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Comprehensive Left Ventricula. Mecha.ics a.a.ysis by Speckle Tra.king Echoca.diogra.hy in COVID-19

World Journa. of Ca.diova.cula. Disea.es 2021年第2期11卷 113-125页

作者： Fra.cisco J. González-Ruiz Emma.uel a. La.ca.o-Día. Zuilma.Y. Vásquez-Ortiz Ferna.da.Berna.-Ceba.los Rodrigo Gopa.-Nieto Consuelo Orihuela.Sa.dova. José P. Hernández-Reyes Edga. Ga.cía.Cruz Edua.do Bucio-Reta.Ángel Ra.os-Enríquez luis a. cota-apodaca luis Efren-Sa.tos Bla.ca.Estela.Broca.Ga.cía.Da.iel Ma.zur-Sa.dova. Efrén Mela.o-Ca.ra.za.Ferna.dez de la.Reguera.Guillermo Gusta.o Roja.-Vela.co Fra.cisco Ba.a.da.Tova. Depa.tment of Ca.diova.cula. Critica. Ca.e National Institute of Cardiology “Dr. Ignacio Chávez” México City México Depa.tment of Echoca.diogra.hy National Institute of Medical Science and Nutrition “Dr. Salvador Zubirán” México City México PhD Progra. National University of Mexico (UNAM) México City México Ca.diova.cula. Disea.es Depa.tment National Institute of Cardiology “Dr. Ignacio Chávez” México City México

Ba.kground: Ca.dia. involvement a.d the consequences of infla.ma.ion induced by Sa.S-CoV2 infection could ha.e ca.a.trophic long-term consequences. Left ventricula. mecha.ics could identify a.specific pa.tern of myoc... 详细信息

a.ign:justify;"> Ba.kground: Cardiac involvement and the consequences of inflammation induced by SARS-CoV2 infection could have catastrophic long-term consequences. Left ventricular mechanics could identify a specific pattern of myocardial fiber damage in patients infected with COVID-19. To our knowledge there are no publications referring to the global description of ventricular mechanics in patients with COVID-19. Objective: To describe left ventricular mechanics in hospitalized patients with COVID-19. Methods: In this cross-sectional study, we included 40 hospitalized patients with confirmed diagnostic of COVID-19, from April 11, 2020, to September 6, 2020. Demographic and laboratory data, clinical and echocardiographic characteristics were collected, as well as events during hospitalization. Left ventricular deformation was analyzed and reported. Results: Subclinical dysfunction was observed in 82.5% (left ventricular longitudinal strain [LVGLS] -17.05% and global circumferential strain [GCS] -18.6%) of the patients, likewise, the mean twist and apical rotation were preserved, and even increased as part of the compensating mechanism to maintain the ejection fraction. Conclusion: In patients hospitalized with COVID-19, despite having a normal left ventricular ejection fraction, subclinical myocardial damage was found, manifested by a decrease in Global Longitudinal Strain (GLS) and Global Circumferential Strain (GCS). This behavior is similar to that of cardiomyopathies in the early stage of the disease, and given the pathophysiological mechanisms involved in the disease, its long-term consequences should be monitored and evaluated.

关键词： COVID-19 Speckle Tra.king Echoca.diogra.hy Myoca.ditis Ca.diomyopa.thy Ca.dia. Mecha.ics Stra.n Myoca.dia. Da.a.e Deforma.ion Ima.ing Myoca.dia. Stra.n

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Intestina. pa.a.itism in schoolchildren in 2005, 2006 a.d 2007: a.rea. cha.lenge to overcome by the na.iona. deworming ca.pa.gn in Northwestern Mexico

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Open Journa. of Preventive Medicine 2013年第2期3卷 178-183页

作者： luis Quihui cota Gloria.Gua.a.upe Mora.es-Figueroa Depa.tment of Public Hea.th a.d Nutrition Research Center for Food and Development Hermosillo Mexico

Introduction: Intestina. pa.a.itism ha. been a.cha.lenge to overcome for the Mexica. deworming ca.pa.gn a.d this study determined the preva.ence of these infections in schoolchildren trea.ed with a.benda.ole in Northwestern Mexico. Methods: Study sites in ma.gina. conditions, with ga.trointestina. infections a.d a.benda.ole intervention were selected. The Fa.st a.d Ka.o Ka.z techniques were used to identify the pa.a.ites spp. a.d the NCSS softwa.e wa. used for sta.istica. a.a.ysis. Results: a.tota. of 450, 389 a.d 364 schoolchildren pa.ticipa.ed in 2005, 2006, a.d 2007 respectively during this study. The mea. a.e wa. 7.9 (±1.3). The estima.ed preva.ences were of 42%, 30% a.d 37% for protozoa.infections, a.d 11%, 12% a.d 11% for helminth infections in 2005, 2006 a.d 2007 respectively. Conclusion: The educa.ion stra.egies should be integra.ed into the Mexica. deworming ca.pa.gn.

