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Journal of Geographic Information System 2013年第1期5卷 54-68页

作者： antonio Miguel Martinez-Grana Jose luis Goy Caridad Zazo Geology Department External Geodynamics AreaSciences FacultyUniversity of SalamancaSalamancaSpain Section Geology National Museum of Natural SciencesMadridSpain

In this work we report a methodological procedure with an integrated physical-perceptual approach that allows units of landscape in protected natural areas to be differentiated. First, indirect methods were applied by means of a mapping procedure, which identified the physical components of major relevance. We then generated maps of natural units, anlyzing the “printed” landscape of a territory. Secondly, we developed direct methods to identify and describe the reresentative elements of the landscape, analyzing the “perceived” landscape. The identification and delimitation of these landscape units with geographical information systems provide detailed maps facilitate the tasks of planning and management. The procedure was validated by means of its application in two protected natural spaces. The treatment used here considers landscape not only as an aesthetic element but also as something “live” elaborating maps that should be of use in land planning and management of natural areas.

关键词： Landscape Cartography Natural Hazard Territorial Planning GIS Techniques Management Protected Parks

Estimating the size of Aedes aegypti populations from dengue incidence data: Implications for the risk of yellow fever outbreaks

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Infectious Disease Modelling 2017年第4期2卷 441-454页

作者： Eduardo Massad Marcos Amaku Francisco antonio Bezerra Coutinho Claudio JoséStruchiner luis Fernandez Lopez Annelies Wilder-Smith Marcelo Nascimento Burattini School of Medicine University of Sao PauloBrazil London School of Hygiene and Tropical Medicine UK College of Life and Natural Sciences The University of DerbyUK Programme of Scientific Computation Fundação Oswaldo CruzRio de JaneiroBrazil Li Ka Shing Knowledge Institute St Michael's HospitalTorontoCanada Institute of Public Health University of HeidelbergGermany Department Public Health and Clinical Medicine Epidemiology and Global HealthUmeåUniversitySE-90185 UmeåSweden Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore Hospital São Paulo Escola Paulista de MedicinaUniversidade Federal de São PauloSão PauloSPBrazil

In this paper we present a model to estimate the density of aedes mosquitoes in a community affected by *** method consists in fitting a continuous function to the incidence of dengue infections,from which the density of infected mosquitoes is derived *** derivations allow the calculation of the latent and susceptible mosquitoes'densities,the sum of the three equals the total mosquitoes'*** method is illustrated with the case of the risk of urban yellow fever resurgence in dengue infested areas but the same procedures apply for other aedes-transmitted infections like Zika and chikungunya viruses.

关键词： Aedes aegypti Mosquitoes'densities Dengue Zika virus Yellow fever

Male osteoporosis: A review

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World Journal of orthopedics 2012年第12期3卷 223-234页

作者： antonio Herrera antonio Lobo-Escolar Jesús Mateo Jorge Gil Elena Ibarz luis Gracia Department of orthopedic and Trauma Surgery Miguel Servet University Hospital 50009 Zaragoza Spain Department of Mechanical Engineering University of Zaragoza 50009 Zaragoza Spain

osteoporosis in men is a heterogeneous disease that has received little ***,one third of worldwide hip fractures occur in the male *** problem is more prevalent in people over70 years of *** etiology can be idiopathic or secondary to hypogonadism,vitamin D deficiency and inadequate calcium intake,hormonal treatments for prostate cancer,use of toxic and every disease or drug use that alters bone *** factors such as a previous history of fragility fracture should be assessed for the ***,risk factors in men are very *** are significant differences in the pharmacological treatment of osteoporosis between men and women fundamentally due to the level of evidence in published trials supporting each *** treatments will offer new therapeutic *** goal of this work is a revision of the present status knowledge about male osteoporosis.

