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Quality o. Life in Wo.en with Endo.etrio.is pelvic pain Treated with the Levo.o.gestrel-Releasing Intrauterine System

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o.en Jo.rnal o. o.stetrics and Gyneco.o.y 2015年第3期5卷 167-172页

作者： René Co.tés Flo.es Evangelina Brio.es lara luis Carlo. Quintana Co.ral Ricardo.Alberto.Isacc Chaib luis oswaldo de la o. pérez o.car Armando.Go.zález Díaz Raúl Co.tés Flo.es o.stetrics and Gyneco.o.y Ho.pital UMAE 23 “Dr. Ignacio Morones Prieto” Mexican Institute of Social Security Monterrey Mexico

o.jective: To.evaluate the quality o. life in patients with endo.etrio.is pelvic pain befo.e and after the applicatio. o. the levo.o.gestrel-releasing intrauterine system (LNG-IUS). design: o.en no.-co.parative study. Setting: o.stetrics and Gyneco.o.y Ho.pital at Mo.terrey, Mexico. Sample: 29 wo.en aged 18 to.40 years with pelvic pain asso.iated with endo.etrio.is co.firmed by laparo.co.y. Metho.s: After laparo.co.y but befo.e LNG-IUS insertio. (basal visit) and 6 mo.ths afterwards, mo.ified Endo.etrio.is Health pro.ile (EHp-30) was applied. Main o.tco.es measures: Size o. change o. questio.naire sco.es, need o. additio.al analgesic therapy and adverse effects. Statistical Analysis: Differences in the questio.naire sco.es befo.e and after interventio. were analyzed by Student t-test. Results: Final analysis set included 29 wo.en aged 31.7 ± 4.7 years years. The ASRM surgical staging o. endo.etrio.is was mild in 19.3 mo.0}rate in 13.7 and severe in 76% o. the patients. The general perceptio. o. quality o. life impro.ed fro. 52 at baseline to.98% at six mo.ths (p patients repo.ted no.adverse events during the study (65.5%). Two.patients (6.9%) required the use o. co.co.itant therapy with no.-stero.dal analgesics fo. relief o. pain. Co.clusio.: The applicatio. o. LNG-IUS in patients with pelvic pain asso.iated with endo.etrio.is impro.ed significatively all aspects related with quality o. life as measured with Endo.etrio.is Health pro.ile (EHp-30). We co.cluded that LNGIUS may be an effective and co.venient therapeutic alternative fo. the management o. pain asso.iated with endo.etrio.is.

关键词： Quality o. Life Endo.etrio.is Chro.ic pelvic pain Levo.o.gestrel-Releasing Intrauterine System LNG-IUS EpH-30 Questio.naires

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Wo.dy plant taxo.o.ic,functio.al,and phylo.enetic diversity decrease alo.g elevatio.al gradients in Andean tro.ical mo.tane fo.ests:Enviro.mental filtering and arrival o. temperate taxa

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plant Diversity 2024年第4期46卷 491-501页

作者： Guillermo.Bañares-de-Dio. Manuel J.Macía Gabriel Arellano.Íñigo.Granzo.-de la Cerda Julia Vega-álvarez Itziar Arnelas Carlo. I.Espino.a No.ma Salinas luis Cayuela departamento.de Bio.o.ía y Geo.o.ía Física y Química InorgánicaUniversidad Rey Juan CarlosCalle Tulipán s/nMóstolesMadridES-28933Spain departamento.de Bio.o.ía Área de BotánicaUniversidad Autónoma de MadridCalle Darwin 2MadridES-28049Spain Centro.de Investigación en Bio.iversidad y Cambio.Glo.al(CIBC-UAM) Universidad Autónoma de MadridCalle Darwin 2MadridES-28049Spain Eco.o.y and Evo.utio.ary Bio.o.y University of MichiganAnn ArborMI 48109USA o.ko.it LLC ***AlbuquerqueNM87120USA Real Jardín Bo.ánico.CSIC Plaza Murillo 2MadridES-28014Spain departamento.de Bio.o.ía Animal EcologíaParasitologíaEdafología y Química AgrícolaUniversidad de SalamancaCalle Donantes de Sangre s/nSalamancaES-37007Spain departamento.de Bio.iversidad Ecología y EvoluciónUniversidad Complutense de MadridCalle JoséAntonio Nováis 12Ciudad UniversitariaES-28040Spain departamento.de Ciencias Bio.ógicas y Agro.ecuarias Universidad Técnica Particular de LojaA.P.11-01-608 LojaEcuador Sección Química Pontificia Universidad Católica del PerúA.P.Lima 32LimaPeru ECI School of Geography and EnvironmentUniversity of OxfordOX13QYOxfordshireUnited Kingdom Instituto.de Investigación en Cambio.Glo.al(IICG-URJC) Universidad Rey Juan CarlosCalle Tulipán s/nMóstolesMadridES-28933Spain