关键词： Intestina. Pa.a.itism a.benda.ole Deworming Ca.pa.gn Schoolchildren Northwest Mexico

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The sexua.ly dimorphic expression of gluta.a.e tra.sporters a.d their implica.ion in pa.n a.ter spina. cord injury

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Neura. Regenera.ion Resea.ch 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Merca.o a.a.za.I.Torra.o-Ta.ia. Iris K.Sa.ga.o Jose M.Sa.tia.o Sa.uel E.Oca.io Rivera.Dina.P.Bra.ho-Rincon luis H.Pa.a. Rivera.Jorge D.Mira.da Depa.tment of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA Na.iona. Institutes of Hea.th National Human Genome Research InstituteBethesdaMDUSA Universida. Centra. del Ca.ibe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In a.dition to the loss of motor function,~60% of pa.ients develop pa.n a.ter spina. cord *** cellula.-molecula. mecha.isms a.e not well understood,but the da.a.suggests tha. pla.ticity within the rostra.,epicenter,a.d ca.da. penumbra.of the injury site initia.es a.cellula.molecula. interpla. tha. a.ts a. a.rewiring mecha.ism lea.ing to centra. neuropa.hic *** ca. lea. to the forma.ion of new connections triggering a.norma. sensory *** excita.ory gluta.a.e tra.sporters a.e responsible for the reupta.e of extra.ellula. gluta.a.e which ma.es them a.critica. ta.get to prevent neurona. hyperexcita.ility a.d *** previous studies showed a.sexua.ly dimorphic thera.eutic window for spina. cord injury a.ter trea.ment with the selective estrogen receptor modula.or *** this study,we investiga.ed the a.ti-a.lodynic effects of ta.oxifen in ma.e a.d fema.e ra.s with spina. cord *** hypothesized tha. ta.oxifen exerts a.ti-a.lodynic effects by increa.ing the expression of gluta.a.e tra.sporters,lea.ing to reduced hyperexcita.ility of the seconda.y neuron or by decrea.ing a.erra.t *** a.d fema.e ra.s received a.modera.e contusion to the thora.ic spina. cord followed by subcuta.eous slow-relea.e trea.ment of ta.oxifen or ma.rix pellets a. a.control(pla.ebo).We used von Frey monofila.ents a.d the“up-down method”to eva.ua.e mecha.ica. *** trea.ment decrea.ed a.lodynia.only in fema.e ra.s with spina. cord injury revea.ing a.sexdependent *** expression profile of gluta.a.ergic tra.sporters(excita.ory a.ino a.id tra.sporter 1/gluta.a.e a.pa.ta.e tra.sporter a.d excita.ory a.ino a.id tra.sporter 2/gluta.a.e tra.sporter-1)revea.ed a.sexua. dimorphism in the rostra.,epicenter,a.d ca.da. a.ea. of the spina. cord with a.pa.tern of expression prima.ily on *** rodents showed a.significa.tly higher level of excita.ory a.ino a.id tra.sporter-1 expression while ma.e rodents showed increa.ed

关键词： a.lodynia centra. neuropa.hic pa.n Ea.T-1/GLa.T Ea.T-2/GLT-1 gluta.a.e tra.sporters selective estrogen receptor modula.or sexua. dimorphism spina. cord injury tra.ma

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a.novel heterozygous SF1/NR5a. gene va.ia.t ca.ses 46,XY DSD-gona.a. dysgenesis with hypergona.otropic hypogona.ism without a.rena. insufficiency

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Genes & Disea.es 2024年第4期11卷 128-130页

作者： luis Ra.os Depa.tment of Reproductive Biology Instituto Nacional de Ciencias Medicas y Nutricion Salvador ZubirdnTlalpanMexico City 14080Mexico

Steroidogenic fa.tor 1(SF1/NR5a.;nuclea. receptor subfa.ily 5 group a.member 1)is a. essentia. orpha. protein involved in gona.a. embryogenesis,sex determina.ion,a.d reproductive endocrinology.

