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A multi-integrated approach on toxicity effects of engineered TiO2 nanoparticles

Frontiers of Environmental Science & Engineering 2015年第5期9卷 793-803页

作者： Ana PICADO Susana M. PAIXAO Liliana MOITA Luis SILVA Mario S. DINIZ Joana LOURENCO Isabel PERES luisa castro Jose Brito CORREIA Joana PEREIRA Isabel FERREIRA Antonio Pedro Alves MATOS Pedro BARQUINHA Elsa MENDONCA LNEG-National Laboratory of Energy and Geology I.P. Lisbon 1649-038 Portugal REQUIMTE Chemistry Department Fine Chemistry and Biotechnology Center Faculty of Sciences and Technology New University of Lisbon Caparica 2829-516 Portugal IMAR-Ocean Institute Department of Sciences and Environmental Engineering Faculty of Sciences and Technology New University of Lisbon Caparica 2829-516 Portugal CENIMAT/I3N and Department of Materials Science Faculty of Sciences and Technology New University of Lisbon Caparica 2829-516 Portugal Pathological Anatomy Curry Cabml Hospital Lisbon 1069-166 Portugal CESAM Faculty of Sciences Lisbon University Lisbon 1749-016 Portugal

The new properties of engineered nanoparti- cles drive the need for new knowledge on the safety, fate, behavior and biologic effects of these particles on organisms and ecosystems. Titanium dioxide nanoparticles have been used extensively for a wide range of applica- tions, e.g, self-cleaning surface coatings, solar cells, water treatment agents, topical sunscreens. Within this scenario increased environmental exposure can be expected but data on the ecotoxicological evaluation ofnanoparticles are still scarce. The main purpose of this work was the evaluation of effects of TiO2 nanoparticles in several organisms, covering different trophic levels, using a battery of aquatic assays. Using fish as a vertebrate model organism tissue histological and ultrastructural observations and the stress enzyme activity were also studied. TiO2 nanoparticles （Aeroxide~ P25）, two phase composition ofanatase （65%） and rutile （35%） with an average particle size value of 27.64-11 nm were used. Results on the ECs0 for the tested aquatic organisms showed toxicity for the bacteria, the algae and the crustacean, being the algae the most sensitive tested organism. The aquatic plant Lemna minor showed no effect on growth. The fish Carassius auratus showed no effect on a 21 day survival test, though at a biochemical level the cytosolic Glutathione-S-Transferase total activity, in intestines, showed a general significant decrease （p〈0.05） after 14 days of exposure for all tested concentrations. The presence of TiO2 nanoparticles aggregates were observed in the intestine lumen but their internalization by intestine cells could not be confirmed.

关键词： ecotoxicity enzymatic analysis histology,transmission electron microscopy (TEM) TiO2-nanoparti-cles

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Loss of efficacy and safety of the switch from infliximab original to infliximab biosimilar(CT-P13)in patients with inflammatory bowel disease

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World Journal of Gastroenterology 2018年第46期24卷 5288-5296页

作者： María Fernanda Guerra Veloz Federico Argüelles-Arias luisa castro Laria Belén Maldonado Pérez Antonio Benítez Roldan Raúl Perea Amarillo Vicente Merino Bohórquez Miguel Angel Calleja Angel Caunedo Alvarez Angel Vilches Arenas Department of Gastroenterology University Hospital Virgen MacarenaSeville 41007Spain Pharmacy Unit University Hospital Virgen MacarenaSeville 41007Spain Preventive Medicine and Public Health University Hospital Virgen MacarenaSeville 41007Spain

