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Modulation of immunity and inflammatory gene expression in the gut, in inflammatory diseases of the gut and in the liver by probiotics

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World Journal of Gastroenterology 2014年第42期20卷 15632-15649页

作者： Julio Plaza-Diaz Carolina gomez-Llorente luis Fontana Angel Gil Department of Biochemistry and Molecular Biology Ⅱ School of Pharmacy and Institute of Nutrition and Food Technology "Jose Mataix" Biomedical Research Center University of Granada

The potential for the positive manipulation of the gut microbiome through the introduction of beneficial microbes, as also known as probiotics, is currently an active area of investigation. The FAO/WHO define probiotics as live microorganisms that confer a health benefit to the host when administered in adequate amounts. However, dead bacteria and bacterial molecular components may also exhibit probiotic properties. The results of clinical studies have demonstrated the clinical potential of probiotics in many pathologies, such as allergic diseases, diarrhea, inflammatory bowel disease and viral infection. Several mechanisms have been proposed to explain the beneficial effects of probiotics, most of which involve gene expression regulation in specific tissues, particularly the intestine and liver. Therefore, the modulation of gene expression mediated by probiotics is an important issue that warrants further investigation. In the present paper, we performed a systematic review of the probiotic-mediated modulation of gene expression that is associated with the immune system and inflammation. Between January 1990 to February 2014, PubMed was searched for articles that were published in English using the MeSH terms “probiotics' and 'gene expression' combined with “intestines', 'liver', 'enterocytes', 'antigen-presenting cells', 'dendritic cells', 'immune system', and 'inflammation'. Two hundred and five original articles matching these criteria were initially selected, although only those articles that included specific gene expression results (77) were later considered for this review and separated into three major topics: the regulation of immunity and inflammatory gene expression in the gut, in inflammatory diseases of the gut and in the liver. Particular strains of Bifidobacteria, Lactobacilli, Escherichia coli, Propionibacterium, Bacillus and Saccharomyces influence the gene expression of mucins, Toll-like receptors, caspases, nuclear factor-κ

关键词： Gene expression Immunity Immunotolerance Inflammation Microbiota Probiotics Gut Liver

Integrating geographical information in the Linked Digital Earth

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International Journal of Digital Earth 2014年第7期7卷 554-575页

作者： luis M.Vilches-Blazquez Boris Villazon-Terrazas Oscar Corcho Asuncion gomez-Perez Ontology Engineering Group Departamento de Inteligencia ArtificialFacultad de InformaticaUniversidad Politecnica de MadridMadridSpain

Many progresses have been made since the Digital Earth notion was envisioned thirteen years ***,the mechanism for integrating geographic informa-tion into the Digital Earth is still quite *** this context,we have developed a process to generate,integrate and publish geospatial Linked Data from several Spanish National *** data-sets are related to four Infrastructure for Spatial Information in the European Community(INSPIRE)themes,specifically with Administrative units,Hydrography,Statistical units,and *** main goal is to combine different sources(heterogeneous,multidisciplinary,multitemporal,multiresolution,and multilingual)using Linked Data *** goal allows the overcoming of current problems of information integration and driving geographical information toward the next decade scenario,that is,‘Linked Digital Earth’.

关键词： geographical information integration Digital Earth Linked Data

Haplotype phasing after joint estimation of recombination and linkage disequilibrium in breeding populations

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Journal of Animal Science and Biotechnology 2014年第1期5卷 38-52页

作者： luis gomez-Raya Amanda M Hulse David Thain Wendy M Rauw Departamento de Mejora Genética Animal Instituto Nacional deInvestigación y Tecnología Agraria y Alimentaria (INIA) Interdisciplinary Program in Genetics Texas A&M University College Station Department of Animal Biotechnology University of Nevada

