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Beneficial effect of reduced oxygen concentration with transfer of blastocysts in IVF patients older than 40 years old

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Health 2010年第9期2卷 1010-1017页

作者： Javier I. García Soledad Sepúlveda luis noriega-hoces 不详

The aim of the present study was to determine the impact of oxygen concentration on implantation, pregnancy and delivery rates in IVF patients older than 40 year old with transfer of blastocysts. Included were 558 women aged 23-45 years old undergoing IVF/ICSI procedures whose embryos were cultured at blastocyst stage under two different oxygen environments (a bi-gas system: 5.6% CO2 in air and a tri-gas system: 5.6% CO2, 5% de O2 and 89.4% N2). The main outcome measures of this study are implantation, pregnancy and delivery rates. Implantation, pregnancy and delivery rates are found to be reduced in women older than 40 years old. The implantation and pregnancy rates are significantly higher in women older than 40 years old from the 5% of O2 group, in comparison to the 20% group (25.00% versus 2.70% and 41.38% versus 5.56%;P < 0.05). The deliveries rates were 13.79% and 5.56% in the 5% and 20% oxygen groups respectively (P: NS). The birthweight was similar in both study groups (P: NS). Gestational age was significantly longer in wo- men from the 5% of O2 group, in comparison to the 20% (36.87 versus 35.87 weeks, P < 0.05). Results indicated that the embryonic culture with 5% of oxygen and transfer of blastocysts in women older than 40 years old improve the results in the in Vitro fertilization/intracytoplasmic injection procedures (IVF/ICSI).

关键词： ART Blastocyst IVF ICSI Oxygen

The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose M.Santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon luis H.Pagan Rivera Jorge D.Miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

A new approach for the treatment of CLL using chlorambucil/hydroxychloroquine-loaded anti-CD20 nanoparticles

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Nano Research 2016年第2期9卷 537-548页

作者： Sara Capolla Nelly Mezzaroba Sonia Zorzet Claudio Tripodo Ramiro Mendoza-Maldonado Marilena Granzotto Francesca Vita Ruben Spretz Gustavo Larsen Sandra noriega Eduardo Mansilla Michele Dal Bo Valter Gattei Gabriele Pozzato luis Nunez Paolo Macor Department of Life Sciences University of Trieste 34127 Trieste Italy Department of Human Pathology University of Palermo 90133 Sicilia Italy Molecular Oncology Unit National Laboratory Consorzio Interuniversitatio per le Biotecnologie (CIB) 34012 Trieste Italy Dipartimento Universitario Clinico di Scienze mediche Chirurgiche e della Salute University of Trieste 34149 Trieste Italy LNK Chemsolutions LLC Lincoln NE 68521 USA Bio-Target Inc. Chicago IL 60637 USA Centro Unico Coordinador de Ablacion e Implante Provincia de Buenos Aires (C.U.CA.I.B.A.) Ministry of Health La Plata Buenos AiresArgentina Clinical and Experimental Onco-Hematology Unit Centro di Riferimento Oncologico Istituto di Ricerca e Cura a Carattere Scientifico(I.R.C.C.S.) 33081 Aviano Italy Callerio Foundation Onlus Institutes of Biological Researches 34127 Trieste Italy

Current approaches for the treatment of chronic lymphocytic leukemia （CLL） have greatly improved the prognosis for survival, but some patients remain refractive to these therapeutic regimens. Hence, in addition to reducing the long-term side- effects of therapeutics for all leukemia patients, there is an urgent need for novel therapeutic strategies for difficult-to-treat leukemia cases. Due to the cytotoxicity of drugs, the major challenge currently is to deliver the therapeutic agents to neoplastic cells while preserving the viability of non-malignant ceils. In this study, we propose a therapeutic approach in which high doses of hydroxychloroquine and chlorambucil were loaded into biodegradable polymeric nanopartides coated with an anti-CD20 *** first demonstrated the ability of the nanoparticles to target and internalize in tumor B-cells. Moreover, these nanoparticles could kill not only p53-mutated]deleted leukemia cells expressing a low amount of CD20, but also circulating primary ceils isolated from chronic lymphocytic leukemia patients. The safety of these nanoparticles was also demonstrated in healthy mice, and their therapeutic effects were shown in a new model of aggressive leukemia. These results showed that anti-CD20 nanoparticles containing hydroxychloroquine and chlorambucil can be effective in controlling aggressive leukemia and provided a rationale for adopting this approach for the treatment of other B-cell disorders.

关键词： chronic lymphocytic leukemia immune targeted nanoparticles treatment xenograft model

A novel heterozygous SF1/NR5A1 gene variant causes 46,XY DSD-gonadal dysgenesis with hypergonadotropic hypogonadism without adrenal insufficiency

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Genes & Diseases 2024年第4期11卷 128-130页

作者： luis Ramos Department of Reproductive Biology Instituto Nacional de Ciencias Medicas y Nutricion Salvador ZubirdnTlalpanMexico City 14080Mexico

Steroidogenic factor 1(SF1/NR5A1;nuclear receptor subfamily 5 group A member 1)is an essential orphan protein involved in gonadal embryogenesis,sex determination,and reproductive endocrinology.

关键词： insufficiency determination gonadal

New frontiers on open standards for geo-spatial science

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Geo-Spatial Information Science 2017年第2期20卷 126-133页

作者： luis Bermudez Open Geospatial Consortium WaylandMAUSA

The process of sharing of data has become easier than ever with the advancement of cloud computing and software ***,big challenges remain such as efficient handling of big geospatial data,supporting and sharing of crowd sourced/citizen science data,integration with semantic heterogeneity,and inclusion of agile processes for continuous improvement of geospatial *** paper discusses the new frontiers regarding these challenges and the related work performed by the Open Geospatial Consortium,the world leading organization focused on developing open geospatial standards that“geo-enable”the Web,wireless,and location-based services and mainstream IT.

