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Management of cancer patients during COVID-19 pandemic at developing countries

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World Journal of Clinical Cases 2020年第16期8卷 3390-3404页

作者： Jaime González-Montero Guillermo Valenzuela Mónica Ahumada Olga Barajas luis villanueva Department Faculty of MedicineUniversity of ChileSantiago 70058Chile Department Hospital Clinico Universidad de Chile and Clínica DávilaChile Department Hospital Clinico Universidad de Chile and Fundación Arturo López-PérezChile Department Hospital Clínico Universidad de Chile and Fundación Arturo López-PerezChile

Cancer patient care requires a multi-disciplinary approach and multiple medical and ethical *** care during a pandemic health crisis requires prioritising the use of resources for patients with a greater chance of survival,especially in developing *** coronavirus disease 2019 crisis has generated new challenges given that cancer patients are normally not prioritised for admission in critical care ***,the development of new cancer drugs and novel adjuvant/neoadjuvant protocols has dramatically improved the prognosis of cancer patients,resulting in a more complex decision-making when prioritising intensive care in pandemic *** this context,it is essential to establish an effective and transparent communication between the oncology team,critical care,and emergency units to make the best decisions,considering the principles of justice and ***,cancer treatment protocols must be adapted to prioritise according to oncologic response and *** technologies are powerful tools to optimise cancer care during pandemics,and we must adapt quickly to this new scenario of clinical care and *** this new challenging pandemic scenario,multi-disciplinary work and effective communication between clinics,technology,science,and ethics is the key to optimising clinical care of cancer patients.

关键词： Cancer Oncology Pandemic COVID-19 SARS-CoV-2

Micro 3D printing of a functional MEMS accelerometer

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Microsystems & Nanoengineering 2022年第5期8卷 69-79页

作者： Simone Pagliano David E.Marschner Damien Maillard Nils Ehrmann Göran Stemme Stefan Braun luis Guillermo villanueva Frank Niklaus KTH Royal Institute of Technology Division of Micro and NanosystemsMalvinas väg 10StockholmSweden École Polytechnique Fédérale de Lausanne(EPFL) Advanced NEMS LaboratoryInstitute of Mechanical Engineering1015 LausanneSwitzerland Hochschule Kaiserslautern University of Applied SciencesInformatik und MikrosystemtechnikCampus ZweibrückenGermany

Microelectromechanical system(MEMS)devices,such as accelerometers,are widely used across industries,including the automotive,consumer electronics,and medical *** are efficiently produced at very high volumes using large-scale semiconductor manufacturing ***,these techniques are not viable for the costefficient manufacturing of specialized MEMS devices at low-and medium-scale ***,applications that require custom-designed MEMS devices for markets with low-and medium-scale volumes of below 5000–10,000 components per year are extremely difficult to address *** 3D printing of MEMS devices could enable the efficient realization and production of MEMS devices at these low-and medium-scale ***,current micro-3D printing technologies have limited capabilities for printing functional ***,we demonstrate a functional 3D-printed MEMS accelerometer using 3D printing by two-photon polymerization in combination with the deposition of a strain gauge transducer by metal *** characterized the responsivity,resonance frequency,and stability over time of the MEMS *** results demonstrate that the 3D printing of functional MEMS is a viable approach that could enable the efficient realization of a variety of custom-designed MEMS devices,addressing new application areas that are difficult or impossible to address using conventional MEMS manufacturing.

关键词： printing accelerometer functional

Pyrolytic carbon resonators for micromechanical thermal analysis

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Microsystems & Nanoengineering 2019年第1期5卷 154-163页

作者： Long Quang Nguyen Peter Emil Larsen Tom Larsen Sanjukta Bose Goswami luis Guillermo villanueva Anja Boisen Stephan Sylvest Keller DNRF and Villum Fonden Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics IDUNTechnical University of Denmark2800 Kgs LyngbyDenmark DTU Nanolab Technical University of Denmark2800 Kgs LyngbyDenmark DTU Health Tech Technical University of Denmark2800 Kgs LyngbyDenmark Advanced NEMS Laboratory Ecole Polytechnique Fédérale de Lausanne1015 LausanneSwitzerland

