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“代糖减热”：开发面向当今消费者的食品与饮料配方

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中国食品工业 2016年第10期 36-37页

作者： Luis fernandez 泰莱公司全球应用开发部门

过去二十年间，广大消费者在食品与饮料的偏好和消费习惯上已经有了显著变化。“信启导向消费”是当前最主流的趋势之一：消费者希望了解更多关于所购食品和饮料产品的信息，以便根据其产品价值及是否有利于其健康做出适当选择。

关键词：饮料配方消费者食品开发消费习惯饮料产品产品价值糖

“代糖减热”：开发面向当今消费者的食品与饮料配方

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食品与发酵工业 2016年第11期42卷 254-254页

作者： Luis fernandez 泰莱公司全球应用开发部门

过去20年间,广大消费者在食品与饮料的偏好和消费习惯上已经有了显著变化。＂信息导向消费＂是当前最主流的趋势之一：消费者希望了解更多关于所购食品和饮料产品的信息,以便根据其产品价值及是否有利于其健康做出适当选择。消费者需求... 详细信息

过去20年间,广大消费者在食品与饮料的偏好和消费习惯上已经有了显著变化。＂信息导向消费＂是当前最主流的趋势之一：消费者希望了解更多关于所购食品和饮料产品的信息,以便根据其产品价值及是否有利于其健康做出适当选择。消费者需求对全球消费者而言,当务之急是减少糖类消费量和卡路里摄入总量。事实上,平均55%的消费者表示正在努力减少食糖量,而有42%的消费者表示正努力减少卡路里摄入量。

关键词：消费者需求饮料配方食品糖类开发消费习惯饮料产品产品价值

Prevalence and risk factors of acute-on-chronic liver failure in a single center from Argentina

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World Journal of Hepatology 2016年第34期8卷 1529-1534页

作者： Cristian Dominguez Eugenia Romero Jorgelina Graciano Jose Luis fernandez luis Viola Division of Gastroenterology Sanatorio Guemes Centro Integral de Gastroenterología

AIM To study the prevalence, characteristics, risk factors and mortality at 28 d of acute-on-chronic liver failure(ACLF).METHODS A total of 100 cirrhotic patients admitted to our hospital for more than one day were included during the period between June 2013 and December 2015. We used the European Association for the Study of the Liver-Chronic Liver Failure-Consortium diagnostic criteria for ACLF, considering it as the acute decompensation of cirrhosis associated with the presence of one or more organ failure. For the diagnosis of organic failure the Chronic Liver Failure-Sequential Organ Failure Assessment score was used. Our population was divided into patients with and without ACLF. Clinical characteristics, presence of precipitating events, potential risk factors for developing ACLF and causes of mortality were analyzed. Mortality at 28 d was evaluated.RESULTS Twenty-nine patients(29%) developed ACLF criteria. Alcoholism, detected in 58 patients(58%), was the major etiological agent of cirrhosis. Bacterial infections were recognized as a precipitating event in 41.3% of cases and gastrointestinal bleeding in 27.5%. No precipitating event was identifiable in 27.5% of patients with ACLF. Comparing patients with and without ACLF, statistically significant risk factors were: Child Pugh score 10.2 ± 2.1 vs 8.4 ± 1.6(P < 0.0001), MELD score 20.7 ± 8.5 vs 12.3 ± 4(P < 0.0001), presence of ascites 27(93%) vs 43(60.5%)(P = 0.001), leukocytosis 15300 ± 8033 per cubic millimeter vs 10770 ± 5601 per cubic millimeter(P < 0.0001), and high plasma levels of C reactive protein values 50.9 ± 46.4 mg/L vs 28.6 ± 23.4 mg/L(P < 0.0019). Mortality rate was 62%(18 patients) vs 5.6%(4 patients), respectively(P < 0.0001).CONCLUSION We observed that the ACLF is a frequent entity in this group of patients and has a significantly higher mortality rate.

关键词： Acute-on-chronic 肝失败尖锐的肝补偿不全肝硬化腹水死亡

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Journal of Intensive Medicine 2022年第2期2卷 103-109页

作者： Diego Gil Carlos Tiscar Maria Gómez Javier Felices luis Gajate Patricia fernandez David Pestaña Tommaso Bardi Department of Anaesthesiology and Critical Care Ramón y Cajal Hospital28034 MadridSpain Department of Psychology Ramón y Cajal Hospital28034 MadridSpain