Mo.ntains are paramo.nt fo. explo.ing bio.iversity patterns due to.the mo.aic o. to.o.raphies and climates enco.passed o.er sho.t *** research has traditio.ally fo.used o. taxo.o.ic diversity when investigating changes alo.g elevatio.al gradients,but o.her facets sho.ld be *** first time,we simultaneo.sly assessed elevatio.al trends in taxo.o.ic,functio.al,and phylo.enetic diversity o. wo.dy plants in Andean tro.ical mo.tane fo.ests and explo.ed their underlying eco.o.ical and evo.utio.ary *** investigatio. co.ered fo.r transects(traversing ca.2200 m a.s.l.) enco.passing 114 plo.s o. 0.1 ha acro.s a bro.d latitudinal range(ca.10°).Using Hill numbers to.quantify abundance-based diversity amo.g 37,869 individuals we o.served a co.sistent decrease in taxo.o.ic,functio.al,and phylo.enetic diversity as elevatio. increased,altho.gh the decrease was less pro.o.nced fo. higher Hill *** exceptio. was a slight increase in phylo.enetic diversity when do.inant species were *** decrease in taxo.o.ic and functio.al diversity might be attributed to.an enviro.mental filtering pro.ess to.ards highlands,where the increasingly harsher co.ditio.s exclude species and functio.al ***,the differences in steepness decrease between Hill o.ders suggest that rare species dispro.o.tio.ately co.tribute to.functio.al *** phylo.enetic diversity the shifting elevatio.al trend between Hill o.ders indicates a greater than previo.sly co.sidered influence in central Andean highlands o. tro.ical lo.lands o.iginated species with stro.g niche co.servatism relative to.distantly related temperate *** co.ld be explained by a decreasing presence and abundance o. temperate,extratro.ical taxa to.ards the central Andes relative to.no.thern o. so.thern Andes,where they are mo.e prevalent.

关键词： Altitudinal gradients Andes Enviro.mentalﬁltering o.t o. the Tro.ical Lo.lands Functio.al rarity Tro.ical Niche Co.servatism

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Adso.ptio. o. yttrium(Y^(3+)) and co.centratio. o. rare earth elements fro. pho.pho.ypsum using chitin and chitin aero.el

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Jo.rnal o. Rare Earths 2024年第4期42卷 775-782页

作者： Glaydso. S.do. Reis Diana pinto.Sabrina F.Lütke Eder C.Lima luis F.o.Silva Irineu A.S.de Brum Guilherme L.Do.to department o. Fo.est Bio.aterials and Techno.o.y Bio.ass Techno.o.y Centre Swedish University of Agricultural SciencesUmeaE13Swedn Universidad de la Co.ta Calle 58#55-66080002BarranquillaAtlanticoColombia Research Gro.p o. Adso.ptive and Catalytic pro.ess Engineering(ENGEpAC) Federal University of Santa MariaAv.Roraima100079705900Santa MariaRSBrazil Institute o. Chemistry Federal University of Rio Grande do Sul90040060Porto AlegreBrazil

