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Pathogenesis and clinical management of arboviral diseases

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World Journal of virology 2025年第1期14卷 9-50页

作者： victoria Cenci Dietrich Juan Marcos Caram Costa Marina Maria Gomes Leite Oliveira Carlos Eduardo Oliveira Aguiar luis Guilherme de Oliveira Silva Marcel Silva Luz Fabian Fellipe Bueno Lemos Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Arboviral diseases are viral infections transmitted to humans through the bites of arthropods,such as mosquitoes,often causing a variety of pathologies associated with high levels of morbidity and *** the past decades,these infections have proven to be a significant challenge to health systems worldwide,particularly following the considerable geographic expansion of the dengue virus(DENv)and its most recent outbreak in Latin America as well as the difficult-tocontrol outbreaks of yellow fever virus(YFv),chikungunya virus(CHIKv),and Zika virus(ZIKv),leaving behind a substantial portion of the population with complications related to these ***,the world is experiencing a period of intense globalization,which,combined with global warming,directly contributes to wider dissemination of arbovirus vectors across the ***,all continents remain on high alert for potential new ***,this review aims to provide a comprehensive understanding of the pathogenesis of the four main arboviruses today(DENv,ZIKv,YFv,and CHIKv)discussing their viral characteristics,immune responses,and mechanisms of viral evasion,as well as important clinical aspects for patient *** includes associated symptoms,laboratory tests,treatments,existing or developing vaccines and the main associated complications,thus integrating a broad historical,scientific and clinical approach.

关键词： Arboviruses Arbovirus infections Dengue Zika virus Yellow fever Chikungunya virus Clinical diagnosis Pathogenesis Flavivirus Togaviridae infections

Mitogenomes of historical type specimens unravel the taxonomy of sportive lemurs(Lepilemur spp.)in Northwest Madagascar

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Zoological Research 2021年第4期42卷 428-432页

作者： Christian Roos Roberto portela Miguez Richard Sabin Edward E.Louis Jr Michael Hofreiter Dietmar Zinner Gene Bank of Primates and Primate Genetics Laboratory German Primate CenterLeibniz Institute for Primate ResearchGoettingen 37077Germany Natural History Museum London SW7 BDUK Center for Conservation and Research Omaha’s Henry Doorly Zoo and AquariumOmahaNebraska 68107USA Institute for Biochemistry and Biology University of PotsdamPotsdam 14476Germany Cognitive Ethology Laboratory German Primate CenterLeibniz Institute for Primate ResearchGoettingen 37077Germany Leibniz Science Campus Primate Cognition Goettingen 37077Germany Department of Primate Cognition Georg-August-UniversityGoettingen 37083Germany

Accurate information on name-bearing types,including corresponding type localities,is essential for proper ***,such geographic information is often missing or *** localities of type specimens collected 100–200 years ago can be difficult to trace due to changes in local names or simple *** a case can be found for the gray-backed sportive lemur(Lepilemur dorsalis),with its type locality imprecisely fixed as Northwest *** recent years,eight species have been newly described for the Inter-River-Systems(IRSs)of this region,however the designation of *** remains controversial due to a lack of a precise type ***,we sequenced the complete mitochondrial genomes(mitogenomes)of type specimens of *** and ***,which is currently recognized as a synonym of *** and compared their sequences with those of samples of known provenance from different *** showed that the two type specimens of *** and *** had identical mitogenome sequences and clustered closely with samples collected in IRS v,indicating that the type locality could be fixed to IRS ***,*** occurs in IRS v,and *** and *** are junior synonyms of *** finding demonstrates the value of type specimens for clarifying phylogeographic and taxonomic questions and clarifies the taxonomy of sportive lemurs in Northwest Madagascar.

关键词： precise identical finding

Antegrade bowel intussusception after remote Whipple and Puestow procedures for treatment of pancreas divisum

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World Journal of Gastroenterology 2007年第44期13卷 5954-5956页

作者： Manuel Gigena Hugo v villar Negar G Knowles John T Cunningham Erik K Outwater luis R Leon Jr University of Arizona Health Science Center and Southern Arizona Veteran Affairs Health Care System Surgery Section Tucson AZ 85723 United States

To date, antegrade intussusception involving a Roux-en-Y reconstruction has been reported only once. We report a case of acute bowel obstruction due to an intussusception involving two Roux-en-Y limbs in a 40-year-old woman with a history of chronic pancreatitis due to pancreas divisum. Four years preceding this event, the patient had undergone a Whipple procedure, and three years prior to that, a Puestow operation. The patient was successfully treated with bowel resection and a side-to-side anastomosis between the most distal aspect of the bowel and the most distal Roux-en-Y reconstruction, which preserved both Roux-en-Y reconstructions.

