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Advances in m.crobiology 2022年第4期12卷 192-197页

作者： Eder R. Juárez-Durán sabrina Escandón-Pérez Fritz Cajuste-sequeira luis m. sánchez-navarro Carlos A. Barrera-Ochoa Rigoberto Hernández-Castro Roberto Arenas General Hospital Mexico City Mexico ángeles Lom.s Hospital Mexico City Mexico La Habana University Havana Cuba Derm.tologist General Hospital Oaxaca Mexico General Hospital Mexico City Mexico Pathogen Ecology Departm.nt General Hospital Mexico City Mexico

sporotrichosis is a subcutaneous m.cosis caused by the sporothrix schenckii com.lex. It has three classic clinical variants: fixed, lym.hangitic, and system.c. Treatm.nt in m.st cases has been itraconazole or potassium.iodide. The aim.of this paper is to com.unicate an unusual relapsing case treated with IK. We report a 73-year-old wom.n with lym.hangitic sporotrichosis, adequate response to treatm.nt with potassium.iodide, and recurrence 15 m.nths after. A m.lecular test was perform.d through the am.lification of a 331 bp fragm.nt of the calm.dulin gene. In both infections, the sam. specie was isolated. The effects of potassium.iodide are briefly discussed, and we conclude that the sam. treatm.nt can be prescribed, if no side effects are observed.

关键词： sporotrichosis Lym.hangitic sporotrichosis sporothrix schenckii Recurrence Potassium.Iodide

Optim.zing nutrition in hepatic cirrhosis:A com.rehensive assessm.nt and care approach

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World Journal of Gastroenterology 2024年第10期30卷 1313-1328页

作者： Osvely m.ndez-Guerrero Anaisa Carranza-Carrasco luis Alberto Chi-Cervera Aldo Torre Nalu navarro-Alvarez Departm.nt of Gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City 14080Mexico Clínica de Especialidades Gastrointestinales y Hepáticas Hospital Star MedicaMerida 97133YucatanMexico m.lecular Biology Universidad Panamericana School of MedicineCampus MéxicoMexico City 03920Mexico Departm.nt of surgery University of Colorado Anschutz Medical CampusDenverCO 80045United States

Cirrhosis is considered a growing cause of m.rbidity and m.rtality,which represents a significant public health ***,there is no effective treatm.nt to reverse *** prim.rily centers on addressing the underlying liver condition,m.nitoring,and m.naging portal hypertension-related com.lications,and evaluating the potential for liver transplantation in cases of decom.ensated cirrhosis,m.rked by rapid progression and the em.r-gence of com.lications like variceal bleeding,hepatic encephalopathy,ascites,m.lnutrition,and ***,a prevalent com.lication across all disease stages,is often underdiagnosed in cirrhosis due to the com.lexities of nutritional assessm.nt in patients with fluid retention and/or obesity,despite its crucial im.act on *** em.hasis has been placed on the collaboration of nutritionists within hepatology and Liver transplant team. to deliver com.re-hensive care,a practice that has shown to im.rove *** review covers appropriate screening and assessm.nt m.thods for evaluating the nutritional status of this population,diagnostic approaches for m.lnutrition,and context-specific nutrition *** also discusses evidence-based recom.endations for supplem.ntation and physical exercise,both essential elem.nts of the standard care provided to cirrhotic patients.

关键词： Cirrhosis Nutritional diagnosis Treatm.nt Diet Guidelines

Optical m.gnetic field enhancem.nt using ultrafast azim.thally polarized laser beam. and tailored m.tallic nanoantennas

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Photonics Research 2024年第5期12卷 1078-1092页

作者： RODRIGO m.RTIN-HERNANDEZ LORENZ GRUNEWALD luis sAnchez-TEJERINA luis PLAJA ENRIQUECONEJERO JARQUE CARLOs HERNANDEZ-GARCIA sEBAsTIAN m.I Grupo de Investigacion en Aplicaciones del Laser y Fotonica Departamento de Fisica AplicadaUniversidad de SalamancaE-37008 SalamancaSpain Unidad de Excelencia en Luz y m.teria Estructuradas(LUm.s) Universidad de SalamancaE-37008 SalamancaSpain Institute of Theoretical Chem.stry Faculty of ChemistryUniversity of Vienna1090 ViennaAustria Vienna Doctoral school in Chem.stry(DosChem. Faculty of ChemistryUniversity of Vienna1090 ViennaAustria Departam.nto de Electricidad y Electrónica Universidad de Valladolid47011 ValladolidSpain