Background:There are insufficient data regarding the impact of acute respiratory distress syndrome related to coronavirus disease 2019(C-ARDS)–caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)–on health-related quality of life(HRQoL)and the occurrence of stress-related disorders in coronavirus disease 2019(COVID-19)intensive care unit(ICU)survivors.The aim of this study is to assess HRQoL and the occurrence of stress-related disorders(acute stress disorder[ASD]and post-traumatic stress disorder[PTSD])in C-ARDS ICU survivors at 1 and 6 months following hospital discharge.Methods:This prospective observational study included 90 patients treated for C-ARDS between March and May 2020 in the ICU and discharged alive from the hospital.All patients included in the study were contacted by telephone 1 month and 6 months post-hospital discharge to assess the presence of symptoms of stress-related disorders and HRQoL using the 8-item Treatment Outcome Post-traumatic Stress Disorder scale(TOP-8)and 36-item Short Form survey(SF-36).We performed univariate analyses to evaluate differences between patients who developed stress and those who did not.We also compared SF-36 scores in our sample with data from the general Spanish population and from cohorts of non–C-ARDS and severe acute respiratory syndrome coronavirus-1(SARS-CoV-1)survivors.Results:There are 24.1%of patients showed symptoms of ASD;in 13.5%of cases the symptoms persisted 6 months later.Risk factors for the development of symptoms of ASD and PTSD are younger age,female sex,obesity,a previously diagnosed psychiatric disease and disease severity at ICU admission(P<0.05).HRQoL was greatly affected by C-ARDS;however,there was improvement on all scales of the SF-36 at the 6-month follow-up(P<0.05).The mean SF-36 score of our sample was higher than those previously reported in non–C-ARDS survivors(P<0.05)for physical functioning(78.0 vs.52.0),role functioning/physical(51.0 vs.31.0),bodily pain(76.1 vs.57.0),vitality(58.6 vs.48.0),social function(72.6

关键词： COVID-19 Post-intensive care syndrome Respiratory distress syndrome,Adult Health-related quality of life Post-traumatic stress disorder

Estimation of mean water vapour residence time during tropical cyclones using a Lagrangian approach

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Tropical Cyclone Research and Review 2022年第2期11卷 76-87页

作者： Albenis Perez-Alarcon Patricia Coll-Hidalgo Jose C.fernandez-Alvarez Raquel Nieto luis Gimeno Centro de Investigacion Marina Universidade de VigoEnvironmental Physics Laboratory(EPhysLab)OurenseSpain Departamento de Meteorología Instituto Superior de Tecnologías y Ciencias AplicadasUniversidad de La HabanaLa HabanaCuba Departamento de Meteorología Empresa Cubana de Navegacion AereaLa HabanaCuba

Tropical cyclone(TC)-related rainfall mostly depends on the atmospheric moisture uptake from local and remote sources.In this study,the mean water vapour residence time(MWVRT)was computed for precipitation related to TCs in each basin and on a global scale by applying a Lagrangian moisture source diagnostic method.According to our results,the highest MWVRT was found for the TCs over the South Indian Ocean and South Pacific Ocean basins(~3.08 days),followed by the Western North Pacific Ocean,Central and East North Pacific Ocean,North Indian Ocean,and North Atlantic Ocean basins(which exhibited values of 2.98,2.94,2.85,and 2.72 days,respectively).We also found a statistically significant(p<0.05)decrease in MWVRT,at a rate of~2.4 h/decade in the North Indian Ocean and~1.0 h/decade in the remaining basins.On average,the MWVRT decreased during the 24 h before TCs made landfall,and the atmospheric parcels precipitated faster after evaporation when TCs moved over land than over the ocean.Further research should focus on the relationship between global warming and MWVRT of atmospheric parcels that precipitate over TC positions.

关键词： Tropical cyclones Water vapour residence time Lagrangian approach Tropical cyclones precipitation

The effect of the infection within the individual host on its propagation in the population

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Infectious Disease Modelling 2018年第1期3卷 345-361页

作者： Franciane Azevedo Marcos Amaku Francisco Antonio Bezerra Coutinho Luis fernandez Lopez Eduardo Massad Faculdade de Engenharia da Computaçaoe Engenharia Eletrica Universidade Federal do Sul e Sudeste do ParaMarabaPABrazil Faculdade de Medicina Universidade de Sao Pauloe LIM01-HCFMUSPAv.Dr.Arnaldo 455Sao PauloSP01246-903Brazil Faculdade de Medicina Veterinariae Zootecnia Universidade de Sao PauloSao PauloSP05508-270Brazil London School of Hygiene and Tropical Medicine LondonUK Escola de Matematica Aplicada Fundaçao Getúlio VargasRio de JaneiroBrazil College of Natural and Life Sciences The University of DerbyDerbyUK

We consider nested or multiscale models to study the effect of the temporal evolution of the disease within the host in the population dynamics of the disease,for one and two infectious agents.We assumed a coupling between the within-host infection rate and the between-host transmission rate.The age of infection within each individual in a population affects the probability of transmission of the disease to a susceptible host and this will affect the temporal evolution of the disease in the host population.To analyze the infection within the host,we consider bacterial-like and viral-like infections.In the model for two infectious agents,we found that,when strain 2 has a basic reproduction number R02 greater than the basic reproduction number R01 of strain 1,strain 2 replaces strain 1 in the population.However,if R02>R01 but the values are closer,the replacement does not occur immediately and both strains can coexist for a long time.We applied the model to a scenario in which patients infected with the hepatitis C virus(HCV)are cleared of HCV when super-infected with the hepatitis A virus(HAV).We compared the time for the replacement of HCV by HAV in the population considering instantaneous and noninstantaneous replacement within the individuals.The model developed can be generalized for more than two infectious agents.

