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Concordance among pulse wave velocity assessment methods: A network meta-analysis

中华医学杂志(英文版) 2024年第17期137卷 2137-2139页

作者： Cavero-Redondo Iván Sequí-dom.nguez Irene Saz-Lara Alicia Garcia-Klepzig Jose luis Lucerón-Lucas-Torres Maribel Martínez-García Irene álvarez-Bueno Celia Martínez-Vizcaíno Vicente CarVasCare Research Group Facultad de Enfermería de Cuenca Universidad de Castilla-La Mancha Cuenca Spain Facultad de Ciencias de la Salud Universidad Autónoma de Chile Talca Chile Health and Social Research Center Universidad de Castilla-La Mancha Cuenca Spain Internal Medicine Department San Carlos University Hospital Madrid Spain Universidad Politécnica y Artística del Paraguay Asunción Paraguay

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A novel heterozygous SF1/NR5A1 gene variant causes 46,XY DSD-gonadal dysgenesis with hypergonadotropic hypogonadism without adrenal insufficiency

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Genes & Diseases 2024年第4期11卷 128-130页

作者： luis Ramos Department of Reproductive Biology Instituto Nacional de Ciencias Medicas y Nutricion Salvador ZubirdnTlalpanMexico City 14080Mexico

Steroidogenic factor 1(SF1/NR5A1;nuclear receptor subfamily 5 group A member 1)is an essential orphan protein involved in gonadal embryogenesis,sex determination,and reproductive endocrinology.

关键词： insufficiency determination gonadal

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Online Demand Response Characterization Based on Variability in Customer Behavior

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 936-946页

作者： Lester Marrero Daniel Sbárbaro luis García-Santander the Department of Electrical Engineering University of ConcepciónConcepción 4070409Chile

This paper proposes an online framework to characterize demand response(DR)over *** proposed framework facilitates obtaining and updating the daily consumption patterns of *** essential concept of response profile class(RPC)is introduced for characterization and complemented by the measure of the variability in customer *** paper uses a modified version of the incremental clustering by fast search and find of density peaks(CFSFDP)algorithm for daily profiles,considering the multivariate normal kernel density estimator and incremental forms of the Davies-Bouldin(i DB)and Xie-Beni(i XB)validity *** studies conducted using real-world and simulated daily profiles of residential and commercial Chilean end-users have demonstrated how the proposed framework can continuously characterize *** proposed framework is proven to achieve realistic customer models for effective energy management by estimating the customer response to price signals at the distribution system operator(DSO)level.

关键词： Demand response(DR) incremental indice online characterization online clustering response profile class(RPC)

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Optimal Design of Hybrid Microgrid in Isolated Communities of Ecuador

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 488-499页

作者： luis A.Pesantes Ruben Hidalgo-León Johnny Rengifo Miguel Torres Jorge Aragundi JoséCordova-Garcia luis F.Ugarte Facultad de Ingeniería en Electricidad y Computación of Escuela Superior Politécnica del Litoral(ESPOL)University GuayaquilEcuador Department of Electrical Engineering at Universidad Técnica Federico Santa María SantiagoChile IEEE

In rural territories, the communities use energy sources based on fossil fuels to supply themselves with electricity, which may address two main problems: greenhouse gas emissions and high fuel prices. Hence, there is an opportunity to include renewable resources in the energy mix. This paper develops an optimization model to determine the optimal sizing, the total annual investment cost in renewable generation, and other operating costs of the components of a hybrid microgrid. By running a k-means clustering algorithm on a meteorological dataset of the community under study, the hourly representative values become input parameters in the proposed optimization model. The method for the optimal design of hybrid microgrid is analyzed in six operating scenarios considering:(1) 24-hour continuous power supply;(2) load shedding percentage;(3) diesel power generator(genset) curtailment;(4) the worst meteorological conditions;(5) the use of renewable energy sources including battery energy storage systems(BESSs);and(6) the use of genset. A mathematical programming language(AMPL) tool is used to find solutions of the proposed optimization model. Results show that the total costs of microgrid in the scenarios that cover 100% of the load demand(without considering the scenario with 100% renewables) increase by over 16% compared with the scenario with genset operation limitation. For the designs with power supply restrictions, the total cost of microgrid in the scenario with load shedding is reduced by over 27% compared with that without load shedding.

