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Explicit Estimates for Solutions of Nonlinear Radiation-type Problems

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Acta Mathematica Sinica,English Series 2015年第7期31卷 1123-1140页

作者： luisa consiglieri Independent Researcher Professor

We establish the existence of weak solutions of a nonlinear radiation-type boundary value problem for elliptic equation on divergence form with discontinuous leading coefficient. Quantitative estimates play a crucial role on the real applications. Our objective is the derivation of explicit expres- sions of the involved constants in the quantitative estimates, the so-called absolute or universal bounds. The dependence on the leading coefficient and on the size of the spatial domain is precise. This work shows that the expressions of those constants are not so elegant as we might expect.

关键词： Elliptic equation estimate regularity radiation-type boundary condition

Existence for a Class of Non-Newtonian Fluids with a Nonlocal Friction Boundary Condition

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Acta Mathematica Sinica,English Series 2006年第2期22卷 523-534页

作者： L.consiglieri Department of Mathematics and CMAF Sciences Faculty of University of Lisbon 1749-016 Lisboa Portugal

We deal with a variational inequality describing the motion of incompressible fluids, whose viscous stress tensors belong to the subdifferential of a functional at the point given by the symmetric part of the velocity gradient, with a nonlocal friction condition on a part of the boundary obtained by a generalized mollification of the stresses. We establish an existence result of a solution to the nonlocal friction problem for this class of non-Newtonian flows. The result is based on the Faedo-Galerkin and Moreau Yosida methods, the duality theory of convex analysis and the Tychonov-Kakutani-Glicksberg fixed point theorem for multi-valued mappings in an appropriate functional space framework.

关键词： Non-Newtonian fluids Coulomb and nonlocal friction

Remotely Activated Nanoparticles for Anticancer Therapy

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Nano-Micro Letters 2021年第1期13卷 174-207页

作者： luisa Racca Valentina Cauda Department of Applied Science and Technology Politecnico di TorinoC.so Duca degli Abruzzi 2410129 TurinItaly

Cancer has nowadays become one of the leading causes of death *** anticancer approaches are associated with different ***,innovative methodologies are being investigated,and several researchers propose the use of remotely activated nanoparticles to trigger cancer cell *** idea is to conjugate two different components,i.e.,an external physical input and *** are given in a harmless dose that once combined together act synergistically to therapeutically treat the cell or tissue of interest,thus also limiting the negative outcomes for the surrounding *** both the properties of the nanomaterial and the involved triggering stimulus,it is possible furthermore to achieve not only a therapeutic effect,but also a powerful platform for imaging at the same time,obtaining a nano-theranostic *** the present review,we highlight the role of nanoparticles as therapeutic or theranostic tools,thus excluding the cases where a molecular drug is *** thus present many examples where the highly cytotoxic power only derives from the active interaction between different physical inputs and *** perform a special focus on mechanical waves responding nanoparticles,in which remotely activated nanoparticles directly become therapeutic agents without the need of the administration of chemotherapeutics or sonosensitizing drugs.

关键词： Anticancer therapy Remotely activated nanomedicine Stimuli-responsive nanoparticles Physical stimulation Radiofrequency Nanoparticle-assisted ultrasound Hyperthermia

Punching of reinforced concrete slab without shear reinforcement: Standard models and new proposal

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Frontiers of Structural and Civil Engineering 2020年第5期14卷 1196-1214页

作者： luisa PANI Flavio STOCHINO Department of Civil Environmental Engineering and ArchitectureUniversity of CagliariCagliari 09123Italy

Reinforced concrete(RC)slabs are characterized by reduced construction time,versatility,and easier space *** structural behavior is not straightforward and,specifically,punching shear strength is a current research *** this study an experimental database of 113 RC slabs without shear reinforcement under punching loads was compiled using data available in the literature.A sensitivity analysis of the parameters involved in the punching shear strength assessment was conducted,which highlighted the importance of the flexural reinforcement that are not typically considered for punching shear *** a discussion of the current international standards,a new proposed model for punching shear strength and rotation of RC slabs without shear reinforcement was *** was based on a simplified load-rotation curve and new failure criteria that takes into account the flexural reinforcement *** experimental database was used to validate the approaches of the current international standards as well as the new proposed *** latter proved to be a potentially useful design tool.