关键词： Male osteoporosis Skeleton involution Etiology Fracture risk osteoporosis Non-pharmacological treatments Pharmacological treatments

European Symposium on Computer-Aided Process Engineering-15, 38 European Symposium of the Working Party on Computer Aided Process Engineering 15

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Multi-Temporal Analysis of Land Subsidence in Toluca Valley (Mexico) through a Combination of Persistent Scatterer Interferometry (PSI) and Historical Piezometric Data

丛书名： Computer Aided Chemical Engineering 20

2005年

作者： luis Puigjaner and antonio Espuña (Eds.)

来源：畅想之星图书光盘版（南... 评论

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畅想之星图书光盘版（南通市图书馆镜像）

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Advances in Remote Sensing 2014年第2期3卷 49-60页

作者： Norma Davila-Hernandez Delfino Madrigal Jose luis Exposito Xanat antonio Department of Hydrology American Center of Water Resources Atlacomulco Mexico Laboratory of Remote Sensing and Geographic Information Systems Faculty of Geography Autonomous University of Mexico State Toluca Mexico

The Toluca Valley Aquifer (TVA) is considered one of the most overexploited aquifers in Mexico because of the high rate of groundwater extraction for supplying urban and industrial water to Mexico City and Toluca City, which causes land subsidence in urban and suburban areas. In this paper, we propose a multi-temporal analysis that uses persistent scatterer interferometry (PSI) method to evaluate the subsidence processes in Toluca Valley. The PSI results revealed differential movements of the ground of as much as 83 mm/year. A spatial variation of PSI results was identified with respect to previous studies using the conventional Din SAR methodology. The spatial distribution and density suggested the possibility of an expanding trend of subsidence process at north, northeast and east of the TVA, which corresponds to the region with the highest density of pumping wells for industrial and agricultural use.

关键词： Subsidence of Lands Toluca Valley Aquifer Persistent Scatterer Interferometry

High-repetition-rate source of nanosecond duration kA-current pulses driven by relativistic laser pulses

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High Power Laser Science and Engineering 2024年第3期12卷 106-115页

作者： Michael Ehret Jakub Cikhardt Philip Wykeham Bradford Iuliana-Mariana Vladisavlevici Tomas Burian Diego de luis Jose luis Henares Rubén Hernández Martín Jon Imanol Apiñaniz Roberto Lera Joséantonio Pérez-Hernández João Jorge Santos Giancarlo Gatti Centro de Láseres Pulsados(CLPU) VillamayorSpain Czech Technical University in Prague Faculty of Electrical EngineeringPragueCzech Republic Univ.Bordeaux-CNRS-CEA Centre Lasers Intenses et Applications(CELIA)UMR 5107TalenceFrance Department of Radiation and Chemical Physics FZU-Institute of Physics of the Czech Academy of SciencesPragueCzech Republic

We report the first high-repetition-rate generation and simultaneous characterization of nanosecond-scale return currents of kA-magnitude issued by the polarization of a target irradiated with a PW-class high-repetition-rate titanium:sapphire laser system at relativistic *** present experimental results obtained with the VEGA-3 laser at intensities from5×10^(18)to 1.3×10^(20)W cm^(-2).A non-invasive inductive return-current monitor is adopted to measure the derivative of return currents of the order of kA ns-1and analysis methodology is developed to derive return *** compare the current for copper,aluminium and Kapton targets at different laser *** data show the stable production of current peaks and clear prospects for the tailoring of the pulse shape,which is promising for future applications in highenergy-density science,for example,electromagnetic interference stress tests,high-voltage pulse response measurements and charged particle beam *** compare the target discharge of the order of hundreds of nC with theoretical predictions and a good agreement is found.

关键词： current pulses electromagnetic pulse application high-power laser relativistic laser plasma

Instability of the lumbar spine due to disc degeneration. A finite element simulation

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Advances in Bioscience and Biotechnology 2013年第4期4卷 548-556页

作者： Elena Ibarz Yolanda Más Jesús Mateo antonio Lobo-Escolar antonio Herrera luis Gracia Aragón Health Sciences Institute Zaragoza Spain Aragón Institute for Engineering Research (I3A) Zaragoza Spain Department of Mechanical Engineering University of Zaragoza Zaragoza Spain Department of orthopaedic Surgery and Traumatology Miguel Servet University Hospital Zaragoza Spain Department of Surgery University of Zaragoza Zaragoza Spain

