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Territorial Planning for Coastal Zones in Chile:The Need for Geographical-Environmental and Natural Risk Indicators for Spatial Decision Support Systems

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International Journal of Geosciences 2013年第6期4卷 17-29页

作者： Fernando Pena-Cortes daniel Rozas-Vasquez Gonzalo Rebolledo Jimmy Pincheira-Ulbrich Miguel Escalona Enrique Hauenstein luis Vargas-Chacoff Carlos Bertran Jaime Tapia Marco Cisternas Laboratorio de Planificacion Territorial Nucleo de Investigacion en Estudios AmbientalesUniversidad Catolica de TemucoTemucoChile Programa de Doctorado en Sistematica y Biodiversidad Universidad de ConcepcionConcepcionChile Escuela de Ciencias Ambientales Facultad de Recursos NaturalesUniversidad Catolica de TemucoTemucoChile Instituto de Ciencias Marinas y Limnologicas Universidad Austral de ChileValdiviaChile Instituto de Quimica de Recursos Naturales Universidad de TalcaTalcaChile Escuela de Ciencias del Mar Pontificia Universidad Catolica de ValparaisoValparaisoChile

Coastal zones are very dynamic and fragile environments, constituting a landscape ever more heterogeneous, fragmented and with increasing levels of complexity due to the changing relationship between man and nature. Integrated coastal zone management therefore requires detailed knowledge of the system and its components, based—to a large extent—on technical and scientific information. However, the information generated must be in line with the political requirements necessary for decision-making and planning. Thus the use of indicators to give a simplified view of the many components of the territory, and at the same time to provide important information about patterns or trends, becomes a tool of the utmost importance. These indicators can be understood as measurable characteristics of the environment, which facilitate comprehension of the processes occurring at different scales and serve as a reference to inform the population and support decision-making. The aim of the present note is to demonstrate briefly the need to develop geographical-environmental and natural risk indicators to facilitate comprehension of the dynamic of spatial and temporal landscape patterns, particularly in coastal environments. This approach offers an historical summary of the natural, socio-economic and political processes which currently make up the territory, and which without doubt will continue to influence it in the future. At the same time, it is proposed that information should be integrated on the basis of this framework with a view to generating spatial decision support systems in a context of planning and integrated management of the coastal zones of Chile.

关键词： Coastal Zone Territorial Planning Indicators Spatial Decision Support System Chile

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Colonic preparation before colonoscopy in constipated and non-constipated patients:A randomized study

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World Journal of Gastroenterology 2013年第31期19卷 5103-5110页

作者： Lisandro Pereyra daniel Cimmino Carlos González Malla Mariano Laporte Nicolás Rotholtz Carlos Peczan Sandra Lencinas Silvia Pedreira Hugo Catalano luis Boerr Department of Endoscopy Hospital Alemán 1118 Buenos Aires Argentina Department of Internal Medicine Hospital Alemán 1118 Buenos Aires Argentina Department of Surgery Hospital Alemán 1118 Buenos Aires Argentina

AIM: To compare the efficacy of different doses of sodium phosphate(NaP) and polyethylenglicol(PEG) alone or with bisacodyl for colonic cleansing in constipated and non-constipated ***: Three hundred and forty-nine patients,older than 18 years old,with low risk for renal damage and who were scheduled for outpatient colonoscopy were randomized to receive one of the following preparations(prep): 90 mL of NaP(prep 1);45 mL of NaP + 20 mg of bisacodyl(prep 2);4 L of PEG(prep 3) or 2 L of PEG + 20 mg of bisacodyl(prep 4).Randomization was stratified by ***,endoscopists,endoscopists' assistants and data analysts were blinded.A blinding challenge was performed to endoscopist in order to reassure *** primary outcome was the efficacy of colonic cleansing using a previous reported *** outcomes were tolerability,compliance,side effects,endoscopist perception about the necessity to repeat the study due to an inadequate colonic preparation and patient overall ***: Information about the primary outcome was obtained from 324 patients(93%).There were no significant differences regarding the preparation quality among different groups in the overall *** was higher in the NaP preparations being even higher in half-dose with bisacodyl: 94%(prep 1),100%(prep 2),81%(prep 3) and 87%(prep 4)(2 vs 1,3 and 4,P < 0.01;1 vs 3,4,P < 0.05).The combination of bisacodyl with NaP was associated with insomnia(P = 0.04).In non-constipated patients the preparation quality was also similar between different groups,but endoscopist appraisal about the need to repeat the study was more frequent in the half-dose PEG plus bisacodyl than in whole dose NaP preparation: 11%(prep 4) vs 2%(prep 1)(P < 0.05).Compliance in this group was also higher with the NaP preparations: 95%(prep 1),100%(prep2) vs 80%(prep 3)(P < 0.05).Bisacodyl was associated with abdominal pain: 13%(prep 1),31%(prep 2),21%(prep 3) and 29%(prep 4),(2,4 vs 1,2