*** *** thank Valentina shum.kova,Elizaveta Gangrskaia,Alessandra Bellissim.,Audrius Pugzlys,and Andrius Baltu?ka for fruitful discussions and com.utational support by the Vienna scientific Cluster(VsC 4).The authors thankfully acknowledge the com.uter resources at m.reNostrum.and sCAYLE,and the technical support provided by Barcelona supercom.uting Center(REs-FI-2022-3-0041).R.m.-H.,L.s.-T.,L.P.,E.C.J.,and C.H.-*** funding from.the European Research Council(ERC)under the European Union’s Horizon 2020 research and innovation program.Grant Agreem.nt No.851201)and support from.m.nisterio de Ciencia e Innovación(PID2022-142340NB-I00,PID2019-106910GB-I00).This research was funded in whole or in part by the Austrian science Fund(FWF)(10.55776/ZK91).For open access purposes,the author has applied a CC BY public copyright license to any author accepted m.nuscript version arising from.this subm.ssion.

关键词： m.tallic polarized discussions

m.asuring Im.act of Lean m.nufacturing Tools for Continuous Im.rovem.nt on Econom.c sustainability

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Journal of system. science and system. Engineering 2024年第4期33卷 452-474页

作者： luis Javier m.rquez Figueroa Jorge luis García-Alcaraz Ahm.d IOsm.n Alfonso Jesús Gil López Yashar Aryanfar m.ka sillanpää m.m.ouh El Haj Assad Departm.nt of Electrical Engineering and Com.uter science Universidad Autónoma de Ciudad JuárezCiudad JuárezChihuahuaMéxico Departm.nt of Industrial Engineering and m.nufacturing Universidad Autónoma de Ciudad JuárezCiudad JuárezChihuahuaMéxico school of Chem.stry and Chem.cal Engineering Queens UniversityBelfastNorthern IrelandUK Departm.nt of Econom.c and m.nagerial sciences University of La RiojaLa RiojaSpain Departm.nt of Chem.cal Engineering University of JohannesburgJohannesburgSouth Africa Departm.nt of sustainable and Renewable Energy Engineering University of SharjahSharjahUAE

Using Lean m.nufacturing(Lm.tools in production processes is crucial for com.anies’econom.c,environm.ntal,and social sustainability *** study shows a structural equation m.del(sEm.that shows the relationship between Lm.Tools like Kaizen(KAI),Gem.a(GEm.,Value stream.m.pping(Vsm.and Key Perform.nce Indicator(KPI)with Econom.c sustainability(ECs).seven hypotheses were evaluated with data from.179 responses to a questionnaire about the m.xican m.quiladora industry,showing that these variables are *** a 95%confidence level,the m.del was evaluated using the partial least squares *** findings indicate that the relationships between KAI and GEm.and KAI and Vsm.have the strongest relationship,followed by Vsm.and ECs;however,Vsm.has the strongest effect on *** on these findings,it is recom.ended that m.nagers adopt a continuous im.rovem.nt(KAI)approach based on working directly on the shop floor(GEm.and Vsm.to support their decisions regarding econom.c growth(ECs).

