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Modulation of immunity and inflammatory gene expression in the gut, in inflammatory diseases of the gut and in the liver by probiotics

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World Journal of Gastroenterology 2014年第42期20卷 15632-15649页

作者： Julio Plaza-Diaz Carolina gomez-Llorente luis Fontana Angel Gil Department of Biochemistry and Molecular Biology Ⅱ School of Pharmacy and Institute of Nutrition and Food Technology "Jose Mataix" Biomedical Research Center University of Granada

The potential for the positive manipulation of the gut microbiome through the introduction of beneficial microbes, as also known as probiotics, is currently an active area of investigation. The FAO/WHO define probiotics as live microorganisms that confer a health benefit to the host when administered in adequate amounts. However, dead bacteria and bacterial molecular components may also exhibit probiotic properties. The results of clinical studies have demonstrated the clinical potential of probiotics in many pathologies, such as allergic diseases, diarrhea, inflammatory bowel disease and viral infection. Several mechanisms have been proposed to explain the beneficial effects of probiotics, most of which involve gene expression regulation in specific tissues, particularly the intestine and liver. Therefore, the modulation of gene expression mediated by probiotics is an important issue that warrants further investigation. In the present paper, we performed a systematic review of the probiotic-mediated modulation of gene expression that is associated with the immune system and inflammation. Between January 1990 to February 2014, PubMed was searched for articles that were published in English using the MeSH terms “probiotics' and 'gene expression' combined with “intestines', 'liver', 'enterocytes', 'antigen-presenting cells', 'dendritic cells', 'immune system', and 'inflammation'. Two hundred and five original articles matching these criteria were initially selected, although only those articles that included specific gene expression results (77) were later considered for this review and separated into three major topics: the regulation of immunity and inflammatory gene expression in the gut, in inflammatory diseases of the gut and in the liver. Particular strains of Bifidobacteria, Lactobacilli, Escherichia coli, Propionibacterium, Bacillus and Saccharomyces influence the gene expression of mucins, Toll-like receptors, caspases, nuclear factor-κ

关键词： Gene expression Immunity Immunotolerance Inflammation Microbiota Probiotics Gut Liver

Integrating geographical information in the Linked Digital Earth

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International Journal of Digital Earth 2014年第7期7卷 554-575页

作者： luis M.Vilches-Blazquez Boris Villazon-Terrazas Oscar Corcho Asuncion gomez-Perez Ontology Engineering Group Departamento de Inteligencia ArtificialFacultad de InformaticaUniversidad Politecnica de MadridMadridSpain

Many progresses have been made since the Digital Earth notion was envisioned thirteen years ***,the mechanism for integrating geographic informa-tion into the Digital Earth is still quite *** this context,we have developed a process to generate,integrate and publish geospatial Linked Data from several Spanish National *** data-sets are related to four Infrastructure for Spatial Information in the European Community(INSPIRE)themes,specifically with Administrative units,Hydrography,Statistical units,and *** main goal is to combine different sources(heterogeneous,multidisciplinary,multitemporal,multiresolution,and multilingual)using Linked Data *** goal allows the overcoming of current problems of information integration and driving geographical information toward the next decade scenario,that is,‘Linked Digital Earth’.

关键词： geographical information integration Digital Earth Linked Data

Haplotype phasing after joint estimation of recombination and linkage disequilibrium in breeding populations

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Journal of Animal Science and Biotechnology 2014年第1期5卷 38-52页

作者： luis gomez-Raya Amanda M Hulse David Thain Wendy M Rauw Departamento de Mejora Genética Animal Instituto Nacional deInvestigación y Tecnología Agraria y Alimentaria (INIA) Interdisciplinary Program in Genetics Texas A&M University College Station Department of Animal Biotechnology University of Nevada

