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Proposed Protocol for Risk Assessment and Stratification

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Occupational Diseases and Environmental Medicine 2020年第3期8卷 99-110页

作者： Teófila Vicente-Herrero Victoria Ramírez Iñiguez de la Torre Teresa del Campo Balsa luis reinoso barbero Alejandro Fernández Montero Juan Carlos Rueda Garrido Asociación Españ ola de Especialistas en Medicina del Trabajo Madrid Spain Occupational Health and Safety Services of Correos Valencia Spain Occupational Health and Safety Services of Correos Albacete Spain Department of Occupational and Prevention at University Hospital Fundación Jiménez Díaz Universidad Autónoma de Madrid Madrid Spain Occupational Medicine Service Grupo Banco Santander Madrid Spain Faculty of Health Sciences Universidad International de la Rioja La Rioja Spain Department of Occupational Medicine Universidad de Navarra Navarra Spain SABIC Medical Services Cartagena Spain

Introduction: COVID-19 disease is a highly contagious viral infection caused by the SARS-CoV-2 coronavirus. There is growing interest in Public Health and Occupational Health in identifying the COVID-19 prognostic factors, needed to stratified patients by risk being necessary to consider occupational variables as well as individual and clinical factors of the workers. Objective: The aim of this study was to perform a tool to identify the more vulnerable workers for COVID-19 that will be useful to value their work limitations. Methods: A review of medical literature about the vulnerability for COVID-19 is taken into account occupational risks and occupational preventive measures. Results: It is proposed an index of vulnerability criteria for COVID-19 in workers based on quantifying individual characteristics, pre-existing medical conditions and its control, high risk of occupational exposure, and prevention and protection strategies in the workplace. The final result is stratified into three degrees of vulnerability that will serve to propose the most appropriate preventive measures. Conclusion: This proposal protocol assesses about the vulnerability for COVID-19 infection in workers to help decide the preventive management at workplace in this pandemic situation.

关键词： COVID-19 Vulnerability Occupational Health Occupational Medicine

Proposed Occupational Vulnerability Index COVID-19

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Occupational Diseases and Environmental Medicine 2020年第4期8卷 175-187页

作者： Mª Teófila Vicente-Herrero Mª Victoria Ramírez Iñiguez de la Torre Mª Teresa del Campo Balsa luis reinoso barbero Juan Carlos Rueda Garrido Cristina Santamaría Navarro Asociación Españ ola de Especialistas en Medicina del Trabajo Madrid Spain Occupational Health and Safety Services of SPP Correos Valencia Spain Occupational Health and Safety Services of SPP Correos Albacete Spain Occupational Health and Safety Services of SPA ITEM-Prevención Albacete Spain Department of Occupational and Prevention at University Hospital Fundación Jiménez Díaz Universidad Autónoma de Madrid Madrid Spain Occupational Medicine Service Grupo Banco Santander Madrid Spain Faculty of Health Sciences Universidad Internacional de la Rioja La Rioja Spain Occupational Medicine SABIC Medical Services Cartagena Spain University-PDI. Instituto de Matemática Multidisciplinar. Universitat Politècnica de València Valencia Spain

Introduction: Vulnerable is someone who can be hurt or receive injury, physically or morally. The work environment appears as one of the dimensions in which social vulnerability develops and social and occupational vulnerability is defined. The literature does not include an assessment of quantified occupational vulnerability as it already exists in the case of social vulnerability. The aim of this paper is to identify and quantify the variables included in the Protocol for the Assessment of Vulnerability to COVID-19 in such a way that the result can be quantified and allows for a predictive effect on the degree of vulnerability. Methodology: The starting point is the design of a protocol proposal that includes 29 variables. Data is collected from a sample of 420 workers, quantifying the results according to each variable, the overall scores for each group of aspects assessed and, finally, the total score that estimates the degree of vulnerability according to established ranges. Results: Variables that have the highest coefficient and, therefore, the greatest weight in the probability of reaching a group of high or medium vulnerability are cardiovascular disease, cancer, and coagulation alteration. The weight of the labour aspects due to inadequate working conditions stands out. Conclusions: The results obtained with this protocol allow us to make a quantified assessment of labour vulnerability to COVID-19 by integrating individual variables of the worker, his working conditions and the preventive actions of his company against COVID-19, and can be useful as an Occupational Vulnerability Index (OVI).

