检索结果-南通市图书馆

Intranasal nerve growth factor for prevention and recovery of the outcomes of traumatic brain injury

Neural Regeneration Research 2023年第4期18卷 773-778页

作者： luigi Manni Giorgio Conti Antonio Chiaretti Marzia Soligo Institute of Translational Pharmacology National Research Council of Italy(CNR)RomeItaly Intensive Pediatric Therapy and Pediatric Trauma Center Department of EmergencyAnesthesiological and Reanimation SciencesFondazione Policlinico Universitario A.Gemelli IRCCSRomeItaly Institute of Pediatrics Department of Woman and Child HealthFondazione Policlinico Universitario A.Gemelli IRCCSRomeItaly

Traumatic brain injury is one of the main causes of mortality and disability *** brain injury is characterized by a primary injury directly induced by the impact,which progresses into a secondary injury that leads to cellular and metabolic damages,starting in the first few hours and days after primary mechanical *** date,traumatic brain injury is not targetable by therapies aimed at preventing and/or limiting the outcomes of secondary damage but only by palliative *** growth factor is a neurotrophin targeting neuronal and non-neuronal cells,potentially useful in preventing/limiting the outcomes of secondary damage in traumatic brain *** potential has further increased in the last two decades since the possibility of reaching neurotrophin targets in the brain through its intranasal delivery has been ***,molecules intranasally delivered to the brain parenchyma may easily bypass the blood-brain barrier and reach their therapeutic targets in the brain,with favorable kinetics,dynamics,and safety *** the first part of this review,we aimed to report the traumatic brain injury-induced dysfunctional mechanisms that may benefit from nerve growth factor *** the second part,we then exposed the experimental evidence relating to the action of nerve growth factor(both in vitro and in vivo,after administration routes other than intranasal)on some of these *** the last part of the work,we,therefore,discussed the few manuscripts that analyze the effects of treatment with nerve growth factor,intranasally delivered to the brain parenchyma,on the outcomes of traumatic brain injury.

关键词： intranasal delivery nerve growth factor pharmacology traumatic brain injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Investigating the role of imprinted genes in pediatric sporadic brain arteriovenous malformations

引用

Neural Regeneration Research 2022年第1期17卷 101-102页

作者： Concetta Scimone luigi Donato Antonina Sidoti Department of Biomedical DentalMorphological and Functional Imaging SciencesUniversity of MessinaMessinaItaly

Arteriovenous malformation AVM is a vascular congenital defect affecting microvasculatu re of both brain and peripheral o rga *** malformation of the brain(bAVM,OMIM#108010),in particular,affects up to 15 per100,000 persons with no sex *** 50%of the patients manifest intracerebral hemorrhage and epileptic seizures,as main clinical symptoms.

关键词： malformation pediatric congenital

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

AFM Measurements and Tip Characterization of Nanoparticles with Different Shapes

引用

Nanomanufacturing and Metrology 2022年第2期5卷 127-138页

作者： Roberto Bellotti Gian Bartolo Picotto luigi Ribotta Istituto Nazionale di Ricerca Metrologica(INRiM) Strada delle Cacce 9110135TorinoItaly Politecnico di Torino Corso Duca degli Abruzzi 2410129TorinoItaly

Unambiguous identification of the measurement methodologies is fundamental to reduce the uncertainty and support traceability of particle shape and size at the nanoscale. In this work, the critical aspects in atomic force microscopy measurements, that is, drawbacks on sample preparation, instrumental parameters, image pre-processing, size reconstruction, and tip enlargement, are discussed in reference to quantitative dimensional measurements on different kinds of nanoparticles (inorganic and biological) with different shapes (spherical, cylindrical, complex geometry). Once the cross-section profile is extracted, top-height measurements on isolated nanoparticles of any shape can be achieved with sub-nanometer accuracy. Lateral resolution is affected by the pixel size and shape of the probe, causing dilation in the atomic force microscopy image. For the reconstruction of critical sizes of inorganic non-spherical nanoparticles, a geometric approach that considers the nominal shape because of the synthesis conditions is presented and discussed.