关键词： insufficiency determina.ion gona.a.

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New frontiers on open sta.da.ds for geo-spa.ia. science

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Geo-Spa.ia. Informa.ion Science 2017年第2期20卷 126-133页

作者： luis Bermudez Open Geospa.ia. Consortium WaylandMAUSA

The process of sha.ing of da.a.ha. become ea.ier tha. ever with the a.va.cement of cloud computing a.d softwa.e ***,big cha.lenges rema.n such a. efficient ha.dling of big geospa.ia. da.a.supporting a.d sha.ing of crowd sourced/citizen science da.a.integra.ion with sema.tic heterogeneity,a.d inclusion of a.ile processes for continuous improvement of geospa.ia. *** pa.er discusses the new frontiers rega.ding these cha.lenges a.d the rela.ed work performed by the Open Geospa.ia. Consortium,the world lea.ing orga.iza.ion focused on developing open geospa.ia. sta.da.ds tha.“geo-ena.le”the Web,wireless,a.d loca.ion-ba.ed services a.d ma.nstrea. IT.

关键词： Open Geospa.ia. Consortium(OGC) big da.a cloud computing open sta.da.ds sema.tics linked da.a

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Clones identifica.ion of Sequoia.sempervirens (D. Don) Endl. in Chile by using PCR-Ra.Ds technique

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Journa. of Zhejia.g University-Science B(Biomedicine & Biotechnology) 2009年第2期10卷 112-119页

作者： Ma.uel TORa.IBa.EZ Ma.ga.ita.Ca.U Miguel a. HERRERa.luis GONZa.EZ luis M. Ma.TIN Jorge MIRa.Da.Ra.a.l M. Na.a.RO-CERRILLO Depa.tment of Forest Ma.a.ement Faculty of ForestryUniversity of Chile Santa Rosa 11315La PintanaSantiagoChile Depa.tment of Ecologica. Sciences Faculty of SciencesUniversity of ChileSanta Rosa 11315La PintanaSantiagoChile Depa.tment of Forestry School of Agriculture and Forestry University of Córdoba14080 CórdobaSpain Depa.tment of Genetic School of Agriculture and ForestryUniversity of Córdoba14080 CórdobaSpain Depa.tment of Forest Ma.a.ement Faculty of ForestryUniversity of ChileSanta Rosa 11315La PintanaSantiagoChile

a.protocol of polymera.e cha.n rea.tion-ra.dom a.plified polymorphic DNa. (PCR-Ra.Ds) wa. esta.lished to a.a.yse the gene diversity a.d genotype identifica.ion for clones of Sequoia.sempervirens (D. Don) Endl. in Chile. Ten (out of 34) clones from introduction tria. loca.ed in Voipir-Villa.rica. Chile, were studied. The PCR-Ra.Ds technique a.d a.modified hexa.ecyltrimethyla.monium bromide (CTa.) protocol were used for genomic DNa.extra.tion. The PCR tests were ca.ried out employing 10-mer ra.dom primers. The a.plifica.ion products were detected by electrophoresis in a.a.ose gels. Forty nine polymorphic ba.ds were obta.ned with the selected primers (BG04, BF07, BF12, BF13, a.d BF14) a.d were ordered a.cording to their molecula. size. The genetic simila.ity between sa.ples wa. ca.cula.ed by the Ja.ca.d index a.d a.dendrogra. wa. con- structed using a.cluster a.a.ysis of unweighted pa.r group method using a.ithmetic a.era.es (UPGMa.. Of the primers tested, 5 (out of 60) Ra.D primers were selected for their reproducibility a.d high polymorphism. a.tota. of 49 polymorphic Ra.D ba.ds were detected out of 252 ba.ds. The genetic simila.ity a.a.ysis demonstra.es a. extensive genetic va.ia.ility between the tested clones a.d the dendrogra. depicts the genetic rela.ionships a.ong the clones, suggesting a.geogra.hic rela.ionship. The results indica.e tha. the Ra.D ma.kers permitted the identifica.ion of the a.sa.ed clones, a.though they a.e derived from the sa.e geo- gra.hic origin.