关键词： Nested model Multiscale model Within-host infection Between-host transmission Infectious disease

Minimally invasive nephrectomy for inflammatory renal disease

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Asian Journal of Urology 2020年第4期7卷 345-350页

作者： Paula Andrea Pena Lynda Torres-Castellanos German Patino Stefania Prada luis Gabriel Villarraga Nicolas fernandez Pontificia Universidad Javeriana School of MedicineBogota D.C.Colombia Department of Urology Hospital Universitario San IgnacioPontificia Universidad JaverianaSchool of MedicineBogota D.C.Colombia Division of Urology Hospital Universitario San IgnacioPontificia Universidad JaverianaBogota D.C.Colombia Division of Urology Hospital Universitario San IgnacioPontificia Universidad JaverianaSchool of MedicineBogota D.C.Colombia Department of Urology Fundacion Santa Fe de BogotaColombia Division of Urology Hospital for SickKidsUniversity of TorontoTorontoCanada

Objective:Once chronic inflammatory renal disease(IRD)develops,it creates a severe peri-fibrotic process,which makes it a relative contraindication for minimally invasive surgery(MIS).Our objective is to show that laparoscopic nephrectomy(LN)is a surgical option in IRD with fewer complications and better outcomes.Methods:Retrospective review of patients who underwent a modified-surgical laparoscopic transperitoneal nephrectomy was performed.Data search included all operated patients between May 2013 and May 2018 that had a pathology result with any renal inflammatory condition(xanthogranulomatous pyelonephritis,chronic nephritis,and renal tuberculosis).We describe intra-operative variables such as operative time,blood loss,conversion rate,postoperative complications and length of hospital stay.Results:There were 51 patients who underwent laparoscopic nephrectomy with a confirmatory pathology report for IRD.We identified four(8%)major complications;three of them required transfusion and one conversion to open surgery.The mean operative time was 233108 min.Mean estimated blood loss was 206242 mL excluding the conversion cases and 281423 mL including them.The mean length of hospital stay was 3.02.0 days.Conclusion:Laparoscopic nephrectomy for IRD can safely be done.It is a reproducible technique with low risks and complication rates.Our experience supports that releasing the kidney first and leaving the hilum for the end is a safe approach when vascular structures are embedded into a single block of inflammatory and scar tissue.

关键词： Inflammation Kidney diseases Laparoscopy Minimally invasive surgical procedures Nephrectomy Nephritis Nephroureterectomy

Water-soluble hollow nanocrystals from self-assembly of AIEEactive Pt(II)metallomesogens

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Nano Research 2021年第1期14卷 245-254页

作者： Cristian Cuerva Javier fernandez-Lodeiro Mercedes Cano Jose luis Capelo-Martinez Carlos Lodeiro BIOSCOPE Research Group LAQV@REQUIMTE Chemistry DepartmentNOVA School of Science and TechnologyNOVA University Lisbon2829-516 CaparicaPortugal PROTEOMASS Scientific Society Rua dos InventoresMadam ParqueCaparica Campus2829-516 CaparicaPortugal Department of Inorganic Chemistry Complutense University of MadridCiudad Universitaria28040 MadridSpain

Luminescent hollow micro-and nanocrystals have been successfully obtained taking advantage of the self-assembly behavior and the aggregation-induced emission enhancement properties of several bispyrazolate Pt(II)metallomesogens decorated with four terminal alkyl chains.Oil-in-water droplets have been used to confine the Pt(II)compounds and drive them to be self-assembled via intermolecular Pt…Pt interactions into spherical aggregates of about 200 or 50 nm.Evaporation of the oil phase generates highly-stable aqueous dispersions of nanocrystals that emit a bright orange light as a result of the existence of^(3)MMLCT excited states.Different methods and conditions have been tested for studying the effect of several parameters such as the temperature and the stirring speed in the final particle size and in the polydispersity index.Moreover,the micro-and nanocrystals are able to entrap hydrophobic drugs between the alkyl chains of the compounds,forming stable dispersions of drug-loaded capsules in water.The droplet method is applied in the area of metallomesogens for the first time to synthesize self-assembled Pt(II)nanocapsules,which opens a new field of study that could allow the use of these liquid crystal materials in biomedical applications.

关键词： R(II)metallomesogens self-assembly luminescent nanomaterials droplets nanocapsules

“代糖减热”：开发面向消费者的食品与饮料配方

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食品安全导刊 2017年第3期 58-58页

作者： Luis fernandez 泰莱公司全球应用开发部门

在过去的20年里，广大消费者在食品与饮料的偏好和消费习惯上已经有了显著变化。“信息导向消费”是当前的主流趋势：消费者希望了解更多关于所购食品和饮料产品的信息，以便根据其产品价值及是否有利于健康做出适当选择。

关键词：饮料配方消费者食品开发消费习惯饮料产品产品价值糖