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Slope reliability and back analysis of failure with geotechnical parameters estimated using Bayesian inference

Journal of Rock Mechanics and Geotechnical Engineering 2019年第3期11卷 628-643页

作者： luis-fernando contreras Edwin T.Brown The University of Queensland St Lucia Campus

A Bayesian approach is proposed for the inference of the geotechnical parameters used in slope *** methodology involves the construction of posterior probability distributions that combine prior information on the parameter values with typical data from laboratory tests and site investigations used in *** posterior distributions are often complex,multidimensional functions whose analysis requires the use of Markov chain Monte Carlo(MCMC)*** procedures are used to draw representative samples of the parameters investigated,providing information on their best estimate values,variability and *** paper describes the methodology to define the posterior distributions of the input parameters for slope design and the use of these results for evaluation of the reliability of a slope with the first order reliability method(FORM).The reliability analysis corresponds to a forward stability analysis of the slope where the factor of safety(FS)is calculated with a surrogate model from the more likely values of the input *** Bayesian model is also used to update the estimation of the input parameters based on the back analysis of slope *** this case,the condition FS?1 is treated as a data point that is compared with the model prediction of *** analysis requires a sufficient number of observations of failure to outbalance the effect of the initial input *** parameters are updated according to their uncertainty,which is determined by the amount of data supporting *** methodology is illustrated with an example of a rock slope characterised with a Hoek-Brown rock mass *** example is used to highlight the advantages of using Bayesian methods for the slope reliability analysis and to show the effects of data support on the results of the updating process from back analysis of failure.

关键词： Bayesian analysis Hoek-Brown criterion Slope reliability Back analysis of failure

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Bayesian data analysis to quantify the uncertainty of intact rock strength

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Journal of Rock Mechanics and Geotechnical Engineering 2018年第1期10卷 11-31页

作者： luis fernando contreras Edwin T.Brown Marc Ruest The University of Queensland St Lucia CampusBrisbaneQLD 4072Australia Golder Associates Pty.Ltd. BrisbaneAustralia

One of the main difficulties in the geotechnical design process lies in dealing with uncertainty. Uncertainty is associated with natural variation of properties, and the imprecision and unpredictability caused by insufficient information on parameters or models. Probabilistic methods are normally used to quantify uncertainty. However, the frequentist approach commonly used for this purpose has some ***, it lacks a formal framework for incorporating knowledge not represented by data. Second, it has limitations in providing a proper measure of the confidence of parameters inferred from data. The Bayesian approach offers a better framework for treating uncertainty in geotechnical design. The advantages of the Bayesian approach for uncertainty quantification are highlighted in this paper with the Bayesian regression analysis of laboratory test data to infer the intact rock strength parameters σand mused in the Hoek-Brown strength criterion. Two case examples are used to illustrate different aspects of the Bayesian methodology and to contrast the approach with a frequentist approach represented by the nonlinear least squares(NLLS) method. The paper discusses the use of a Student’s t-distribution versus a normal distribution to handle outliers, the consideration of absolute versus relative residuals, and the comparison of quality of fitting results based on standard errors and Bayes factors. Uncertainty quantification with confidence and prediction intervals of the frequentist approach is compared with that based on scatter plots and bands of fitted envelopes of the Bayesian approach. Finally, the Bayesian method is extended to consider two improvements of the fitting analysis. The first is the case in which the Hoek-Brown parameter, a, is treated as a variable to improve the fitting in the triaxial region. The second is the incorporation of the uncertainty in the estimation of the direct tensile strength from Brazilian test results within the overall evaluati

关键词： Uncertainty Intact rock strength Bayesian analysis Hoek-Brown criterion

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Portal Venous Thrombosis and Splenic Hemangioma, Secondary to Acute Pancreatitis: Case Report

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Open Journal of Gastroenterology 2024年第1期14卷 11-17页