关键词： Colonic cleansing Sodium phosphate Polyethylenglicol Bisacodyl constipation Colonoscopy

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Nrf2 and Snail-1 in the prevention of experimental liver fibrosis by caffeine

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World Journal of Gastroenterology 2013年第47期19卷 9020-9033页

作者： daniela Gordillo-Bastidas Edén Oceguera-Contreras Adriana Salazar-Montes Jaime González-Cuevas luis daniel Hernández-Ortega Juan Armendáriz-Borunda nstitute of Molecular Biology in Medicine and Gene Therapy/CUCS University of GuadalajaraGuadalajaraJalisco 44100México

AIM:To determine the molecular mechanisms involved in experimental hepatic fibrosis prevention by caffeine(CFA).METHODS:Liver fibrosis was induced in Wistar rats by intraperitoneal thioacetamide or bile duct ligation and they were concomitantly treated with CFA(15 mg/kg per day).Fibrosis and inflammatory cell infiltrate were evaluated and classified by Knodell *** infiltrate was quantified by immunohistochemistry(anti-CD11b).Gene expression was analyzed by quantitative reverse transcription-polymerase chain reaction for collagenⅠ?(Col-1),connective tissue growth factor(CTGF),transforming growth factorβ1(TGF-β1),tumor necrosis factor alpha(TNF-α),interleukin-1(IL-1),IL-6,superoxide dismutase(SOD)and catalase(CAT).Activation of Nrf2 and Snail-1 was analyzed by ***-αexpression was proved by enzyme-linked immunosorbant assay,CAT activity was performed by ***:CFA treatment diminished fibrosis index in treated *** Knodell index showed both lower fibrosis and *** of profibrogenic genes CTGF,Col-1 and TGF-β1 and proinflammatory genes TNF-α,IL-6 and IL-1 was substantially diminished with CFA treatment with less CD11b positive *** lower values of transcriptional factor Snail-1 were detected in CFA treated rats compared with cirrhotic rats without treatment;in contrast Nrf2was increased in the presence of *** of SOD and CAT was greater in animals treated with CFA showing a strong correlation between mRNA expression and enzyme ***:Our results suggest that CFA inhibits the transcriptional factor Snail-1,down-regulating profibrogenic genes,and activates Nrf2 inducing antioxidant enzymes system,preventing inflammation and fibrosis.

关键词： Liver fibrosis Caffeine Thioacetamide Bile duct ligation Profibrogenic genes Proinflammatory cytokines Antioxidant enzymes

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动态交通政策的长期优化设计——通过定价机制寻求社会福利最大化

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城市交通 2014年第3期12卷 83-94页

作者： luis A.Guzman daniel de la Hoz Andrés Monzón 刘斌 TRANSyT交通研究中心马德里工业大学西班牙马德里28036 中国城市规划设计研究院北京100037

针对交通政策设计中决策过程的可选方法展开探讨。探索对出行政策进行综合预测、评价、优化以实现决策方案最优的可能性。从长远来看,为了适应像城市这样一个动态系统,采用了用地与交通相互影响模型(LUTI)的长期评估方法。在评估的全过... 详细信息