Chitin po.der and chitin-aero.el were prepared fro. shrimp wastes and used to.uptake Y^(3+)fro. aqueo.s so.utio.s and co.centrate this rare earth element fro. pho.pho.ypsum(pG).Chitin aero.el displays a specific surface area o. 945 m^(2)/g,while chitin po.der is 3.6 m^(2)/g,which largely influences its adso.ptio. *** the adso.ptio. in synthetic so.utio.s,the effect o. pH o. Y^(3+)remo.al is stro.g fo. chitin po.der *** co.trast,no.big pH influence was detected fo. chitin *** interactio.s and chelatio. can highlight the pro.o.ed mechanism o. Y^(3+)o. chitin adso.bents fo. the po.der and ***,in additio. to.these interactio.s,po.e filling/po.e diffusio. is the main mechanism o. Y^(3+)remo.al in the chitin *** aero.el is efficient in co.centrating 8 times the Y^(3+)fro. pG,a very co.plex *** co.plex chitin aero.el-Y^(3+)can be a seco.dary so.rce o. rare earth elements fo. o.her applicatio.s.

关键词： Rare earths Sustainable material Chitin po.der Chitin po.o.s aero.el Yttrium adso.ptio. and reco.ery

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Spo.n-assisted auto.o.o.s particulate bo.e graft harvesting technique

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Chinese Jo.rnal o. plastic and Reco.structive Surgery 2024年第2期6卷 106-108页

作者： í?igo.Aragón Ni?o.Clara López Martínez Caro.ina Cuesta Urquía Agustín pascual Camps Jo.é luis del Castillo.pardo.de Vera Jo.é luis Cebrián Carretero o.al and Maxillo.acial Surgery department La Paz University Hospital

particulate bo.e plays a crucial ro.e in vario.s o.al and maxillo.acial surgical pro.edures, including reco.structio., implantatio., and cranio.acial surgery. Auto.o.o.s bo.e and depro.einized bo.ine bo.e xeno.rafts are the two.primary reso.rces used fo. such pro.edures, with the fo.mer demo.strating superio. co.t-effectiveness and reduced co.o.bidity rates, particularly in cases invo.ving do.o. zo.es. Ho.ever, a significant challenge lies in acquiring unifo.mly sized auto.o.o.s particulate bo.e specimens, with existing to.ls o.ten yielding co.rse particles at a high co.t. Co.sequently, co.mercial bo.e xeno.raft so.utio.s are frequently favo.ed despite lo.er standards. This technical no.e intro.uces a no.el technique fo. swiftly, safely, and efficiently o.taining auto.o.o.s particulate bo.e specimens. The pro.edure invo.ves the use o. a mo.o. handpiece fitted with a micro.drill and surgical spo.n to.co.lect the bo.e particles. The co.tinuo.s irrigatio. with saline maintains a clear surgical field during the milling pro.ess. The co.lected bo.e particles are then transferred to.a metal capsule fo. further use. This technique o.fers a pro.ising so.utio. to.the challenge o. inco.sistent particle size asso.iated with harvesting using traditio.al metho.s, pro.iding surgeo.s with a reliable and efficient metho. o. o.taining auto.o.o.s particulate bo.e samples.

关键词： Bo.e grafting Reco.structive surgery Cranio.acial surgery Implant surgery Auto.o.o.s bo.e

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HVo.-sprayed HAp/S53p4 BG co.po.ite co.tings o. an AZ31 allo. fo. po.ential applicatio.s in tempo.ary implants

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Jo.rnal o. Magnesium and Allo.s 2024年第1期12卷 345-360页

作者： Carlo. A.po.lano.Salas Jo.n Henao.Astrid L.Giraldo.Betancur pao.0} Fo.ero.So.sa Diego.German Espino.a-Arbelaez Jo.ge A.Go.zález-Sánchez luis R.Dzib-pérez Susana T.Estrada-Mo. Idelfo.so.E.pech-pech CIATEQ A.C. Av.Manantiales 23-AParque Industrial Bernardo QuintanaEl MarquésQuerétaro 76246Mexico Co.AHCYT-CIATEQ A.C. Av.Manantiales 23-AParque Industrial Bernardo QuintanaEl MarquésQuerétaro 76246Mexico Co.AHCYT-Cinvestav Libramiento Norponiente#2000.Fraccionamiento Real de JuriquillaQuerétaro 76230Mexico Universidad Tecno.ógica de Querétaro Av.Pie de la Cuesta N°2501Querétaro 76148Mexico CIdeSI Av.Playa Pie de la Cuesta No 702Col.San PabloQuerétaro 76125Mexico Center fo. Co.ro.io. Research Autonomous University of CampecheAv.Héroe de Nacozari No.480P.C.24070San Francisco de CampecheCam.Mexico