关键词： punching shear strength reinforced concrete slabs reinforcement ratio

The importance of trans-generational effects in Lepidoptera

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Current Zoology 2016年第5期62卷 489-499页

作者： luisa WOESTMANN Marjo SAASTAMOINEN Metapopulation Research Centre Department of Biosciences University of Helsinki Finland

The importance of trans-generational effects in shaping an individuals＇ phenotype and fitness, and consequently even impacting population dynamics is increasingly apparent. Most of the research on trans-generational effects still focuses on plants, mammals, and birds. In the past few years, however, increasing number of studies, especially on maternal effects, have highlighted their im- portance also in many insect systems. Lepidoptera, specifically butterflies, have been used as model systems for studying the role of phenotypic plasticity within generations. As ectotherms, they are highly sensitive to environmental variation, and indeed many butterflies show adaptive phenotypic plasticity in response to environmental conditions. Here, we synthesize what is known about trans-generational effects in Lepidoptera, compile evidence for different environmental cues that are important drivers of trans-generational effects, and point out which offspring traits are mainly impacted. Finally, we emphasize directions for future research that are needed for better understanding of the adaptive nature of trans-generational effects in Lepidoptera in particular, but potentially also in other organisms.

关键词： butterfly maternal effect moth offspring quality paternal effect plasticity.

Genetic Identification of Quantitative Trait Loci for Contents of Mineral Nutrients in Rice Grain

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Journal of Integrative Plant Biology 2009年第1期51卷 84-92页

作者： Ana luisa Garcia-Oliveira Department of Plant Genetics and Breeding and State Key Laboratory of Plant Physiology and Biochemistry China Agricultural University National Centre for Evaluation of Agricultural Wild Plant Rice Beijing Key Laboratory of Crop Genetic Improvement and Genome of Ministry of Agriculture

In present study, Fe, Zn, Mn, Cu, Ca, Mg, P and K contents of 85 introgression lines （ILs） derived from a cross between an elite indica cultivar Teqing and the wild rice （Oryza rufipogon） were measured by inductively coupled argon plasma （ICAP） spectrometry. Substantial variation was observed for all traits and most of the mineral elements were significantly positive correlated or independent except for Fe with Cu. A total of 31 putative quantitative trait loci （QTLs） were detected for these eight mineral elements by single point analysis. Wild rice （O. rufipogon） contributed favorable alleles for most of the QTLs （26 QTLs）, and chromosomes 1,9 and 12 exhibited 14 QTLs （45%） for these traits. One major effect of QTL for zinc content accounted for the largest proportion of phenotypic variation （11%-19%） was detected near the simple sequence repeats marker RM152 on chromosome 8. The co-locations of QTLs for some mineral elements observed in this mapping population suggested the relationship was at a molecular level among these traits and could be helpful for simultaneous improvement of these traits in rice grain by marker assisted selection.

关键词： introgression lines mineral elements Oryza sativa Oryza rufipogon quantitative trait loci.

