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Effects of resveratrol and other polyphenols in hepatic steatosis

World Journal of Gastroenterology 2014年第23期20卷 7366-7380页

作者： Leixuri Aguirre Maria Puy Portillo Elizabeth Hijona luis buja Nutrition and Obesity Group Department of Nutrition and Food ScienceUniversity of Basque Country (UPV/EHU) and Centro de Investigación Lucio Lascaray01006 VitoriaSpain Centro de Investigación Biomédica en Fisiopatología de la Obesidad y Nutrición (CIBERobn) Instituto de Salud Carlos Ⅲ01006 VitoriaSpain Department of Gastroenterology University of the Basque Country (UPV/EHU)Donostia Hospital and Biodonostia Institute20014 San SebastiánSpain Centro de Investigación Biomédica en Enfermedades Hepáticas (CIBERehd) Instituto de Salud Carlos Ⅲ20014 San SebastianSpain

Non-alcoholic fatty liver disease covers a wide spectrum of liver pathologies which range from simple steatosis to non-alcoholic *** are members of a very large family of plant-derived compounds that can have beneficial effects on human health,and thus their study has become an increasingly important area of human nutrition *** aim of the present review is to compile published data concerning the effects of both isolated polyphenols as well as polyphenol extracts,on hepatocyte and liver fat accumulation under different steatosis-inducing *** results reported clearly show that this group of biomolecules is able to reduce fat accumulation,but further studies are needed to establish the optimal dose and treatment period *** regard to the potential mechanisms of action,there is a good *** anti-lipidogenic effect of polyphenols is mainly due to reduced fatty acid and triacylglycerol synthesis,increased in fatty acid oxidation,and reduced of oxidative stress and *** a general conclusion,it can be stated that polyphenols are biomolecules which produce hepatoprotective *** date,these beneficial effects have been demonstrated in cultured cells and animal ***,studies performed in humans are needed before these molecules can be considered as truly useful tools in the prevention of liver steatosis.

关键词： Polyphenols Resveratrol Quercetin liver Steatosis

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