A novel method for haplotype phasing in families after joint estimation of recombination fraction and linkage disequilibrium is developed. Results from Monte Carlo computer simulations show that the newly developed E.M. algorithm is accurate if true recombination fraction is 0 even for single families of relatively small sizes. Estimates of recombination fraction and linkage disequilibrium were 0.00 （SD 0.00） and 0.19 （SD 0.03） for simulated recombination fraction and linkage disequilibrium of 0.00 and 0.20, respectively. A genome fragmentation phasing strategy was developed and used for phasing haplotypes in a sire and 36 progeny using the 50 k Illumina BeadChip by： a） estimation of the recombination fraction and LD in consecutive SNPs using family information, b） linkage analyses between fragments, c） phasing of haplotypes in parents and progeny and in following generations. Homozygous SNPs in progeny allowed determination of paternal fragment inheritance, and deduction of SNP sequence information of haplotypes from dams. The strategy also allowed detection of genotyping errors. A total of 613 recombination events were detected after linkage analysis was carried out between fragments. Hot and cold spots were identified at the individual （sire level）. SNPs for which the sire and calf were heterozygotes became informative （over 90%） after the phasing of haplotypes. Average of regions of identity between half-sibs when comparing its maternal inherited haplotypes （with at least 20 SNP） in common was 0.11 with a maximum of 0.29 and a minimum of 0.05. A Monte-Carlo simulation of BTA1 with the same linkage disequilibrium structure and genetic linkage as the cattle family yielded a 99.98 and 99.94% of correct phases for informative SNPs in sire and calves, respectively.

关键词： Breeding Haplotype phasing Linkage disequilibrium SNP

Nutritional quality and physiological effects of halal meat:A pilot study in non-Muslim consumers

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Food Bioscience 2022年第5期49卷 738-745页

作者： Cristina Carrasco Trinidad Perez-Palacios luis Miguel Luengo Sergio gomez Miguel Fajardo María de los Angeles gomez Ana Beatriz Rodríguez Neuroimmunophysiology and Chrononutrition Research Group Department of Physiology(Faculty of Sciences)University of Extremadura06006BadajozSpain Research Institute of Meat and Meat Products(IProCar) University of Extremadura10003C´aceresSpain Service of Endocrinology and Nutrition University Hospital of Badajoz06006BadajozSpain Service of Clinical Analysis University Hospital of Badajoz06006BadajozSpain Service of Microbiology University Hospital of Badajoz06006BadajozSpain

Despite the current controversy,red meat remains essential to the proper functioning of our *** the trend meat products available for consumers,halal meat is becoming an interesting choice,independently of their religious ***,little is known about its nutritional content and possible health *** this reason,a comparative analysis of the physical-chemical and nutritional properties between halal and non-halal meats(beef and lamb)was ***,a pilot study was performed by University of Extremadura analysing the impact of its consumption on body composition,gut microbiota,biomarkers,and antioxidant *** healthier lipid profile founded in halal meat may have had a positive impact on the weight,muscle mass,body fat and antioxidant status of the participants,without altering the gut microbiota and levels of biomarkers such as glucose,insulin,or *** research can help meat consumers to choose healthier and more eco-friendly products.

关键词： Halal meat Lipid profile Body composition gut microbiota Antioxidant status Biomarkers

A Regulatory Module Controlling CA-Mediated Endosperm Cell Expansion Is Critical for Seed Germination in Arabidopsis

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Molecular Plant 2019年第1期12卷 71-85页

作者： Rocio Sanchez-Montesino Laura Bouza-Morcillo Julietta Marquez Melania Ghita Salva Duran-Nebreda luis gomez Michael J.Holdsworth George Bassel luis Onate-Sanchez Centro de Biotecnologia y Genomica de Plantas Universidad Politecnica de Madrid-lnstituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria Campus de MontegancedoPozuelo de AlarconMaddd 28223Spain School of Biosciences University of NottinghamLoughborough LE12 5RDUK School of Biosciences University of BirminghamBirmingham B15 23-rUK Departamento de Sistemas y Recursos Naturales E.T.S.I.MontesForestal y del Medio NaturalCampus de Moncloa28040 MadridSpain

A key component of seed germination is the interplay of mechanical forces governing embryo growth and the surrounding restraining endosperm *** cell separation is therefore thought to play a critical role in the control of this developmental *** we demonstrate that in Arabidopsis thaliana seeds,endosperm cell expansion is a key component of *** cells expand to accommodate embryo growth prior to *** show that this is an actively regulated process supported by spatiotemporal control of the cell expansion gene EXPANSIN 2 (EXPA2).The NAC transcription factors NAC25 and NACIL were identified as upstream regulators of EXPA2 expression,gibbereliinmediated endosperm expansion,and seed *** DELLA protein RGL2 repressed activation of the EXPA2 promoter by NAC25/*** together,our findings uncover a key role of the GA/ DELLA-NAC25/NACIL-EXPA2 network in regulating endosperm cell expansion to control the seed-toseedling transition.

