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Overcoming antibiotic-resistant Helicobacter pylori infection:Current challenges and emerging approaches

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World Journal of Gastroenterology 2025年第10期31卷 7-29页

作者： Gabriel Reis Rocha Fabian Fellipe Bueno Lemos luis Guilherme de Oliveira Silva Marcel Silva Luz Gabriel lima Correa Santos Samuel Luca Rocha Pinheiro Mariana Santos Calmon Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Recent studies have shown a noticeable increase in global Helicobacter pylori(***)resistance,with clarithromycin resistance surpassing 15%in various ***,inadequate epidemiological monitoring,especially in developing countries,and the absence of uniform testing methods lead to discrepancies between regions and a possible underestimation of resistance *** complexity of treating *** is driven by its highly dynamic genome,which is prone to frequent mutations contributing to phenotypical *** usual course of action in empirical treatment involves using a combination of various drugs simultaneously,leading to significant resistance selection pressure and potential side *** emergence of *** strains resistant to multiple drugs is closely tied to failures in first-line treatment,highlighting the need to prevent further resistance by using optimal initial empirical therapy or regimens guided by antibiotic susceptibility testing,requiring a collection of mixed samples and multiple isolates for accurate *** emergence of new treatments like potassium-competitive acid blockers offers a hopeful approach to decrease antimicrobial usage while still ensuring effectiveness in comparison to traditional therapies with proton pump ***,the use of probiotics is under investigation to identify specific strains and formulations that may mitigate therapy-associated adverse effects.

关键词： Helicobacter pylori Antibiotic resistance Multidrug resistance Heteroresistance Empirical treatment Antimicrobial susceptibility testing

Ischemic colitis with small-vessel occlusion,simultaneous total colectomy and liver transplantation:A case report

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World Journal of Transplantation 2025年第2期15卷 337-343页

作者： Leonardo Yuri Kasputis Zanini Fabiana Roberto lima Michel Ribeiro fernandes Paola Sofia Espinoza Alvarez Marcello de Souza Silva Antônio Paulo Ramos Martins Filho Tomazo Antonio Prince Franzini Lucas Souto Nacif department of Surgery Federal University of São PauloSão Paulo 04023-062Brazil department of Liver and Gastrointestinal Transplant Hospital 9 de JulhoSão Paulo 01409-002Brazil department of Pathology University of São Paulo School of MedicineSão Paulo 05403-900Brazil department of Surgical Pathology Hospital 9 de JulhoSão Paulo 01409-002Brazil department of Gastrointestinal Endoscopy Unit Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo 05403-010Brazil department of Endoscopy Hospital 9 de JulhoSão Paulo 01409-002Brazil

BACKGROUND The colon is the hollow viscera that proportionally has the lowest vascular supply and is more predisposed to ischemic *** the context of end-stage liver disease,various components may explain this group's greater predisposition to colonic ischemic ***,portal hypertension generates a process of coagulopathy,impairing local *** case report describes a case of ischemic colitis with small-vessel occlusion found during liver transplantation in a patient with decompensated end-stage liver *** SUMMARY A 64-year-old man with liver cirrhosis due to non-alcoholic steatohepatitis and hepatocellular *** patient underwent liver transplantation due to hepatic *** donor was a 53-year-old man who had died of a hemorrhagic *** examination revealed diffuse ischemic colitis with significant distention and *** to the condition of the colon,a subtotal colectomy was *** transplantation with warm ischemia time of 35 minutes,cold ischemia of 6 hours 30 minutes and total ischemia time of 7 hours 5 *** patient improved clinically with oral tract function and physiotherapy,but unfortunately,he developed a bloodstream infection,a new septic shock and died six months after *** Simultaneous total colectomy and orthotopic liver transplantation represent a rare *** events have a high mortality rate in the general population and are particularly important in cirrhotic patients.

