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Neuraxial anesthesia versus general anesthesia in patients undergoing three-dimensional laparoscopic radical prostatectomy:Preliminary results of a prospective comparative study

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Asian Journal of Urology 2023年第3期10卷 329-336页

作者： Stefano Alba Deborah Fimognari Fabio Croceross luigi ascalone Carmine Pullano Fernando Chiaravalloti Francesco Chiaradia Umberto Carbonara Matteo Ferro Ottavio de Cobelli Vincenzo Pagliarulo Giuseppe Lucarelli Michele Battaglia Rocco Damiano Francesco Cantiello Department of Urology Romolo HospitalRocca di NetoKrItaly Department of Urology Magna Graecia University of CatanzaroCatanzaroItaly Department of Anesthesiology Villa PiaRomaItaly Department of Anesthesiology Romolo HospitalRocca di Neto KrItaly Universita degli Studi di Bari Aldo Moro Department of UrologyBariItaly Division of Urology European Institute of Oncology(IEO)IRCCSMilanItaly Department of Oncology and Hematology Oncology Faculty of Medicine and SurgeryUniversity of MilanMilanItaly Department of Urology Vito Fazzi HospitalLecceItaly Department of Emergency and Organ Transplantation-Urology Andrology and Kidney Transplantation UnitUniversity of BariBariItaly

Objective:Neuraxial anesthesia(NA)showed to reduce both morbidity and mortality in patients undergoing laparoscopic *** aimed to investigate the use of NA in patients undergoing transperitoneal three-dimensional laparoscopic radical prostatectomy(t-3DLRP)and compare the intraoperative and postoperative outcomes with a control group of patients undergoing t-3DLRP under general anesthesia(GA).Methods:A prospective,double-center,double-surgeon study cohort of 84 consecutive patients undergoing t-3DLRP between June 2019 and June 2021 was analyzed.A study group of 42 patients undergoing t-3DLRP under NA was compared with a control group of 42 patients undergoing t-3DLRP under ***:The two group were similar in all demographic,clinical,and pathological *** blood gas parameters were within physiologic limits in both *** relaxation was adequate for surgery during both NA and *** length of stay was 1 day shorter for NA group than GA group(5 days vs.6 days,p=0.05).t-3DLRP under NA had a statistically lower rate of minor complications(4.8%vs.19.0%,p=0.03)and less postoperative pain(median numeric rating scale 3 vs.4,p=0.01)compared to *** major complications were observed in both *** more patients were willing to undergo a similar intervention under NA than GA(p=0.04).Conclusion:t-3DLRP under NA is a feasible and safe procedure,with less postoperative pain and fewer minor complications than the same procedure under *** allows the maintenance of muscle relaxation and respiratory excursions without interfering with surgery.

关键词： Laparoscopy Prostate cancer Radical prostatectomy Postoperative complications Neuraxial anesthesia General anesthesia

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On the emission lines in active galactic nuclei with relativistic jets

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Research in Astronomy and Astrophysics 2012年第4期12卷 359-368页

作者： luigi Foschini INAF-Osservatorio Astronomico di Brera Via E. Bianchi 46 23807 Merate (LC) Italy

The effect of the observed continuum emitted from a relativistic jet on the measurement of the full width at half maximum （FWHM） of an emission line is analyzed. If the jet contribution is not properly subtracted, the FWHM of the line could seem narrower than it should. The cases of an emission line detected in BL Lac objects and γ-ray Narrow-Line Seyfert 1 galaxies （γ-NLS1s） are addressed. It is shown that the smallness of the observed FWHM of the Lyα lines detected in three well-known BL Lacs is an effect due to the combined action of both the relativistic jet and a weak accretion disk. Once the Doppler boosting effect of the jet continuum is removed, the intrinsic FWHM values of the lines are found to be in the usual range. By contrast, the narrow permitted lines in γ-NLS1s are really narrow, since the disk and the lines are much more powerful. This also confirms that γ-NLS1 is really a new class of γ-ray emitting AGN, different from blazars and radio galaxies.

