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Prevalence of sensitive skin and its biophysical response in a Mexican population

World Journal of Dermatology 2013年第1期2卷 1-7页

作者： Diana Hernández-Blanco Juan Pablo Castanedo-Cázares Adriana Ehnis-Pérez Isabel Jasso-ávila luis conde-salazar Bertha Torres-álvarez Department of Dermatology Hospital Central "Dr. Ignacio Morones Prieto" Instituto Nacional de Medicina y Seguridad en el Trabajo CNNT-Madrid

AIM: To describe the frequency and biophysical response of sensitive skin in Mexican subjects, using the lactic acid ***: The lactic acid stinging test was applied to 250 healthy volunteers, both sexes, 18 years of age or older, without any active dermatoses on the test site. Volunteers were university students, workers of public institutions, and general population from San luis Potosi, Mexico. Participants were not excluded based on socioeconomic status. Demographic data were obtained through a questionnaire. Skin phototype was obtained through colorimetry. Subjects were randomized to receive 10% lactic acid on one nasolabial fold and placebo on the other side. The presence and intensity of adverse sensations, such as itching, burning, or stinging, was evaluated through a 10-point VisualAnalogue Scale(VAS) prior to treatment and at 3, 5, 8 and 10 min after the intervention. Subjects with a VAS of 2 or higher were considered positive for the test. A VAS lower than 2 was considered a normal response to skin manipulation. Simultaneously, biophysical changes and barrier function were assessed by colorimetry, transepidermal water loss(TEWL), and capacitance. To decrease measurement variations by skin manipulation, the nasolabial fold was segmented in four areas of 1 cm2 for each time measurement. Descriptive analyses were made using central tendency measures. Analyses of data were performed using two-tailed c2 test, Fisher's test, t-test, logistic regression, or Mann-Whitney U test for non-parametric values between groups. RESULTS: Of the included 246 subjects, 68% were women and the mean age was 32 years. The most frequent skin phototype was Ⅴ(ranges Ⅱ-Ⅴ). Thirty-six percent of the subjects identified themselves as having sensitive skin. Fifty-two percent of the subjects were positive to the lactic acid stinging test, with a mean VAS of 4.5 at 3 min. Subjects with the self-diagnosis of sensitive skin were more likely to be positive for the test(80% vs 36%, P

关键词： Sensitive skin Lactic acid test Transepidermal water loss Colorimetry Capacitance

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Linear viscoelastic behavior of asphalt binders and mixtures containing very high percentages of reclaimed asphalt pavement

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Frontiers of Structural and Civil Engineering 2023年第8期17卷 1211-1227页

作者： Reza IMANINASAB luis LORIA-salazar Alan CARTER Construction Engineering Department École de Technologie Supérieure(ÉTS)University of QuebecMontreal H3C 1K3Canada Civil Engineering Department Universidad Isaac NewtonSan José10108Costa Rica

The primary aim of this study is to correlate the impact of aggregates,if any,on the viscoelastic behavior of rejuvenated asphalt mixtures containing very high amounts of reclaimed asphalt pavement(RAP)(>50%).First,gradation of 100%RAP was rectified,using a modified Bailey method by adding virgin aggregates to achieve two coarse dense-graded and one fine dense-graded *** modulus test was then performed from−35 to+35℃and 0.01–10 *** addition to performance grade(PG)testing,extracted and recovered binders from different asphalt mixtures underwent shear complex modulus test within−8℃to high temperature PG and frequencies from 0.001 to 30 ***−Cole,Black space,complex modulus and phase angle master curves were constructed and ShiftHomothety-Shift in time-Shift(SHStS)transformation was used to compare the linear viscoelastic behavior of asphalt binders and *** influence of aggregates on the viscoelastic behavior of asphalt mixtures depends on temperature and/or *** role of asphalt binders in the behavior of asphalt mixtures is more pronounced at high temperatures and the effect of the aggregate structure increases as the temperature *** maximum difference(60%to 70%)in the viscoelastic behavior of the binder and mixture based on SHStS transformed Cole−Cole curves is within the phase angle of 15°–20°.