A novel method for haplotype phasing in families after joint estimation of recombination fraction and linkage disequilibrium is developed. Results from Monte Carlo computer simulations show that the newly developed E.M. algorithm is accurate if true recombination fraction is 0 even for single families of relatively small sizes. Estimates of recombination fraction and linkage disequilibrium were 0.00 （SD 0.00） and 0.19 （SD 0.03） for simulated recombination fraction and linkage disequilibrium of 0.00 and 0.20, respectively. A genome fragmentation phasing strategy was developed and used for phasing haplotypes in a sire and 36 progeny using the 50 k Illumina BeadChip by： a） estimation of the recombination fraction and LD in consecutive SNPs using family information, b） linkage analyses between fragments, c） phasing of haplotypes in parents and progeny and in following generations. Homozygous SNPs in progeny allowed determination of paternal fragment inheritance, and deduction of SNP sequence information of haplotypes from dams. The strategy also allowed detection of genotyping errors. A total of 613 recombination events were detected after linkage analysis was carried out between fragments. Hot and cold spots were identified at the individual （sire level）. SNPs for which the sire and calf were heterozygotes became informative （over 90%） after the phasing of haplotypes. Average of regions of identity between half-sibs when comparing its maternal inherited haplotypes （with at least 20 SNP） in common was 0.11 with a maximum of 0.29 and a minimum of 0.05. A Monte-Carlo simulation of BTA1 with the same linkage disequilibrium structure and genetic linkage as the cattle family yielded a 99.98 and 99.94% of correct phases for informative SNPs in sire and calves, respectively.

关键词： Breeding Haplotype phasing Linkage disequilibrium SNP

A novel and stretchable carbon-nanotube/Ni@TiO_(2):W photocatalytic composite for the complete removal of diclofenac drug from the drinking water

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Journal of Environmental Sciences 2023年第4期126卷 575-589页

作者： Ernesto Valadez-Renteria Rafael Perez-Gonzalez Christian gomez-Solis luis Armando Diaz-Torres Armando Encinas Jorge Oliva Vicente Rodriguez-Gonzalez Consejo Nacional de Ciencia y Tecnología-División de Materiales Avanzados Instituto Potosino de Investigación Científica y TecnológicaSan Luis Potosí78216México División de Ciencias e Ingenierías Universidad de GuanajuatoLeón 37150México Grupo de Espectroscopia de Materiales Avanzados y Nanoestructurados(GEMANA) Centro de Investigaciones enópticaA.C.Lomas Del CampestreLeón 37150México

We present the structural,morphological and photocatalytic properties of stretchable composites made with carbon nanotubes (CNTs),silicon rubber and Ni@TiO_(2):W nanoparticles(TiWNi NPs) with average size of 37±2 *** images showed that the TiWNi NPs decorated the surface of the CNT fibers,which are oriented in a preferential *** NPs presented a mixture of anatase/rutile phases with cubic *** performance of the TiWNi powders and stretchable composites was evaluated for the photocatalytic degradation of diclofenac (DCF) anti-inflammatory drug under ultraviolet-visible *** results revealed that the maximum DCF degradation percentages were 34.6%,91.9%,97.1%,98.5%and 100%for the CNT composite (stretched at 0%),TiWNi powders,CNT+TiWNi(stretched at 0%),CNT+TiWNi (stretched at 50%) and CNT+TiWNi (stretched at 100%),***,stretching the CNT+TiWNi composites was a good strategy to enhance the DCF degradation percentage from 97.1%to 100%,since stretching created additional defects (oxygen vacancies) that acted as electron sink,delaying the electron-hole recombination,and favors the DCF ***/absorbance measurements confirmed the presence of such ***,the reactive oxygen species (ROS) were determined by the scavenger’s experiments and found that the main ROS were the·OH and O_(2)-radicals,which attacked the DCF molecules,causing their *** results of this investigation confirmed that the stretchable CNT/TiWNi-based composites are a viable alternative to remove pharmaceutical contaminants from water and can be manually separated from the decontaminated water,which is unviable using photocatalytic powders.

关键词： Diclofenac Pharmaceutical contaminant TiO_(2) Carbon nanotubes Stretchable composite Photocatalysis

Effect of synthesis variables of plasma synthesized polymers on growth of HepG2 cells

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BIOCELL 2017年第2期41卷 41-43页

作者： ELIZABETH PEREZ-TEJADA JUAN MORALES-CORONA luis ERNESTO gomez-QUIROZ MARIA CONCEPCIONGUTIERREZ-RUIZ ROBERTO OLAYO Departamento de Química.Universidad Autónoma Metropolitana Unidad IztapalapaApdo.Postal 55-534IztapalapaCDMXCP 09340 Departamento de Ciencias de la Salud.Universidad Autónoma Metropolitana Unidad IztapalapaApdo.Postal 55-534IztapalapaCDMXCP 09340 Departamento de Física.Universidad Autónoma Metropolitana Unidad IztapalapaApdo.Postal 55-534IztapalapaMéxicoD.F.CP 09340 CECyT No.8 Instituto Politécnico NacionalAve.de las Granjas 618Jardín AzpeitiaAzcapotzalcoCDMXCP 02530

Low pressure plasma polymer films were synthesized using pyrrole and allylamine monomers and adding iodine was used(or not)for the reaction in both *** were polymerized on glass substrates under the same reaction *** of allylamine was also studied at different operating *** thin polymer films were used as culture surfaces for HepG2 cells,a cell line derived from a human *** proliferation,differentiation and two-dimensional propagation until obtaining monolayer of the cells was studied on the different synthetized films and correlations were established between the conditions of synthesis,the physicochemical characteristics obtained and the performance as substrates for the cellular growth.