针对交通政策设计中决策过程的可选方法展开探讨。探索对出行政策进行综合预测、评价、优化以实现决策方案最优的可能性。从长远来看,为了适应像城市这样一个动态系统,采用了用地与交通相互影响模型(LUTI)的长期评估方法。在评估的全过程中,通过成本效益分析来衡量实施LUTI动态决策所产生的社会福利,然后通过优化程序使其达到最大化。这一模型在马德里市收费站最优定价策略项目中得到验证,该项目要求保证系统效率、社会公平以及环境质量。与其他定价方案相比,最优方案能以相对较低的收费产生更多的社会盈余。该实践结果突出强调了不同因素对研究区域以及对社会福利盈余的主要贡献者的影响,从而反思采用的成本分析方法是否可以作为设计可持续政策的最佳方法。

关键词：城市交通政策成本效益分析法政策优化可持续交通

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TREFACE: A New Computerized Test of Emotional Stroop with Facial Expressions

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Journal of Behavioral and Brain Science 2022年第7期12卷 342-358页

作者： Edward prada Corina Satler Maria C. H. Tavares Ana Garcia Lia Martinez Cândida Alves Eliza Lacerda Carlos Tomaz Laboratory of Neurosciences and Behavior Department of Physiological Sciences University of Brasília Brasília Brazil Faculty of Psychology Social Sciences Department Universidad Pontificia Bolivariana Seccional Bucaramanga Bucaramanga Colombia Faculty of Ceilandia University of Brasília Brasília Brazil Laboratory of Neurosciences and Behavior Master’s Program in Environment CEUMA University S&atilde o luis Brazil

Using the conflict principle of the Stroop task, “effect of interference in color naming”, the present study proposes to create a computational version of the emotional Stroop task, called TREFACE, for its acronyms in Portuguese “Teste de Reconhecimento de Expressões Faciais com Conflito Emocional” (Facial Expression Recognition Test with Emotional Conflict). In this protocol, four fixed styles of presentation were generated according to the condition: Congruent Word Reading, Incongruent Word Reading, Congruent Recognition of Face Expression and Incongruent Recognition of Face Expression, counterbalanced in terms of each facial expression, word and gender of the photo character. Forty-two healthy volunteers completed the task. Results revealed that a task associated with word reading allows better performance than a task associated with face recognition. It was also identified that in the congruent condition, there is an advantage in terms of the correct responses. Additionally, the data regarding recognition of face expression showed greater difficulty when the image was not congruent with the word. In general, the results suggest that the emotional attribute can compromise the ability to recognize the faces, reaching the functioning of mechanisms such as cognitive control and regulation of emotions. Thus, the TREFACE paradigm can be considered a good assessment tool for monitoring emotional conflict, in addition to presenting itself as a new instrument in Portuguese language for assessing emotional working memory in healthy individuals and, eventually, in different pathologies that affect the functioning of cortical areas related to executive functions.

关键词： Emotions Memory Facial Recognition Conflict Emotional Stroop Executive Functions

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Sustainability Assessment of Alternatives for Heat Generation and Transfer in Saunas

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Journal of Environmental Protection 2015年第12期6卷 1378-1393页

作者： Nora Munguia luis Velazquez Rafael Perez daniel Rincón Martha Marin Biagio F. Giannetti Cecília M. V. B. Almeida Feni Agostinho Sustainability Graduate Program Industrial Engineering Department University of Sonora (UNISON) Hermosillo Mexico Work Environment Department University of Massachusetts Lowell Lowell MA USA Production Engineering Graduate Program Paulista University (UNIP) S&#227 o Paulo Brazil