关键词： Nanoparticles(NPs) Atomic force microscopy(AFM) Size reconstruction Spherical shape Complex shape AFM probe Uncertainty

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Study on carnauba wax as phase-change material integrated in evacuated-tube collector for solar-thermal heat production

引用

Clean Energy 2023年第3期7卷 547-554页

作者： Ruben Bartali MicheleBolognese NicolaFronza LucaPrattico AlbertoZanetti TiagoOsorio luigi Crema Fondazione Bruno Kessler Centre on Sustainable EnergyVia Sommarive 1838123 TrentoItaly University ofÉvora-Renewable Energies Chair Palácio VimiosoLargo Marquês de Marialva7002-554ÉvoraPortugal

The evacuated-tube collector(ETC)for solar heat production is one of the most efficient systems to convert Sun energy into usable ***,some technological barriers are still present in solar-thermal heat systems that limit the use of these technologies to decarbonize *** important obstacle is the requirement for heat at stable temperatures,which is not always achievable by solar fields,*** *** that reason,in this work,we studied the phase-change materials embedded in the ETC to keep stable the water temperature for a short period(minutes,hours).In this study,carnauba wax was used as a sustainable phase-change material(PCM),to avoid the use of PCM based on hydrocarbon *** PCM has been packaged using a polyethylene bag inserted into an ETC with heat-pipe technologies and *** collector has been tested outdoors under solar irradiation and under shading *** experimental results show that is possible to detect a sensible effect of the PCM on the temperature using 4 kg of carnauba wax while there is an important effect on the temperature stabilization using 9 kg of *** 9 kg of the PCM,we observed a stability of the outlet water temperature at 65°C for 30 minutes under shading conditions.

关键词： energy storage carnauba wax ETC solar collector solar heat PCM

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Vibro-acoustic characteristics of multifunctional carbon fiber reinforced panel

引用

Defence Technology（防务技术） 2023年第6期24卷 129-139页

作者： Liberata Guadagno Marialuigia Raimondo luigi Vertuccio Giuseppina Barra Maurizio Arena Massimo Viscardi Department of Industrial Engineering University of SalernoVia Giovanni Paolo II13284084FiscianoSAItaly Department of Engineering University of Campania“Luigi Vanvitelli”Via Roma 29I-81031AversaItaly Department of Industrial Engineering Aerospace SectionUniversity of Naples“Federico Ⅱ”Via Claudio 2180125NaplesItaly

This paper deals with the assessment of vibro-acoustic properties of a multifunctional carbon fiber reinfo rced panel manu factured by bulk infu sion,a modified resin film infusion *** components of the epoxy resin were chosen to contrast the electrical insulating property and poor flame resistance of the epoxy resins impregnating carbon woven *** confer electrical conductivity to the resin a percentage of 0.5 wt%of Multi-Wall Carbon Nanotubes(MWCNTs)was dispersed in the resin,whereas to increase flame resistance a percentage of 5 wt%of Glycidil Polyhedral Oligomeric Silsesquioxanes(GPOSS)was solubilized in the epoxy ***,as hardener agents,a mixture of 4,4’-DiaminoDiphenyl Sulfone(DDS)(53.4 wt%)and Bis(3-Aminophenyl)Methyl Phosphine Oxide(BAMPO)(46.7 wt%)was *** values of the electrical conductivity were found satisfactory enough,being4.02×10^(-2)S/m for the multifunctional resin and 1.39×10^(4)S/m for the in-plane conductivity of the panel,whereas the Limiting Oxygen Index(LOI)value of the multifunctional resin was found to increase from 27%to 36%.Considering these promising results,an experimental assessment of the vibro-acoustic properties of the manufactured multifunctional panel was also *** panel was tested mainly to evaluate its low-frequency vibration damping and sound insulation *** manufactured panel demonstrated an improved efficiency if compared to a baseline configuration,presenting almost the double modal damping and a gain of 10 dB on the global noise reduction.

关键词： Composite materials Electrical properties Damping Tunneling atomic force microscopy(TUNA) Vibro-acoustic properties

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Stable Methylammonium-Free p-i-n Perovskite Solar Cells and Mini-Modules with Phenothiazine Dimers as Hole-Transporting Materials