Thermal analysis is essential for the characterization of polymers and ***,the currently established methods require a large amount of ***,we present pyrolytic carbon resonators as promising tools for micromechanical thermal analysis(MTA)of nanograms of *** clamped pre-stressed beams with a resonance frequency of 233±4 kHz and a quality factor(Q factor)of 800±200 were *** of the electrical conductivity of the pyrolytic carbon allowed us to explore resistive heating for integrated temperature *** was achieved by monitoring the resonance frequency and quality factor of the carbon resonators with and without a deposited sample as a function of *** prove the potential of pyrolytic carbon resonators as thermal analysis tools,the glass transition temperature(T_(g))of semicrystalline poly(L-lactic acid)(PLLA)and the melting temperature(T_(m))of poly(caprolactone)(PCL)were *** results show that the T_(g) of PLLA and T_(m) of PCL are 61.0±0.8℃ and 60.0±1.0℃,respectively,which are in excellent agreement with the values measured by differential scanning calorimetry(DSC).

关键词： temperature carbon thermal

Design and fabrication of a vigorous“cavitation-on-a-chip”device with a multiple microchannel configuration

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Microsystems & Nanoengineering 2021年第3期7卷 149-161页

作者： Farzad Rokhsar Talabazar Mohammad Jafarpour Merve Zuvin Hongjian Chen Moein Talebian Gevari luis Guillermo villanueva Dmitry Grishenkov Ali Koşar Morteza Ghorbani Faculty of Engineering and Natural Science Sabanci UniversityTuzlaIstanbulTurkey Sabanci University Nanotechnology Research and Application Center TuzlaIstanbulTurkey Advanced NEMS Laboratory École Polytechnique Fédérale de Lausanne(EPFL)CH-1015LausanneSwitzerland Department of Biomedical Engineering and Health Systems KTH Royal Institute of TechnologySE-14157StockholmSweden Division of Solid State Electronics Department of Electrical EngineeringTheÅngström LaboratoryUppsala UniversityUppsalaSweden Center of Excellence for Functional Surfaces and Interfaces for Nano-Diagnostics(EFSUN) Sabanci UniversityOrhanliTuzlaIstanbulTurkey

Hydrodynamic cavitation is one of the major phase change phenomena and occurs with a sudden decrease in the local static pressure within a *** the emergence of microelectromechanical systems(MEMS),high-speed microfluidic devices have attracted considerable attention and been implemented in many fields,including cavitation *** this study,a new generation of‘cavitation-on-a-chip’devices with eight parallel structured microchannels is *** new device is designed with the motivation of decreasing the upstream pressure(input energy)required for facile hydrodynamic cavitation *** and a poly(vinyl alcohol)(PVA)microbubble(MB)suspension are used as the working *** results show that the cavitation inception upstream pressure can be reduced with the proposed device in comparison with previous studies with a single flow restrictive ***,using PVA MBs further results in a reduction in the upstream pressure required for cavitation *** this new device,different cavitating flow patterns with various intensities can be observed at a constant cavitation number and fixed upstream pressure within the same ***,cavitating flows intensify faster in the proposed device for both water and the water–PVA MB suspension in comparison to previous *** to these features,this next-generation‘cavitation-on-a-chip’device has a high potential for implementation in applications involving microfluidic/organ-on-a-chip devices,such as integrated drug release and tissue engineering.

关键词： cavitation bubble faster

Manufacture and characterization of graphene membranes with suspended silicon proof masses for MEMS and NEMS applications

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Microsystems & Nanoengineering 2020年第1期6卷 1050-1066页

作者： Xuge Fan Anderson D.Smith Fredrik Forsberg Stefan Wagner Stephan Schroder Sayedeh Shirin Afyouni Akbari Andreas C.Fischer luis Guillermo villanueva Mikael Ostling Max C.Lemme Frank Niklaus Division of Micro and Nanosystems School of Electrical Engineering and Computer ScienceKTH Royal Institute of TechnologySE-10044 StockholmSweden Division of Integrated Devices and Circuits School of Electrical Engineering and Computer ScienceKTH Royal Institute of TechnologySE-16440 KistaSweden Faculty of Electrical Engineering and Information Technology RWTH Aachen UniversityOtto-Blumenthal-Str.2552074 AachenGermany Advanced NEMS Group École Polytechnique Fédérale de Lausanne(EPFL)1015 LausanneSwitzerland Silex Microsystems AB 17526 JärfällaSweden AMO GmbH Advanced Microelectronic Center Aachen(AMICA)Otto-Blumnethal-Str.2552074 AachenGermany