In the search for renewable energy sources, solar energy appears, among others, as a powerful alternative;mainly for those countries located at Earth’s equatorial region. This is the case of a Fresnel device that uses solar radiation to warm-up the air;for instance, within saunas. Authors coined the term sustainable technological innovation to refer to a technological innovation in accordance to the principles of sustainability. The object of this research was comparing the sustainability of a Fresnel Lens Solar Concentration (FLSC) against the sustainability of other twelve alternatives to generate heat. This article assesses the sustainability of fourteen technological options for heat generation and transfer to saunas in the northwest region of Mexico where temperatures often reach above 45 C and where there is a greater potential for exploiting solar energy. Emergy accounting, economic analysis, and global warming potential are the three indicators considered in quantifying sustainability. Results show that infrared ceramic photovoltaic, infrared carbon photovoltaic and infrared metal photovoltaic are the most sustainable systems. The Fresnel device reached the fourth and tenth position, using electricity from photovoltaic and from grid respectively, among all fourteen assessed devices, respectively. Although Fresnel equipment does not release any global warming gases into the atmosphere, or even it demands low amount of non-renewable resources, 1.40 and 4.47 E17 seJF/yr. it requires high economic investment, 20,800 and 79,600 USD/yr, for the implementation and operation phases, which decrease its sustainability performance compared to twelve other evaluated devices.

关键词： emergy heat generation and transfer sustainable technology innovation saunas

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Cerebral dopamine neurotrophic factor transfection in dopamine neurons using neurotensin-polyplex nanoparticles reverses 6-hydroxydopamine-induced nigrostriatal neurodegeneration

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Neural Regeneration Research 2022年第4期17卷 854-866页

作者： Manuel A.Fernandez-Parrilla David Reyes-Corona Yazmin M.Flores-Martinez Rasajna Nadella Michael J.Bannon Lourdes Escobedo Minerva Maldonado-Berny Jaime Santoyo-Salazar luis O.Soto-Rojas Claudia Luna-Herrera Jose Ayala-Davila Juan A.Gonzalez-Barrios Gonzalo Flores Maria E.Gutierrez-Castillo Armando JEspadas-Alvarez Irma A.Martínez-Dávila Porfirio Nava daniel Martinez-Fong Departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa Institucional de Biomedicina Molecular Escuela Nacional de Medicina y HomeopatíaInstituto Politécnico NacionalCiudad de MéxicoMéxico Department of Biosciences IIIT-SrikakulamRajiv Gandhi University of Knowledge Technologies(RGUKT)Andhra PradeshIndia Department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de MéxicoTlalnepantla de BazEdo.de MéxicoMéxico Departamento de Fisiología Escuela Nacional de Ciencias BiológicasCiudad de MéxicoMéxico Laboratorio de Medicina Genómica Hospital Regional“1°de Octubre”ISSSTECiudad de MéxicoMéxico Laboratorio de Neuropsiquiatría Instituto de FisiologíaBenemérita Universidad Autónoma de PueblaPueblaPueblaMéxico Departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Programa de Nanociencias y nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Overexpression of neurotrophic factors in nigral dopamine neurons is a promising approach to reverse neurodegeneration of the nigrostriatal dopamine system,a hallmark in Parkinson's *** human cerebral dopamine neurotrophic factor(h CDNF)has recently emerged as a strong candidate for Parkinson's disease *** study shows that h CDNF expression in dopamine neurons using the neurotensinpolyplex nanoparticle system reverses 6-hydroxydopamine-induced morphological,biochemical,and behavioral *** independent electron microscopy techniques showed that the neurotensin-polyplex nanoparticles containing the h CDNF gene,ranging in size from 20 to 150 nm,enabled the expression of a secretable h CDNF in *** injection in the substantia nigra compacta on day 21 after the 6-hydroxydopamine lesion resulted in detectable h CDNF in dopamine neurons,whose levels remained constant throughout the study in the substantia nigra compacta and *** with the lesioned group,tyrosine hydroxylase-positive(TH^(+))nigral cell population and TH+fiber density rose in the substantia nigra compacta and striatum after h CDNF *** increase inβIII-tubulin and growth-associated protein 43 phospho-S41(GAP43 p)followed TH^(+)cell recovery,as well as dopamine and its catabolite *** reversal(80%)of drugactivated circling behavior and full recovery of spontaneous motor and non-motor behavior were ***-derived neurotrophic factor recovery in dopamine neurons that also occurred suggests its participation in the neurotrophic *** findings support the potential of nanoparticle-mediated h CDNF gene delivery to develop a disease-modifying treatment against Parkinson's *** Institutional Animal Care and Use Committee of Centro de Investigación y de Estudios Avanzados approved our experimental procedures for animal use(authorization No.162-15)on June 9,2019.