关键词： Open Geospatial Consortium(OGC) big data cloud computing open standards semantics linked data

Pharmaceutical applications of spouted beds: A review on solid dosage forms

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Particuology 2019年第1期17卷 126-136页

作者： luis Alexandre Pedro de Freitas Faculdade de Ciencias Farmaceuticas de Ribeirao Preto University of Sao PauloVia do Cafe s/n. Campus USPRibeirao Preto14040-903Sao Paulo. Brazil

Spouted beds (SBs) have a long history of successful applications for preparation of solid dosage forms of pharmaceuticals. The well-known versatility of SBs, provided by different design and operational factors, and their efficient mixing of solids allow for engineering of technological characteristics of pharmaceutical solid forms. Particle properties like morphology, size, porosity, flowability, and dissolution rate can be improved by managing geometric and operational conditions for spouting. Drying is probably the most disseminated operation for pharmaceutical processing in SBs, and many studies have investigated drying of medicinal plant extracts such as achiote (Bixa orellana sp.), guarana (Paullinia cupana sp.), passion flower (Passiflora alata D.), and rosemary (Rosmarinus officinalis L.) with excellent pharmacotechnical and stability results. Another important application is coating of tablets and gelatin capsules, and previous studies have shown that SBs and spout–fluid beds may be advantageous over traditional pan coating, especially for polymeric film coating. Recently, an alternative process for improving drug bioavailability has involved preparation of β-cyclodextrin inclusion complexes in SBs. The first study to propose SBs for this pharmaceutical application explored the advantage of obtaining solid forms of inclusion complexes in just one step, and obtained expressive increases in drug solubility. The technique has been applied in subsequent studies on inclusion complexes of the medication carvedilol and uxi (Endopleura uchi L.) extracts.

关键词： Coating Drying Granulation Inclusion Microencapsulation

Dynamics of air transport networks：A review from a complex systems perspective

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Chinese Journal of Aeronautics 2017年第2期30卷 469-478页

作者： luis E.C.Rocha Department of Public Health Sciences Karolinska Institutet Stockholm 17177 Sweden Department of Mathematics University of Namur 5000 Belgium

Air transport systems are highly dynamic at temporal scales from minutes to *** dynamic behavior not only characterizes the evolution of the system but also affect the system＇s *** the evolutionary mechanisms is thus fundamental in order to better design optimal air transport networks that benefits companies,passengers and the *** this review,we briefly present and discuss the state-of-the-art on time-evolving air transport *** distinguish the structural analysis of sequences of network snapshots,ideal for long-term network evolution（*** evolution）,and temporal paths,preferred for short-term dynamics（*** evolution）.We emphasize that most previous research focused on the first modeling approach（***-term） whereas only a few studies look at high-resolution temporal *** conclude the review highlighting that much research remains to be done,both to apply already available methods and to develop new measures for temporal paths on air transport *** particular,we identify that the study of delays,network resilience and optimization of resources（aircraft and crew） are critical topics.

关键词： Air transport Airport network Complex network Dynamic network Temporal network

Performance assessment of two-dimensional hydraulic models for generation of flood inundation maps in mountain river basins

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Water Science and Engineering 2019年第1期12卷 11-18页

作者： Juan Pinos luis Timbe Department of Water Resources and Environmental Sciences University of Cuenca

Hydraulic models for the generation of flood inundation maps are not commonly applied in mountain river basins because of the difficulty in modeling the hydraulic behavior and the complex topography. This paper presents a comparative analysis of the performance of four twodimensional hydraulic models (HEC-RAS 2D, Iber 2D, Flood Modeller 2D, and PCSWMM 2D) with respect to the generation of flood inundation maps. The study area covers a 5-km reach of the Santa B-arbara River located in the Ecuadorian Andes, at 2330 masl, in Gualaceo. The model's performance was evaluated based on the water surface elevation and flood extent, in terms of the mean absolute difference and measure of fit. The analysis revealed that, for a given case, Iber 2D has the best performance in simulating the water level and inundation for flood events with 20- and 50-year return periods, respectively, followed by Flood Modeller 2D, HEC-RAS 2D, and PCSWMM 2D in terms of their performance. Grid resolution, the way in which hydraulic structures are mimicked, the model code, and the default value of the parameters are considered the main sources of prediction uncertainty.

关键词： Two-dimensional hydraulic models Flood modeling Flood extent Water surface elevation High mountain river Ecuador

Cardiovascular risk prediction in the elderly

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Journal of Geriatric Cardiology 2019年第5期16卷 414-420页

作者： Kartik Kumar luis Afonso Division of Cardiology Wayne State University Detroit Medical Center

Heart failure(HF)in the elderly,besides being a leading cause of mortality and morbidity,is rapidly increasing in prevalence with patients aged 65 and older accounting for more than 75%of heart failure *** patients have historically been unrepresented in clinical HF trials and often present with multiple comorbidities,including frailty,depression,nutritional,functional and cognitive ***,pharmacologic challenges such as adherence to therapy,polypharmacy,altered drug pharmacokinetics and/or renal derangements make them less likely to receive guideline-directed medical therapies for *** of these various interrelated domains is key and should prompt a multidisciplinary,holistic management approach so as to optimize prognosis in this vulnerable subset of the population.

关键词： Biomarkers Cardiovascular risk prediction Heart failure