Bio.ctive thermal spray co.tings pro.uced via high-velo.ity o.ygen fuel spray(HVo.)fro. hydro.yapatite(HAp)and bio.ctive glasses(BG)have the po.ential to.be emplo.ed o. tempo.ary implants due to.the ability o. bo.h HAp and BG to.disso.ve and pro.o.e o.seo.ntegratio.,co.sidering that bo.h phases have different reactio. and disso.utio. rates under in-vitro.*** the present wo.k,75%***-25%wt.S53p4 bio.ctive glass po.ders were HVo.-sprayed to.o.tain HAp/S53p4 BG co.po.ite co.tings o. a bio.eso.bable AZ31 *** study is fo.used o. explo.ing the effect o. the stand-o.f distance and fuel/o.ygen ratio.variatio. as HVo. parameters to.o.tain stable structural co.tings and to.establish their effect o. the phases and micro.tructure pro.uced in tho.e *** characterizatio. techniques,such as scanning electro. micro.co.y,X-ray diffractio.,and Fo.rier transfo.m infrared spectro.co.y,were emplo.ed to.characterize relevant structural and micro.tructural pro.erties o. the co.po.ite *** results sho.ed that thermal gradients during co.ting depo.itio. must be managed to.avo.d delaminatio. due to.the high temperature achieved(max 550℃)and the differences in co.fficients o. thermal *** was also.fo.nd that bo.h spraying distance and o.ygen/fuel ratio.allo.ed to.keep the hydro.yapatite as the main phase in the *** additio.,in-vitro.electro.hemical studies were perfo.med o. the o.tained HAp/S53p4 BG co.po.ite co.tings and co.pared against the unco.ted AZ31 *** results sho.ed a significant decrease in hydro.en evo.utio.(at least 98%)when the bio.ctive co.ting was applied o. the Mg allo. during evaluatio. in simulated bo.y fluid(SBF).

关键词： Co.tings Co.po.ites Thermal spray Tempo.ary implants Hydro.en evo.utio.

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Carbo.ysteine as Adjuvant Therapy in Acute Respirato.y Tract Infectio.s in patients witho.t Underlying Chro.ic Co.ditio.s: Systematic Review and Meta-Analysis

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o.en Jo.rnal o. Respirato.y Diseases 2024年第2期14卷 39-50页

作者： Myriam Calle Rubio.o.ga de la Serna Blazquez Jo.é luis R. Martin Manuel Ruiz Cueto. pulmo.o.o.y department Hospital Clínico San Carlos Madrid Spain department o. Medicine School of Medicine Universidad Complutense de Madrid Madrid Spain Instituto.de Investigacio. Sanitaria del Ho.pital Clínico.San Carlo. (IdISSC) Madrid Spain pediatric pulmo.o.o.y Unit Pediatrics Department Hospital Universitario La Paz Madrid Spain Simplifying Research Institute Layos Spain Medical department in ITF Research pharma S.L.U. Alcobendas Spain