作者： Gustavo Adolfo Hernández Valdez Harvey Yair Zamora Veliz Estefany Gilberty Mendoza Verdin Quitzia Mayanim Rentería Fonseca Itzel Velázquez Viniegra Janette Alejandra Gamiño Gutierrez Diana Rita Velázquez Jimenez Florencio Favian Andrade luis fernando Baez Bustos Jorge Morales Rojas María Jacqueline Martínez Tejeda Graciela Gaddy Robles Martínez Juan Antonio contreras Escamilla Departamento de Medicina Interna ISSSTE Tepic General Hospital APP Tepic Nayarit México General Surgery Department ISSSTE Tepic General Hospital APP Tepic Nayarit México Hospital Civil Fray Antonio Alcalde Guadalajara Jalisco México

We present an unusual case of portal vein thrombosis with a splanchnic hemangioma secondary to acute biliary pancreatitis. We report a 45-year-old patient, who has systemic arterial hypertension in treatment, was admitted for abdominal pain in the epigastrium, with irradiation to the right hypochondrium, accompanied by nausea and vomiting of 10 occasions of bile content, physical examination with pain in the right hypochondrium, Murphy positive. We have laboratory studies with a lipase of 788, so a diagnosis of pancreatitis is made with an etiology to be determined. The laboratories suggestive of acute biliary pancreatitis (lipase 788.71);an imaging study was subsequently performed (ultrasonography) with the result of stone in the common bile duct. A laparoscopy was performed with relative improvement, so he was discharged and returned 20 days after surgery due to abdominal pain of the same intensity in the left hypochondrium. Ending his hospitalization with a splenectomy for splenic hemangioma with portal vein thrombosis.

关键词： Pancreatitis Esplenic Hemangioma Esplenectomy Portal Vein Thrombosis Surgery

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加夫列尔·加西亚·马尔克斯图书馆,巴塞罗那,西班牙

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世界建筑 2024年第5期 76-81页

作者：无 Elena Orte Guillermo Sevillano Marta Romero Jesús Lopez luis Sierra Ana Patricia Minguito Pablo Corroto María Abellán Sara contreras RitaÁlvarez Tabio MiguelÁngel Maure Jesús Granada(摄影) SUMA建筑设计事务所不详

加布里埃尔·加西亚·马尔克斯图书馆是巴塞罗那的第40座图书馆,也是巴塞罗那30年计划的结晶。该计划旨在建立一个由优秀社区与区域设施组成的密集网络。这座图书馆位于圣马蒂德普罗旺斯区,为53,000人提供服务。关联式建筑图书馆被设计... 详细信息

加布里埃尔·加西亚·马尔克斯图书馆是巴塞罗那的第40座图书馆,也是巴塞罗那30年计划的结晶。该计划旨在建立一个由优秀社区与区域设施组成的密集网络。这座图书馆位于圣马蒂德普罗旺斯区,为53,000人提供服务。关联式建筑图书馆被设计成一座雕塑式实体建筑,让人联想到堆叠的书籍及其折叠的书页。该馆坐落在一处高架广场上,方便周围行人来往。同时,它又在空地上悬挑而出,门廊由现有的树木环绕,形成了一座城市大厅。不同大小及结构的开口定义了其不同立面与周围环境的关系。

关键词：巴塞罗那普罗旺斯周围环境加布里埃尔加西亚·马尔克斯图书馆关联式西班牙

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Sanger Sequencing Implementation in Clinically Ill Patients for Bacterial and Fungal Pathogens Identification

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Advances in Infectious Diseases 2022年第3期12卷 363-382页

作者： Víctor Fong-Flores Andrea Murillo-Gallo luis contreras-Ojeda Aarón Barraza Departamento de Medicina Interna Benemérito Hospital General Juan María de Salvatierra La Paz México Laboratorio Biotechnologika A2 La Paz México CONACyT-CIBNOR Instituto Politécnico Nacional 195 La Paz México