关键词： Battery energy storage system(BESS) isolated community microgrid renewable energy optimization

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Nutritional Supplement Ocoxin® Combined with Gemcitabine-Based Chemotherapy in Patients with Advanced Pancreatic Adenocarcinoma

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Open Journal of Gastroenterology 2024年第8期14卷 267-287页

作者： Mayté Lima-Pérez Jorge luis Soriano-García Masiel González-Meisozo Jorge luis Soriano-Lorenzo Vilma Fleites-Calvo Dunia Morales-Morgado Carlos dom.nguez-Álvarez Iván Ramón-Concepción Raidel Rodríguez-Barrios Alicia Tarinas-Reyes Ivis Mendoza-Hernández Rolando Uranga-Piña Clinical Oncology Department Ameijeiras Hospital Havana Cuba Clinical Pathology Department Ameijeiras Hospital Havana Cuba Clinical Section National Coordinating Centre for Clinical Trials Havana Cuba Biostatistics Section National Coordinating Centre for Clinical Trials Havana Cuba

Background: the quality of life (QoL) of patients with pancreatic ductal adenocarcinoma (PDAC), with its limited survival, can be affected by chemotherapy-induced toxicity. The main objective was to evaluate the effect of introducing ocoxin oral solution (OOS) in combination with standard therapy on quality of life. Methods: Thirty patients were enrolled in an exploratory, prospective, single-centre clinical trial in the oncology department of “Hermanos Ameijeiras” University Hospital in Havana, Cuba. Quality of life was measured using the EORTC QLQ-C30 questionnaire and toxicity was assessed using the NCI-CTC-AE classification version 5.0. Results: There was stability in the scores over time for overall QoL and the functional scale criteria, while in terms of symptoms, fatigue, pain and loss of appetite were reduced. No grade 3 - 4 adverse events (AEs) were recorded, and only 14.9% of toxicities were classified as grade 2, and these were considered to be unrelated to OOS. Biochemical and nutritional parameters were normalised at 12 months compared to the baseline values. Conclusions: This clinical study is the first report of the use of OOS in patients with advanced pancreatic cancer, and demonstrates that it is able to maintain optimal quality of life with reduced severity of toxicity during and after combination treatment with gemcitabine-based chemotherapy.

关键词： EORTC QLQ-C30 Ocoxin Chemotherapy Pancreatic Cancer Quality of Life

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Optical magnetic field enhancement using ultrafast azimuthally polarized laser beams and tailored metallic nanoantennas

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Photonics Research 2024年第5期12卷 1078-1092页

作者： RODRIGO MARTIN-HERNANDEZ LORENZ GRUNEWALD luis SANCHEZ-TEJERINA luis PLAJA ENRIQUECONEJERO JARQUE CARLOS HERNANDEZ-GARCIA SEBASTIAN MAI Grupo de Investigacion en Aplicaciones del Laser y Fotonica Departamento de Fisica AplicadaUniversidad de SalamancaE-37008 SalamancaSpain Unidad de Excelencia en Luz y Materia Estructuradas(LUMES) Universidad de SalamancaE-37008 SalamancaSpain Institute of Theoretical Chemistry Faculty of ChemistryUniversity of Vienna1090 ViennaAustria Vienna Doctoral School in Chemistry(DoSChem) Faculty of ChemistryUniversity of Vienna1090 ViennaAustria Departamento de Electricidad y Electrónica Universidad de Valladolid47011 ValladolidSpain

*** *** thank Valentina Shumakova,Elizaveta Gangrskaia,Alessandra Bellissimo,Audrius Pugzlys,and Andrius Baltu?ka for fruitful discussions and computational support by the Vienna Scientific Cluster(VSC 4).The authors thankfully acknowledge the computer resources at MareNostrum and SCAYLE,and the technical support provided by Barcelona Supercomputing Center(RES-FI-2022-3-0041).R.M.-H.,L.S.-T.,L.P.,E.C.J.,and C.H.-*** funding from the European Research Council(ERC)under the European Union’s Horizon 2020 research and innovation program(Grant Agreement No.851201)and support from Ministerio de Ciencia e Innovación(PID2022-142340NB-I00,PID2019-106910GB-I00).This research was funded in whole or in part by the Austrian Science Fund(FWF)(10.55776/ZK91).For open access purposes,the author has applied a CC BY public copyright license to any author accepted manuscript version arising from this submission.

关键词： metallic polarized discussions

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Common interacting genetic variation shapes susceptibility to type 1 diabetes in a Colombian Caribbean community:In search of shared genetic markers

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Genes & Diseases 2024年第4期11卷 106-108页

作者： Gloria Garavito-De Egea Alex dom.nguez-Vargas Jorg e l.Velez Gustavo Aroca luis Fagng Elkin Navarro-Quiroz Zilac Espitaleta Kenny Del Toro-Camargo Leticia Martinez-Ariza Tatiana Gonzalez-Vargas Susana Garcia Mauricio Arcos-Burgos Eduardo Egea Universidad del Norte Division Ciencias de la SaludBarranquillaColombia Universidad Simon Bolivar Facultad de Ciencias de la SaludBarranquillaColombia Clinica de la Costa Grupo de Investigacion en NefrologiaBarranquillaColombia Universidad de Antioquia Grupo de Investigacion en Psiquiatria(GIPSI)Departamento de PsiquiatriaInstituto de Investigaciones MedicasFacultad de MedicinaMedellinColombia

Genome-wide association studies(GWASs)have identified hundreds of loci across the human genome conferring susceptibility to autoimmune diseases(AIDs),some of which are shared between more than two ***,this univariate ... 详细信息