关键词： line: profiles—galaxies: jets—BL Lacertae Objects: general—galaxies: Seyfert

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The pseudogenes of eukaryotic translation elongation factors (EEFs): Role in cancer and other human diseases

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Genes & Diseases 2022年第4期9卷 941-958页

作者： luigi Cristiano R&D Division Prestige18 via VecchiaTerranuova BraccioliniAR 52028Italy

The eukaryotic translation elongation factors (EEFs), i.e. EEF1A1, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF1E1 and EEF2, are coding-genes that play a central role in the elongation step of translation but are often altered in cancer. Less investigated are their pseudogenes. Recently, it was demonstrated that pseudogenes have a key regulatory role in the cell, especially via non-coding RNAs, and that the aberrant expression of ncRNAs has an important role in cancer development and progression. The present review paper, for the first time, collects all that published about the EEFs pseudogenes to create a base for future investigations. For most of them, the studies are in their infancy, while for others the studies suggest their involvement in normal cell physiology but also in various human diseases. However, more investigations are needed to understand their functions in both normal and cancer cells and to define which can be useful biomarkers or therapeutic targets.

关键词： Cancer EEFs Non-coding RNA Pseudogene Translation Translation elongation factor

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High intensity focused ultrasound,liver disease and bridging therapy

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World Journal of Gastroenterology 2013年第43期19卷 7494-7499页

作者： Mearini luigi Deparment of Urology University of PerugiaAzienda Ospedaliera di Perugia06100 PerugiaItaly

High-intensity focused ultrasound(HIFU)is a noninvasive modality that uses an extracorporeal source of focused ultrasound *** technique was introduced by Lynn et al and is able to induce coagulative necrosis in selected tissues without damaging adjacent *** HIFU has been studied for 50years,recent technological developments now allow its use for tumours of the liver,prostate and other *** liver disease,HIFU has been used to treat unresectable,advanced stages of hepatocellular carcinoma(HCC)and liver *** carcinoma is a serious health problem worldwide and is endemic in some areas because of its association with hepatitis B and C viruses(in 20%of cases).Liver transplantation(LT)has become one of the best treatments available because it removes both the tumour and the underlying liver disease such as cirrhosis(which is present in approximately 80%of cases).The prerequisite for longterm transplant success depends on tumour load and strict selection criteria regarding the size and number of tumour *** need to obtain the optimal benefit from the limited number of organs available has prompted strict selection criteria limited to only those patients with early HCC who have a better long-term outcome after *** so-called"bridging therapy"has the aim of controlling disease burden for patients who are on the organ transplant waiting *** various treatment options,transarterial chemoembolisation and radiofrequency ablation are the most popular treatment ***,Cheung et al demonstrated that HIFU ablation is a safe and effective method for the treatment of HCC patients with advanced cirrhosis as a bridging therapy and that it reduced the dropout rate from the liver transplant waiting *** this commentary,we discuss the current value of HIFU in the treatment of liver disease,including its value as a bridging therapy,and examine the potential advantages of other therapeutic strategies.

关键词： High-intensity focused ultrasound Hepatocellular carcinoma Liver transplantation Bridging therapy Waiting list

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Overview of Al-based nanoenergetic ingredients for solid rocket propulsion

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Defence Technology（防务技术） 2018年第5期14卷 357-365页

作者： luigi T.DeLuca Politecnico di Milano MilanItaly Nanjing University of Science and Technology NanjingChina

The introduction of nano-sized energetic ingredients first occurred in Russia about 60 years ago and arose great expectations in the rocket propulsion community, thanks to the higher energy densities and faster energy release rates exhibited with respect to conventional ingredients. But, despite intense worldwide research programs, still today mostly laboratory level applications are reported and often for scientific purposes only. A number of practical reasons prevent the applications at industrial level: inert native coating of the energetic particles, nonuniform dispersion, aging, excessive viscosity of the slurry propellant, possible limitations in mechanical properties, more demanding safety issues, cost, and so *** paper describes the main features in terms of performance of solid rocket propellants loaded with nanometals and intends to emphasize the unique properties or operating conditions made possible by the addition of the nano-sized energetic ingredients. Steady and unsteady combustion regimes are examined.