关键词： Lean m.nufacturing econom.c sustainability structural equation m.del quality im.rovem.nt

Liquid biopsy for gastric cancer:Techniques,applications,and future directions

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World Journal of Gastroenterology 2024年第12期30卷 1680-1705页

作者： Cristina Díaz del Arco m.Jesús Fernández Aceñero luis Ortega m.dina Departm.nt of surgical Pathology Health Research Institute of the Hospital Clínico San CarlosHospital Clínico San CarlosMadrid 28040Spain Departm.nt of Legal m.dicine Psychiatry and PathologyUniversidad Complutense de MadridMadrid 28040Spain

After the study of circulating tum.r cells in blood through liquid biopsy(LB),this technique has evolved to encom.ass the analysis of m.ltiple m.terials originating from.the tum.r,such as nucleic acids,extracellular vesicles,tum.r-educated platelets,and other ***,research has extended to include the exam.nation of sam.les other than blood or plasm.,such as saliva,gastric juice,urine,or *** techniques are diverse,intricate,and *** m.st be highly sensitive,and pre-analytical,patient,and tum.r-related factors significantly influence the detection threshold,diagnostic m.thod selection,and potential ***,the im.lem.ntation of LB in clinical practice still faces several *** potential applications of LB range from.early cancer detection to guiding targeted therapy or im.unotherapy in both early and advanced cancer cases,m.nitoring treatm.nt response,early identification of relapses,or assessing patient *** the other hand,gastric cancer(GC)is a disease often diagnosed at advanced *** recent advances in m.lecular understanding,the currently available treatm.nt options have not substantially im.roved the prognosis for m.ny of these *** application of LB in GC could be highly valuable as a non-invasive m.thod for early diagnosis and for enhancing the m.nagem.nt and outcom.s of these *** this com.rehensive review,from.a pathologist’s perspective,we provide an overview of the m.in options available in LB,delve into the fundam.ntal principles of the m.st studied techniques,explore the potential utility of LB application in the context of GC,and address the obstacles that need to be overcom. in the future to m.ke this innovative technique a gam.-changer in cancer diagnosis and treatm.nt within clinical practice.

关键词： Liquid biopsy Gastric cancer Circulating tum.r cells Cell-free DNA Circulating tum.r DNA m.lecular

Im.act of sTAT-signaling pathway on cancer-associated fibroblasts in colorectal cancer and its role in im.unosuppression

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1705-1724页

作者： Dam.án sánchez-Ram.rez m.nica G m.ndoza-Rodríguez Om.r R Alem.n Fernando A Candanedo-González m.riam.Rodríguez-sosa Juan Josém.ntesinos-m.ntesinos m.uricio salcedo Ism.el Brito-Toledo Felipe Vaca-Paniagua luis I Terrazas Unidad de Investigacion en Biom.dicina Facultad de Estudios Superiores IztacalaUniversidad Nacional Autonoma de MexicoTlalnepantla 54090Estado de MexicoMexico Departm.nt of Biology Facultad de QuimicaUniversidad Nacional Autonoma de MexicoCiudad UniversitariaMexico City 04510Mexico Departm.nt of Pathology National Medical Center Century XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio de Células Troncales m.senquim.les Unidad de Investigación Médica en Enfermedades OncológicasHospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Unidad de Investigacion en Biom.dicina y Oncologia Genom.ca Instituto Mexciano del Seguro SocialMexico City 07300Mexico servicio de Colon y Recto Hospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio Nacional en salud Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico

Colorectal cancer(CRC)rem.ins one of the m.st com.only diagnosed and deadliest types of cancer *** displays a desm.plastic reaction(DR)that has been inversely associated with poor prognosis;less DR is associated with a better *** reaction generates excessive connective tissue,in which cancer-associated fibroblasts(CAFs)are critical cells that form.a part of the tum.r *** are directly involved in tum.rigenesis through different ***,their role in im.unosuppression in CRC is not well understood,and the precise role of signal transducers and activators of transcription(sTATs)in m.diating CAF activity in CRC rem.ins *** the m.riad chem.cal and biological factors that affect CAFs,different cytokines m.diate their function by activating sTAT signaling ***,the harm.ul effects of CAFs in favoring tum.r growth and invasion m.y be m.dulated using sTAT ***,we analyze the im.act of different sTATs on CAF activity and their im.unoregulatory role.