Space-Time Decomposition of Kalman Filter

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Numerical Mathematics(Theory,Methods and Applications) 2023年第4期16卷 847-882页

作者： luisa D’Amore Rosalba Cacciapuoti University of Naples Federico II NaplesItaly

We present an innovative interpretation of Kalman filter(KF)combining the ideas of Schwarz domain decomposition(DD)and parallel in time(PinT)*** we call it *** contrast to standard DD approaches which are already incorporated in KF and other state estimation models,implementing a straightforward data parallelism inside the loop over time,DD-KF ab-initio partitions the whole model,including filter equations and dynamic model along both space and time directions/*** a consequence,we get local KFs reproducing the original filter at smaller dimensions on local ***,sub problems could be solved in *** order to enforce the matching of local solutions on overlapping regions,and then to achieve the same global solution of KF,local KFs are slightly modified by adding a correction term keeping track of contributions of adjacent subdomains to overlapping *** a correction term balances localization errors along overlapping regions,acting as a regularization constraint on local ***,such a localization excludes remote observations from each analyzed location improving the conditioning of the error covariance *** dynamic model we consider shallow water equations which can be regarded a consistent tool to get a proof of concept of the reliability assessment of DD-KF in monitoring and forecasting of weather systems and ocean currents.

关键词： Data assimilation Kalman filter domain decomposition filter localization model reduction numerical algorithm

Leaky gut, dysbiosis, and enteric glia activation: the trilogy behind the intestinal origin of Parkinson’s disease

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Neural Regeneration Research 2020年第6期15卷 1037-1038页

作者： luisa Seguella Giovanni Sarnelli Giuseppe Esposito Department of Physiology and Pharmacology“V.Erspamer”-Sapienza University RomeItaly(Seguella LEsposito G)Department of Clinical Medicine and SurgeryUniversity of Naples“Federico II”NaplesItaly(Sarnelli G)

Early diagnosis of Parkinson’s disease(PD):how we can improve the therapeutic approach:PD is a neurodegenerative disease characterized by motor dysfunctions(tremor,rigidity,bradykinesia and impaired posture/balance)elicited by selective depletion of dopaminergic(DA)neurons in substantia nigra pars *** neuron loss is associated with neuronal inclusions of the phosphorylatedα-synuclein protein called Lewy body(Shults,2006).Although the underlying neurodegenerative process is not affected,the management of PD patients has been revolutionized with the introduction of levodopa and DA drugs in the routine therapy,which ensures initial symptomatic relief of motor functions through the DA supply in the nigrostriatal *** drugs are currently the best option for treating PD,although their chronic use is associated with progressive dopamine resistance and loss of effectiveness in the recovery of motor *** therapeutic strategies,including agonists of DA receptors,monoamine oxide B inhibitors,and even deep brain stimulation techniques have been developed to overcome these clinical ***,these therapeutic approaches cannot restore PD-compromised functions,as irreversible DA neurodegeneration has occurred in substantia nigra pars compacta when first motor symptoms *** nigrostriatal system is traditionally considered as the first region affected by neuronal impairment in Parkinsonisms;however,α-synuclein aggregation appears in a pre-motor stage of the disease in the enteric nervous system(ENS).

关键词： impaired routine overcome

Evaluation of trace element mobilization and control under different fluidized bed combustion scenarios

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Clean Energy 2018年第2期2卷 167-174页

作者： María luisa Contreras Alberto Bahillo CIEMAT Department of EnergyAvdaComplutense 4028040 MadridSpain

As consequence of its relatively abundant reserves compared to other energy sources,coal will continue to be widely employed in power *** reduce coal’s negative impact on the environment,new approaches have been evaluated and adopted by various countries in recent years to minimize CO_(2) *** developments focused on the selection of new fuels(such as biomass fuels)to combine with coal to reduce emissions from coal combustion,whereas subsequent approaches aimed at implementing new processes for CO_(2) capture and storage,such as oxy-fuel *** addition,coal combustion is one of the main anthropogenic sources of trace elements(TE)emitted to the *** increasing knowledge acquired as to the impact of these pollutants in the environment has led to more restricted emission standards for some of these elements and to increased research on the technologies and pathways to control these *** article reviews the main factors involved in TE capture by comparing results obtained for Hg and other TEs under different control *** the effect of novel combustion processes and the potential of different pollution control techniques toward these pollutants are discussed.

关键词： trace elements mercury oxy-fuel combustion cofiring biomass