The diagnosis of bacterial or fungal infections requires the identification of the pathogen etiology in the shortest time possible. Although some biomarkers are used as indicators of bacterial infections, their specificity and sensitivity are highly variable, and there is no direct relationship between the level increase of these biomarkers for mycosis. It is common to obtain negative microbiological cultures in patients infected by non-culturable, intracellular bacteria or mycosis, even though there is a high clinical suspicion of infection. This study identifies the pathogen present in critically infected patients through 16S and 18S/eEF1 genes detection by polymerase chain reaction (PCR) coupled with Sanger sequencing. Thirty clinical samples were evaluated by PCR, of which 40% were positive for fungi, 23.33% for bacteria, 26.7% for fungi and bacteria, and 10% for no pathogen. The PCRs outcomes period for bacteria or fungi was one day compared to seven and up to 14 days (on average) of microbiological culture for bacteria and fungi. Then, we assessed the relationship with the most used biomarkers (procalcitonin, C-reactive protein, globular sedimentation velocity, and the neutrophil-lymphocyte index). This combination of molecular techniques has been shown as helpful in identifying intracellular bacteria and fungi that are difficult to culture by conventional methods. Screening with genomic markers 16S and 18S/eEF1 by PCR allowed us to optimize the time to obtain the result of the infection caused by bacteria or fungi. Also, identifying the specific etiological microorganism by Sanger sequencing was very helpful in avoiding the progression of the disease and setting targeted treatment with better clinical outcomes.

关键词： Pathogen Identification Bacteria Fungi PCR Sanger Sequencing

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Lignin in storage and renewable energy applications： A review

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Journal of Energy Chemistry 2018年第5期27卷 1422-1438页

作者： Jose luis Espinoza-Acosta Patricia I. Torres-Chavez Jorge L. Olmedo-Martinez Alejandro Vega-Rios Sergio Flores-Gallardo E. Armando Zaragoza-contreras Department of Engineering and Materials Chemistry Centro de Investigacion en Materiales Avanzados Miguel de Cervantes # 120. Complejo Industrial Chihuahua Chihuahua Mexico Departamento de Investigacion y Posgrado en Alimentos (DIPA) Universidad de Sonora Hermosillo Sonora Mexico

Lignin is a cheap, abundant and non-toxic group of complex phenolic polymers obtained in large amounts from the papermaking and cellulosic biofuel industries. Although the application of lignin has been ex- plored in these and several more industries, there are limited applications of lignin in the energy industry. However, numerous research revealed a great interest in the exploration of this renewable biopolymer in storage energy devices. Some of these applications include the use of lignin as an expander for lead-acid batteries, electrodes for primary and rechargeable batteries, electrodes for electronic double layer capac- itors and electrochemical pseudocapacitors, and to feed different types of fuel cells. The use of lignin in energy storage devices improves not only the performance of these devices but also decreases the price and toxicity, contributing to obtaining greener energy devices. Based on the above, this review provides an overview of the main research work related to the use of lignin as a renewable component, suitable to replace some synthetic and toxic compounds used in the fabrication of energy storage devices with particular emphasis on batteries, advanced supercapacitors, and solar and fuel cells.

关键词： Lignin Batteries Lithium-ion batteries Supercapacitors Solar cells Fuel cells

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Structural Analysis of TiC and TiC-C Core-Shell Nanostructures Produced by Pulsed-Laser Ablation

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Journal of Materials Science and Chemical Engineering 2023年第7期11卷 1-13页

作者： luis Enrique Iniesta Piña Miguel Ángel Camacho López Rafael Vilchis Néstor Víctor Hugo Castrejón Sánchez Delfino Reyes contreras Mestría en Ciencia de Materiales Facultad de Química Campus Rosedal Universidad Autónoma del Estado de México Toluca México Laboratorio de Fotomedicina Biofotónica y Espectroscopía Láser de Pulsos Ultracortos Facultad de Medicina Universidad Autónoma del Estado de México Toluca México Centro Conjunto de Investigación en Química Sustentable UAEM-UNAM Toluca México TecNM/Tecnológico de Estudios Superiores de Jocotitlán Jocotitlán México Laboratorio de Acústica y Nanomateriales Facultad de Ciencias Campus el Cerrillo Universidad Autónoma del Estado de México Toluca México

This paper reports on the ablation process of a pure Ti solid target immersed in a C-enriched acetone solution, leading to the production of titanium carbide (TiC) and Ti-C core-shell nanostructures. The used route of synthesis is generally called pulsed laser ablation in liquid (PLAL). The presence of carbon structures in the solution contributed to the carbon content in the produced Ti-based nanomaterials. The atomic composition of the produced nanostructures was analyzed using SEM-EDS, while TEM micrographs revealed the formation of spherical TiC and core-shell nanostructures ranging from 40 to 100 nm. The identification of atomic planes by HRTEM confirmed a 10 nm diameter C-shell with a graphite structure surrounding the Ti-core. Raman spectroscopy allowed for the identification of D and G peaks for graphite and a Raman signal at 380 and 600 cm−1, assigned to TiC. The results contribute to the state-of-the-art production of TiC and Ti-C core-shell nanostructures using the PLAL route.