关键词： RAP complex modulus SHStS transformation rejuvenation behavior of asphalt binder and mixture

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Experimental analysis of infragravity waves in two eroded microtidal beaches

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Acta Oceanologica Sinica 2017年第5期36卷 31-43页

作者： MARIO conde-Frias luis Otero JUAN Camilo Restrepo JUAN Carlos Ortiz Geosciences Research Group GE04 Department of PhysicsUniversidad del NorteBarranquilla 081007Colombia

This work aims to contribute to the characterization and understanding ofinfragravity waves on two beaches with erosion problems. For this reason, we have used an array of ADCP and a pressure sensor to measure wave parameters and pressure inside and outside of the surf zone during the dry and rainy period in the beaches of Galerazamba and Manzanillo del Mar （both dissipative and eroded beaches） located in the Colombian Caribbean coast. Based on these measurements, we have carried out a spectral analysis in order to identify the frequency components that characterize the wave and its energy; thus, we identified the characteristic frequencies of iufragravity waves to finally filter the infragravity signal on each beach in different seasonal periods. Among the results of the Welch spectrum applied to surface elevation time series, we found that, the frequencies＇ energy of the sea-swell band decreases due to bottom friction and wave breaking as the wave approaches the shore, while the frequencies＇ energy of the infragravity band increases significantly. In addition, for the wavelet analysis, we could observe how the energy of the infragravity band, especially the lowest frequencies gain energy as the waves approaches the coast. Furthermore, based on the infragravity wave obtained from the extreme wave event registered during the field campaign we can conclude that the contribution of this signal is important in the erosion problems presented in the beaches of Galerazamba and Manzanillo del Mar. Finally, these results show the need to realize other studies that allow us to understand deeply, the role of infragravity waves on the morphological changes that occurs in these beaches.

关键词： infragravity waves long waves experimental analysis fourier analysis wavelet transform

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New gene therapy strategies for hepatic fibrosis

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World Journal of Gastroenterology 2015年第13期21卷 3813-3825页

作者： Adriana M salazar-Montes luis D Hernández-Ortega Martha S Lucano-Landeros Juan Armendariz-Borunda Department of Molecular Biology and Genomics Institute for Molecular Biology and Gene TherapyUniversity of GuadalajaraGuadalajaraJalisco 44281México

The liver is the largest internal organ of the body, which may suffer acute or chronic injury induced by many factors, leading to cirrhosis and hepatocarcinoma. Cirrhosis is the irreversible end result of fibrous scarring and hepatocellular regeneration, characterized by diffuse disorganization of the normal hepatic structure, regenerative nodules and fibrotic tissue. Cirrhosis is associated with a high co-morbidity and mortality without effective treatment, and much research has been aimed at developing new therapeutic strategies to guarantee recovery. Liver-based gene therapy has been used to downregulate specific genes, to block the expression of deleterious genes, to delivery therapeutic genes, to prevent allograft rejection and to augment liver regeneration. Viral and non-viral vectors have been used, with viral vectors proving to be more efficient. This review provides an overview of the main strategies used in liver-gene therapy represented by non-viral vectors, viral vectors, novel administration methods like hydrodynamic injection, hybrids of two viral vectors and blocking molecules, with the hope of translating findings from the laboratory to the patient′s bed-side.

关键词： Gene therapy Hepatic fibrosis Viral vectors Non-vi

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Comparison of biological fitness in crosses between subspecies of Meccus phyllosomus （Hemiptera： Reduviidae： Triatominae） in southern Mexico

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Insect Science 2017年第1期24卷 114-121页

作者： Jose Alejandro Martinez-Ibarra Benjamin Nogueda-Torres luis Fernando salazar-Montano Juan Carlos Garcia-Lino Demver Arroyo-Reyes Juan Angel Hernandez-Navarro Area de Entomologia Medica Universidad de Guadalajara Ciudad Guzman Jalisco Mexico Becario de COFAA Escuela Nacional de Ciencias Biologicas Instituto Politecnico Nacional D.F. Mexico Carrera de Medicina Departamento de Salud y Bienestar Centro Universitario del Sur Universidad de Guadalajara Ciudad Guzman Jalisco Mexico