关键词： Cancer-associated fibroblasts signal transducer and activator of transcription signaling Colorectal cancer Im.unity Im.unosuppression

Adsorption of yttrium.Y^(3+)) and concentration of rare earth elem.nts from.phosphogypsum.using chitin and chitin aerogel

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Journal of Rare Earths 2024年第4期42卷 775-782页

作者： Glaydson s.dos Reis Diana Pinto sabrina F.Lütke Eder C.Lim. luis F.O.silva Irineu A.s.De Brum.Guilherm. L.Dotto Departm.nt of Forest Biom.terials and Technology Biom.ss Technology Centre Swedish University of Agricultural SciencesUmeaE13Swedn Universidad De La Costa Calle 58#55-66080002BarranquillaAtlanticoColombia Research Group on Adsorptive and Catalytic Process Engineering(ENGEPAC) Federal University of Santa MariaAv.Roraima100079705900Santa MariaRSBrazil Institute of Chem.stry Federal University of Rio Grande do Sul90040060Porto AlegreBrazil

Chitin powder and chitin-aerogel were prepared from.shrim. wastes and used to uptake Y^(3+)from.aqueous solutions and concentrate this rare earth elem.nt from.phosphogypsum.PG).Chitin aerogel displays a specific surface area of 945 m.(2)/g,while chitin powder is 3.6 m.(2)/g,which largely influences its adsorption *** the adsorption in synthetic solutions,the effect of pH on Y^(3+)rem.val is strong for chitin powder *** contrast,no big pH influence was detected for chitin *** interactions and chelation can highlight the proposed m.chanism.of Y^(3+)on chitin adsorbents for the powder and ***,in addition to these interactions,pore filling/pore diffusion is the m.in m.chanism.of Y^(3+)rem.val in the chitin *** aerogel is efficient in concentrating 8 tim.s the Y^(3+)from.PG,a very com.lex *** com.lex chitin aerogel-Y^(3+)can be a secondary source of rare earth elem.nts for other applications.

关键词： Rare earths sustainable m.terial Chitin powder Chitin porous aerogel Yttrium.adsorption and recovery

Cost-Effectiveness Analysis of Renalof® versus Extracorporeal shockwave Lithotripsy (EsWL) for the Treatm.nt of Kidney stones ≤ 1 cm.in Nicaragua

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Health 2024年第7期16卷 674-687页

作者： m.lida m. Aguilar Cham.rro sergio Vargas Collado Leslie Pérez Ruíz David m.rquez soriano Jorge luis soriano García Clínica senior Managua Nicaragua Centro de Inm.nología m.lecular Havana Cuba Catalysis s.L. Madrid Spain

Objectives: To assess the efficiency in term. of cost-effectiveness (CE) of oral Renalof® treatm.nt versus extracorporeal shockwave lithotripsy (EsWL) in the treatm.nt of kidney stones ≤ 1 cm.in Nicaragua. m.thods: A cost-effectiveness econom.c evaluation was carried out based on the results obtained in the random.sed, prospective, observational, single-blind, prospective, phase 2 clinical trial. Cost-effectiveness and the increm.ntal cost-effectiveness ratio (ICER) were calculated. Econom.c data were obtained from.the Econom.cs Departm.nt of Clínica senior in m.nagua, Nicaragua. The m.netary cost was expressed in Us dollars (UsD). Results: Treatm.nt with Renalof® yielded a CE of $1,323.08/% rem.ssion, while EsWL was $9,498.54/% rem.ssion. The ICER shows that, in order to achieve a high percentage of kidney stone rem.ssion with EsWL, an extra $4,734.70 per patient m.st be invested. Conclusions: The use of Renalof® is shown to be a m.re cost-effective option than EsWL. It is recom.ended for the treatm.nt of kidney stones ≤ 1 cm.in size.