关键词： Laser Ablation TiC Nanoparticles Core-Shell Nanoparticles Pulsed Laser

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Melatonin modifies SOX2^+ cell proliferation in dentate gyrus and modulates SIRT1 and MECP2 in long-term sleep deprivation

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Neural Regeneration Research 2019年第10期14卷 1787-1795页

作者： Alan Hinojosa-Godínez luis F. Jave-Suarez Mario Flores-Soto Alma Y. Gálvez-contreras Sonia Luquín Edith Oregon-Romero Oscar González-Pérez Rocio E. González-Castaneda Laboratorio de Microscopía de Alta Resolución Departamento de NeurocienciasCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMéxico Laboratorio de Neurociencias Facultad de PsicologíaUniversidad de ColimaColimaMéxico División de Inmunología Centro de Investigación Biomédica de OccidenteInstituto Mexicano del Seguro SocialGuadalajaraMéxico División de Neurociencias Centro de Investigación Biomédica de OccidenteInstituto Mexicano del Seguro SocialGuadalajaraMéxico Instituto de Investigación en Ciencias Biomédicas (IICB) Departamento de Biología Molecular y GenómicaCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMéxico Unidad de Atención en Neurociencias Departamento de Neurociencias. Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMéxico

Melatonin is a pleiotropic molecule that,after a short-term sleep deprivation,promotes the proliferation of neural stem cells in the adult ***,this effect has not been observed in long-term sleep *** precise mechanism exerted by melatonin on the modulation of neural stem cells is not entirely elucidated,but evidence indicates that epigenetic regulators may be involved in this *** this study,we investigated the effect of melatonin treatment during a 96-hour sleep deprivation and analyzed the expression of epigenetic modulators predicted by computational text mining and keyword *** results showed that the administration of melatonin under sleep-deprived conditions increased the MECP2 expression and reduced the SIRT1 expression in the dentate *** observed that let-7 b,mir-132,and mir-124 were highly expressed in the dentate gyrus after melatonin administration,but they were not modified by sleep *** addition,we found more Sox2^+/5-bromo-2’-deoxyuridine(BrdU)^+cells in the subgranular zone of the sleep-deprived group treated with melatonin than in the untreated *** findings may support the notion that melatonin modifies the expression of epigenetic mediators that,in turn,regulate the proliferation of neural progenitor cells in the adult dentate gyrus under long-term sleep-deprived *** procedures performed in this study were approved by the Animal Ethics Committee of the University of Guadalajara,Mexico(approval ***-16610)on January 2,2016.

关键词： sleep-deprivation melatonin microRNA neurogenesis Sirtuin 1 SIRT1 methyl-CpG-binding protein 2 MECP2 epigenetic text-mining mir-9 let-7b

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Synthesis and Characterization of ZnO Film on Stainless Steel Wire and Bioaerosol Antimicrobial Activity Evaluation

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Journal of Environmental Science and Engineering(A) 2015年第9期4卷 455-466页

作者： Alfonso Espitia Cabrera Jose luis contreras Larios IlyaEspitia-Cabrera Ma-Teresa Nunez Cardona Doris Neri Cortes luis Raul Tovar Galvez Energy Department Metropolitan Autonomous University Azcapotzalco 02200 Mexico Chemical Engineering School Michoacan University of San Nicolas of Hidalgo Morelia 58030 Mexico Man and lts Environment Department Metropolitan Autonomous University Xochimilco 04960 Mexico Biochemistry Department Biological Sciences National School National Polytechnic Institute Mexico D.F. 07738 Mexico Interdisciplinary Centre of Research and Studies on Environment and Development National Polytechnic Institute Mexico D.F.07340 Mexico