BACKGROUND Infliximab original has changed the natural history of inflammatory bowel diseases(IBD) over the past two decades. However, the recent expiration of its patent has allowed the entry of the first Infliximab biosimilar into the European and Spanish markets. Currently switching drugs data in IBD are limited. AIM To compare the efficacy of infliximab biosimilar, CT-P13, against infliximab original, analyzing the loss of response of both at the 12 mo follow-up in patients with *** An observational study of two cohorts has been conducted. One retrospective cohort that included patients with IBD treated with Infliximab original, and a prospective cohort of patients who were switching from infliximab original to infliximab biosimilar(CT-P13). We had analyzed the overall efficacy and loss of efficacy in patients in remission at the end of one year after treatment with the original drug compared to the results of the year of treatment with the ***98 patients(CD 67, CU 31) were included in both cohorts. The overall efficacy for infliximab original per year of treatment was 71% vs 68.2% for infliximab biosimilar(P = 0.80). The loss of overall efficacy at 12 mo for infliximab original was 6.6% vs 14.5% for infliximab biosimilar(P = 0.806). The loss of efficacy in patients who were in basal remission was 16.3% for infliximab original vs 27.1% for infliximab biosimilar. Adverse events were 9.2% for infliximab original vs 11.2% for infliximab biosimilar. CONCLUSION The overall efficacy and loss of treatment response with infliximab biosimilar(CT-P13) is similar to that observed with infliximab original in patients who were switching at the 12 mo follow-up. There is no difference in the rate of adverse events.

关键词： Crohn’s disease Ulcerative colitis CT-P13 Inflammatory bowel disease Biosimilar agent Infliximab original Efficacy

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Fecal immunochemical test accuracy in average-risk colorectal cancer screening

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World Journal of Gastroenterology 2014年第4期20卷 1038-1047页

作者： Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines castro luisa de castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators Department of Gastroenterology Complexo Hospitalario Universitario de Vigo Department of Gastroenterology Complexo Hospitalario Universitario de Ourense Department of Clinical Analysis Complexo Hospitalario Universitario de Vigo Department of Pathology Complexo Hospitalario Universitario de Vigo Department of Gastroenterology Donostia Hospital Biodonostia Institute University of the Basque Country UPV/EHU

AIM: To assess the fecal immunochemical test (FIT) accuracy for colorectal cancer (CRC) and advanced neoplasia (AN) detection in CRC screening.

关键词： Colorectal neoplasms Early detection of cancer Sensitivity and specificity Adenoma Occult blood Cost-benefit analysis

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The off-crust origin of granite batholiths

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Geoscience Frontiers 2014年第1期5卷 63-75页

作者： Antonio castro Unidad Asociada de Petrología Experimental CSIC-Universidad de Huelva.Campus El Carmen21071 Huelva Spain

Granitod batholiths of I-type features （mostly granodiorites and tonalites）, and particularly those forming the large plutonic associations of active continental margins and intracontinental collisional belts, represent the most outstanding magmatic episodes occurred in the continental crust. The origin of magmas, however, remains controversial. The application of principles from phase equilibria is crucial to understand the problem of granitoid magma generation. An adequate comparison between rock com- positions and experimental liquids has been addressed by using a projected compositional space in the plane F（Fe ＋ Mg）-Anorthite-Orthoclase. Many calc-alkaline granitoid trends can be considered cotectic liquids. Assimilation of country rocks and other not-cotectic processes are identified in the projected diagram. The identification of cotectic patterns in batholith implies high temperatures of magma segregation and fractionation （or partial melting） from an intermediate （andesitic） source. The com- parison of batholiths with lower crust granulites, in terms of major-element geochemistry, yields that both represent liquids and solid residues respectively from a common andesitic system. This is compatible with magmas being formed by melting, and eventual reaction with the peridotite mantle, of subducted mOlanges that are finally relaminated as magmas to the lower crust. Thus, the off-crust generation of granitoids batholiths constitutes a new paradigm in which important geological implica- tions can be satisfactorily explained. Geochemical features of Cordilleran-type batholiths are totally compatible with this new conception.