关键词： Hepatocytes Pyrrole Allylamine Plasma Polymerization

Statins and endocrine resistance in breast cancer

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Cancer Drug Resistance 2021年第2期4卷 356-364页

作者： Tara Hyder Juan luis gomez Marti Azadeh Nasrazadani Adam M.Brufsky University of Pittsburgh Physicians PittsburghPA 15213USA Department of Pathology University of Pittsburgh School of MedicinePittsburghPA 15213USA UPMC Hillman Cancer Center Magee Women's HospitalPittsburghPA 15213USA.

Most breast cancers are hormone-receptor positive(HR+).However,more women eventually die from HR+breast cancer than from either HER2+or triple negative breast *** therapies continue to be the mainstay of *** 40%of these cases,recurrences in early-stage disease and progression in the metastatic setting are largely a function of the development of endocrine resistance.A multitude of mediators and pathways have been associated with endocrine resistance in breast cancer including the mevalonate pathway,which is integral to cholesterol *** mevalonate pathway and the downstream activation of associated cytoplasmic pathways including PI3K-AKT-mTOR and RAS-MEK-ERK have been known to affect cancer cell proliferation,cell survival,cell invasion,and *** are important mechanisms leading to the inevitable development of endocrine resistance in HR+breast *** are a class of drugs that inhibits HMG-CoA reductase,an enzyme in the mevalonate pathway that plays a central role in cholesterol *** vitro and in vitro studies suggest that the role of statins in blocking the mevalonate pathway effectively disrupts downstream pathways involved in estrogen receptor expression and cellular processes such as cell survival,proliferation,stress,cell cycle,inhibition of apoptosis,and *** these key mechanisms heralds a role for statins in the prevention of endocrine resistance.

关键词： Statin HMGCR endocrine resistance autophagy PI3K mTOR

Endoscopic identification of endoluminal esophageal landmarks for radial and longitudinal orientation and lesion location

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World Journal of Gastroenterology 2019年第4期25卷 498-508页

作者： Fabian Emura Rene gomez-Esquivel Carlos Rodriguez-Reyes Petros Benias Javier Preciado Michael Wallace luis Giraldo-Cadavid Division of Gastroenterology Universidad de La Sabana Advanced Gastrointestinal Endoscopy EmuraCenter LatinoAmerica Emura Foundation for the Promotion of Cancer Research Unidad de Endoscopia Digestiva Clínica Pediátrica Colsanitas Division of Digestive Diseases and Nutrition Morsani College of Medicine University of South Florida Division of Gastroenterology North Shore-Long Island Jewish Medical Center Unidad de Exploraciones Digestivas Clinica Universitaria Colombia Department of Gastroenterology and Hepatology Mayo Clinic Department of Internal Medicine. Universidad de La Sabana Division of Interventional Pulmonology Fundacion Neumologica Colombiana

AIM To characterize esophageal endoluminal landmarks to permit radial and longitudinal esophageal orientation and accurate lesion *** Distance from the incisors and radial orientation were estimated for the main left bronchus and the left atrium landmarks in 207 consecutive patients using white light examination. A sub-study was also performed using white light followed by endoscopic ultrasound(EUS) in 25 consecutive patients to confirm the *** scope orientation throughout the exam was maintained at the natural axis,where the left esophageal quadrant corresponds to the area between 6 and 9 o'clock. When an anatomical landmark was identified, it was recorded with a photograph and its quadrant orientation and distance from the incisors were determined. The reference points to obtain the distances and radial orientation were as follows: the midpoint of the left main bronchus and the most intense pulsatile zone of the left atrium. With the video processor system set to moderate insufflation, measurements were obtained at the end of the patients' air *** The left main bronchus and left atrium esophageal landmarks were identified using white light in 99% and 100% of subjects at a mean distance of 25.8 cm(SD2.3), and 31.4 cm(SD 2.4) from the incisors, respectively. The left main bronchus landmark was found to be a tubular, concave, non-pulsatile, esophageal external compression, occupying approximately 1/4 of the circumference. The left atrium landmark was identified as a round, convex, pulsatile, esophageal external compression, occupying approximately 1/4 of the circumference. Both landmarks were identified using white light on the anterior esophageal quadrant. In the substudy, the left main bronchus was identified in 24(92%) patients at 25.4 cm(SD2.1) and 26.7 cm(SD 1.9) from the incisors, by white light and EUS, *** left atrium was recognized in all patients at 30.5 cm(SD 1.9), and 31.6 cm(SD2.3) from the incisors, by b