关键词： Nanoaluminum Solid rocket propellant Burning rate Combustion Propulsion Performance

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Changes in Soil Organic Carbon After Five Years of Biowaste Compost Application in a Mediterranean Vegetable Cropping System

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Pedosphere 2017年第2期27卷 328-337页

作者： Salvatore BAIANO luigi MORRA Council for Agricultural Research and Analysis of Agricultural Economics (CREA)-Researeh Center for Cereals and Industrial Crop Laboratory of Caserta Via Torrino 2 Caserta 81100 (Italy)

Biowaste compost can influence soil organic matter accumulation directly or indirectly. A 5-year experiment was conducted to assess the influence of biowaste compost on the process of soil aggregation and soil organic carbon （SOC） accumulation in a Mediterranean vegetable cropping system. The study involved four treatments： biowaste compost （COM）, mineral NPK fertilizers （MIN）, biowaste compost with half-dose N fertilizer （COMN）, and unfertilized control （CK）. The SOC stocks were increased in COM, COMN, and MIN by 20.2, 14.9, and 2.4 Mg ha-1 over CK, respectively. The SOC concentration was significantly related to mean weight diameter of aggregates （MWD）（P 〈 0.05, R^2 = 0.798 4） when CK was excluded from regression analysis. Compared to CK, COM and COMN increased the SOC amount in macroaggregates （〉 250 μm） by 2.7 and 0.6 g kg-1 soil, respectively, while MIN showed a loss of 0.4 g kg-1 soil. The SOC amount in free microaggregates （53-250 ttm） increased by 0.9, 1.6, and 1.0 g kg-1 soil for COM, COMN, and MIN, respectively, while those in the free silt plus clay aggregates （~ 53 ~m） did not vary significantly. However, when separating SOC in particle-size fractions, we found that more stable organic carbon associated with mineral fraction 〈 53 μm （MOM-C） increased significantly by 3.4, 2.2, and 0.7 g kg-1 soil for COM, COMN, and MIN, respectively, over CK, while SOC amount in fine particulate organic matter （POM） fraction （53-250 μm） increased only by 0.3 g kg-1 soil for both COM and COMN, with no difference in coarse POM 〉 250 μm. Therefore, we consider that biowaste compost could be effective in improving soil structure and long-term C sequestration as more stable MOM-C.

关键词： aggregates carbon sequestration mineral-associated organic matter particle-size fraction particulate organic matter,soil structure

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Stratified gas-liquid floweAn analysis of steady state and dynamic simulation for gas-condensate systems

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Petroleum 2019年第2期5卷 128-132页

作者： luigi Raimondi Process Simulation Services Via Piave 1720027 Rescaldina Italy

In the transport of gas-liquid mixtures,where the amount of liquid condensate is low,a stratified flowpattern is predicted by mechanistic two-phase flow *** this case,the momentum balance between liquid and the gas phases is the key relation for the calculation of the steady state flow equilibrium and the existing liquid *** latter value is particularly important at low production rates for pipelines with a large number of upward and downward inclined pipe segments(making V shaped sections)where liquid can easily accumulate in the lower *** error in predicting the liquid inventory has critical consequences on the evaluation of the total pressure drop along the *** results obtained from steady state simulation can be far from reality or,at least,cannot be reproduced by a dynamic simulation of the same operating *** topics are analysed using a multiphase flow simulator developed by the author(XPSIM,eXtended Process SIMulation)which can perform compositional and fluid-mechanical analysis at the same *** state and dynamic simulations are developed for the Ormen-Lange pipeline(about 120 km long):large differences are found between the steady state and dynamic solutions.