关键词： Batholith Granodiorite Andesite Relamination Granulite Lower crust

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Unsuitable use of spin and pseudospin symmetries with a pseudoscalar Cornell potential

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Chinese Physics B 2014年第9期23卷 60-61页

作者： L.B.castro A.S.de castro Departamento de Física CFM Universidade Federal de Santa Catarina Departamento de Física Universidade Federal do Maranho Campus Universtitrio do Bacanga Departamento de Física e Química Campus de Guaratinguet Universidade Estadual Paulista

The concepts of spin and pseudospin symmetries has been used as mere rhetorics to decorate the pseudoscalar potential [Chin. Phys. B 22 090301 （2013）]. It is also pointed out that a more complete analysis of the bou... 详细信息

关键词： Dirac equation pseudoscalar Comell potential spin symmetry pseudospin symmetry

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Oxidative damage in the progression of chronic liver disease to hepatocellular carcinoma:An intricate pathway

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World Journal of Gastroenterology 2014年第12期20卷 3078-3086页

作者： Romilda Cardin Marika Piciocchi Marina Bortolami Andromachi Kotsafti luisa Barzon Enrico Lavezzo Alessandro Sinigaglia Kryssia Isabel Rodriguez-castro Massimo Rugge Fabio Farinati Department of Surgery Oncology and GastroenterologyUniversity of Padova Department of Molecular Medicine University of Padova Department of Medicine University of Padova

The histo-pathologic and molecular mechanisms leading to initiation and progression of hepatocellular carcinoma (HCC) are still ill-defined; however, there is increasing evidence that the gradual accumulation of mutations, genetic and epigenetic changes which occur in preneoplastic hepatocytes results in the development of dysplastic foci, nodules, and finally, overt HCC. As well as many other neoplasias, liver cancer is considered an “inflammatory cancer”, arising from a context of inflammation, and characterized by inflammation-related mechanisms that favor tumor cell survival, proliferation, and invasion. Molecular mechanisms that link inflammation and neoplasia have been widely investigated, and it has been well established that inflammatory cells recruited at these sites with ongoing inflammatory activity release chemokines that enhance the production of reactive oxygen species. The latter, in turn, probably have a major pathogenic role in the continuum starting from hepatitis followed by chronic inflammation, and ultimately leading to cancer. The relationship amongst chronic liver injury, free radical production, and development of HCC is explored in the present review, particularly in the light of the complex network that involves oxidative DNA damage, cytokine synthesis, telomere dysfunction, and microRNA regulation.

关键词： Reactive oxygen species Viral hepatitis Hepatocellular carcinoma Telomere dysfunction Cytokines mitochondria Antioxidant mechanisms MicroRNA and circulating free DNA

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The role of BRCA 1 and BRCA2 in prostate cancer

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Asian Journal of Andrology 2012年第3期14卷 409-414,I0006页

作者： Elena castro Rosalind Eeles Oncogenetics Team The Institute of Cancer Research Sutton SM2 5NG UK Academic Urology Unit The Royal Marsden NH Foundation Trust London SW3 6J J UK

One of the strongest risk factors for prostate cancer is a family history of the disease. Germline mutations in the breast cancer predisposition gene 2 （BRCA2） are the genetic events known to date that confer the highest risk of prostate cancer （8.6-fold in men ≤ 65 years）. Although the role of BRCA2 and BRCA1 in prostate tumorigenesis remains unrevealed, deleterious mutations in both genes have been associated with more aggressive disease and poor clinical outcomes. The increasing incidence of prostate cancer worldwide supports the need for new methods to predict outcome and identify patients with potentially lethal forms of the disease. As we present here, BRCA germline mutations, mainly in the BRCA2gene, are one of those predictive factors. We will also discuss the implications of these mutations in the management of prostate cancer and hypothesize on the potential for the development of strategies for sooradic cases with similar characteristics.

关键词： BRCA1 BRCA2 prostate cancer

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Recent progress on isospin breaking corrections and their impact on the muon g-2 value

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Chinese Physics C 2010年第6期34卷 712-717页

作者： Gabriel López castro Departamento de Física CinvestavApartado Postal 14-74007000 MxicoD.F Mxico

We describe some recent results on isospin breaking corrections which are of relevance for predictions of the leading order hadronic contribution to the muon anomalous magnetic moment aμ^*** when using τ lepton data. When these corrections are applied to the new combined data on the π^±π^0 spectral function, the prediction for aμ^*** based on τ lepton data gets closer to the one obtained using e^＋e^- data.

