed results about the impact of CEOs’financial literacy(CFL)on small and medium-sized enterprises’(SMEs)*** relationship can be motivated by relevant variables,which are missing in the previous literature and make a difference as *** this sense,based on the theoretical framework related to upper echelon theory and resource-based view,this study focuses on the mediating effect of risk-taking attitude and management control systems(MCS)*** data from 310 SMEs gathered using a qualitative research questionnaire are analyzed using structural equation modeling ***,estimations are carried out considering the partial least square *** show that MCS and managers’risk attitudes fully mediate the relationship between financial literacy(FL)and *** these two mediating variables,the implementation of MCS stands out because it also enables the mediating effect of CEOs’risk-taking in the CFL–technological innovation *** the results do not support the significant direct relationship between FL and risk attitude,they confirm an indirect effect through ***,based on the study findings,SMEs’directors and owners,business associations,and public authorities can improve SMEs’technological innovation by implementing training programs and policies to foster *** can also acknowledge the interdependency between organizational factors and individual characteristics to enhance SMEs’technological innovation.

关键词： Financial literacy Technological innovation Small and medium-sized enterprises Risk-taking Management control systems

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基于CML的级联失效下异质多层交通网络节点抵抗特性研究

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中国公路学报 2022年第1期35卷 263-274页

作者：王秋玲朱璋元陈红孙健官文英 RIVERA-durón R R 长安大学运输工程学院陕西西安710064 长安大学未来交通学院陕西西安710064 西北工业大学无人系统技术研究院陕西西安710072

为了有效刻画拟合实际的多层交通网络级联失效过程,识别多层网络中对整体韧性安全影响显著的对象,提升交通网络抵抗失效的能力,建立一种基于耦合映象格子(Coupled Map Lattice, CML)的级联失效模型。首先,将交通管控措施赋予交通网络节... 详细信息

为了有效刻画拟合实际的多层交通网络级联失效过程,识别多层网络中对整体韧性安全影响显著的对象,提升交通网络抵抗失效的能力,建立一种基于耦合映象格子(Coupled Map Lattice, CML)的级联失效模型。首先,将交通管控措施赋予交通网络节点额外的容纳能力引申为节点抵抗特性,通过为CML添加抵抗参数H,形成考虑抵抗特性的级联失效(HCML)模型,沿常值-拓扑关联-时变拓扑关联的路径深化H的表征方式,并在小世界(Small World, SW)网络上对比3类表征方式的优劣;其次,应用Space H方法建立异质3层公共交通网络,对比度值与介数2种时变拓扑指标关联的抵抗效果,探究不同交通层抵抗系数对网络失效的影响程度;最后,在6组不同的网络结构上进行HCML模型与传统模型的对比,讨论建网方法、网络规模等不同网络性质的差异对模型有效性的影响,并结合实际客运数据验证HCML模型优越性。研究结果表明:3类表征方式中时变拓扑关联可以兼顾其余2类的优点;同等条件中网络在介数关联的抵抗特性作用下失效增速更缓,模型识别得到的对网络整体失效影响更大交通方式符合客流量实际;HCML模型在多种不同类型的多层交通网络中均可以有效实施,相比于传统模型,HCML模型的最终失效比例平均下降了5.78%,与实际交通级联失效过程更加拟合。

关键词：交通工程级联失效耦合映象格子多层交通网络抵抗特性异质性

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Short-term outcomes of robotic liver resection: An initial singleinstitution experience

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World Journal of Hepatology 2022年第1期14卷 224-233页

作者： Manuel durán Javier Briceño Ana Padial Ferdinando Massimiliano Anelli Juan Manuel Sánchez-Hidalgo María Dolores Ayllón Rafael Calleja-Lozano Carmen García-Gaitan Unit of Hepatobiliary Surgery and Liver Transplantation General and Digestive Surgery DepartmentReina Sofia University HospitalCordoba 14004Spain GC18 Translational Research in Surgery of Solid Organ Transplantation Maimonides Biomedical Research InstituteCórdoba 14004Spain GE09 Research in Peritoneal and Retroperitoneal Oncological Surgery Maimonides Biomedical Research InstituteCórdoba 14004Spain Department of Anesthesiology and Resuscitation Reina Sofia University HospitalCordoba 14004Spain

BACKGROUnD Liver surgery has traditionally been characterized by the complexity of its procedures and potentially high rates of morbidity and mortality in inexperienced *** robotic approach has gradually been introduced in liver surgery and has increased notably in recent ***,few centers currently perform robotic liver surgery and experiences in robot-assisted surgical procedures continue to be limited compared to the laparoscopic *** To analyze the outcomes and feasibility of an initial robotic liver program implemented in an experienced laparoscopic hepatobiliary *** A total of forty consecutive patients underwent robotic liver resection(da Vinci Xi,***,United States)between June 2019 and January *** were prospectively followed and retrospectively *** characteristics and perioperative and short-term outcomes were *** are expressed as mean and standard *** study was approved by the Institutional Review *** The mean age of patients was 59.55 years,of which 18(45%)were *** mean body mass index was 29.41 kg/m^(2).nine patients(22.5%)were *** were divided by type of resection as follows:Ten segmentectomies,three wedge resections,ten left lateral sectionectomies,six bisegmentectomies(two VVI bisegmentectomies and four IVb-V bisegmentectomies),two right anterior sectionectomies,five left hepatectomies and two right *** lesions occurred in twenty-nine(72.5%)of the *** mean operative time was 258.11 min and two patients were transfused intraoperatively(5%).Inflow occlusion was used in thirty cases(75%)and the mean total clamping time was 32.62 *** was a single conversion due to uncontrollable *** postoperative complications(Clavien–Dindo>Ⅲb)occurred in three patients(7.5%)and mortality in one(2.5%).no patient required readmission to the *** mean hospital stay was 5.6 *** Althou

关键词： Robotics Hepatectomy Minimally invasive surgery Liver surgery Da vinci

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