Understanding the biological parameters of some triatomine subspecies of Meccus phyllosomus （Burmeister） is a crucial first step in estimating the epidemiologie importance of this group. Biological parameters related to hatching, lifetime, number of blood meals to molt, percentage of females at the end of the cycle, number of laid eggs, and mortality for each instar of 3 M. phyllosomus subspecies [M. p. mazzottii （Usinger）, M. p. pallidipennis （Stal）, and M. p. phyllosomus] and their laboratory hybrids were evaluated and compared. No significant differences （P 〉 0.05） were found among the experimental hybrids （MaPa, MaPhy, PaPhy） and reciprocal cohorts. In 5 （hatching, number of blood meals to molt, accumulative mortality, percentage of females, and mean number of laid eggs） of the 6 studied parameters （with the exception of development time）, the hybrid cohorts had better fitness results than the parental cohorts involved in each set of crosses. The increase in hybrid fitness found in our study could lead to an increase in the epidemiologic risks caused by transmission of Trypanosoma cruzi to humans.

关键词： biological parameters Chagas disease Meccus subspecies Mexico tri- atomines Trypanosoma cruzi transmission

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Multi-temporal NDVI analysis using UAV images of tree crowns in a northern Mexican pine-oak forest

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Journal of Forestry Research 2023年第6期34卷 1855-1867页

作者： Joséluis Gallardo-salazar Marcela Rosas-Chavoya Marín Pompa-García Pablito Marcelo López-Serrano Emily García-Montiel Arnulfo Meléndez-Soto Sergio Iván Jiménez-Jiménez Instituto de Investigaciones Agropecuarias y Forestales Universidad Michoacana de San Nicolás de Hidalgo(UMSNH)58330 MoreliaMichoacánMexico Programa Institucional de Doctorado en Ciencias Agropecuarias y Forestales Universidad Juárez del Estado de DurangoRío Papaloapan y Blvd.DurangoValle del Sur s/n34120 DurangoDurangoMéxico Facultad de Ciencias Forestales Universidad Juárez del Estado de DurangoRío Papaloapan y Blvd.DurangoValle del Sur s/n34120 DurangoDurangoMéxico Instituto de Silvicultura e Industria de la Madera Universidad Juárez del Estado de DurangoBoulevard del Guadiana 501Ciudad UniversitariaTorre de Investigación34120 DurangoMéxico INIFAP-CENID RASPA Centro Nacional de Investigación Disciplinaria en Relación Agua-Suelo-Planta-Atmósfera Margen derecha canal Sacramento km 6.5Zona industrial35140 Gómez PalacioDurangoMexico

The use of unmanned aerial vehicles(UAV)for forest monitoring has grown significantly in recent years,providing information with high spatial resolution and temporal *** with multispectral sensors allow the use of indexes such as the normalized difference vegetation index(NDVI),which determines the vigor,physiological stress and photo synthetic activity of *** study aimed to analyze the spectral responses and variations of NDVI in tree crowns,as well as their correlation with climatic factors over the course of one *** study area encompassed a 1.6-ha site in Durango,Mexico,where Pinus cembroides,Pinus engelmannii,and Quercus grisea *** images were acquired with UAV and information on meteorological variables was obtained from NASA/POWER *** ANOVA explored possible differences in NDVI among the three *** correlation was performed to identify the linear relationship between NDVI and meteorological *** differences in NDVI values were found at the genus level(Pinus and Quercus),possibly related to the physiological features of the species and their *** grisea had the lowest NDVI values throughout the year which may be attributed to its sensitivity to relative humidity and *** the use of UAV with a multispectral sensor for NDVI monitoring allowed genera differentiation,in more complex forest analyses hyperspectral and LiDAR sensors should be integrated,as well other vegetation indexes be considered.