关键词： cell expansion cell-wall remodeling enzymes endosperm expansin NAC transcription factors seed germination

A novel and stretchable carbon-nanotube/Ni@TiO_(2):W photocatalytic composite for the complete removal of diclofenac drug from the drinking water

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Journal of Environmental Sciences 2023年第4期126卷 575-589页

作者： Ernesto Valadez-Renteria Rafael Perez-Gonzalez Christian gomez-Solis luis Armando Diaz-Torres Armando Encinas Jorge Oliva Vicente Rodriguez-Gonzalez Consejo Nacional de Ciencia y Tecnología-División de Materiales Avanzados Instituto Potosino de Investigación Científica y TecnológicaSan Luis Potosí78216México División de Ciencias e Ingenierías Universidad de GuanajuatoLeón 37150México Grupo de Espectroscopia de Materiales Avanzados y Nanoestructurados(GEMANA) Centro de Investigaciones enópticaA.C.Lomas Del CampestreLeón 37150México

We present the structural,morphological and photocatalytic properties of stretchable composites made with carbon nanotubes (CNTs),silicon rubber and Ni@TiO_(2):W nanoparticles(TiWNi NPs) with average size of 37±2 *** images showed that the TiWNi NPs decorated the surface of the CNT fibers,which are oriented in a preferential *** NPs presented a mixture of anatase/rutile phases with cubic *** performance of the TiWNi powders and stretchable composites was evaluated for the photocatalytic degradation of diclofenac (DCF) anti-inflammatory drug under ultraviolet-visible *** results revealed that the maximum DCF degradation percentages were 34.6%,91.9%,97.1%,98.5%and 100%for the CNT composite (stretched at 0%),TiWNi powders,CNT+TiWNi(stretched at 0%),CNT+TiWNi (stretched at 50%) and CNT+TiWNi (stretched at 100%),***,stretching the CNT+TiWNi composites was a good strategy to enhance the DCF degradation percentage from 97.1%to 100%,since stretching created additional defects (oxygen vacancies) that acted as electron sink,delaying the electron-hole recombination,and favors the DCF ***/absorbance measurements confirmed the presence of such ***,the reactive oxygen species (ROS) were determined by the scavenger’s experiments and found that the main ROS were the·OH and O_(2)-radicals,which attacked the DCF molecules,causing their *** results of this investigation confirmed that the stretchable CNT/TiWNi-based composites are a viable alternative to remove pharmaceutical contaminants from water and can be manually separated from the decontaminated water,which is unviable using photocatalytic powders.

关键词： Diclofenac Pharmaceutical contaminant TiO_(2) Carbon nanotubes Stretchable composite Photocatalysis

Intermittent chaos for ergodic light trapping in a photonic fiber plate

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Light(Science & Applications) 2016年第1期5卷 209-215页

作者： Marina Mariano Gregory Kozyreff luis G Gerling Pablo Romero-gomez Joaquim Puigdollers Jorge Bravo-Abad Jordi Martorell ICFO-Institut de Ciencies Fotoniques The Barcelona Institute of Science and TechnologyCastelldefels(Barcelona)08860Spain Département de Physique UniversitéLibre de Bruxelles(ULB)Campus de la PlaineBruxelles B-1050Belgium Departament Enginyeria Electrònica Universitat Politècnica de CatalunyaBarcelona 08034Spain Departamento de Física Teórica de la Materia Condensada and Condensed Matter Physics Center(IFIMAC) Universidad Autónoma de MadridMadrid 28049Spain Departament de Física Universitat Politècnica de CatalunyaTerrassa 08222Spain