关键词： flow dynamic state

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Compact n-Manifolds via(n+l)-Colored Graphs:a New Approach

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Algebra Colloquium 2020年第1期27卷 95-120页

作者： luigi Grasselli Michele Mulazzani Dipartimcnto di Scicnze e Metodi dell'Ingegneria Universita di Modena e Reggio Emilia Via Giovanni Amendola2-Pad.Morselli 42122 Reggio EmiliaItaly Dipartimento di Matematica and ARCES Universita di Bologna Piazza di Porta San Donato 540126 BolognaItaly

We introduce a representation via(n+l)-colored graphs of compact n-manifolds with(possibly empty)boundary,which appears to be very convenient for computer aided study and *** construction is a generalization to arbitrary dimension of the one recently given by Cristofori and Mulazzani in dimension three,and it is dual to the one given by Pezzana in the *** this context we establish some results concerning the topology of the represented manifolds:suspensions,fundamental groups,connected sums and moves between graphs representing the same *** results of compact orientable 4-manifolds representable by graphs up to six vertices are obtained,together with some properties of the G-degree of 5-colored graphs relating this approach to tensor models theory.

关键词： compact manifolds colored graphs fundamental groups dipole moves

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Insights from human sleep research on neural mechanisms of Alzheimer’s disease

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Neural Regeneration Research 2020年第7期15卷 1251-1252页

作者： Susanna Cordone luigi De Gennaro Department of Psychology University of Rome"Sapienza"RomeItaly IRCCS Fondazione Santa Lucia RomeItaly

Alzheimer's disease(AD)is considered as the major cause of dementia and affects about 50 million people in world population,with an expected increase of 27%in the coming decades,as reported by the most recent AD *** fast-growing empirical evidence is highlighting the close relationship between sleep and AD since the preclinical stage of the disease,pointing to an important role of sleep in the occurrence and progression of AD.

关键词： sleep Alzheimer clinical

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Recent advances of versatile reagents as controllable building blocks in organic synthesis

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Chinese Chemical Letters 2024年第2期35卷 24-43页

作者： Shaomin Chen luigi Vaccaro Yanlong Gu Key Laboratory of Material Chemistry for Energy Conversion and Storage Ministry of EducationHubei Key Laboratory of Material Chemistry and Service FailureSchool of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan 430074China Laboratory of Green S.O.C. Dipartimento di ChimicaBiologia e BiotecnologieUniversità degli Studi di PerugiaVia Elce di Sotto 8Perugia 06123Italy School of Chemistry and Chemical Engineering The Key Laboratory for Green Processing of Chemical Engineering of Xinjiang BingtuanShihezi UniversityShihezi 832004China

Diversity-oriented synthesis is a powerful and interesting synthetic tool for the rapid construction of structurally complex and privileged scaffolds from readily accessible starting *** date,diversity-oriented synthesis mostly relies on the employment of versatile *** reagents can be regulated as controllable and flexible building blocks for multipurpose *** the past decade,a variety of multifunctional reagents have been ***,most versatile reagents usually need multi-step synthesis,thus restricting their wide application to a large *** terms of the practicalities and universalities,we prefer to pay more attention to the utilization of simple and practical versatile reagents with multiple reactivities,mainly including atropaldehyde acetals,aryl methyl ketones,vinylene carbonate,vinyl azides,aryldiazonium salts,rongalite,halodifluoromethyl *** importantly,these versatile reagents can also play different roles simultaneously in the same reaction,in which their different reactivities are converged into the final target *** strategy can not only offer more possibilities for the synthesis of several active pharmaceutical ingredients,but also minimize the occurrence of some side reactions by lessening the varieties of ***,a perspective is given at the end of this review.

关键词： Versatile reagents Divergent synthesis Dual synthons Bond cleavage Tandem reactions

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