关键词： Whipple procedure Puestow procedure Pancreas divisum Intussusception Bowel obstruction

Prenatal radiographic evaluation of congenital transverse limb deficiencies:A scoping review

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World Journal of Orthopedics 2023年第3期14卷 155-165页

作者： Neeraj vij luis F Goncalves Aaron Llanes Sean Youn Mohan v Belthur Department of Orthopedic Surgery Phoenix Children’s HospitalPhoenixAZ 85016United States Department of Radiology Phoenix Children's HospitalPhoenixAZ 85016United States Department of Orthopedics University of Arizona College of Medicine-PhoenixPhoenixAZ 85004United States

BACKGROUND Congenital transverse deficiencies are horizontal deficiencies of the long bones that occur with a reported incidence as high 0.38%.They can occur alone or represent a manifestation of a various clinical *** has tradi-tionally comprised of conventional radiography and prenatal imaging *** has been much advancement regarding prenatal imaging modalities to allow for early diagnosis and appropriate *** To summarize the current state of knowledge on congenital transverse limb deficiencies and to provide an update regarding the radiographic evaluation of congenital transverse limb *** This IRB-exempt scoping review followed the PRISMA-ScR checklist for scoping reviews *** search engines were searched for a total of 265 *** authors reviewed these during the screening *** these,51 studies were included in our *** magnetic resonance imaging(MRI),3D Ultrasound,and multidetector Computed tomography(CT)exist are emerging modalities that have the potential to improve *** Use of the appropriate classification system,three-dimensional ultrasonography with a maximum intensity projection,and appropriate use of prenatal MRI and prenatal CT can improve diagnosis and inter-provider *** Further scholarly efforts are required to develop improve standardized guidelines regarding the pre-natal radiographic evaluation of congenital limb deficiencies.

关键词： Terminal deficiencies Roentgenographic evaluation Pediatric skeletal deficiencies Early diagnosis Patient-centered care Prenatal imaging©The Author(s)2023.Published by Baishideng Publishing Group Inc.All rights reserved.

The emotional structuring of the Andean territory: Mapping embodied narratives in Coporaque, Peru

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Frontiers of Architectural Research 2023年第5期12卷 985-998页

作者： Gonzalo Ríos-vizcarra luis Enrique Calatayud-Rosado Aleixandre Brian Duche-Perez víctor Cano-Ciborro Faculty of Architecture and Civil and Environmental Engineering Universidad Católica de Santa MaríaArequipa 04001Peru Faculty of Social Sciences and Technologies and Humanities Universidad Católica de Santa MaríaArequipa 04001Peru The Higher Technical School of Architecture of Madrid Polytechnic University of MadridMadrid 28040Spain

This research explores the subject of territory,understood based on the life world of Andean inhabitants of the Colca valley(Arequipa,Peru),who are descendants of ancient local Indigenous groups that,since prehistoric times,have known how to adapt to the rugged geographical reality of the *** a phenomenological approach,which assesses the subjective experience,it was possible to corroborate the existence of routine patterns of spatiality that preserve the emotional essence of past territorial conceptions,which have prevailed despite the hegemonic impositions systematically forced upon the land ever since the Spanish conquest in the 16th *** carrying out coexistence fieldwork in situ,five layers of territorial sense have been registered,which,besides being very useful in order to optimize and give coherence to their agricultural and animal husbandry tasks,are periodically represented through verbal and corporal narratives,which have been mapped in this work in order to make their dynamics of symbolization visible and to conclude in the existence of an emotional Andean territory.

关键词： Life world Territory Affection Andean Colca valley Phenomenology Narratives

Multiple intrahepatic pseudocysts in acute pancreatitis

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World Journal of Gastroenterology 2007年第34期13卷 4655-4657页

作者： David Casado luis Sabater Julio Calvete Empar Mayordomo luis Aparisi Juan Sastre Salvador Lledo Department of Surgery Liver Biliary and Pancreatic Unit University of Valencia Spain Department of Pathology University of Valencia Spain Laboratory of Pancreatic Function Hospital Clinic University of Valencia Spain Department of Physiology University of Valencia Spain

Liver pseudocysts are a very rare complication in acute pancreatitis with only a few cases previously described. The lack of experience and literature on this condition leads to difficulties in the differential diagnosis and management. We report herein a case of acute pancreatitis who developed multiple intrahepatic pseudocysts. After complete imaging evaluation, the diagnosis was still unclear and the patient was operated on. The presence of liver lesions in patients with acute pancreatitis should raise the possibility of intrahepatic pseudocysts.