Graphene’s unparalleled strength,chemical stability,ultimate surface-to-volume ratio and excellent electronic properties make it an ideal candidate as a material for membranes in micro-and nanoelectromechanical systems(MEMS and NEMS).However,the integration of graphene into MEMS or NEMS devices and suspended structures such as proof masses on graphene membranes raises several technological challenges,including collapse and rupture of the *** have developed a robust route for realizing membranes made of double-layer CVD graphene and suspending large silicon proof masses on membranes with high *** have demonstrated the manufacture of square graphene membranes with side lengths from 7µm to 110µm,and suspended proof masses consisting of solid silicon cubes that are from 5µm×5µm×16.4µm to 100µm×100µm×16.4µm in *** approach is compatible with wafer-scale MEMS and semiconductor manufacturing technologies,and the manufacturing yields of the graphene membranes with suspended proof masses were>90%,with>70%of the graphene membranes having>90%graphene area without visible *** measured resonance frequencies of the realized structures ranged from tens to hundreds of kHz,with quality factors ranging from 63 to *** graphene membranes with suspended proof masses were extremely robust,and were able to withstand indentation forces from an atomic force microscope(AFM)tip of up to~*** proposed approach for the reliable and large-scale manufacture of graphene membranes with suspended proof masses will enable the development and study of innovative NEMS devices with new functionalities and improved performances.

关键词： proof characterization hundreds

Phagocytosis: A Practical Approach for Evaluating Neutrophil Function in Health and Disease

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Modern Research in Inflammation 2024年第2期13卷 9-28页

作者： Oscar Rojas-Espinosa Patricia Arce-Paredes Sergio Islas-Trujillo luis Enrique Becerril-villanueva María Dolores Ponce-Regalado Departamento de Inmunologa Escuela Nacional de Ciencias Biolgicas Instituto Politcnico Nacional Ciudad de Mxico Mxico Laboratorio de Psicoinmunologa Instituto Nacional de Psiquiatra Ramn de la Fuente Ciudad de Mxico Mxico Departamento de Ciencias de la Salud Centro Universitario de los Altos Universidad de Guadalajara Jalisco Mxico

Neutrophils, crucial players in the effector phase of the immune response, are recognized as important mediators of both innate and adaptive immune responses. Through the production of pro- and anti-inflammatory cytokines, they modulate the function of T and other lymphoid cells. Countless reports have highlighted the importance of these cells as efficient antimicrobial agents and annotated their involvement in the pathology of infectious and noninfectious diseases. The development of modern, sophisticated technologies has allowed the study of the functions of these cells in clinical settings. These advanced technologies include fluorescence-activated cell sorters, confocal microscopy, automated cell image analyzers, and live cell analysis instruments. Unfortunately, the cost of these modern instruments, maintenance, reagents, and the need for qualified technicians prohibit their use in low-income laboratories and universities in developing countries. With this in mind, we propose a series of basic tests that can be used in low-input clinical laboratories and universities to evaluate the function of neutrophils in health and disease. Our methodology allows us to assess in a practical and low-cost manner the functions of neutrophils in the phagocytic process, including opsonization, ingestion, ROI production (NBT reduction), myeloperoxidase content, phagosome-lysosome fusion, microbicidal activity, and NET production. Thus, under a disadvantageous ambiance, this may guide physicians in deciding whether a patient’s illness involves phagocytic defects without imposing a heavy financial *** Abstract[-rId13-]

关键词： Phagocytosis Neutrophils Microbicidal Activity Netosis

通过残留水再利用绿化干旱城市:智利北部的多学科项目

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AMBIO－人类环境杂志 2003年第4期32卷 264-268页

作者： luis Cáceres villanueva Jose Delatorre Fernando De La Riva Vinka Monardes 林宝法安托法加斯塔大学化学工程系阿图罗.普拉特大学沙漠农业系塔拉帕卡大学农学系安托法加斯塔大学沙漠研究所

本文描述了智利北部的一个项目,其目的是促进处于普遍缺水及土壤和水中含盐量高条件下的干旱地区适当绿地和花园的发展。现场研完试验了选定的本地和引入的观赏植物的适合性。植物生长,水和土壤质量、海洋飞沫、气候、废水处理以及灌溉... 详细信息