Extracting the light trapped in a waveguide,or the opposite effect of trapping light in a thin region and guiding it perpendicular to its incident propagation direction,is essential for optimal energetic performance in illumination,display or light harvesting *** we demonstrate that the paradoxical goal of letting as much light in or out while maintaining the wave effectively trapped can be achieved with a periodic array of interpenetrated fibers forming a photonic fiber *** entering perpendicular to that plate may be trapped in an intermittent chaotic trajectory,leading to an optically ergodic *** fabricated such a photonic fiber plate and showed that for a solar cell incorporated on one of the plate surfaces,light absorption is greatly *** this,we found the unexpected result that a more chaotic photon trajectory reduces the production of photon scattering entropy.

关键词： chaos ergodicity fiber light-guiding plate light harvesting light trapping

Effect of synthesis variables of plasma synthesized polymers on growth of HepG2 cells

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BIOCELL 2017年第2期41卷 41-43页

作者： ELIZABETH PEREZ-TEJADA JUAN MORALES-CORONA luis ERNESTO gomez-QUIROZ MARIA CONCEPCIONGUTIERREZ-RUIZ ROBERTO OLAYO Departamento de Química.Universidad Autónoma Metropolitana Unidad IztapalapaApdo.Postal 55-534IztapalapaCDMXCP 09340 Departamento de Ciencias de la Salud.Universidad Autónoma Metropolitana Unidad IztapalapaApdo.Postal 55-534IztapalapaCDMXCP 09340 Departamento de Física.Universidad Autónoma Metropolitana Unidad IztapalapaApdo.Postal 55-534IztapalapaMéxicoD.F.CP 09340 CECyT No.8 Instituto Politécnico NacionalAve.de las Granjas 618Jardín AzpeitiaAzcapotzalcoCDMXCP 02530

Low pressure plasma polymer films were synthesized using pyrrole and allylamine monomers and adding iodine was used(or not)for the reaction in both *** were polymerized on glass substrates under the same reaction *** of allylamine was also studied at different operating *** thin polymer films were used as culture surfaces for HepG2 cells,a cell line derived from a human *** proliferation,differentiation and two-dimensional propagation until obtaining monolayer of the cells was studied on the different synthetized films and correlations were established between the conditions of synthesis,the physicochemical characteristics obtained and the performance as substrates for the cellular growth.

关键词： Hepatocytes Pyrrole Allylamine Plasma Polymerization

Statins and endocrine resistance in breast cancer

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Cancer Drug Resistance 2021年第2期4卷 356-364页

作者： Tara Hyder Juan luis gomez Marti Azadeh Nasrazadani Adam M.Brufsky University of Pittsburgh Physicians PittsburghPA 15213USA Department of Pathology University of Pittsburgh School of MedicinePittsburghPA 15213USA UPMC Hillman Cancer Center Magee Women's HospitalPittsburghPA 15213USA.

Most breast cancers are hormone-receptor positive(HR+).However,more women eventually die from HR+breast cancer than from either HER2+or triple negative breast *** therapies continue to be the mainstay of *** 40%of these cases,recurrences in early-stage disease and progression in the metastatic setting are largely a function of the development of endocrine resistance.A multitude of mediators and pathways have been associated with endocrine resistance in breast cancer including the mevalonate pathway,which is integral to cholesterol *** mevalonate pathway and the downstream activation of associated cytoplasmic pathways including PI3K-AKT-mTOR and RAS-MEK-ERK have been known to affect cancer cell proliferation,cell survival,cell invasion,and *** are important mechanisms leading to the inevitable development of endocrine resistance in HR+breast *** are a class of drugs that inhibits HMG-CoA reductase,an enzyme in the mevalonate pathway that plays a central role in cholesterol *** vitro and in vitro studies suggest that the role of statins in blocking the mevalonate pathway effectively disrupts downstream pathways involved in estrogen receptor expression and cellular processes such as cell survival,proliferation,stress,cell cycle,inhibition of apoptosis,and *** these key mechanisms heralds a role for statins in the prevention of endocrine resistance.

关键词： Statin HMGCR endocrine resistance autophagy PI3K mTOR