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Orthotopic induction of CH157MN convexity and skull base meningiomas into nude mice using stereotactic surgery and MRI characterization

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Animal Models and Experimental Medicine 2019年第1期2卷 58-63页

作者： Francesca La Cava Alberto Fringuello Mingo Pietro Irrera Aldo Di Vito Alessia Cordaro Chiara Brioschi Sonia Colombo Serra Claudia Cabella Enzo Terreno luigi miragoli Department of Molecular Biotechnologies and Health Sciences Center of Excellence for Preclinical Imaging (CEIP) University of Torino Bracco Research Centre Bracco Imaging SpA Department of Molecular Biotechnologies and Health Sciences Center of Excellence for Preclinical Imaging CEIP University of Torino

Meningioma in vivo research is hampered by the difficulty of establishing an easy and reproducible orthotopic model able to mimic the characteristics of a human meningioma. Moreover, leptomeningeal dissemination and high mortality are often associated with such orthotopical models, making them useless for clinical translation studies. An optimized method for inducing meningiomas in nude mice at two different sites is described in this paper and the high reproducibility and low mortality of the models are demonstrated. Skull base meningiomas were induced in the auditory meatus and convexity meningiomas were induced on the brain surface of 23 and 24 nude mice, respectively. Both models led to the development of a mass easily observable by imaging methods. Dynamic contrast enhanced MRI was used as a tool to monitor and characterize the pathology onset and progression. At the end of the study, histology was performed to confirm the neoplastic origin of the diseased mass.

关键词： animal models neuroscience pharmaceutical development preclinical imaging solid tumors

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