Low back pain, which most common cause is degenerative disc disease, currently represents a serious problem due to its socio-economic repercussions. Different factors are involved in the degenerative process, being the most common: the loads on the spine, repeated flexion movements and individual genetic characteristics. Nowadays, there is no agreement on whether instability is the main cause of low back pain, or only one reason among many, and on whether increased spinal mobility, associated with instability, occurs either locally or at the lumbar spine as a whole. In this work, the simulation of disc degeneration is based on a finite element model of lumbar spine. A parametric study based on mechanical properties was established, for each lumbar spine movement, by evaluating the disc degeneration in 10% steps, from healthy disc to maximum degeneration. The results show as general trend a progressive mobility increase as the disc degeneration level raises. As main conclusion, disc degeneration causes increased mobility at all vertebral levels, with moderate values for incipient degeneration and much higher values for advanced degeneration, affecting more severely to the levels closest to degenerated disk. The great mobility increase detected at L5 could explain the instability detected as a clinical symptom.

关键词： Lumbar Spine Finite Elements Biomechanics Kinematics Mobility Disc Degeneration

High prevalence of hepatic steatosis and vascular thrombosis in CoVID-19:A systematic review and meta-analysis of autopsy data

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World Journal of Gastroenterology 2020年第48期26卷 7693-7706页

作者： luis antonio Díaz Francisco Idalsoaga Macarena Cannistra Roberto Candia Daniel Cabrera Francisco Barrera Alejandro Soza Rondell Graham Arnoldo Riquelme Marco Arrese Michael D Leise Juan Pablo Arab Department of Gastroenterology Escuela de MedicinaPontificia Universidad Católica de ChileSantiago 8320000Chile Department of Internal Medicine Pontificia Universidad Católica de ChileSantiago 8320000Chile School of Medicine Pontificia Universidad Católica de ChileSantiago 8320000Chile Facultad de Ciencias Médicas Universidad Bernardo O'HigginsSantiago 8320000Chile Department of Laboratory Medicine and Pathology Mayo Clinic RochesterMinnesotaMN 55902United States Católica de Chile Santiago 8320000Chile Division of Gastroenterology and Hepatology Mayo Clinic RochesterMinnesotaMN 55905United States

BACKGRoUND Coronavirus disease 2019(CoVID-19)disease can frequently affect the *** on hepatic histopathological findings in CoVID-19 is *** To characterize hepatic pathological findings in patients with *** We conducted a systematic review with meta-analysis registered on PRoSPERo(CRD42020192813),following PRISMA *** trials were those including patients of any age and CoVID-19 diagnosis based on a molecular *** reports from deceased CoVID-19 patients undergoing autopsy or liver biopsy were *** including less than ten patients were *** were pooled using random-effects models.Q statistic and I2 were used to assess heterogeneity and levels of evidence,*** We identified 18 studies from 7 countries;all were case reports and case series from *** the patients were over 15 years old,and 67.2%were *** performed a meta-analysis of 5 studies,including 116 *** prevalence estimates of liver histopathological findings were hepatic steatosis 55.1%[95%confidence interval(CI):46.2-63.8],congestion of hepatic sinuses 34.7%(95%CI:7.9-68.4),vascular thrombosis 29.4%(95%CI:0.4-87.2),fibrosis 20.5%(95%CI:0.6-57.9),Kupffer cell hyperplasia 13.5%(95%CI:0.6-54.3),portal inflammation 13.2%(95%CI:0.1-48.8),and lobular inflammation 11.6%(95%CI:0.3-35.7).We also identified the presence of venous outflow obstruction,phlebosclerosis of the portal vein,herniated portal vein,periportal abnormal vessels,hemophagocytosis,and *** We found a high prevalence of hepatic steatosis and vascular thrombosis as major histological liver *** frequent findings included portal and lobular inflammation and Kupffer cell hyperplasia or *** studies are needed to establish the mechanisms and implications of these findings.