关键词： Multispectral images Normalized diff erence Vegetation index Phenology Unmanned aerial vehicles Multitemporal analysis

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Estimation of visceral fat is useful for the diagnosis of significant fibrosis in patients with non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2020年第42期26卷 6658-6668页

作者： Marta Hernández-conde Elba Llop Carlos Fernández Carrillo Beatriz Tormo Javier Abad luis Rodriguez Christie Perelló Marta López Gomez Joséluis Martínez-Porras Natalia Fernández Puga Maria Trapero-Marugan Enrique Fraga Carlos Ferre Aracil Joséluis Calleja Panero Gastroenterology and Hepatology Department IDIPHISAHospital Universitario Puerta de Hierro-MajadahondaMadrid 28222Spain Centro de Investigación Biomédica en Red en elÁrea temática de Enfermedades Hepáticas Instituto de Salud Carlos IIIMadrid 28029Spain

BACKGROUND Obesity is a risk factor for non-alcoholic fatty liver disease(NAFLD),although obese patients with NAFLD do not always develop significant *** distribution of body fat could predict the risk of NAFLD *** To investigate the role of bioelectrical impedance-estimated visceral fat(VF)in assessing NAFLD *** In this cross-sectional study,patients with biopsy-proven NAFLD were prospectively *** patients underwent anthropometric evaluation,blood tests and bioelectrical impedance *** Between 2017 and 2020,119 patients were included[66.4%male,56 years(SD 10.7),62.2%obese,61.3%with metabolic syndrome].Sixty of them(50.4%)showed significant fibrosis(≥F2)in liver ***,VF and metabolic syndrome were associated with significant fibrosis(61 years vs 52 years,16.4 vs 13.1,73.3%vs 49.2%,respectively;P<0.001 for all).In the multivariate analysis,VF and age were independently associated with significant fibrosis(VF,OR:1.11,95%CI:1.02-1.22,P=0.02;age,OR:1.08,95%CI:1.03-1.12,P<0.01).A model including these variables showed and area under the receiver operating characteristic curve(AUROC)of 0.75,which was not inferior to transient elastography or NAFLD fibrosis score *** developed a nomogram including age and VF for assessing significant fibrosis in routine *** VF is a surrogate marker of liver fibrosis in patients with *** impedance analysis is an inexpensive and simple method that can be combined with age to guide patient referral when other resources may be unavailable.

关键词： Non-alcoholic fatty liver disease Visceral fat Liver fibrosis Bioimpedanciometry Metabolic syndrome Obesity

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Nrf2 and Snail-1 in the prevention of experimental liver fibrosis by caffeine

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World Journal of Gastroenterology 2013年第47期19卷 9020-9033页

作者： Daniela Gordillo-Bastidas Edén Oceguera-Contreras Adriana salazar-Montes Jaime González-Cuevas luis Daniel Hernández-Ortega Juan Armendáriz-Borunda nstitute of Molecular Biology in Medicine and Gene Therapy/CUCS University of GuadalajaraGuadalajaraJalisco 44100México

AIM:To determine the molecular mechanisms involved in experimental hepatic fibrosis prevention by caffeine(CFA).METHODS:Liver fibrosis was induced in Wistar rats by intraperitoneal thioacetamide or bile duct ligation and they were concomitantly treated with CFA(15 mg/kg per day).Fibrosis and inflammatory cell infiltrate were evaluated and classified by Knodell *** infiltrate was quantified by immunohistochemistry(anti-CD11b).Gene expression was analyzed by quantitative reverse transcription-polymerase chain reaction for collagenⅠ?(Col-1),connective tissue growth factor(CTGF),transforming growth factorβ1(TGF-β1),tumor necrosis factor alpha(TNF-α),interleukin-1(IL-1),IL-6,superoxide dismutase(SOD)and catalase(CAT).Activation of Nrf2 and Snail-1 was analyzed by ***-αexpression was proved by enzyme-linked immunosorbant assay,CAT activity was performed by ***:CFA treatment diminished fibrosis index in treated *** Knodell index showed both lower fibrosis and *** of profibrogenic genes CTGF,Col-1 and TGF-β1 and proinflammatory genes TNF-α,IL-6 and IL-1 was substantially diminished with CFA treatment with less CD11b positive *** lower values of transcriptional factor Snail-1 were detected in CFA treated rats compared with cirrhotic rats without treatment;in contrast Nrf2was increased in the presence of *** of SOD and CAT was greater in animals treated with CFA showing a strong correlation between mRNA expression and enzyme ***:Our results suggest that CFA inhibits the transcriptional factor Snail-1,down-regulating profibrogenic genes,and activates Nrf2 inducing antioxidant enzymes system,preventing inflammation and fibrosis.