关键词： axonal growth brain-derived neurotrophic factor gene delivery nanoparticles neuritogenesis neuronal cytoskeleton neuroregeneration neurorestoration neurotrophic therapy Parkinson's disease reinnervation substantia nigra

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Risk of colorectal polyps in patients with sporadic gastric polyps:A case-control study

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World Journal of Gastrointestinal Endoscopy 2013年第5期5卷 240-245页

作者： daniel Gustavo Cimmino José Manuel Mella Pablo Luna Raquel González Lisandro Pereyra Carolina Fischer Adriana Mohaidle Beatriz Vizcaino Mario Andres Medrano Adrián Hadad Silvia Pedreira luis Boerr Digestive Endoscopy and Gastroenterology Units Internal Medicine DepartmentHospital AlemánBuenos AiresCP 1118Argentina

AIM:To assess the risk of colonic polyps,adenomas and advanced neoplastic lesions(ANL) in patients with sporadic gastric polyps,especially those with fundic gland polyps(FGP).METHODS:Clinical records of patients who had performed an upper and a lower digestive endoscopy between September 2007 and August 2008 were retrospectively analyzed.A case-control study was carried out,calling patients with gastric polyps as 'cases' and patients without gastric polyps as 'controls'.The risk of colonic polyps,adenomas and ANL(villous component ≥ 25%,size ≥ 10 mm,or high grade dysplasia) was assessed [odds ratio(OR) and its corresponding 95%CI].RESULTS:Two hundred and forty seven patients were analyzed:78 with gastric polyps(cases) and 169 without gastric polyps(controls).Among the cases,the majority of gastric polyps were FGP(80%,CI:69-88) and hyperplastic(20%,CI:12-31);25% had colonic polyps(25% hyperplastic and 68% adenomas,from which 45% were ANL).Among the controls,20% had colonic polyps(31% hyperplastic and 63% adenomas,from which 41% were ANL).The patients with sporadic FGP had an OR of 1.56(CI:0.80-3.04) for colonic polyps,an OR of 1.78(CI:0.82-3.84) for colonic adenomas,and an OR of 0.80(CI:0.21-2.98) for *** results were found in patients with gastric polyps in ***:The results of this study did not show more risk of colorectal adenomas or ANL neither in patients with sporadic gastric polyps nor in those with FGP.

关键词： Colorectal polyps Advanced neoplastic lesions Gastric polyps Fundic gland polyps gastric polyps Case-control study

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EEG Mapping of Cortical Activation Related to Emotional Stroop with Facial Expressions: A TREFACE Study

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Journal of Behavioral and Brain Science 2022年第10期12卷 514-532页

作者： Edward prada Maria C. H. Tavares Ana Garcia Corina Satler Lia Martinez Cândida H. L. Alves Carlos Tomaz Laboratory of Neurosciences and Behavior Department of Physiological Sciences University of Bras&iacute lia Bras&iacute lia Brazil Faculty of Psychology Social Sciences Department Universidad Pontificia Bolivariana Seccional Bucaramanga Bucaramanga Colombia University of Brasí lia Ceilandia Campus Bras&iacute lia Brazil Department of Psychology Federal University of Maranh&atilde o S&atilde o Luí s Brazil Laboratory of Neurosciences and Behavior Master’s Program in Environment CEUMA University S&atilde o luis Brazil