关键词： COVID-19 Index Occupational Vulnerability Occupational Health Occupational Medicine

Postanesthetic Emergence Delirium in Children: Qualitative Differences between Sevoflurane vs Desflurane: A Randomized Clinical Trial

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Open Journal of Anesthesiology 2022年第10期12卷 322-337页

作者： Elena Fernández Dueñas Pascual Sanabria Carretero Francisco reinoso-barbero Ana Fernández Dueñas Leopoldo Martínez Martínez Department of Pediatric Anesthesia-Critical Care-Pain Treatment La Paz University Hospital Madrid Spain Idipaz Foundation La Paz University Hospital Madrid Spain Directorate General of Public Health Ministry of Health Madrid Spain Department of Pediatric Surgery La Paz University Hospital Madrid Spain

Background: Emergence Delirium (ED) is considered a usual complication in pediatric anesthesia. Aim: Analyze the quantitative and qualitative differences in ED in children receiving general anesthesia with sevoflurane or desflurane in day case surgery. Materials and Methods: Two hundred and two children, ASA I-II, who required outpatient elective day case surgery, were assigned to receive anesthesia with sevoflurane or desflurane. ED was assessed by a masked investigator using the Pediatric Anesthesia Emergence Delirium (PAED) scale at 5 and 15 minutes (min). Results: Mean time to wake up was shorter with desflurane compared with sevoflurane (6.0 versus 8.3 min, p = 0.0001). The overall incidence of ED was 21.3% and Postoperative Maladaptive Behavior Changes (POMBC) incidence was 22%;however, these were not related. Main factors found to be associated with ED were younger age, postoperative pain and preoperative anxiety. Although there were not statistically significant differences in ED incidence between sevoflurane (26.4%, 95% CI 17.3% - 35.4%) and desflurane anesthesia (16.3%, 95% CI 8.8% - 23.8%) (p = 0.18), scores of items 1 and 2 from PAED scale (eye contact and purposeful actions, items related to the patients’ connection with their surroundings) were significantly higher in sevoflurane than in desflurane group (p = 0.034 and p = 0.021 respectively). Conclusion: Recovery after anesthetic maintenance with desflurane is faster and as safe as sevoflurane, including postoperative behavioral disorders. Although desflurane did not statistically decrease ED incidence as compared with sevoflurane, patients who were agitated with desflurane were qualitatively less disoriented and disconnected from their surroundings.

关键词： Inhaled Agents Sevoflurane Desflurane Emergence Agitation Pediatric

Exploring Alternatives to Create Digital Twins from and for Process Simulation

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Journal of Computer Science Research 2024年第1期6卷 16-30页

作者： Jaime barbero-Sánchez Alicia Megía-Ortega Víctor R.Ferro Jose-luis Valverde Department of Chemical Engineering University of Castilla La ManchaAvda.Camilo JoséCela 12Ciudad Real13071Spain Department of Chemical Engineering Autonomous University of MadridCantoblancoMadrid28049Spain

In this work,Digital Twins based on Neural Networks for the steady state production of styrene were ***,both the Aspen Technology AI Model Builder(alternative 1)and a homemade MS Excel VBA code connected to Aspen HYSYS and Aspen Plus(alternative 2)were used with this same *** raw data used for generating the Digital Twins were obtained from process simulations using Aspen HYSYS and/or Aspen Plus,which were connected through a recycle-like stream via automation for solving the entire simulation *** HYSYS was used for solving the pre-heating,reaction,and stabilization sections of the process whereas Aspen Plus ensured the computing of the separation and purification *** alternatives led to an excellent prediction showing the capability of creating Digital Twins from and for process simulation.

关键词： Digital Twin Aspen Hybrid Model Builder Aspen HYSYS Aspen Plus Automation MS Excel-VBA

Jatropha curcas L. and J. macrocarpaGriseb: Seed Morphology, Viability, Dormancy, Germination and Growth of Seedlings

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American Journal of Plant Sciences 2018年第9期9卷 1835-1854页