关键词： Ischemic colitis Liver transplantation End-stage liver disease Acute-on-chronic liver failure Case report

Utilizing complementary therapy to enhance quality of life and reduce stress and fatigue in pediatric cancer patients

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World Journal of Clinical Cases 2025年第11期13卷 12-18页

作者： luis Carlos Lopes-Júnior Regina Aparecida Garcia de lima department of Nursing Federal University of Espírito SantoVitoria 29043-900Espirito SantoBrazil department of Maternal-Infant and Public Health Nursing University of São Paulo at Ribeirão Preto College of NursingRibeirão Preto 14040-902Sao PauloBrazil

The international scientific literature presents still incipient results regarding the management of cancer symptom clusters by oncology nursing,especially in pediatric *** is a promising field of investigation for clinical nurses and researchers,and when it is subsidized by medium-range theories,they co-rroborate the diagnoses and interventions of nursing in oncology,enhancing the science of nursing *** minireview article aims to discuss the utilizing the hospital clowns as a complementary therapy,to enhance quality of life and reduce stress and fatigue in pediatric cancer ***,the evidence presented so far pointed out that complementary therapy might help improve the quality of life of pediatric cancer patients,and that complementary therapy usage should be part of a health comprehensive care model,delivering therapeutic approaches that might enhance the mind-body during a pediatric cancer patients’life *** results of scientific investigations by nurses,particularly those linked to the basic sciences,play a critical role in advancing personalized care in pediatric integrative oncology.

关键词： Cancer symptom clusters Pediatrics Pediatric cancer patients Pediatric integrative oncology Complementary therapies Oncology nursing Hospital clowns Cancer-related fatigue Psychological stress Biomarkers

Do Child–Turcotte–Pugh and nutritional assessments predict survival in cirrhosis: A longitudinal study

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World Journal of Hepatology 2025年第1期17卷 29-40页

作者： Randhall B Carteri Claudio A Marroni luis F Ferreira Letícia P Pinto Juliana Czermainski Cristiane V Tovo Sabrina A fernandes department of Nutrition Centro Universitário CESUCACachoeirinha 94935-630Brazil Postgraduate in Hepatology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90050-170Brazil School of Electronics Electrical Engineering and Computer ScienceQueen’s University BelfastBelfast BT95BNNorthern IrelandUnited Kingdom

BACKGROUND Cirrhotic patients face heightened energy demands,leading to rapid glycogen depletion,protein degradation,oxidative stress,and inflammation,which drive disease progression and *** disruptions cause cellular damage and parenchymal changes,resulting in vascular alterations,portal hypertension,and liver dysfunction,significantly affecting patient *** To analyze the association between Child–Turcotte–Pugh(CTP)scores and di-fferent nutritional indicators with survival in a 15-year follow-up *** This was a retrospective cohort study with 129 cirrhotic patients of both sexes aged>18 *** of cirrhosis was made by liver *** first year of data collection was 2007,and data regarding outcomes were collected in *** were gathered from medical records,and grouped by different methods,including CTP,handgrip strength,and triceps skinfold *** prognostic values for mortality were assessed using Kaplan–Meier curves and multivariate binary logistic regression *** The coefficient for CTP was the only statistically significant variable(Wald=5.193,P=0.023).This suggests that with a negative change in CTP classification score,the odds of survival decrease 52.6%.The other evaluated variables did not significantly predict survival outcomes in the ***–Meier survival curves also indicated that CTP classification was the only significant *** Although different classifications showed specific differences in stratification,only CTP showed significant predictive *** score remains a simple and effective predictive tool for cirrhotic patients even after longer follow-up.

关键词： Liver cirrhosis Child–Turcotte–Pugh Prognosis Liver transplantation Nutritional assessment

秘鲁中部曼塔罗盆地土壤地球化学特征及质量评价

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地学前缘 2025年第1期32卷 219-235页

作者：刘君安朱意萍姜瀚涛 César de La Cruz POMA Oliberth Pascual GODOY luis Enrique Vargas RODRíGUEZ 郭维民姚春彦王天刚张明姚仲友中国地质调查局南京地质调查中心江苏南京210016 秘鲁地质矿产冶金研究院(INGEMMET) 秘鲁利马15074

为加强中国与秘鲁两国地学合作,推广我国优势的地球化学调查与研究方法,中国地质调查局与秘鲁地质矿产冶金研究院(INGEMMET)以秘鲁中部曼塔罗(Mantaro)盆地为研究区共同开展了多目标地球化学调查,以我国现行相关行业规范为标准,采集样... 详细信息