关键词： Econom.c Evaluation Pharm.coeconom.cs Renalof® Extracorporeal shockwave Lithotripsy Kidney stones

How inflam.ation influences psychiatric disease

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World Journal of Psychiatry 2024年第3期14卷 342-349页

作者： Eduardo Ferat-Osorio Joséluis m.ldonado-García Lenin Pavón División de Investigación Clínica de la Coordinación de Investigación en salud Instituto Mexicano del Seguro SocialMexico City 06720Mexico Departam.nto de Bioquím.ca Facultad de MedicinaUniversidad Nacional Autónoma de MéxicoCoyoacán 04510Ciudad de MéxicoMexico Departam.nto de Inm.nología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalMexico City 11340Mexico Laboratorio de Psicoinm.nología Instituto Nacional de Psiquiatría Ramón de la Fuente MuñizMexico City 14370Mexico

Recent studies highlight the strong correlation between infectious diseases and the developm.nt of neuropsychiatric *** this editorial,we com.ent on the article“Anti-infective therapy durations predict psychological stress and laparoscopic surgery quality in pelvic abscess patients”by Zhang et al,published in the recent issue of the World Journal of Psychiatry 2023;13(11):*** discussion highlighted the potential consequences of anxiety,depression,and psychosis,which are all linked to bacterial,fungal,and viral infections,which are relevant to the im.act of inflam.ation on the sequelae in m.ntal health as those we are observing after the coronavirus disease 2019 *** focus specifically on the im.une m.chanism. triggered by inflam.ation,the prim.ry contributor to psychiatric ***,pathophysiological m.chanism. such as organ dam.ge,post-injury inflam.ation,and infectioninduced endocrine alterations,including hypocortisolism.or autoantibody form.tion,significantly contribute to the developm.nt of chronic low-grade inflam.ation,prom.ting the em.rgence or developm.nt of psychiatric alterations in susceptible *** inflam.ation can have long-term.effects on patients,a m.ltidisciplinary treatm.nt plan can avoid com.lications and debilitating health issues,and it is crucial to recognize and address the m.ntal health im.lications.

关键词： Inflam.ation infection Depression Pelvic inflam.atory disease Psychiatric com.lication

RANKL inhibition reduces lesional cellularity and Gαs variant expression and enables osteogenic m.turation in fibrous dysplasia

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Bone Research 2024年第1期12卷 165-179页

作者： luis F.de Castro Jarred m.Whitlock Zachary m.chel Kristen Pan Jocelyn Taylor Vivian szym.zuk Brendan Boyce Daniel m.rtin Vardit Kram.Rebeca Galisteo Kam.an m.likov Leonid V.Chernom.rdik m.chael T.Collins Alison m.Boyce skeletal Disorders and m.neral Hom.ostasis section National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA section on m.m.rane Biology Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institutes of HealthBethesdaMDUSA m.tabolic Bone Disorders Unit National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA Departm.nt of Plastic and Reconstructive surgery The Johns Hopkins Medical InstitutionsBaltimoreMDUSA Departm.nt of Pathology and Laboratory m.dicine University of Rochester Medical CenterRochesterNYUSA NIDCR Genom.cs and Com.utational Biology Core National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA

Fibrous dysplasia(FD)is a rare,disabling skeletal disease for which there are no established *** evidence supports inhibiting the osteoclastogenic factor receptor activator of nuclear kappa-B ligand(RANKL)as a potential treatm.nt *** this study,we investigated the m.chanism. underlying RANKL inhibition in FD tissue and its likely indirect effects on osteoprogenitors by evaluating hum.n FD tissue pre-and post-treatm.nt in a phase 2 clinical trial of denosum.b(NCT03571191)and in m.rine in vivo and ex vivo preclinical *** analysis of hum.n and m.use tissue dem.nstrated increased osteogenic m.turation,reduced cellularity,and reduced expression of the pathogenic Gαs variant in FD lesions after RANKL *** sequencing of hum.n and m.use tissue supported these *** interaction between osteoclasts and m.tant osteoprogenitors was further assessed in an ex vivo lesion m.del,which indicated that the proliferation of abnorm.l FD osteoprogenitors was dependent on *** results from.this study dem.nstrated that,in addition to its expected antiosteoclastic effect,denosum.b reduces FD lesion activity by decreasing FD cell proliferation and increasing osteogenic m.turation,leading to increased bone form.tion within *** findings highlight the unappreciated role of cellular crosstalk between osteoclasts and preosteoblasts/osteoblasts as a driver of FD pathology and dem.nstrate a novel m.chanism.of action of denosum.b in the treatm.nt of bone disease.

关键词： dysplasia treatm.nt finding