关键词： Esophagus Natural landmark Radial orientation Longitudinal orientation Four-quadrants Left main bronchus Left atrium

Inverted Meckel’s diverticulum diagnosed using capsule endoscopy: A case report

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World Journal of Gastroenterology 2021年第36期27卷 6154-6160页

作者： Ismael El Hajra Martínez Marta Calvo Joséluis Martínez-Porras Lucia gomez-Pimpollo Garcia Jose L Rodriguez Carmen Leon Joséluis Calleja Panero Department of Gastroenterology Hospital Universitario Puerta de HierroMadrid 28222Spain Department of Radiology Hospital Universitario Puerta de HierroMadrid 28222Spain Department of Diagnostic Pathology Hospital Universitario Puerta de HierroMadrid 28222Spain Department of Surgery Hospital Universitario Puerta de HierroMadrid 28222Spain

BACKGROUND Meckel’s diverticulum is a common asymptomatic congenital gastrointestinal ***,its presentation as an inverted Meckel's diverticulum is a rare complication,of which few cases have been reported in the *** SUMMARY Here,we report the case of a 33-year-old man with iron deficiency anemia without manifestation of gastrointestinal *** upper gastrointestinal endoscopy and total colonoscopy were performed,but no abnormalities were found within the observed ***,a capsule endoscopy was performed and offered us a clue to subsequently confirm the diagnosis of inverted Meckel's diverticulum via computed tomography *** intestinal resection surgery was *** final pathology report described a Meckel’s *** Since inverted Meckel's diverticulum is an uncommon disease and its clinical presentation is not specific,it may go undetected by capsule *** diagnosis and treatment of this disease requires a high index of clinical suspicion.

关键词： Inverted Meckel’s diverticulum Capsule endoscopy Anemia study Small bowel tumor Case report

Improvement of the Human Resource Management of Service Enterprises in Maturity Phrase-Implementing the Balance Scorecard Tool

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Improvement of the Human Resource Management of Service Ente...

作者：沙路（luis Chavez gomez）海南大学

学位级别：硕士

公司的生命周期是可以划分阶段的,在每个公司的生命周期中,每个阶段都没有一个持续时间或显式点的到来,它涉及公司的目标和价值观的定义及其行为者。在成熟阶段,公司应该担心的激励和保留员工,试图延长公司寿命以及降低离职率。这将在... 详细信息

公司的生命周期是可以划分阶段的,在每个公司的生命周期中,每个阶段都没有一个持续时间或显式点的到来,它涉及公司的目标和价值观的定义及其行为者。在成熟阶段,公司应该担心的激励和保留员工,试图延长公司寿命以及降低离职率。这将在本文的假说的基础。具体而言,一方面,人力资本微分方程将表示所有者期望在长期稳定和组织的成功。另一方面,公司还应该有助于降低成本,以及提高收入,并实现深入分析,而且可以通过设立研究创新商业活动的方式的跨学科小组的内部流程进行改进。本研究打算分析和测量公司在成熟阶段,通过使用平衡计分卡,研究影响人力资本服务公司的人力资源管理实践,以确定公司本身的运行效率。研究普兰和诺顿最初提出的相互影响的子系统。通过面向人力资源领域的研究,使用平衡计分卡进行分析。结果显示一家公司中员工成为很重要的资产。我们使用一种方法,使我们能够改善人力资源管理,确定人力资源领域有子系统帮助公司确定量化指标和定性的补充报告。平衡计分卡被证明是一个非常有用的来评价组织绩效的工具,使我们能够整合人力资源,有更广泛的角度来看待人力资源管理实践对员工绩效子系统的影响。

关键词：平衡记分卡员工绩效效率人力资源管理