ZnO thin films were prepared by electrophoretic deposition on stainless steel wire sieve, using zinc acetate as a precursor. The film was sintered and characterised by Scanning Electron Microscopy （SEM）, X-Ray Diffraction （XRD） and chemisorption of oxygen. A culture bacterial consortium composed by gram negative rod-shaped microbes was prepared in a liquid agar in a flask. It was transported by air through a reactor equipped with a UV lamp with 3 and 5 sieves of a stainless steel wire coated with ZnO film. It was exposed in continuous in five experiments to photocatalytic advanced oxidation. The experiments showed a total efficiency for colony forming unit reduction of a maximum of 99.66% for a residence time of 20 seconds with 5 stainless steel wire where exposed in continuous to UV. Also they were evaluated at 7.5 seconds, observing that the contribution of residence time and amount of catalytic for the CFU reduction was quite similar. Variance analysis showed that the efficiency was significant with the no parametric Kruskal-Wallis test with P 〈 0.05. This technology could be used to clean indoor air of closed environments such as hospitals, crowded buildings or public transportation systems where airborne bacteria has been documented.

关键词： Photocatalytic oxidation ZnO thin film antibacterial activity ZnO film on stainless steel wire. I

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Higher cardiovascular risk scores and liver fibrosis risk estimated by biomarkers in patients with metabolic-dysfunction-associated fatty liver disease

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World Journal of Hepatology 2022年第8期14卷 1633-1642页

作者： Giovanni Alejandro Salgado Alvarez Samanta Mayanin Pinto Galvez Uriel Garcia Mora Ana Delfina Cano contreras Cristina Durán Rosas Bryan Adrián Priego-Parra Arturo Triana Romero Mercedes Amieva Balmori Federico Roesch Dietlen Sophia Eugenia Martinez Vazquez Ines Osvely Mendez Guerrero luis Alberto Chi-Cervera Raúl Bernal Reyes Leonardo Alberto Martinez Roriguez Maria Eugenia Icaza Chavez Jose Maria Remes Troche Instituto de Investigaciones Médico-biologicas Universidad VeracruzanaVeracruz 91700VeracruzMexico Department of Gastroenterología Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMéxico 14080MéxicoMexico Clínica de Especialidades Gastrointestinales y Hepáticas Hospital Star MedicaMerida 97133YucatanMexico Department of Gastroenterologia Sociedad Española de BeneficenciaPachuca 42000HidalgoMexico Department of Gastroenterologia Clínica de Rehabilitación Metabólica Digestiva y HepáticaMexico 14080MexicoMexico Department of Gastroenterologia Hospital Star Médica de MéridaMerida 97133YucatanMexico

BACKGROUND The definition of metabolic-dysfunction-associated fatty liver disease(MAFLD)allows identification of metabolically complicated *** risk scores are related to cardiovascular risk(CVR)scores and could be useful for the identification of patients at risk of systemic *** To evaluate the relationship between MAFLD and CVR using the Framingham risk score in a group of Mexican *** Cross-sectional,observational and descriptive study carried out in a cohort of 585 volunteers in the state of Veracruz with MAFLD *** risk of liver fibrosis was calculated with aspartate aminotransferase-to-platelet ratio index,nonalcoholic fatty liver disease score and fibrosis-4,as well as with transient hepatic elastography with Fibroscan~?.The CVR was determined by the Framingham *** One hundred and twenty-five participants(21.4%)with MAFLD criteria were evaluated,average age 54.4 years,63.2%were women,body mass index 32.3 kg/m~*** Framingham CVR was high in 43 patients(33.9%).Transient elastography was performed in 55.2%of volunteers;39.1%with high CVR and predominance in advanced fibrosis(F3–F4).The logistic regression analysis showed that liver fibrosis,diabetes and hypertension independently increased *** One of every three patients with MAFLD had a high CVR,and in those with high fibrosis risk,the CVR risk was even greater.

关键词： Fatty liver Cardiovascular risk Hepatic steatosis Fibrosis Liver disease

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