关键词： isospin breaking tau decays muon magnetic moment radiative corrections

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King's College criteria and the Clichy-Villejuif criteria require adjustments for assessing acute liver failure due to yellow fever

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World Journal of Transplantation 2025年第1期15卷 124-134页

作者： Bruno da Silva Athanasio Antonio Marcio de Faria Andrade Vivian Vasconcelos Costa Juliano Felix castro Silverio Leonardo Macedo Garcia Mauro Martins Teixeira Daniele da Gloria Souza Paula Vieira Teixeira Vidigal Cristiano Xavier Lima Department of Surgery Federal University of Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Liver Transplantation Unit Felicio Rocho HospitalBelo Horizonte 30110-934Minas GeraisBrazil Department of Morphology Federal University of Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil Department of Biochemistry and Immunology Federal University of Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil Department of Pathology Federal University of Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Acute liver failure(ALF)is a severe condition characterized by rapid deterioration of liver function in individuals without preexisting liver *** transplantation(LT)is the most impactful *** fever(YF)is an infectious disease that primarily affects the liver and has a high mortality ***,LT can be a viable option for treating rare cases with extensive liver ***,the criteria for assessing the severity of ALF and determining the indications for transplantation have not been specifically validated for cases caused by *** To present necessary adjustments to established scoring systems for ALF secondary to *** This was an observational,retrospective,single-center *** consecutive patients with confirmed ALF due to YF were monitored in the intensive care unit by a specialized liver transplant team during a three-month epidemic outbreak in *** hospitalization,general supportive therapeutic measures were implemented,and the patients were regularly assessed using the King's College criteria and the Clichy-Villejuif criteria to determine the severity of liver *** is considered a viable measure for patients with signs of end-stage liver *** Eight of 14(57%)patients developed severe neurological alterations within the first 96 hours after hospital *** patients underwent emergency LT,and despite a moderate viral infection of the graft after transplantation,the 5-year survival rate was 50%.Although the King's College criteria and the Clichy-Villejuif criteria are the main scoring systems for ALF,they are insufficient for predicting the risk of mortality in this context,primarily because of low serum bilirubin levels in the final stage of the disease and significant disparities between coagulation abnormalities and patient *** To ensure good applicability in cases of YF-induced ALF,the authors suggest adaptations to the King's College and Clichy-Vill

关键词： Yellow fever Acute liver failure Liver transplantation King's College criteria Clichy-Villejuif criteria

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Documentary research on social innovation in health in Latin America

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Infectious Diseases of Poverty 2020年第2期9卷 92-92页

作者： Diana Maria castro-Arroyave luisa Fernanda Duque-Paz Centro Internacional de Entrenamiento e Investigaciones Medicas(CIDEIM) CaliColombia Icesi University CaliColombia

Background:Identifying social innovation in health initiatives,promoting quality of life through them,and transforming current health conditions demand the knowledge,comprehension and appropriation of the theoretical and methodological developments of this concept Academic developments in social innovation have mainly occurred in and been documented for English-speaking countries,although relevant experiences have been implemented in Latin *** this article,we describe and analyze how social innovation in health is being approached and understood in this *** text:To identify the theoretical and methodological developments of social innovation in health between 2013 and 2018,a scoping review with a mixed approach was carried *** texts in English,Spanish and Portuguese were selected for a process of reflexive analysis of intra and intertextual *** approaches identified in the studied initiatives were *** most applied approaches were innovation in health,technological innovation in health and social innovation,each with twelve publications,and social innovation in health and ecohealth with ten and seven publications *** approaches showed a general interest in reaching the goals of the Sustainable Development Goals(SDGs),the Alma Ata Declaration and the Ottawa ***:The social innovation in health approach in Latin America adopts educational strategies,identifies risk factors,optimizes resources,promotes interculturality,participation,community empowerment,and enhances intersectorality and *** an approach,process,program or solution,social innovation in health is a conceptual category under *** research provides a baseline for other systematic reviews on the subject.

关键词： Community-based health Documental research Public health Social innovation in health Social change

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