引用

能源与环境材料（英文） 2023年第6期6卷 383-392页

作者： luigi Angelo Castriotta Rossella Infantino luigi Vesce Maurizio Stefanelli Alessio Dessì Carmen Coppola Massimo Calamante Gianna Reginato Alessandro Mordini Adalgisa Sinicropi Aldo Di Carlo Lorenzo Zani Carlo Centre for Hybrid and Organic Solar Energy(C.H.O.S.E.) Department of Electronic EngineeringUniversity of Rome Tor Vergata00133 RomeItaly Institute of Chemistry of Organometallic Compounds(CNR-ICCOM Via Madonna del Piano 1050019 Sesto FiorentinoItaly Department of Biotechnology Chemistry and PharmacyUniversity of SienaVia Aldo Moro 253100 SienaItaly Institute of Chemistry of Organometallic Compounds(CNR-ICCOM Via Madonna del Piano 1050019 Sesto FiorentinoItaly Department of Biotechnology Chemistry and PharmacyUniversity of SienaVia Aldo Moro 253100 SienaItaly Dr.C.Coppola Prof.A.Sinicropi CSGIConsorzio per lo Sviluppo dei Sistemi a Grande InterfaseVia della Lastruccia 350019 Sesto FiorentinoItaly Institute of Chemistry of Organometallic Compounds(CNR-ICCOM Via Madonna del Piano 1050019 Sesto FiorentinoItaly Department of Chemistry"U.Schiff' University of FlorenceVia della Lastruccia 1350019 Sesto FiorentinoItaly Institute of Chemistry of Organometallic Compounds(CNR-ICCOM Via Madonna del Piano 1050019 Sesto FiorentinoItaly Department of Biotechnology Chemistry and PharmacyUniversity of SienaVia Aldo Moro 253100 SienaItaly Dr.C.Coppola Prof.A.Sinicropi CSGIConsorzio per lo Sviluppo dei Sistemi a Grande InterfaseVia della Lastruccia 350019 Sesto FiorentinoItaly Carlo Centre for Hybrid and Organic Solar Energy(C.H.O.S.E.) Department of Electronic EngineeringUniversity of Rome Tor Vergata00133 RomeItaly Institute of Structure of Matter(CNR-ISM) Via del Fosso del Cavaliere 10000133 RomeItaly

During the last decade,perovskite solar technologies underwent an impressive development,with power conversion efficiencies reaching 25.5％for single-junction devices and 29.8％for Silicon-Perovskite tandem *** though research mainly focused on improving the efficiency of perovskite photovoltaics(PV),stability and scalability remain fundamental aspects of a mature photovoltaics *** n-i-p structure perovskite solar cells,using poly-triaryl(amine)(PTAA)as hole transport layer(HTL)allowed to achieve marked improvements in device stability compared with other common hole *** p-i-n structure,poly-triaryl(amine)is also routinely used as dopant-free hole transport layer,but problems in perovskite film growth,and its limited resistance to stress and imperfect batch-to-batch reproducibility,hamper its use for device *** previous computational investigations,in this work,we report the synthesis of two small-molecule organic hole transport layers(BPT-1,2),aiming to solve the above-mentioned issues and allow upscale to the module *** using BPT-1 and methylammonium-free perovskite,*** conversion efficiencies of 17.26％and 15.42％on a small area(0.09 cm2)and mini-module size(2.25 cm2),respectively,were obtained,with a better reproducibility than with poly-triaryl(amine).Moreover,BPT-1 was demonstrated to yield more stable devices compared with poly-triaryl(amine)under ISOS-D1,T1,and L1 accelerated life-test protocols,reaching maximum T90 values＞1000 h on all tests.

关键词： methylammonium-free perovskite mini-modules organic hole-transporting layers perovskite solar cells stability studies

来源：评论

学校读者我要写书评

暂无评论

Effects of particle size and content of RDX on burning stability of RDXbased propellants

引用

Defence Technology（防务技术） 2022年第7期18卷 1247-1256页

作者： Bin-bin Wang Xin Liao luigi T.DeLuca Wei-dong He School of Chemical Engineering Nanjing University of Science and TechnologyNanjing210094China Key Laboratory of Special Energy Materials Ministry of EducationNanjing210094China SPLab Department of Aerospace EngineeringPolitecnico di Milano(RET)MilanI-20156Italy

Particle size and content of RDX are the two main factors that affect the burning stability of RDX-based propellants. However, these effects and the corresponding mechanisms are still controversial. In this work, we investigated the physicochemical processes during burning and the corresponding mechanisms through the technologies of structure compactness analysis on the base of voidage measurement and theoretical interfacial area estimation, apparent burning rate measurement using closed vessel(CV)and extinguished burning surface characterization relying on interrupted closed vessel(ICV) and scanning electron microscope(SEM). The results indicate that the voidage increased with the increase of RDX content and particle size due to the increasing interfacial area and increasing interface gap size,respectively. The apparent burning rate increased with the increase of RDX particle size because of the decreasing RDX specific surface area on the burning surface, which could decrease the heat absorbing rates of the melting and evaporation processes of RDX in the condensed phase. Similarly, the apparent burning rate decreased with the increase of RDX content at pressures lower than around 55 MPa due to the increasing RDX specific surface area. Whereas, an opposite trend could be observed at pressures higher than around 55 MPa, which was attributed to the increasing heat feedback from the gas phase as the result of the increasing propellant energy. For propellants containing very coarse RDX particles, such as 97.8 and 199.4 μm average size, the apparent burning rate increased stably with a flat extinguished surface at pressures lower than around 30 MPa, while increased sharply above around 30 MPa with the extinguished surface becoming more and more rugged as the pressure increased. In addition, the turning degree of u-p curve increased with the increase of coarse RDX content and particle size, and could be reduced by improving the structure compactness.