TREFACE (Test for Recognition of Facial Expressions with Emotional Conflict) is a computerized model for investigating the emotional factor in executive functions based on the Stroop paradigm, for the recognition of emotional expressions in human faces. To investigate the influence of the emotional component at the cortical level, the electroencephalographic (EEG) recording technique was used to measure the involvement of cortical areas during the execution of certain tasks. Thirty Brazilian native Portuguese-speaking graduate students were evaluated on their anxiety and depression levels and on their well-being at the time of the session. The EEG recording was performed in 19 channels during the execution of the TREFACE test in the 3 stages established by the model-guided training, reading, and recognition—both with congruent conditions, when the image corresponds to the word shown, and incongruent condition, when there is no correspondence. The results showed better performance in the reading stage and in congruent conditions, while greater intensity of cortical activation in the recognition stage and in incongruent conditions. In a complementary way, specific frontal activations were observed: intense theta frequency activation in the left extension representing the frontal recruitment of posterior regions in information processing;also, activation in alpha frequency in the right frontotemporal line, illustrating the executive processing in the control of attention, in addition to the dorsal manifestation of the prefrontal side, for emotional performance. Activations in beta and gamma frequencies were displayed in a more intensely distributed way in the recognition stage. The results of this mapping of cortical activity in our study can help to understand how words and images of faces can be regulated in everyday life and in clinical contexts, suggesting an integrated model that includes the neural bases of the regulation strategy.

关键词： EEG Emotion Facial Expressions Executive Functions Stroop TREFACE

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Alterations in fibrinolytic system proteins PAI-1,MMP-3,MMP-8,TIMP-1 and TIMP-2 in post-cholecystectomy bile duct injury

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Journal of Biomedical Science and Engineering 2013年第8期6卷 58-67页

作者： Jose Manuel Hermosillo-Sandoval luis Miguel Román-Pintos Adolfo daniel Rodriguez-Carrizález Ernesto Germán Cardona-Munoz Fermin Paul Pacheco-Moisés Genaro Gabriel Ortiz Alejandra Guillermina Miranda-Diaz Department of Surgery Specialties Hospital of the National Occidental Medical CentreSocial Security Institute of Mexico(Departamento de CirugíaHospital de Especialidades del Centro Médico Nacional de OccidenteInstituto Mexicano del Seguro Social)GuadalajaraMéxico University Health Sciences Centre University of Guadalajara(Centro Universitario de Ciencias de la SaludUniversidad de Guadalajara)GuadalajaraMéxico University Centre for Exact and Engineering Sciences University of Guadalajara(Centro Universitario de Ciencias Exactas e IngenieríasUniversidad de Guadalajara)GuadalajaraMéxico Pathology and Oxidative Stress Laboratory Division of NeurosciencesOccidental Biomedical Research CentreSocial Security Institute of Mexico(Laboratorio de Estrés Oxidativo&PatologíaDivision de NeurocienciasCentro de Investigacion Biomédica de OccidenteInstituto Mexicano del Seguro Social)GuadalajaraMéxico

Introduction: In bile duct injuries (BDI), cholestasis and cholangitis can alter the fibrinolytic system by promoting an increase of extracellular matrix depositions which favor an imbalance between metalloproteinases (MMPs) and their tissue inhibitors (TIMPs). Materials and Methods: Levels of PAI-1, MMP-3, MMP-8, TIMP-1 and TIMP-2 in 35 patients with post-cholecystectomy BDI by complete biliary obstruction were measured and compared to a healthy control group. Sirius red staining and immune staining for MMP-3 and MMP-8 were also undertaken in liver biopsies. Results: Levels of PAI-1, TIMP-1, TIMP-2 and MMP-8 were higher in BDI than healthy controls: 15 ± 2 ng/mL vs 7.1 ± 2 ng/mL (p 0.024);539 ± 64 ng/mL vs 256 ± 13 ng/mL (p p p 2 vs. 22865.7 ± 3865 μm2 in healthy controls (p 2 vs. 30744.2 ± 5810.2 μm2 (p 2 vs. 116337.9 ± 24803.3 μm2 (p 0.55). These results suggest an imbalance between fibrogenic/fibrinolytic protein levels. Interestingly, expression of the fibrinolytic protein MMP-8 was increased in serum and liver biopsies in BDI. Conclusion: We found an imbalance of profibrogenic molecules which promote extracellular matrix deposition. The over-expression of fibrinolytic proteins such as MMP-8 could limit liver fibrosis, preventing hepatic dysfunction in post-cholecystectomy BDI.

关键词： Cholecystectomy Bile Duct Injury(BDI) Plasminogen Activator Inhibitor Type 1(PAI-1) Tissue Inhibitors of Metalloproteinases(TIMP’s) Metalloproteinases(MMP’s)

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