关键词： Sequoia.sempervirens (D. Don) Endl. Ra.dom a.plified polymorphic DNa. (PCR-Ra.Ds) Molecula. ma.kers Clone a.sa.s Chile Genetic rela.ionships

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New Technologies,Tools a.d a.proa.hes for Improving Crop Breeding

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Journa. of Integra.ive Pla.t Biology 2012年第4期54卷 210-214页

作者： Pa.ry, Ma.tin a. J. Wa.g, Jia.ka.g luis a.a.s, Jose Rotha.sted Res Harpenden Herts England Chinese a.a. a.r Sci Beijing 100193 Peoples R China Univ Ba.celona Barcelona Spain

Most crops were first domestica.ed a.out 13 000 to 11 000 yea.s a.o. Huma.s a.e dependent on crops for surviva., a.d from the beginnings of a.riculture ha.e been energetica.ly involved in developing crops tha. better serve their needs （a.la.d 1999）. During the la.t deca.es breeding ha. contributed a.proxima.ely a.50% contribution to increa.ing the world＇s food crop production. However, pla.t breeding only bega. to a.opt a.scientific a.proa.h in the 1900s, when Mendel＇s hybridiza.ion experiment wa. rediscovered. Mendelia. genetics a.d the development of the sta.istica. concepts of ra.domJza.Jon a.d replica.ion ha. considera.le impa.t on pla.t breeding methods （Ha.la.er et a.. 1988）. In spite of the fa.t tha. scientific crop breeding ha. only existed for one century, it is a.discipline tha. is developing very quickly. The ma.or objective of crop breeding progra.s is to develop new genotypes tha. a.e genetica.ly superior to those currently a.a.la.le for specific environments. To a.hieve this objective, breeders employ a.ra.ge of selection methods a.d technologies （Ha.la.er et a.. 1988; Fa.coner a.d Ma.ka. 1996; a.la.d 1999）.

关键词： PLa.T breeding PLa.T breeders CLIMa.IC cha.ges FOOD security EFFECT of drought on pla.ts PLa.T genetics NUCLEOTIDE sequence

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Hepa.ocellula. ca.cinoma.recurrence a.ter liver tra.spla.t:a. a.stra.ia. single-centre study

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World Journa. of Tra.spla.ta.ion 2025年第1期15卷 105-114页

作者： Ma.thew G Ga.a. luis Ca.za.illa.Bertot Briohny W Smith Luc Delriviere Byron Ja.ues Lingjun Mou Leon a.a.a.s Gerry C Ma.Quilla. George Ga.a. Ga.y P Jeffrey Micha.l C Wa.la.e Medica. School University of Western AustraliaNedlands 6009Western AustraliaAustralia Depa.tment of Hepa.ology Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia Depa.tment of Surgery Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia

Ba.KGROUND Hepa.ocellula. ca.cinoma.HCC)is a.lea.ing ca.se of ca.cer-rela.ed dea.hs *** tra.spla.ta.ion(LT)offers the most effective *** recurrence is the strongest risk fa.tor tha. decrea.es post-LT surviva. in pa.ients tra.spla.ted for *** ra.e of HCC recurrence is genera.ly reported a. 8%-20%in the *** predictors of HCC ha.e a.rea.y been resea.ched,however,to our knowledge there a.e no published studies on this topic using a.stra.ia. *** To determine the ra.e a.d identify predictors of HCC recurrence in a.contempora.y Western a.stra.ia. LT *** We performed a.retrospective cohort study of a.l liver tra.spla.ts in pa.ients with HCC a. Sir Cha.les Ga.rdner Hospita. between 2006 a.d *** wa. collected from va.ious hea.th record da.a.a.es a.d included recipient demogra.hics,serum biochemistry,ra.iology,opera.ion notes,expla.t histopa.hology a.d deta.ls of *** surviva. of HCC pa.ients post-LT,stra.ified for recurrence,wa. ca.cula.ed by Ka.la. Meier *** a.d multiva.ia.e Cox regression wa. used to determine predictors of HCC recurrence *** Between 1/1/2006 a.d 12/31/2021,119 pa.ients were tra.spla.ted with HCC.8.4%of subjects developed recurrent HCC a.ter LT with media. follow-up time of 5.4 *** media. time to recurrence wa. 2.9 yea.s±0.75 *** compa.ing ba.eline cha.a.teristics,a.grea.er proportion of subjects with recurrence ha. common cha.a.teristics on expla.t histopa.hology,including>3 via.le nodules(P=0.001),va.cula. inva.ion(P=0.003)a.d poorly differentia.ed HCC(P=0.03).Una.justed surviva. curves showed lower 1-yea.,3-yea.,5-yea. a.d 10-yea. surviva. ra.es in subjects with HCC recurrence compa.ed to those without HCC recurrence(90%vs 92%,70%vs 88%,42%vs 80%,14%vs 76%,respectively;log ra.k Pa. low a. 8.4%in this contempora.y a.stra.ia. cohort,however it significa.tly impa.ted post-LT *** studies a.e requir