关键词： susceptibility diseases diabetes

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Unraveling the interaction between soil microbiomes and their potential for restoring polluted soils

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Frontiers of Environmental Science & Engineering 2024年第8期18卷 149-151页

作者： Carlos O.Lomeli-Ortega Mingming Sun Jose luis Balcazar Catalan Institute for Water Research(ICRA-CERCA) Girona 17003Spain University of Girona Girona 17004Spain Soil Ecology Laboratory College of Resources and Environmental SciencesNanjing Agricultural UniversityNanjing 210095China

Soils are not exempt from anthropogenic pollution,which can eventually cause disturbance of the microbial communities and areas without any kind of *** soil microbiota,bacteria play an important role in pollutant degradation,enabling them to thrive in contaminated *** this,several techniques have been used to increase the number of pollutantdegrading bacteria in situ or for subsequent ***,bacteriophages exhibit a high tolerance to pollutants and enhance bacterial metabolic activity through phage-encoded auxiliary metabolic genes(AMGs),thereby augmenting their skills for nutrient assimilation,resistance to phage infection,antibiotic resistance,heavy metal resistance,and degradation of pesticides and xenobiotics,among *** phage-encoded AMGs have been described during the last few years,but their diversity,distribution,and function have not been extensively explored,warranting further ***,we highlight soil microbiome interactions,especially bacterium and phage interactions to understand this unexplored world with a high potential for restoring polluted soils.

关键词： Auxiliary metabolic genes Microbiome Pollutants Soils Viruses

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Measuring Impact of Lean Manufacturing Tools for Continuous Improvement on Economic Sustainability

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Journal of Systems Science and Systems Engineering 2024年第4期33卷 452-474页

作者： luis Javier Márquez Figueroa Jorge luis García-Alcaraz Ahmed I.Osman Alfonso Jesús Gil López Yashar Aryanfar Mika Sillanpää Mamdouh El Haj Assad Department of Electrical Engineering and Computer Science Universidad Autónoma de Ciudad JuárezCiudad JuárezChihuahuaMéxico Department of Industrial Engineering and Manufacturing Universidad Autónoma de Ciudad JuárezCiudad JuárezChihuahuaMéxico School of Chemistry and Chemical Engineering Queens UniversityBelfastNorthern IrelandUK Department of Economic and Managerial Sciences University of La RiojaLa RiojaSpain Department of Chemical Engineering University of JohannesburgJohannesburgSouth Africa Department of Sustainable and Renewable Energy Engineering University of SharjahSharjahUAE

Using Lean Manufacturing(LM)tools in production processes is crucial for companies’economic,environmental,and social sustainability *** study shows a structural equation model(SEM)that shows the relationship between LM Tools like Kaizen(KAI),Gemba(GEM),Value Stream Mapping(VSM)and Key Performance Indicator(KPI)with Economic Sustainability(ECS).Seven hypotheses were evaluated with data from 179 responses to a questionnaire about the Mexican maquiladora industry,showing that these variables are *** a 95%confidence level,the model was evaluated using the partial least squares *** findings indicate that the relationships between KAI and GEM and KAI and VSM have the strongest relationship,followed by VSM and ECS;however,VSM has the strongest effect on *** on these findings,it is recommended that managers adopt a continuous improvement(KAI)approach based on working directly on the shop floor(GEM and VSM)to support their decisions regarding economic growth(ECS).

关键词： Lean manufacturing economic sustainability structural equation model quality improvement

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Sex-specific life-history trait expression in hybrids of a cave- and surface-dwelling fish (Poecilia mexicana, Poecilidae)

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Current Zoology 2024年第4期70卷 421-429页

作者： Rüdiger Riesch luis R.Arriaga Ingo Schlupp Department of Biological Sciences Royal Holloway University of LondonEghamTW20 OEXUK CEFE CNRSUnivMontpellierEPHEIRDMontpellierFrance Department of Biology University of OklahomaNormanOK 73019USA

Evaluating the fitness of hybrids can provide important insights into genetic differences between species or diverging *** focused on surface-and cave-ecotypes of the widespread Atlantic molly Poecilia mexicana and raised F1 hybrids of reciprocal crosses to sexual maturity in a common-garden *** were reared in a fully factorial 2 x 2 design consisting of lighting(light ***)and resource availability(high *** food).We quantified survival,ability to realize their full reproductive potential(i.e.,completed maturation for males and 3 consecutive births for females)and essential life-history *** to the performance of pure cave and surface fish from a previous experiment,F1s had the highest death rate and the lowest proportion of fish that reached their full reproductive *** also uncovered an intriguing pattern of sex-specific phenotype expression,because male hybrids expressed cave molly life histories,while female hybrids expressed surface molly life *** results provide evidence for strong selection against hybrids in the cave molly system,but also sug-gest a complex pattern of sex-specific(opposing)dominance,with certain surface molly genes being dominant in female hybrids and certain cavemollygenes beingdominant in malehybrids.

关键词： dominance life-history evolution local adaptation postzygotic isolation selection against hybrids.

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