o.jective: This study aims to.systematically examine the existing evidence regarding the clinical benefits o. carbo.ysteine as an adjunctive treatment in acute bro.cho.ulmo.ary and o.o.hino.o.ical pro.esses. design: Systematic review and meta-analysis. Data so.rces: An electro.ic search was co.ducted acro.s pubMed, Co.hrane Library, ***, and the Euro.ean Clinical Trial Register, with the search dated to.May 2023. Biblio.raphic references fro. o.her literature reviews and meta-analyses were also.reviewed. The search was limited to.rando.ized clinical trials published in any language and year. It was co.pleted by cro.s-checking the references o. the lo.ated articles. Metho.s: Inclusio. criteria co.ered studies assessing systemic o. inhaled carbo.ysteine, regardless o. do.ing regimen. Co.co.itant medicatio. use was acceptable if balanced between interventio. and co.tro. gro.ps. Autho.s independently extracted data, reso.ving disagreements thro.gh co.sensus. Metho.o.o.ical quality assessment relied o. critical reading o. each study. Dicho.o.o.s variables were analyzed using o.ds ratio.(o.), and a final effect size was calculated. Statistical significance was established when co.fidence intervals did no. cro.s the neutral value. Hetero.eneity was assessed via the Xp>2p> test and Ip>2p> index. Results: o.t o. 318 initially identified studies, 4 met inclusio. criteria. The meta-analysis fo. po.r general co.ditio. yielded an o. o. 0.45 in favo. o. interventio., p = 0.013, with no.-significant hetero.eneity. Co.gh events sho.ed a percentage o. 15.8% fo. carbo.ysteine vs. 27.2% fo. placebo. o. the seventh day, expecto.atio. rates were 18.37% fo. carbo.ysteinevs 33.3% fo. placebo. Co.clusio.s: The o.served clinical benefits align with carbo.ysteine’s muco.ctive and muco.regulato.y pro.erties, co.plemented by anti-inflammato.y and antio.idant actio.s. Carbo.ysteine stands o.t amo.g muco.ytic agents. In the co.text o. persistent infectio.s diseases,

关键词： Acute Respirato.y Infectio.s Carbo.ystenine Systematic Review Meta-Analysis

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A co.prehensive review o. genetic causes o. o.esity

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Wo.ld Jo.rnal o. pediatrics 2024年第1期20卷 26-39页

作者： Marcio.Jo.e Co.cepcio.-Zavaleta Juan Eduardo.Quiro.-Aldave Maria del Carmen Durand-Vasquez Elman Ro.1}ndo.Gamarra-o.o.io.Juan del Carmen Valencia de la Cruz Claudia Mercedes Barrueto.Callirgo. Susan Luciana puelles-Leo. Elena de Jesus Alvarado.Leo. Frans Leiva-Cabrera Francisca Elena Zavaleta-Gutierrez luis Alberto.Co.cepcio.-Urteaga Jo.e paz-Ibarra Universidad Cientifica del Sur Bolivar 2150 AvenuePueblo Libre15084LimaPeru Divisio. o. Medicine Hospital de Apoyo ChepénChepenPeru Divisio. o. Family Medicine Hospital de Apoyo ChepénChepenPeru Divisio. o. Endo.rino.o.y Hospital Victor Lazarte EchegarayTrujilloPeru Divisio. o. pediatrics Hospital de Apoyo ChepenChepenPeru Divisio. o. Internal Medicine Hospital de Apoyo ChepenChepenPeru Divisio. o. Genetics Universidad Nacional de TrujilloTrujilloPeru Divisio. o. Neo.ato.o.y Hospital Belen de TrujilloTrujilloPeru Divisio. o. Internal Medicine Universidad Nacional de TrujilloTrujilloPeru department o. Medicine School of MedicineUniversidad Nacional Mayor de San MarcosLimaPeru

Backgro.nd o.esity is a multifacto.ial chro.ic disease with a high,increasing wo.ldwide *** causes acco.nt fo. 7%o. the cases in children with extreme *** so.rces This narrative review was co.ducted by searching fo. papers published in the pubMed/MEDLINE,Embase and SciELo.databases and included 161 *** search used the fo.lo.ing search terms:"o.esity","o.esity and genetics","leptin","prader-Willi syndro.e",and"melano.o.tins".The types o. studies included were systematic reviews,clinical trials,pro.pective co.o.t studies,cro.s-sectio.al and pro.pective studies,narrative reviews,and case *** The leptin-melano.o.tin pathway is primarily respo.sible fo. the regulatio. o. appetite and bo.y ***,several impo.tant aspects o. the patho.hysio.o.y o. o.esity remain *** causes o. o.esity can be gro.ped into.syndro.ic,mo.o.enic,and po.ygenic causes and sho.ld be assessed in children with extreme o.esity befo.e the age o. 5 years,hyperphagia,o. a family histo.y o. extreme o.esity.A micro.rray study,an analysis o. the melano.o.tin type 4 recepto. gene mutatio.s and leptin levels sho.ld be perfo.med fo. this *** are three therapeutic levels:lifestyle mo.ificatio.s,pharmaco.o.ical treatment,and bariatric *** Genetic study techno.o.ies are in co.stant develo.ment;ho.ever,we are still far fro. having a perso.alized appro.ch to.genetic causes o. o.esity.A significant pro.o.tio. o. the affected individuals are asso.iated with genetic causes;ho.ever,there are still barriers to.its appro.ch,as it co.tinues to.be underdiagno.ed.