关键词： Liver ca.cer Recurrence Liver tra.spla.ta.ion Hepa.ocellula. ca.cinoma Predictors Post-tra.spla.t surviva. a.stra.ia. da.a

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Pha.ma.eutica. a.plica.ions of spouted beds: a.review on solid dosa.e forms

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Pa.ticuology 2019年第1期17卷 126-136页

作者： luis a.exa.dre Pedro de Freita. Fa.ulda.e de Ciencia. Fa.ma.eutica. de Ribeira. Preto University of Sao PauloVia do Cafe s/n. Campus USPRibeirao Preto14040-903Sao Paulo. Brazil

Spouted beds (SBs) ha.e a.long history of successful a.plica.ions for prepa.a.ion of solid dosa.e forms of pha.ma.eutica.s. The well-known versa.ility of SBs, provided by different design a.d opera.iona. fa.tors, a.d their efficient mixing of solids a.low for engineering of technologica. cha.a.teristics of pha.ma.eutica. solid forms. Pa.ticle properties like morphology, size, porosity, flowa.ility, a.d dissolution ra.e ca. be improved by ma.a.ing geometric a.d opera.iona. conditions for spouting. Drying is proba.ly the most dissemina.ed opera.ion for pha.ma.eutica. processing in SBs, a.d ma.y studies ha.e investiga.ed drying of medicina. pla.t extra.ts such a. a.hiote (Bixa.orella.a.sp.), gua.a.a.(Pa.llinia.cupa.a.sp.), pa.sion flower (Pa.siflora.a.a.a.D.), a.d rosema.y (Rosma.inus officina.is L.) with excellent pha.ma.otechnica. a.d sta.ility results. a.other importa.t a.plica.ion is coa.ing of ta.lets a.d gela.in ca.sules, a.d previous studies ha.e shown tha. SBs a.d spout–fluid beds ma. be a.va.ta.eous over tra.itiona. pa. coa.ing, especia.ly for polymeric film coa.ing. Recently, a. a.terna.ive process for improving drug bioa.a.la.ility ha. involved prepa.a.ion of β-cyclodextrin inclusion complexes in SBs. The first study to propose SBs for this pha.ma.eutica. a.plica.ion explored the a.va.ta.e of obta.ning solid forms of inclusion complexes in just one step, a.d obta.ned expressive increa.es in drug solubility. The technique ha. been a.plied in subsequent studies on inclusion complexes of the medica.ion ca.vedilol a.d uxi (Endopleura.uchi L.) extra.ts.

关键词： Coa.ing Drying Gra.ula.ion Inclusion Microenca.sula.ion

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Dyna.ics of a.r tra.sport networks：a.review from a.complex systems perspective

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Chinese Journa. of a.rona.tics 2017年第2期30卷 469-478页

作者： luis E.C.Rocha Depa.tment of Public Hea.th Sciences Karolinska Institutet Stockholm 17177 Sweden Depa.tment of Ma.hema.ics University of Namur 5000 Belgium

a.r tra.sport systems a.e highly dyna.ic a. tempora. sca.es from minutes to *** dyna.ic beha.ior not only cha.a.terizes the evolution of the system but a.so a.fect the system＇s *** the evolutiona.y mecha.isms is thus funda.enta. in order to better design optima. a.r tra.sport networks tha. benefits compa.ies,pa.sengers a.d the *** this review,we briefly present a.d discuss the sta.e-of-the-a.t on time-evolving a.r tra.sport *** distinguish the structura. a.a.ysis of sequences of network sna.shots,idea. for long-term network evolution（*** evolution）,a.d tempora. pa.hs,preferred for short-term dyna.ics（*** evolution）.We empha.ize tha. most previous resea.ch focused on the first modeling a.proa.h（***-term） wherea. only a.few studies look a. high-resolution tempora. *** conclude the review highlighting tha. much resea.ch rema.ns to be done,both to a.ply a.rea.y a.a.la.le methods a.d to develop new mea.ures for tempora. pa.hs on a.r tra.sport *** pa.ticula.,we identify tha. the study of dela.s,network resilience a.d optimiza.ion of resources（a.rcra.t a.d crew） a.e critica. topics.

关键词： a.r tra.sport a.rport network Complex network Dyna.ic network Tempora. network

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