关键词： Liver fibrosis Caffeine Thioacetamide Bile duct ligation Profibrogenic genes Proinflammatory cytokines Antioxidant enzymes

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Emergency Short-Stay Unit as an Effective Alternative to In-Hospital Admission for Acute Exacerbation of Chronic Heart Failure

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International Journal of Clinical Medicine 2014年第19期5卷 1200-1206页

作者： Albert salazar luis Garcia-Eroles Gemma Craywinckel Xavier Corbella Hospital de la Santa Creu i Sant Pau Barcelona Spain

Study Objective: To determine whether a new emergency department short-stay unit (EDSSU) was an effective alternative to conventional hospital units (HU) for acute exacerbation of chronic heart failure patients. Methods: Design: A comparative analysis was used to identify differences among patients admitted to EDSSU (n = 1546) and those admitted to the internal medicine (n = 552) or cardiology wards (n = 336) during the period of the study (January 1, 2008 to December 31, 2012). Setting: The study was performed at Sant Pau Hospital, a 500-bed teaching tertiary care referral center in Barcelona, Spain. The ED attends about 144,000 emergency visits per year. Participants: We studied retrospectively the characteristics of patients hospitalized with an acute exacerbation of chronic heart failure between January 1, 2008 and December 31, 2012 (n = 2434). We chose charts of patients from the hospital discharge database and selected according to the 9th revision of the International Classification of Diseases Codes. We used the computerized database to obtain outcome data on all patients. Results: Statistically significant differences were found in terms of mean age (HU: 77.38 (14.44) years versus EDSSU: 82.43 (8.72) years;p p p p = 0.998). There were statistically significant differences regarding sex (HU women = 60.6%;EDDSU women = 67.7%;p p < 0.001). Conclusion: The EDSSU proved to be an effective and safe measure in emergency care of patients with acute heart failure (AHF).

关键词： Emergency Short-Stay AHF

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Fruit Set in Orange with Phytohormones and Its Relation to Endogenous Levels of GA3

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Journal of Life Sciences 2013年第8期7卷 836-838页

作者： Juan Jose Galvan Luna luis Alonso Valdez Aguilar Andres Martinez Cano Ovidio salazar salazar Departamento de Horticultura Universidad Aut6noma Agraria Antonio Narro Saltillo 25315 Coahuila Mexico Division de Postgrado Universidad Autonoma de Tamaulipas Ciudad Victoria Tamaulipas Mexico

This research work aims to contribute in increasing the fruit set in citrus, given its importance in determining fruit yield. The authors evaluated the effects of phytohormones （auxins, gibberellins and cytokinins） in the mooring and features of orange fruit in cultivars Washington navel and Thomson （Citrus sinensis （L.） Osb.）, The experiment was established in a split plot randomized complete block design with five treatments and four replications. Flower tissue samples were stored in liquid N until the extraction of gibberellins and the identification and quantification of GA3. The results showed statistically significant difference （P 〈 0.05） between treatments in the number of fruits retained 129 d after flowering and the percentage of final tie. GA3 content ranged, on a dry weight basis, from 1.66 mg＇g1 in the control to 20.79 mg.g-1 in the high dose. The mean dose （32.2 mg.L-1 auxins, gibberellins 32.2 mg L-1 and 83.2 mg.L-1 cytokinins） caused the largest increase in fruit set.

关键词： Orange Washington navel Thomson auxins gibberellins cytokinins.

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