关键词： Leptin Melano.o.tin o.esity prader-Willi syndro.e precisio. medicine

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Adult neuro.enesis:a real ho.e o. a delusio.?

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Neural Regeneratio. Research 2024年第1期19卷 6-15页

作者： Ghulam Hussain Rabia Akram Haseeb Anwar Faiqa Sajid Tehreem Iman Hyung So. Han Chand Raza Jo.e-luis Go.zalez de Aguilar Neuro.hemicalbio.o.y and Genetics labo.ato.y(NGL) Department of PhysiologyFaculty of Life SciencesGovernment College UniversityFaisalabadPunjabPakistan department o. physio.o.y School of MedicineClinical Omics InstituteKyungpook National UniversityDaeguKorea department o. Zo.lo.y Faculty of Chemistry and Life SciencesGovernment College UniversityLahorePakistan INSERM U1118Mécanismes Centraux et Péripheriques de la NeurodégénérescenceStrasbourgFranceUniversitéde StrasbourgStrasbourgFrance

Adult neuro.enesis,the pro.ess o. creating new neuro.s,invo.ves the co.rdinated divisio.,migratio.,and differentiatio. o. neural stem *** pro.ess is restricted to.neuro.enic niches lo.ated in two.distinct areas o. the brain:the subgranular zo.e o. the dentate gyrus o. the hippo.ampus and the subventricular zo.e o. the lateral ventricle,where new neuro.s are generated and then migrate to.the o.facto.y *** has been tho.ght to.o.cur o.ly during the embryo.ic and early po.tnatal stages and to.decline with age due to.a co.tinuo.s depletio. o. neural stem ***,recent years have seen tremendo.s pro.ress in o.r understanding o. adult brain neuro.enesis,bridging the kno.ledge gap between embryo.ic and adult ***,we discuss the current status o. adult brain neuro.enesis in light o. what we kno. abo.t neural stem *** this no.io.,we talk abo.t the impo.tance o. intra cellular signaling mo.ecules in mo.ilizing endo.eno.s neural stem cell pro.ife *** o. the current understanding,we can declare that these mo.ecules play a ro.e in targeting neuro.enesis in the mature ***,to.achieve this go.l,we need to.avo.d the undesired pro.iferatio. o. neural stem cells by co.tro.ling the necessary checkpo.nts,which can lead to.tumo.igenesis and pro.e to.be a curse instead o. a blessing o. ho.e.

关键词： adult neuro.enesis aging brain-derived neuro.ro.hic facto. dentate gyrus hippo.ampus neural stem cells neuro.ro.hic facto.s No.ch o.idative stress stem cells subgranular zo.e

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Measuring Impact o. Lean Manufacturing To.ls fo. Co.tinuo.s Impro.ement o. Eco.o.ic Sustainability

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Jo.rnal o. Systems Science and Systems Engineering 2024年第4期33卷 452-474页

作者： luis Javier Márquez Figuero. Jo.ge luis García-Alcaraz Ahmed Io.man Alfo.so.Jesús Gil López Yashar Aryanfar Mika Sillanpää Mamdo.h El Haj Assad department o. Electrical Engineering and Co.puter Science Universidad Autónoma de Ciudad JuárezCiudad JuárezChihuahuaMéxico department o. Industrial Engineering and Manufacturing Universidad Autónoma de Ciudad JuárezCiudad JuárezChihuahuaMéxico Scho.l o. Chemistry and Chemical Engineering Queens UniversityBelfastNorthern IrelandUK department o. Eco.o.ic and Managerial Sciences University of La RiojaLa RiojaSpain department o. Chemical Engineering University of JohannesburgJohannesburgSouth Africa department o. Sustainable and Renewable Energy Engineering University of SharjahSharjahUAE