为加强中国与秘鲁两国地学合作,推广我国优势的地球化学调查与研究方法,中国地质调查局与秘鲁地质矿产冶金研究院(INGEMMET)以秘鲁中部曼塔罗(Mantaro)盆地为研究区共同开展了多目标地球化学调查,以我国现行相关行业规范为标准,采集样品并于我国实验室进行分析测试。调查和研究表明:研究区土壤总体呈弱碱性,Au元素强烈富集,I、C、C_(org)、Cd和N等指标较富集;土壤养分指标N和P较丰富,K则较缺乏,土壤养分综合等级以较丰富(二等)为主,面积占比为74.1%,土壤肥力较好;土壤环境评价指标中,Zn和Pb在少量地区存在轻微—重度污染,Cd和As则有较大面积的污染,土壤环境综合等级以轻微污染和轻度污染为主,污染地区主要分布于曼塔罗河两侧5 km范围内,重度污染区则主要分布于紧邻曼塔罗河地区和人口密度最大的万卡约市周边,重金属污染较严重,污染空间分布与曼塔罗河密切相关;土壤质量综合评价等级主要为中等—劣等,面积占比达83.18%,优质和良好级土壤面积仅占16.82%。综上所述,秘鲁曼塔罗盆地地区土壤养分较丰富,土壤重金属污染较严重,土壤综合质量为中等偏差,建议秘鲁有关部门加强对曼塔罗河及上游重金属污染源的环境管理与整治。

关键词：曼塔罗盆地多目标地球化学调查土地质量地球化学特征秘鲁

Abiotic stress on seed germination and plant growth of Zeyheria tuberculosa

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Journal of Forestry Research 2023年第5期34卷 1511-1522页

作者： Robson luis Silva de Medeiros Rinaldo Cesar de Paula Joao Vitor Oliveira de Souza Joao Pedro Peixoto fernandes department of Agricultural Sciences School of Agricultural and Veterinarian SciencesSao Paulo State University(Unesp)14884-900JaboticabalSao PauloBrazil

Zeyheria tuberculosa(Vell.)Bureau ex *** among the Brazilian flora threatened with *** has high-quality wood and can be used to recover herbicidecontaminated ***,abiotic stresses can harm seed germination and seedling development under adverse conditions and need to be understood to improve autochthonous or indigenous biodiversity conservation and strengthen reforestation *** study evaluated the effects of temperature,water and saline stress on *** seed germination and water stress on seedling *** laboratory experiments evaluated germination under:(1)different temperatures(20,25,30,35 and 40℃);(2)different water potentials simulated with polyethylene glycol(PEG6000)at 25 and 30℃;and,(3)different osmotic potentials simulated with NaCl at 25 and 30℃.In addition,a greenhouse experiment subjected seedlings to five water regimes(20%,35%,50%,65%and 80%of maximum substrate water holding capacity).In the laboratory,seedling biometry and germination were evaluated,while physiological and morphological parameters were assessed in the *** potential of seeds increased at 25 and 30℃.Germination and vigor decreased as water and saline stresses *** tolerance thresholds for water and salt stresses were-0.6 and-0.4 MPa,*** the greenhouse,the most restrictive water regimes reduced seedling physiological and morphological *** development was compromised at moisture levels below50%field capacity.

关键词： Bignoniaceae Climate change Ipê-felpudo Ipê-preto Water stress

Effects of Soluble Silicate and Nanosilica Application on Rice Nutrition in an Oxisol

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Pedosphere 2018年第4期28卷 597-606页

作者： Rita de Cassia FELIX ALVAREZ Renato de Mello PRADO Guilherme FELISBERTO Angelica Cristina fernandes deUS Raimundo Leonardo lima de OLIVEIRA Federal University of Mato Grosso do Sul Chapadao do Sul 79560-000 (Brazil) University of the State of Sao Paulo UNESP School of Agronomic Sciences Department of Soils and Fertilizers Jaboticabal 14884-900 (Brazil)

Silicon （Si） has been supplied to plants via application of calcium silicate to soil; however, high doses of calcium silicate are required because of its low solubility. Nanoparticles can reduce Si doses and be applied to seeding furrows. This study investigated the effects of liquid Si sources, i.e., highly soluble silicate （115.2 g L^-1 Si and 60.5 g L^-1 Na20） and nanosilica （〈 200 nm）, on Si uptake by rice plants, plant lignification, plant C：N：P stoichiometry, plant physiology, and grain yield using an Oxisol under greanhouse condistions. The treatments included the application of nanosilica and soluble silicate to seeding furrows at Si doses of 0, 605, 1210, and 2 420 g ha^-1. Plant uptake and treatment effects were evaluated by measuring C and lignin contents, Si, N, and P accumulation, physiological characteristics, and grain yield of rice. The deposition of silica bodies and amorphous silica in the flag leaves was analyzed using scanning electron microscopy. Application of liquid Si increased Si accumulation in rice by 47.3% in relation to the control （0 g ha^-1 Si）, regardless of the Si sources used. Nanosilica application increased leaf lignin content by 112.7% when compared to that in the control. Silicon moderately affected the net C assimilation （increased by 1.83%） and transpiration rates （increased by 48.3%）; however, Si influenced neither plant growth nor grain yield of rice. These results are explained by the lack of biotic or abiotic stress in rice plants during the experiment. To the best of our knowledge, in Brazilian agriculture, this is the first report on the use of nanosilica as a Si fertilizer and its effect on plant nutrition. This study provides evidence that rice plants absorb and accumulate nanoparticles; however, further studies are required to investigate the use of nanoparticles in other plant species.