关键词： RDX particle Size and content Structure compactness Apparent burning rate Extinguished surface Burning stability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Simulation of Urban Land Expansion Under Ecological Constraints in Harbin-Changchun Urban Agglomeration,China

引用

Chinese Geographical Science 2022年第3期32卷 438-455页

作者： GUO Rong WU Tong WU Xiaochen luigi Stendardo WANG Yueqin Key Laboratory of Cold Region Urban and Rural Human Settlement Environment Science and Technology Ministry of Industry and Information Technology/School of ArchitectureHarbin Institute of TechnologyHarbin 150006China Department of Civil Architectural and Environmental EngineeringPadova UniversityPadova 35131Italy School of Economics and Management Northeast Forestry UniversityHarbin 150040China

Under the demand of urban expansion and the constraints of China’s’National Main Functional Area Planning’policy,urban agglomerations are facing with a huge contradiction between land utilization and ecological protection,especially for HarbinChangchun urban agglomeration who owns a large number of land used for the protection of agricultural production and ecological *** alleviate this contradiction and provide insight into future land use patterns under different ecological constraints’scenarios,we introduced the patch-based land use simulation(PLUS)model and simulated urban expansion of the Harbin-Changchun urban *** verifying the accuracy of the simulation result in 2018,we predicted future urban expansion under the constraints of three different ecological scenarios in *** morphological spatial pattern analysis(MSPA)method and minimum cumulative resistance(MCR)model were also introduced to identify different levels of ecological security pattern(ESP)as ecological *** predicted result of the optimal protection(OP)scenario showed less proportion of water and forest than those of natural expansion(NE)and basic protection(BP)scenarios in *** conclusions are that the PLUS model can improve the simulation accuracy at urban agglomeration scale compared with other cellular automata(CA)models,and the future urban expansion under OP scenario has the least threat to the ecosystem,while the expansion under the natural expansion(NE)scenario poses the greatest threat to the *** with the MSPA and MCR methods,PLUS model can also be used in other spatial simulations of urban agglomerations under ecological constraints.

关键词： urban land expansion patch-based land use simulation(PLUS)model Harbin-Changchun urban agglomeration scenario simulation ecological constraints China

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Burning rate analysis of laser controlled 5-aminotetrazole propellant

引用

Defence Technology（防务技术） 2023年第4期22卷 10-27页

作者： Nianbai He Ruiqi Shen luigi T.DeLuca Lizhi Wu Wei Zhang Yinghua Ye School of Chemical Engineering Nanjing University of Science and Technology210094JiangsuChina Institute of Space Propulsion Nanjing University of Science and Technology210094JiangsuChina Space Propulsion Laboratory(Ret) Department of Aerospace Science and TechnologyPolitecnico di Milano20156MilanItaly

As an innovative propulsion technique, laser augmented chemical propulsion(LACP) seems superior to the traditional ones. However, the corresponding combustion theories have still to be ascertained for LACP. Burning rate of 5-aminotetrazole(5-ATZ) propellant has been studied by testing pressed samples under different combustor pressures and laser powers. Based on micro computed tomography(Micro CT),an advanced thickness-over-time(TOT) method to characterize the regression of the produced nonplanar burning surface is established. Because of a shell structure covering the combustion surface,the burning rate of the implemented 5-ATZ propellant is not constant during laser ablation. Resorting to functional fitting, a new law of non-constant burning including the effect of the observed unique burning surface structures is proposed. Accordingly, applicable combustion conditions of 5-ATZ based propellants have been preliminarily speculated for future research activities.