本文描述了智利北部的一个项目,其目的是促进处于普遍缺水及土壤和水中含盐量高条件下的干旱地区适当绿地和花园的发展。现场研完试验了选定的本地和引入的观赏植物的适合性。植物生长,水和土壤质量、海洋飞沫、气候、废水处理以及灌溉作业问题等是专门研究和探讨的课题。

关键词：残留水循环利用绿化干旱城市智利北部土壤含盐量水处理

Direct seawater splitting for hydrogen production:Recent advances in materials synthesis and technological innovation

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Green Energy & Environment 2025年第1期10卷 11-33页

作者： Yilin Zhao Zhipeng Yu Aimin Ge Lujia Liu Joaquim luis Faria Guiyin Xu Meifang Zhu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Center for Advanced Low-dimension MaterialsCollege of Materials Science and EngineeringDonghua UniversityShanghai201620China International Iberian Nanotechnology Laboratory(INL) Avenida Mestre Jose VeigaBraga4715-330Portugal The MacDiarmid Institute for Advanced Materials and Nanotechnology School of Chemical and Physical SciencesVictoria University of WellingtonWellington6012New Zealand LSRE-LCM-Laboratory of Separation and Reaction Engineering-Laboratory of Catalysis and Materials Faculty of EngineeringUniversity of PortoRua Dr.Roberto Frias s/nPorto4200-465Portugal ALiCE-Associate Laboratory in Chemical Engineering Faculty of EngineeringUniversity of PortoRua Dr.Roberto Frias s/nPorto4200-465Portugal

Direct seawater splitting has emerged as a popular and promising research direction for synthesising clean,green,non-polluting,and sustainable hydrogen energy without depending on high-purity water in the face of the world’s shortage of fossil ***,efficient seawater splitting is hindered by slow kinetics caused by the ultra-low conductivity and the presence of bacteria,microorganisms,and stray ions in ***,producing hydrogen on an industrial scale is challenging due to the high production *** present review addresses these challenges from the catalyst point of view,namely,that designing catalysts with high catalytic activity and stability can directly affect the rate and effect of seawater *** the ion transfer perspective,designing membranes can block harmful ions,improving the stability of seawater *** the energy point of view,mixed seawater systems and self-powered systems also provide new and low-energy research systems for seawater ***,ideas and directions for further research on direct seawater splitting in the future are pointed out,with the aim of achieving low-cost and high-efficiency hydrogen production.

关键词： Seawater splitting Catalyst Membranes Mixed seawater systems Self-powered systems

Mouse models of pancreatic cancer

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World Journal of Gastroenterology 2012年第12期18卷 1286-1294页

作者： Marta Herreros-villanueva Elizabeth Hijona Angel Cosme luis Bujanda Schulze Center for Novel Therapeutics Division of Oncology ResearchDepartment of MedicineMayo ClinicRochesterMN 55905United States Department of Gastroenterology Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBERehd)University of the Basque CountryDonostia HospitalSan Sebastian 20014Spain Department of Gastroenterology Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBERehd)University of the Basque CountryDonostia Hospital

Pancreatic cancer is one of the most lethal of human malignancies ranking 4th among cancer-related death in the western world and in the United States,and potent therapeutic options are *** during the last few years there have been important advances in the understanding of the molecular events responsible for the development of pancreatic cancer,currently specific mechanisms of treatment resistance remain poorly understood and new effective systemic drugs need to be developed and *** vivo models to study pancreatic cancer and approach this issue remain limited and present different molecular features that must be considered in the studies depending on the purpose to fit special research *** the last few years,several genetically engineered mouse models of pancreatic exocrine neoplasia have been *** models mimic the disease as they reproduce genetic alterations implicated in the progression of pancreatic *** alterations such as activating mutations in KRas,or TGFb and/or inactivation of tumoral suppressors such as p53,INK4A/ARF BRCA2 and Smad4 are the most common drivers to pancreatic carcinogenesis and have been used to create transgenic *** mouse models have a spectrum of pathologic changes,from pancreatic intraepithelial neoplasia to lesions that progress histologically culminating in fully invasive and metastatic disease and represent the most useful preclinical model *** models can characterize the cellular and molecular pathology of pancreatic neoplasia and cancer and constitute the best tool to investigate new therapeutic approaches,chemopreventive and/or anticancer ***,we review and update the current mouse models that reproduce different stages of human pancreatic ductal adenocarcinoma and will have clinical relevance in future pancreatic cancer developments.

关键词： K-Ras Mouse models Transgenic Pancre-atic cancer Xenografts