关键词： C:N:P stoichiometry grain yield leaf lignin net C assimilation plant physiology silicon source

Multielement determination in orange juice by ICP-MS associated with data mining for the classification of organic samples

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Information Processing in Agriculture 2017年第3期4卷 199-205页

作者： Christian Turra Marcio Dias de lima Elisabete A.de Nadai fernandes Marcio Arruda Bacchi Fernando Barbosa Jr. Rommel Barbosa Centro de Energia Nuclear na Agricultura Universidade de Sao PauloPiracicabaBrazil USP-Ribeirao Preto Brazil Instituto de Informatica Universidade Federal de GoiasGoianiaGOBrazil Instituto Federal de Educacao Ciencia e Tecnologia de Goias GoianiaGOBrazil

The aim of this study was to discriminate organic from conventional orange juice based on chemical elements and data mining applications.A comprehensive sampling of organic and conventional oranges was carried out in Borborema,state of Sao Paulo,*** fruits of the variety Valencia(Citrus sinensis(L.)Osbeck)budded on Rangpur lime(Citrus limonia Osbeck)were *** chemical elements were determined in 57 orange samples grown in organic and conventional *** order to classify these samples,data mining techniques(Support Vector Machine(SVM)and Multilayer Perceptron(MLP))were combined with feature selection(F-score and chi-squared).SVM with chi-squared had a better performance compared with the other techniques because it reached 93.00% accuracy using only seven chemical components(Cu,Cs,Zn,Al,Mn,Rb and Sr),and correctly classified 96.73% of the samples grown in an organic system.

关键词： Data mining Support vector machines Multilayer perceptron Orange juice Trace elements Inductively coupled plasma mass spectrometry(ICP-MS)

Feeding ecology of a highly aerial bird during its long breeding season

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Avian Research 2023年第1期14卷 62-69页

作者： Sandra fernandes Vanessa A.Mata luis P.da Silva CIBIO Centro de Investigacão em Biodiversidade e Recursos GenéticosInBIO Laboratório AssociadoCampus de VairãoUniversidade do Porto4485-661Vairão Portugal departamento de Biologia Faculdade de CiênciasUniversidade do Porto4099-002PortoPortugal BIOPOLIS Program in Genomics Biodiversity and Land PlanningCIBIOCampus de Vairão4485-661VairãaoPortugal

Pallid Swifts(Apus pallidus),as other swifts,are birds extremely adapted to an aerial lifestyle,showing unique adaptations that allow them to fly almost *** diet of these non-stopping high-altitudinal aerial birds has been mostly studied through techniques that fail to produce highly resolved prey identifications,and for that have been replaced by molecular techniques,such as DNA *** samples of Pallid Swifts were monthly collected from a colony in the north of Portugal during the breeding *** from the faecal samples was used to sex the birds and to identify the arthropods present in the diet through DNA *** the detected prey items,74 families were identified belonging to 16 orders,with Hymenoptera and Hemiptera being the most frequently *** were seasonal variations in diet richness,composition and prey *** the diet of males and females,although no differences were found between the diet of males and females in terms of composition and richness,there were differences in the size of arthropods preyed by the different sexes,with males feeding on larger *** large seasonal variation in Pallid Swifts’diet during the breeding season is probably a result of spatiotemporal variation in aerial prey,of which swifts likely predate *** no significant differences were detected in diet richness and composition between sexes,the fact that males consumed larger prey may suggest the existence of sexual dietary segregation in this group of *** last,several pest species were found in these swifts’diet,which,if studied through DNA metabarcoding,can be used to monitor small arthropods,including airborne pests.

关键词： AMerial foraging Apus plius Dietary s-ssonal variation FReeding omlogy Metahercoding Opimel foraging theoary