Using Lean Manufacturing(LM)to.ls in pro.uctio. pro.esses is crucial fo. co.panies’eco.o.ic,enviro.mental,and so.ial sustainability *** study sho.s a structural equatio. mo.0}l(SEM)that sho.s the relatio.ship between LM To.ls like Kaizen(KAI),Gemba(GEM),Value Stream Mapping(VSM)and Key perfo.mance Indicato.(KpI)with Eco.o.ic Sustainability(ECS).Seven hypo.heses were evaluated with data fro. 179 respo.ses to.a questio.naire abo.t the Mexican maquilado.a industry,sho.ing that these variables are *** a 95%co.fidence level,the mo.0}l was evaluated using the partial least squares *** findings indicate that the relatio.ships between KAI and GEM and KAI and VSM have the stro.gest relatio.ship,fo.lo.ed by VSM and ECS;ho.ever,VSM has the stro.gest effect o. *** o. these findings,it is reco.mended that managers ado.t a co.tinuo.s impro.ement(KAI)appro.ch based o. wo.king directly o. the sho. flo.r(GEM and VSM)to.suppo.t their decisio.s regarding eco.o.ic gro.th(ECS).

关键词： Lean manufacturing eco.o.ic sustainability structural equatio. mo.0}l quality impro.ement

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Impact o. STAT-signaling pathway o. cancer-asso.iated fibro.lasts in co.o.ectal cancer and its ro.e in immuno.uppressio.

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Wo.ld Jo.rnal o. Gastro.ntestinal o.co.o.y 2024年第5期16卷 1705-1724页

作者： Damián Sánchez-Ramírez Mónica G Mendo.a-Ro.ríguez o.ar R Alemán Fernando.A Candanedo.Go.zález Miriam Ro.ríguez-So.a Juan Jo.éMo.tesino.-Mo.tesino. Mauricio.Salcedo.Ismael Brito.To.edo.Felipe Vaca-paniagua luis I Terrazas Unidad de Investigacio. en Bio.edicina Facultad de Estudios Superiores IztacalaUniversidad Nacional Autonoma de MexicoTlalnepantla 54090Estado de MexicoMexico department o. Bio.o.y Facultad de QuimicaUniversidad Nacional Autonoma de MexicoCiudad UniversitariaMexico City 04510Mexico department o. patho.o.y National Medical Center Century XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico labo.ato.io.de Células Tro.cales Mesenquimales Unidad de Investigación Médica en Enfermedades OncológicasHospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Unidad de Investigacio. en Bio.edicina y o.co.o.ia Geno.ica Instituto Mexciano del Seguro SocialMexico City 07300Mexico Servicio.de Co.o. y Recto Hospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico labo.ato.io.Nacio.al en Salud Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico

Co.o.ectal cancer(CRC)remains o.e o. the mo.t co.mo.ly diagno.ed and deadliest types o. cancer *** displays a desmo.lastic reactio.(DR)that has been inversely asso.iated with po.r pro.no.is;less DR is asso.iated with a better *** reactio. generates excessive co.nective tissue,in which cancer-asso.iated fibro.lasts(CAFs)are critical cells that fo.m a part o. the tumo. *** are directly invo.ved in tumo.igenesis thro.gh different ***,their ro.e in immuno.uppressio. in CRC is no. well understo.d,and the precise ro.e o. signal transducers and activato.s o. transcriptio.(STATs)in mediating CAF activity in CRC remains *** the myriad chemical and bio.o.ical facto.s that affect CAFs,different cyto.ines mediate their functio. by activating STAT signaling ***,the harmful effects o. CAFs in favo.ing tumo. gro.th and invasio. may be mo.ulated using STAT ***,we analyze the impact o. different STATs o. CAF activity and their immuno.egulato.y ro.e.

关键词： Cancer-asso.iated fibro.lasts Signal transducer and activato. o. transcriptio. signaling Co.o.ectal cancer Immunity Immuno.uppressio.

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