关键词： 5-Aminotetrazole(5-ATZ) Laser-augmented chemical propulsion(LACP) Non-constant burning rate Micro computed tomography(MicroCT) Non-planar burning surface

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Transperineal laser ablation of the prostate as a treatment for benign prostatic hyperplasia and prostate cancer: The results of a Delphi consensus project

引用

Asian Journal of Urology 2024年第2期11卷 271-279页

作者： Andrea Cocci Marta Pezzoli Fernando Bianco Franco Blefari Pierluigi Bove Francois Cornud Gaetano De Rienzo Paolo Destefanis Danilo Di Trapani Alessandro Giacobbe Luca Giovanessi Antonino Laganà Giovanni Lughezzani Guglielmo Manenti Gianluca Muto Gianluigi Patelli Novello Pinzi Stefano Regusci Giorgio I.Russo Juan I.M.Salamanca Matteo Salvi luigi Silvestri Fabrizio Verweij Eric Walser Riccardo GBertolo Valerio Iacovelli Alessandro Bertaccini Debora Marchiori Hugo Davila Pasquale Ditonno Paolo Gontero Gennaro Iapicca Theo M De Reijke Vito Ricapito Pierluca Pellegrini Andrea Minervini Sergio Serni Francesco Sessa Department of Urology Careggi HospitalUniversity of FlorenceFlorenceItaly Urology Section University of FlorenceFlorenceItaly Urological Research Network MiamiFLUSA Urology Section Prato HospitalPratoItaly Torvergata Oncoscience Research Centre of Excellence TORDepartment of Experimental MedicineUniversity of Rome Tor VergataRomeItaly Department of Urology San Carlo di Nancy HospitalRomeItaly Department of Radiology Hôpital CochinParis Descartes UniversityParisFrance Urology and Andrology Unit II Department of Emergency and Organ TransplantationUniversity of BariBariItaly Unit of Urology Cittàdella Salute e della Scienza HospitalUniversity of TurinTurinItaly Urology Unit Buccheri La Ferla Fatebenefratelli HospitalPalermoItaly Department of Urology Humanitas Gradenigo HospitalTurinItaly Urology Unit Surgical DepartmentFondazione Poliambulanza Istituto OspedalieroBresciaItaly Departement of Urology “S.Giovanni Evangelista”HospitalTivoliItaly Humanitas Clinical and Research CentereIRCCS Department of UrologyRozzanoItaly Department of Biomedical Sciences Humanitas UniversityPieve EmanueleItaly Department of Biomedicine and Prevention University of Rome“Tor Vergata”RomeItaly Department of Diagnostic Imaging and Interventional Radiology University of Rome“Tor Vergata”RomeItaly Department of Interventional Radiology Pesenti-Fenaroli Hospital-ASST Bergamo EstAlzano LombardoItaly Department of Urology University of SienaSienaItaly Swiss International Prostate Center GenevaSwitzerland Clinique Générale Beaulieu GenevaSwitzerland Department of Urology University of CataniaItaly Department of Urology Puerta de Hierro-Majadahonda University HospitalMadridSpain Lyx Institute of Urology Universidad Francisco de VitoriaMadridSpain Department of Medico-Surgical Sciences and Biotechnologies Sapienza University of RomeFaculty of Pharmacy and MedicineUrology Unit ICOTLatinaItaly Department of Urology European Institute of Oncology(IEO)IRCCSMilanItaly Department of Radiology D

Objective: To evaluate transperineal laser ablation (TPLA) with Echolaser® (Echolaser® TPLA, Elesta S.p.A., Calenzano, Italy) as a treatment for benign prostatic hyperplasia (BPH) and prostate cancer (PCa) using the Delphi consensus ***: Italian and international experts on BPH and PCa participated in a collaborative consensus project. During two rounds, they expressed their opinions on Echolaser® TPLA for the treatment of BPH and PCa answering online questionnaires on indications, methodology, and potential complications of this technology. Level of agreement or disagreement to reach consensus was set at 75%. If the consensus was not achieved, questions were modified after each round. A final round was performed during an online meeting, in which results were discussed and ***: Thirty-two out of forty invited experts participated and consensus was reached on all topics. Agreement was achieved on recommending Echolaser® TPLA as a treatment of BPH in patients with ample range of prostate volume, from 80 mL (80%), comorbidities (100%), antiplatelet or anticoagulant treatment (96%), indwelling catheter (77%), and strong will of preserving ejaculatory function (100%). Majority of respondents agreed that Echolaser® TPLA is a potential option for the treatment of localized PCa (78%) and recommended it for low-risk PCa (90%). During the final round, experts concluded that it can be used for intermediate-risk PCa and it should be proposed as an effective alternative to radical prostatectomy for patients with strong will of avoiding urinary incontinence and sexual dysfunction. Almost all participants agreed that the transperineal approach of this organ-sparing technique is safer than transrectal and transurethral approaches typical of other techniques (97% of agreement among experts). Pre-procedural assessment, technical aspects, post-procedural catheterization, pharmacological therapy, and expected outcomes were discussed, leading t

关键词： Transperineal laser ablation Prostatecancer Benignprostatic hyperplasia Delphi consensus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：