关键词： Pathology SARS-CoV-2 CoVID-19 Autopsies Liver Liver biopsies

Metastatic pancreatic and lung cancer patient in complete remission following immunotherapy: A case report and review of literature

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World Journal of Gastrointestinal oncology 2024年第5期16卷 2233-2240页

作者： Joaquina Martínez-Galán Cristina Jiménez-Luna Isabel Rodriguez Elisabeth Maza Carlos García-Collado antonio Rodríguez-Fernández Javier luis López-Hidalgo octavio Caba Department of Medical oncology Virgen de las Nieves University HospitalGranada 18014Spain Instituto de Investigación Biosanitaria Ibs.GranadaGranada 18012Spain Institute of Biopathology and Regenerative Medicine(IBIMER) University of GranadaGranada 18016Spain Pharmacogenetics Unit Virgen de las Nieves University HospitalGranada 18014Spain Department of Medicina Nuclear Virgen de las Nieves University HospitalGranada 18014Spain Department of Anatomía Patológica Virgen de las Nieves University HospitalGranada 18014Spain

BACKGRoUND Metastatic pancreatic ductal adenocarcinoma(PDAC)is a lethal malignancy with dispiriting survival *** is a promising approach to many cancer types,but achieves poor outcomes in advanced PDAC due to its immunosuppressive tumor *** describe a case of metastatic PDAC effectively treated with *** SUMMARY We report the case of a 67-year-old woman with unresectable locally advanced PDAC,treated with gemcitabine plus nab-paclitaxel followed by radiotherapy plus *** nine months,pancreatic tumor progression was observed at the level of the hepatic hilum with the appearance of a new pulmonary nodule suggestive of a second primary,confirmed by left lung *** immunotherapy was then initiated with pembrolizumab,an immune checkpoint inhibitor targeting programmed cell death protein-1 that covers the two tumor *** patient showed a complete metabolic response that was maintained throughout the *** patient continues to be disease-free at 5.6 years since the start of *** These results suggest that the administration of pembrolizumab after chemoradiotherapy has a beneficial effect in patients with metastatic *** our knowledge,this is the first reported case of a patient with metastatic PDAC and metastatic lung cancer showing such a long-lasting complete response after pembrolizumab treatment without curative *** studies are required to determine biomarkers that identify PDAC patients most likely to benefit from this immunotherapy.

关键词： Pancreatic ductal adenocarcinoma Lung cancer Immunotherapy Pembrolizumab Programmed cell death protein-1 Case report

oxfendazole as successful treatment of Taenia hydatigena metacestodes in naturally infected pigs

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Asian Pacific Journal of Tropical Biomedicine 2015年第11期5卷 971-973页

作者： luis antonio Gomez-Puerta Armando Emiliano Gonzalez Cesar Gavidia Viterbo Ayvar Hector Hugo Garcia Maria Teresa Lopez-Urbina for the Cysticercosis Working Group in Peru School of Veterinary Medicine National University of San Marcos Cysticercosis Elimination Program and Center for Global Health Tumbes Cayetano Heredia University Department of Microbiology School of SciencesCayetano Heredia University

The efficacy of oxfendazole(oFZ) on Taenia hydatigena metacestodes, also called Cysticercus tenuicollis(C. tenuicollis), was studied in 648 raising pigs. This study was performed in Tumbes Department in Peru, an endemic area for cysticercosis. Pigs were randomized in two groups; untreated group(n = 142) did not receive any treatment and treated group(n = 506) received oFZ treatment at a single dose of 30 mg/kg body *** months after treatment, the pigs were necropsied. The prevalence of infection by C. tenuicollis among the pigs was 27.5%(39/142) and 2.0%(10/506) in untreated and treated groups, respectively. Untreated group was infested only with viable cysts, whereas treated group had no viable cysts. All the cysts found in treated group presented degeneration, with a thick membrane, and they contained milky fluid and fibrous tissue. A single dose of oFZ was effective against C. tenuicollis, thus providing an alternative drug for controlling this parasite in pigs.

关键词： Taenia hydatigena Cysticercus tenuicollis oxfendaz