作者： Nancy E. de las M. Tavecchio Ana E. Vigliocco Oscar A. Terenti Diego Wassner Herminda E. reinoso Hilda E. Pedranzani Laboratorio Fisiología Vegetal Facultad de Ingeniería y Ciencias Agropecuarias Universidad Nacional de San Luis Villa Mercedes Argentina Departamento de Ciencias Naturales Facultad de Ciencias Exactas Físico-Químicas y Naturales Universidad Nacional de Río Cuarto Río Cuarto Argentina Estacion Experimental Agropecuaria INTA-SAN LUIS Villa Mercedes Argentina Departamento de Producción Vegetal Facultad de Agronomía Cátedra de Cultivos Industriales Universidad de Buenos Aires Buenos Aires Argentina Laboratorio de Fisiología Vegetal Facultad de Química Bioquímica y Farmacia Universidad Nacional de San Luis San Luis Argentina

To achieve a good production of a crop, it is essential to know the ability of the species to successfully complete two critical stages in the life cycle such as germination and seedling establishment. In this paper we study in comparative form structure of the seed, the importance of tegument in dormancy, the effect of accelerated aging on seed germination and viability, and the early and late growth in J. curcas and J. macrocarpa. External morphology of the seeds allow difference and internally also the embryos show evident differences. J. macrocarpa germination is around 0% - 4%. The total removal of tegument showed a 50% increase and the other treatments between 0% - 10%. Aging accelerated by Tetrazolium test allowed a comparative analysis of VP and GP. J. curcas maintains both to 96 h, while J. macrocarpa the seed viability is registered along the all treatment. J. macrocarpa seeds have less synchronicity than those of J. curcas. ABA and JAs were detected in tegument of J. macrocarpa and J. curcas seeds. JA could have a roll in inhibition of germination of J. macrocarpa seeds. Early and late growth, FW and DW of root, hypocotyl, epicotyl and leaf of J. curcas were significantly different in both species.

关键词： Dormancy Germination Phytohormones Growth Seeds Viability

Potential Technological Use of Reserves of Jatropha curcasand J. macrocarpaGriseb. Seeds

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American Journal of Plant Sciences 2019年第8期10卷 1444-1456页

作者： Nancy E. de las M. Tavecchio Marta S. Dardanelli Yanina B. Reguera Herminda E. reinoso Oscar A. Terenti Marisa M. Garbero Hilda E. Pedranzani Departamento de Ciencias Agropecuarias Facultad de Ingeniería y Ciencias Agropecuarias Universidad Nacional de San Luis San Luis Argentina Departamento de Biología Molecular Facultad de Ciencias Exactas Físico-Químicas y Naturales Universidad Nacional de Río Cuarto Córdoba Argentina Departamento de Ciencias Naturales Facultad de Ciencias Exactas Físico-Químicas y Naturales Universidad Nacional de Río Cuarto Córdoba Argentina Laboratorio de semillas EEA INTA San Luis Argentina Departamento de Bioquímica y Ciencias Biológicas Facultad de Química Bioquímica y Farmacia Universidad Nacional de San Luis San Luis Argentina

J. curcas and J. macrocarpa are useful for restoring degraded areas and their seeds contain oils for biodiesel production. The aim of the work was to determine the reserve substances in the endosperm and the embryo of J. curcas and J. macrocarpa which is important in understanding the germination process, the establishment of these species and its industrial employment. Seeds were imbibed in distilled water for 24 h, to facilitate removal of seed coat with the aim to separate the embryo and nutritive tissues. In both species, the endosperm contained aleurone grains consisting of a crystalloid and globoid, lipids of red color and the starch was not observed. Four major fatty acids were determined in J. curcas seed: oleic, palmitic, stearic, palmitoleic and oleic fatty acid represents about 70% oil content. Oleic acid was the most abundant in J. macrocarpa seeds, while, there was not palmitoleic acid. Seed with predominantly unsaturated fatty acids is ideal for biodiesel industry. The means of the sugar content were: 14.3 μg/mg in endosperm and 104.76 μg/mg in embryo of J. curcas and 6.48 μg/mg in endosperm and 59.20 μg/mg in embryo of J. macrocarpa. The means of the protein content were: 4.2 μg/mg in endosperm and 45.02 μg/mg in embryo of J. curcas and 3.26 μg/mg in endosperm and 31.08 μg/mg in embryo of J. macrocarpa. Sugar and protein contents of Jatropha seeds were significantly higher in embryo in both species (p 0.1), which suggests early mobilization towards the embryo during imbibition period.

关键词： Fatty Acids J. curcas J. macrocarpa Proteins Seeds Sugars