关键词： Pancreatic pseudocyst Liver pseudocyst Intrahepatic pseudocyst

Risk factors for acute kidney injury after partial hepatectomy

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World Journal of Hepatology 2017年第18期9卷 815-822页

作者： luis Cesar Bredt luis Alberto Batista Peres Department of Surgical Oncology and Hepa- tobiliary Surgery University Hospital of Western Paraná State University of Western Paraná Department of Nephrology University Hospital of Western Paraná State University of Western Paraná

To identify risk factors for the occurrence of acute kidney injury (AKI) in the postoperative period of partial hepatectomies. METHODSRetrospective analysis of 446 consecutive resections in 405 patients, analyzing clinical characteristics, preoperative laboratory data, intraoperative data, and postoperative laboratory data and clinical evolution. Adopting the International Club of Ascites criteria for the definition of AKI, potential predictors of AKI by logistic regression were identified. RESULTSOf the total 446 partial liver resections, postoperative AKI occurred in 80 cases (17.9%). Identified predictors of AKI were: Non-dialytic chronic kidney injury (CKI), biliary obstruction, the Model for End-Stage Liver Disease (MELD) score, the extent of hepatic resection, the occurrence of intraoperative hemodynamic instability, post-hepatectomy haemorrhage, and postoperative sepsis. CONCLUSIONThe MELD score, the presence of non-dialytic CKI and biliary obstruction in the preoperative period, and perioperative hemodynamics instability, bleeding, and sepsis are risk factors for the occurrence of AKI in patients that underwent partial hepatectomy.

关键词： Kidney injury Hepatectomy Postoperative Liver Resection

Methylation of DAPK and THBS1 genes in esophageal gastric-type columnar metaplasia

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World Journal of Gastroenterology 2016年第18期22卷 4567-4575页

作者： Roberto Herrera-Goepfert luis F Onate-Ocana José luis Mosqueda-vargas luis A Herrera Clementina Castro Julia Mendoza Rodrigo González-Barrios Department of Pathology Instituto Nacional de Cancerologia (INCan) 10480 Mexico DF Mexico Clinical Research Division Instituto Nacional de Cancerologia (INCan) 10480 Mexico DF Mexico Unidad de Investigacion Biomedica en Cancer Instituto Nacional de Cancerologia (INCan)-Instituto de Investigaciones Biomedicas (IIB) Universidad Nacional Autonoma de Mexico (UNAM) 14080 Mexico DF Mexico

AIM: To explore methylation of DAPK, THBS1, CDH-1, and p14 genes, and Helicobacter pylori(H. pylori) status in individuals harboring esophageal columnar ***: Distal esophageal mucosal samples obtained by endoscopy and histologically diagnosed as gastric-type(non-specialized) columnar metaplasia, were studied thoroughly. DNA was extracted from paraffin blocks, and methylation status of deathassociated protein kinase(DAPK), thrombospondin-1(THBS1), cadherin-1(CDH1), and p14 genes, was examined using a methyl-sensitive polymerase chain reaction(MS-PCR) and sodium bisulfite modification protocol. H. pylori cag A status was determined by ***: In total, 68 subjects(33 females and 35 males), with a mean age of 52 years, were included. H. pylori cag A positive was present in the esophageal gastric-type metaplastic mucosa of 18 individuals. DAPK, THSB1, CDH1, and p14 gene promoters were methylated by MS-PCR in 40(58.8%), 33(48.5%), 46(67.6%), and 23(33.8%) cases of the 68 esophageal samples. H. pyloristatus was associated with methylation of DAPK(P = 0.003) and THBS1(P = 0.019).CONCLUSION: DNA methylation occurs in cases of gastric-type(non-specialized) columnar metaplasia of the esophagus, and this modification is associated with H. pylori cag A positive infection.

关键词： DNA methylation Esophageal columnar metaplasia Thrombospondin-1 Death-associated protein kinase Helicobacter pylori cagA

Sintering study of Ti6Al4v powders with different particle sizes and their mechanical properties

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International Journal of Minerals,Metallurgy and Materials 2018年第12期25卷 1389-1401页

作者： Joséluis Cabezas-villa JoséLemus-Ruiz Didier Bouvard Omar Jiménez Héctor Javier vergara-Hernández luis Olmos University Michoacana of San Nicolás of Hidalgo IIMMMorelia 58060México University Grenoble Alpes CNRSSIMaPGrenoble 38000France University of Guadalajara Departamento de Ingeniería de ProyectosZapopan 45100México National Technological Institute of Mexico I.T.MoreliaMorelia 58120México University Michoacana of San Nicolás of Hidalgo INICITMorelia 58060México

Ti6Al4v powders with three different particle size distributions(0–20, 20–45, and 45–75 μm) were used to evaluate the effect of the particle size distribution on the solid-state sintering and their mechanical properties. The sintering kinetics was determined by dilatometry at temperatures from 900 to 1260°C. The mechanical properties of the sintered samples were evaluated by microhardness and compression tests. The sintering kinetics indicated that the predominant mechanism depends on the relative density irrespective of the particle size used. The mechanical properties of the sintered samples are adversely affected by increasing pore volume fraction. The elastic Young's modulus and yield stress follow a power law function of the relative density. The fracture behavior after compression is linked to the neck size developed during sintering, exhibiting two different mechanisms of failure: interparticle neck breaking and intergranular cracking in samples with relative densities below and above of 90%, respectively. The main conclusion is that relative density is responsible for the kinetics, mechanical properties, and failure behavior of Ti6 Al4 v powders.

关键词： Ti6Al4v powders dilatometry microhardness sintering kinetics compression failure behavior